Rattus norvegicus

90 known processes

Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

(Aliases: Ncx3)

Slc8a3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550854120.875
cation transportGO:00068123820.818
inorganic cation transmembrane transportGO:00986622020.777
ion transmembrane transportGO:00342203650.711
neurological system processGO:00508772190.685
cation transmembrane transportGO:00986552630.677
metal ion transportGO:00300012890.608
synaptic transmissionGO:00072682350.517
positive regulation of cell motilityGO:2000147970.501
Rat
regulation of ion transmembrane transportGO:00347651210.447
action potentialGO:0001508540.411
regulation of synaptic transmissionGO:00508041410.410
inorganic ion transmembrane transportGO:00986602290.396
homeostatic processGO:00425923310.393
feeding behaviorGO:0007631530.381
leukocyte activationGO:0045321760.345
regulation of membrane potentialGO:00423911100.338
immune system processGO:00023762040.328
chemical homeostasisGO:00488782920.326
cell cell signalingGO:00072673350.311
transmission of nerve impulseGO:0019226420.308
macromolecular complex subunit organizationGO:00439333390.304
response to estradiolGO:00323551640.303
response to woundingGO:00096112540.297
monovalent inorganic cation transportGO:00156721720.290
response to inorganic substanceGO:00100353770.287
Rat
sodium ion transportGO:0006814820.285
positive regulation of secretionGO:00510471400.273
secretion by cellGO:00329402480.261
protein complex subunit organizationGO:00718223020.249
regulation of cell activationGO:0050865500.248
nitrogen compound transportGO:00717052290.247
multicellular organismal signalingGO:0035637440.228
Rat
cellular response to glucocorticoid stimulusGO:0071385680.227
sensory perception of painGO:0019233730.226
regulation of smooth muscle cell proliferationGO:0048660750.224
positive regulation of transportGO:00510502450.224
response to external biotic stimulusGO:00432072210.222
response to ethanolGO:00454711620.217
hormone transportGO:00099141210.215
positive regulation of developmental processGO:00510942830.213
positive regulation of signalingGO:00230562700.213
cellular response to endogenous stimulusGO:00714953770.213
intracellular signal transductionGO:00355563140.212
Rat
neuropeptide signaling pathwayGO:0007218290.210
single organism reproductive processGO:00447022970.207
negative regulation of cell proliferationGO:00082851190.206
localization of cellGO:00516742020.201
Rat
cellular ion homeostasisGO:00068731840.201
sensory perceptionGO:00076001010.199
regulation of saliva secretionGO:004687730.196
regulation of hormone levelsGO:00108171870.192
response to other organismGO:00517072200.190
ion homeostasisGO:00508012120.184
phasic smooth muscle contractionGO:001482130.184
cellular component assemblyGO:00226073600.183
muscle cell proliferationGO:0033002840.183
regulation of secretionGO:00510462240.180
smooth muscle cell proliferationGO:0048659770.175
cellular component biogenesisGO:00440853680.174
positive regulation of synaptic transmissionGO:0050806620.172
locomotionGO:00400112370.169
Rat
cellular metal ion homeostasisGO:00068751720.168
saliva secretionGO:004654130.168
organelle organizationGO:00069962660.168
regulation of cell proliferationGO:00421273590.166
positive regulation of response to stimulusGO:00485842850.165
cellular component movementGO:00069282480.162
Rat
neuron neuron synaptic transmissionGO:0007270600.160
immune responseGO:00069551040.158
response to ammonium ionGO:0060359710.155
cellular response to hormone stimulusGO:00328702470.153
organic hydroxy compound metabolic processGO:19016151150.150
regulation of cellular component movementGO:00512701500.149
Rat
neuronal action potentialGO:0019228350.147
regulation of metal ion transportGO:00109591180.142
Rat
positive regulation of cell communicationGO:00106472710.134
defecationGO:003042110.134
lymphocyte activationGO:0046649430.133
regulation of secretion by cellGO:19035302080.133
protein heterooligomerizationGO:0051291890.132
cell migrationGO:00164771970.132
Rat
developmental growthGO:00485891000.130
anion transportGO:00068201780.128
cellular response to nitrogen compoundGO:19016992100.128
positive regulation of cell migrationGO:0030335960.127
Rat
response to cocaineGO:0042220390.125
regulation of programmed cell deathGO:00430673410.122
inflammatory responseGO:00069541500.122
response to lipopolysaccharideGO:00324961910.121
positive regulation of signal transductionGO:00099671750.120
behaviorGO:00076102050.117
protein complex assemblyGO:00064612630.116
positive regulation of locomotionGO:00400171020.115
Rat
regulation of locomotionGO:00400121480.114
Rat
regulation of blood circulationGO:19035221100.113
Rat
organic anion transportGO:00157111320.113
synaptic transmission gabaergicGO:0051932220.112
regulation of cell motilityGO:20001451310.112
Rat
regulation of calcium ion transportGO:0051924770.110
Rat
cellular chemical homeostasisGO:00550822470.109
regulation of hormone secretionGO:00468831060.106
hormone secretionGO:00468791150.105
synaptic transmission glutamatergicGO:0035249330.105
positive regulation of secretion by cellGO:19035321280.099
regulation of ion transportGO:00432692450.098
Rat
regulation of epithelial cell proliferationGO:0050678490.097
cellular homeostasisGO:00197252520.097
cardiovascular system developmentGO:00723581340.097
cellular response to organonitrogen compoundGO:00714171970.097
secretionGO:00469033070.096
positive regulation of cellular component movementGO:00512721020.095
Rat
signal releaseGO:00230611450.095
erk1 and erk2 cascadeGO:0070371480.094
anatomical structure morphogenesisGO:00096532980.094
macromolecular complex assemblyGO:00650032730.091
cation homeostasisGO:00550801950.091
regulation of signal transductionGO:00099663180.090
axon ensheathmentGO:0008366400.089
ensheathment of neuronsGO:0007272400.089
peristalsisGO:003043220.089
positive regulation of hormone secretionGO:0046887650.088
regulation of leukocyte activationGO:0002694450.088
negative regulation of cell deathGO:00605482290.088
regulation of cell migrationGO:00303341280.088
Rat
myelinationGO:0042552390.087
positive regulation of serotonin secretionGO:001406410.087
axonogenesisGO:0007409710.086
positive regulation of immune system processGO:0002684900.085
lymphocyte proliferationGO:0046651290.084
cellular response to corticosteroid stimulusGO:0071384690.083
cell activationGO:0001775970.083
regulation of transmembrane transportGO:00347621220.081
multicellular organism reproductionGO:00325042330.080
oxoacid metabolic processGO:00434362900.080
divalent inorganic cation homeostasisGO:00725071650.080
cellular divalent inorganic cation homeostasisGO:00725031620.080
response to molecule of bacterial originGO:00022371940.079
sexual reproductionGO:00199531480.079
regulation of peptide hormone secretionGO:0090276800.077
protein oligomerizationGO:00512591910.077
response to bacteriumGO:00096172000.076
regulation of peptide secretionGO:0002791820.075
peptide secretionGO:0002790860.075
cellular cation homeostasisGO:00300031800.074
organophosphate biosynthetic processGO:00904071430.074
regulation of anatomical structure morphogenesisGO:00226031410.073
regulation of apoptotic processGO:00429813350.073
anion transmembrane transportGO:0098656770.072
positive regulation of cellular component organizationGO:00511302000.072
regulation of multicellular organismal developmentGO:20000263760.070
regulation of immune system processGO:00026821230.070
epithelial cell proliferationGO:0050673540.070
response to estrogenGO:00436272320.069
somatostatin receptor signaling pathwayGO:003816940.069
regulation of defecationGO:200029210.069
multicellular organismal reproductive processGO:00486092330.067
response to metal ionGO:00100382530.066
agingGO:00075682410.066
protein localizationGO:00081041910.066
regulation of axonogenesisGO:0050770370.066
positive regulation of phosphate metabolic processGO:00459372620.065
positive regulation of peptide secretionGO:0002793520.065
regulation of feeding behaviorGO:0060259140.065
amide transportGO:00428861050.064
reproductive processGO:00224143720.064
positive regulation of multicellular organismal processGO:00512403870.064
angiogenesisGO:0001525530.063
chemotaxisGO:0006935660.062
metal ion homeostasisGO:00550651860.062
response to biotic stimulusGO:00096072260.062
response to corticosteroidGO:00319602350.061
memoryGO:0007613540.061
urinary tract smooth muscle contractionGO:001484840.061
amine transportGO:0015837570.061
blood vessel morphogenesisGO:0048514580.060
adult behaviorGO:0030534160.060
negative regulation of calcium ion importGO:009028120.060
regulation of growthGO:00400081050.059
regulation of peptide transportGO:0090087870.059
neuron differentiationGO:00301823680.059
positive regulation of cytoskeleton organizationGO:0051495260.059
peptide transportGO:0015833970.059
enzyme linked receptor protein signaling pathwayGO:00071671160.058
response to acid chemicalGO:00011012220.057
response to glucocorticoidGO:00513842230.057
cellular response to organic cyclic compoundGO:00714072020.057
negative regulation of apoptotic processGO:00430661810.057
regulation of action potentialGO:0098900140.057
response to peptide hormoneGO:00434342780.057
divalent inorganic cation transportGO:00725111340.057
rhythmic processGO:00485111560.057
regulation of cell differentiationGO:00455953200.056
nucleic acid templated transcriptionGO:00976593790.056
regulation of synaptic transmission glutamatergicGO:0051966260.055
macromolecule localizationGO:00330362520.055
protein complex biogenesisGO:00702712630.055
response to mechanical stimulusGO:00096121340.054
amino acid transportGO:0006865700.054
regulation of cellular amine metabolic processGO:003323880.054
regulation of ion transmembrane transporter activityGO:0032412480.053
exploration behaviorGO:003564010.053
regenerationGO:00310991630.053
regulation of synaptic plasticityGO:0048167700.052
negative regulation of signalingGO:00230571570.052
response to oxygen levelsGO:00704822650.052
Rat
regulation of intracellular signal transductionGO:19025312180.051
positive regulation of saliva secretionGO:004687830.051
synaptic transmission glycinergicGO:006001220.050
response to decreased oxygen levelsGO:00362932370.050
Rat
cell morphogenesisGO:00009021420.050
muscle system processGO:00030121150.050
Rat
cytoskeleton organizationGO:00070101110.049
growthGO:00400071650.049
regulation of cellular localizationGO:00603412630.049
Rat
brain developmentGO:00074202470.048
regulation of anatomical structure sizeGO:00900661350.048
cellular response to oxygen containing compoundGO:19017013860.046
g protein coupled receptor signaling pathwayGO:00071862420.046
peptidyl tyrosine phosphorylationGO:0018108720.046
ribose phosphate biosynthetic processGO:0046390870.045
ovulation cycleGO:0042698670.045
organ regenerationGO:00311001010.045
digestive system processGO:0022600240.044
peptide hormone secretionGO:0030072840.044
negative regulation of synaptic transmissionGO:0050805290.044
positive regulation of smooth muscle cell proliferationGO:0048661510.044
positive regulation of nitrogen compound metabolic processGO:00511733340.044
negative regulation of defecationGO:200029310.043
exocytosisGO:0006887600.043
negative regulation of transportGO:00510511360.043
blood vessel developmentGO:0001568690.043
organophosphate metabolic processGO:00196373700.043
transcription from rna polymerase ii promoterGO:00063662520.042
regulation of homeostatic processGO:00328441010.042
Rat
positive regulation of response to external stimulusGO:0032103510.042
ovulation cycle processGO:0022602500.041
insulin secretionGO:0030073690.041
acute inflammatory responseGO:0002526580.041
positive regulation of neuron projection developmentGO:0010976990.040
synaptic transmission cholinergicGO:0007271110.040
actin filament based processGO:0030029860.040
cellular ketone metabolic processGO:0042180510.040
angiotensin mediated drinking behaviorGO:000305120.040
single organism membrane organizationGO:0044802740.040
regulation of response to external stimulusGO:00321011060.040
alcohol metabolic processGO:0006066770.039
positive regulation of action potentialGO:004576080.039
micturitionGO:006007340.039
positive regulation of neurogenesisGO:00507691650.039
regulation of amine transportGO:0051952540.039
heart processGO:0003015570.039
Rat
regulation of hydrolase activityGO:00513361430.038
biological adhesionGO:00226101100.038
regulation of angiogenesisGO:0045765390.038
organic acid transportGO:00158491160.038
nucleotide metabolic processGO:00091172790.038
regulation of cell developmentGO:00602842630.037
cellular macromolecule localizationGO:00707271220.037
neuron projection developmentGO:00311752730.037
single organism organelle organizationGO:19025891800.037
cell growthGO:00160491040.037
negative regulation of response to external stimulusGO:0032102370.037
vesicle mediated transportGO:00161921810.037
cellular response to stressGO:00335542690.036
Rat
cell projection morphogenesisGO:00488581230.036
response to extracellular stimulusGO:00099913800.036
Rat
regulation of system processGO:00440572080.036
Rat
cell adhesionGO:00071551100.035
apoptotic processGO:00069153810.035
epithelium developmentGO:0060429960.035
response to nicotineGO:0035094510.035
response to ketoneGO:19016541820.035
tissue developmentGO:00098882520.035
purine nucleotide metabolic processGO:00061632290.035
amine metabolic processGO:0009308380.034
regulation of cellular component organizationGO:00511283680.034
monocarboxylic acid transportGO:0015718520.034
regulation of neurogenesisGO:00507672470.034
regulation of neuron deathGO:19012141150.034
potassium ion transportGO:0006813970.034
response to hypoxiaGO:00016662310.034
Rat
divalent metal ion transportGO:00708381320.034
central nervous system developmentGO:00074173110.034
positive regulation of protein metabolic processGO:00512471780.033
cellular amine metabolic processGO:0044106380.033
amino acid transmembrane transportGO:0003333330.033
calcium ion importGO:0070509220.033
carboxylic acid transportGO:00469421150.033
regulation of nervous system developmentGO:00519602640.032
digestionGO:0007586260.032
membrane organizationGO:0061024940.032
positive regulation of peptide hormone secretionGO:0090277500.032
carbohydrate derivative biosynthetic processGO:19011371240.032
cellular component morphogenesisGO:00329891550.032
organic acid metabolic processGO:00060822920.032
regulation of phosphate metabolic processGO:00192203490.032
negative regulation of response to stimulusGO:00485851550.031
dopamine transportGO:0015872180.031
organic hydroxy compound biosynthetic processGO:1901617510.031
regulation of nucleotide biosynthetic processGO:0030808470.031
actin cytoskeleton organizationGO:0030036730.031
negative regulation of cell communicationGO:00106481580.030
positive regulation of cell deathGO:00109421840.030
actin filament organizationGO:0007015420.030
positive regulation of cell differentiationGO:00455972170.030
cognitionGO:0050890920.030
regulation of insulin secretionGO:0050796650.030
positive regulation of rna biosynthetic processGO:19026801970.030
regulation of cellular ketone metabolic processGO:0010565270.030
reproductionGO:00000032450.030
catabolic processGO:00090563510.030
carbohydrate derivative metabolic processGO:19011353460.029
cell morphogenesis involved in neuron differentiationGO:00486671060.029
cellular protein localizationGO:00346131220.029
purine nucleotide biosynthetic processGO:0006164830.029
regulation of defense responseGO:0031347680.029
positive regulation of nervous system developmentGO:00519621780.029
cellular amino acid metabolic processGO:00065201070.029
regulation of neuron differentiationGO:00456642080.029
neuron developmentGO:00486662860.029
calcium ion homeostasisGO:00550741620.029
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.029
smooth muscle cell migrationGO:0014909360.028
cellular calcium ion homeostasisGO:00068741600.028
learning or memoryGO:0007611900.028
second messenger mediated signalingGO:0019932510.028
Rat
muscle contractionGO:0006936880.028
Rat
cellular response to ammonium ionGO:0071242170.028
regulation of cellular amino acid metabolic processGO:000652120.028
programmed cell deathGO:00125013920.028
positive regulation of intracellular signal transductionGO:19025331380.028
motor neuron axon guidanceGO:000804510.027
positive regulation of neuron differentiationGO:00456661260.027
negative regulation of secretion by cellGO:1903531720.027
positive regulation of phosphorus metabolic processGO:00105622620.027
heart contractionGO:0060047570.027
Rat
regulation of leukocyte mediated immunityGO:0002703190.027
phototransduction visible lightGO:000760320.026
response to peptideGO:19016522920.026
response to growth factorGO:00708481890.026
forebrain developmentGO:0030900980.026
ossificationGO:0001503700.026
single organism cellular localizationGO:19025801020.026
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.026
hormone mediated signaling pathwayGO:0009755230.026
positive regulation of synaptic transmission glutamatergicGO:0051968130.026
potassium ion transmembrane transportGO:0071805710.025
cyclic nucleotide biosynthetic processGO:0009190630.025
behavioral response to nicotineGO:003509520.025
anatomical structure formation involved in morphogenesisGO:0048646830.025
defense responseGO:00069521940.025
positive regulation of immune responseGO:0050778420.025
hormone metabolic processGO:0042445690.025
regulation of behaviorGO:0050795610.025
mapk cascadeGO:00001651400.025
negative regulation of programmed cell deathGO:00430691830.025
single organism intracellular transportGO:19025821660.025
positive regulation of nucleotide metabolic processGO:0045981910.025
cellular response to peptide hormone stimulusGO:00713751200.025
positive regulation of exocytosisGO:0045921190.025
blood circulationGO:00080151830.024
Rat
embryonic skeletal system developmentGO:004870630.024
regulation of molecular functionGO:00650093980.024
cellular potassium ion transportGO:0071804720.024
alcohol biosynthetic processGO:0046165380.024
glutamate receptor signaling pathwayGO:0007215430.024
response to alkaloidGO:00432791320.024
positive regulation of defense responseGO:0031349370.024
regulation of immune responseGO:0050776550.024
axon developmentGO:0061564960.024
negative regulation of synaptic transmission gabaergicGO:003222960.024
response to monosaccharideGO:00342841590.023
Rat
epithelial cell migrationGO:0010631190.023
circulatory system processGO:00030131830.023
Rat
behavioral response to painGO:004826650.023
ribonucleotide metabolic processGO:00092592310.023
purine containing compound biosynthetic processGO:0072522850.023
serotonin receptor signaling pathwayGO:0007210100.023
cellular response to drugGO:0035690300.023
regulation of phosphorus metabolic processGO:00511743490.023
calcium ion transportGO:00068161310.023
negative regulation of ion transportGO:0043271510.023
vitamin transportGO:0051180140.023
cell motilityGO:00488702020.023
Rat
gliogenesisGO:0042063930.023
negative regulation of developmental processGO:00510931250.022
neuronal ion channel clusteringGO:004516130.022
regulation of nucleotide metabolic processGO:00061401170.022
neuron deathGO:00709971270.022
response to dexamethasoneGO:0071548490.022
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.022
actin filament bundle organizationGO:0061572190.022
reproductive structure developmentGO:00486081280.022
positive regulation of nucleobase containing compound metabolic processGO:00459353190.022
negative regulation of neuron differentiationGO:0045665620.022
response to nutrientGO:00075842480.022
Rat
adenylate cyclase inhibiting opioid receptor signaling pathwayGO:003163520.022
positive regulation of insulin secretionGO:0032024360.022
single organism behaviorGO:00447081300.021
urinary bladder smooth muscle contractionGO:001483240.021
sodium ion transmembrane transportGO:0035725670.021
lipid metabolic processGO:00066292830.021
cell projection organizationGO:00300303020.021
vascular process in circulatory systemGO:0003018960.021
positive regulation of ion transportGO:0043270940.021
muscle tissue developmentGO:0060537580.021
positive regulation of cell activationGO:0050867340.021
brain renin angiotensin systemGO:000203530.021
small molecule biosynthetic processGO:00442831240.021
regulation of purine nucleotide metabolic processGO:19005421150.021
nucleoside phosphate biosynthetic processGO:19012931020.021
regulation of transporter activityGO:0032409500.021
immune effector processGO:0002252530.021
regulation of cell projection organizationGO:00313441750.021
response to retinoic acidGO:0032526630.021
excretionGO:0007588240.021
regulation of phosphorylationGO:00423252480.020
regulation of erk1 and erk2 cascadeGO:0070372410.020
regulation of heart contractionGO:0008016480.020
Rat
positive regulation of molecular functionGO:00440932300.020
liver developmentGO:0001889900.020
response to nutrient levelsGO:00316673700.020
Rat
nucleotide biosynthetic processGO:0009165980.020
cellular response to growth factor stimulusGO:00713631620.020
establishment of protein localizationGO:00451841410.020
activation of mapkk activityGO:0000186180.020
regulation of ion homeostasisGO:2000021630.020
Rat
drinking behaviorGO:0042756110.020
intracellular transportGO:00469071850.020
ribose phosphate metabolic processGO:00196932350.020
cellular response to histamineGO:007142030.020
single organism carbohydrate metabolic processGO:00447231180.019
organonitrogen compound biosynthetic processGO:19015661670.019
carboxylic acid metabolic processGO:00197522890.019
mechanoreceptor differentiationGO:004249020.019
multicellular organism growthGO:003526410.019
smooth muscle contractionGO:0006939370.019
regulation of purine nucleotide biosynthetic processGO:1900371460.019
positive regulation of leukocyte activationGO:0002696300.019
regulation of blood pressureGO:0008217830.019
regulation of catecholamine secretionGO:0050433320.019
negative regulation of multicellular organismal processGO:00512412030.019
regulation of potassium ion transportGO:0043266290.019
neurotransmitter gated ion channel clusteringGO:007257830.019
gonad developmentGO:00084061040.019
wound healingGO:00420601220.019
regulation of organ formationGO:000315620.019
regulation of receptor recyclingGO:000191960.018
adenylate cyclase activating g protein coupled receptor signaling pathwayGO:0007189240.018
mesoderm developmentGO:000749820.018
development of primary female sexual characteristicsGO:0046545560.018
developmental inductionGO:003112820.018
female sex differentiationGO:0046660590.018
regulation of stem cell proliferationGO:0072091140.018
positive regulation of cell proliferationGO:00082842490.018
positive regulation of cellular component biogenesisGO:0044089550.018
organic substance catabolic processGO:19015753160.018
regulation of cellular component biogenesisGO:0044087860.018
regulation of neuron projection developmentGO:00109751610.018
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.018
intracellular protein transportGO:0006886790.018
adult locomotory behaviorGO:000834440.018
regulation of exocytosisGO:0017157370.018
regulation of developmental growthGO:0048638450.018
response to cytokineGO:00340972150.018
positive regulation of somatostatin secretionGO:009027440.018
positive regulation of cellular amine metabolic processGO:003324030.017
camp biosynthetic processGO:0006171470.017
cellular response to alcoholGO:0097306870.017
positive regulation of hydrolase activityGO:0051345860.017
eye developmentGO:0001654500.017
negative regulation of peptide hormone secretionGO:0090278300.017
generation of ovulation cycle rhythmGO:006011220.017
regulation of protein metabolic processGO:00512462890.017
mononuclear cell proliferationGO:0032943290.017
urogenital system developmentGO:0001655780.017
body fluid secretionGO:0007589410.017
somatostatin signaling pathwayGO:003817040.017
calcium ion transmembrane transportGO:0070588700.017
regulation of camp metabolic processGO:0030814430.017
multi multicellular organism processGO:00447061380.017
learningGO:0007612330.017
rna metabolic processGO:00160704060.017
smooth muscle contraction involved in micturitionGO:006008310.017
neuron projection morphogenesisGO:00488121220.017
striated muscle tissue developmentGO:0014706580.017
neuromuscular synaptic transmissionGO:000727420.017
negative regulation of metabolic processGO:00098923310.017
regulation of vasoconstrictionGO:0019229440.016
positive regulation of cellular amino acid metabolic processGO:004576410.016
regulation of cytoskeleton organizationGO:0051493490.016

Slc8a3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.079
nervous system diseaseDOID:86300.079
musculoskeletal system diseaseDOID:1700.043
eye and adnexa diseaseDOID:149200.035
sensory system diseaseDOID:005015500.035
eye diseaseDOID:561400.025
central nervous system diseaseDOID:33100.023