IMP: Integrative Multi-species Prediction

Rattus norvegicus

50 known processes

Supt5h

suppressor of Ty 5 homolog (S. cerevisiae)

RGD: 1563807
Entrez: 308472
Ensembl: ENSRNOG00000032034

Process Predictions
Disease Predictions

Supt5h biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
spindle organization	GO:0007051	2	0.205
protein localization to organelle	GO:0033365	57	0.145
cellular component biogenesis	GO:0044085	368	0.126
establishment of protein localization	GO:0045184	141	0.126
mitotic spindle organization	GO:0007052	2	0.122
organelle organization	GO:0006996	266	0.109
protein complex subunit organization	GO:0071822	302	0.105
cell projection organization	GO:0030030	302	0.103
macromolecular complex subunit organization	GO:0043933	339	0.102
vesicle mediated transport	GO:0016192	181	0.099
regulation of apoptotic process	GO:0042981	335	0.093
protein complex assembly	GO:0006461	263	0.088
cellular ketone metabolic process	GO:0042180	51	0.082
transcription dna templated	GO:0006351	377	0.079
cell fate determination	GO:0001709	2	0.077
intracellular transport	GO:0046907	185	0.076
protein targeting	GO:0006605	61	0.073
single organism organelle organization	GO:1902589	180	0.072
protein import	GO:0017038	37	0.070
nitrogen compound transport	GO:0071705	229	0.069
positive regulation of cellular protein metabolic process	GO:0032270	167	0.069
reproductive process	GO:0022414	372	0.068
neuron differentiation	GO:0030182	368	0.061
immune system process	GO:0002376	204	0.060
positive regulation of protein metabolic process	GO:0051247	178	0.060
sensory organ development	GO:0007423	74	0.054
ribonucleotide metabolic process	GO:0009259	231	0.054
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.051
purine ribonucleotide metabolic process	GO:0009150	227	0.050
anatomical structure morphogenesis	GO:0009653	298	0.048
regulation of cellular component organization	GO:0051128	368	0.047
macromolecule localization	GO:0033036	252	0.046
protein localization	GO:0008104	191	0.045
mitochondrion localization	GO:0051646	6	0.045
protein complex biogenesis	GO:0070271	263	0.043
protein phosphorylation	GO:0006468	345	0.042
single organism intracellular transport	GO:1902582	166	0.042
cellular component movement	GO:0006928	248	0.041
cell cell signaling	GO:0007267	335	0.040
intracellular protein transport	GO:0006886	79	0.039
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.039
axon development	GO:0061564	96	0.038
protein deubiquitination	GO:0016579	4	0.037
membrane organization	GO:0061024	94	0.037
organic hydroxy compound metabolic process	GO:1901615	115	0.037
cellular macromolecule localization	GO:0070727	122	0.036
innate immune response	GO:0045087	35	0.036
eye morphogenesis	GO:0048592	4	0.036
protein transport	GO:0015031	132	0.035
response to other organism	GO:0051707	220	0.035
cellular amine metabolic process	GO:0044106	38	0.034
cellular protein localization	GO:0034613	122	0.034
positive regulation of protein phosphorylation	GO:0001934	135	0.033
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.032
amine metabolic process	GO:0009308	38	0.032
cellular component morphogenesis	GO:0032989	155	0.032
regulation of cellular amino acid metabolic process	GO:0006521	2	0.032
regulation of programmed cell death	GO:0043067	341	0.032
ribose phosphate metabolic process	GO:0019693	235	0.032
growth	GO:0040007	165	0.031
cell cycle	GO:0007049	101	0.030
multicellular organism growth	GO:0035264	1	0.030
macromolecular complex assembly	GO:0065003	273	0.030
programmed cell death	GO:0012501	392	0.030
neuron projection development	GO:0031175	273	0.030
locomotion	GO:0040011	237	0.029
cellular macromolecular complex assembly	GO:0034622	58	0.029
synaptic transmission	GO:0007268	235	0.029
positive regulation of phosphorylation	GO:0042327	177	0.029
neuron development	GO:0048666	286	0.029
nucleic acid transport	GO:0050657	3	0.028
nucleoside triphosphate catabolic process	GO:0009143	123	0.028
protein localization to chromosome centromeric region	GO:0071459	1	0.027
cell morphogenesis	GO:0000902	142	0.027
regulation of protein kinase activity	GO:0045859	105	0.027
regulation of protein transport	GO:0051223	68	0.027
reactive oxygen species biosynthetic process	GO:1903409	8	0.026
guanosine containing compound catabolic process	GO:1901069	71	0.026
regulation of cellular protein metabolic process	GO:0032268	267	0.026
regulation of cellular ketone metabolic process	GO:0010565	27	0.024
rna metabolic process	GO:0016070	406	0.024
catabolic process	GO:0009056	351	0.024
negative regulation of apoptotic process	GO:0043066	181	0.024
cellular lipid metabolic process	GO:0044255	208	0.024
cellular amino acid metabolic process	GO:0006520	107	0.023
carbohydrate derivative metabolic process	GO:1901135	346	0.023
positive regulation of multicellular organismal process	GO:0051240	387	0.023
rna localization	GO:0006403	4	0.023
response to biotic stimulus	GO:0009607	226	0.023
peptidyl amino acid modification	GO:0018193	126	0.023
regulation of nucleic acid templated transcription	GO:1903506	380	0.022
single organism cellular localization	GO:1902580	102	0.022
intracellular signal transduction	GO:0035556	314	0.022
purine nucleotide metabolic process	GO:0006163	229	0.022
positive regulation of gene expression	GO:0010628	244	0.021
endomembrane system organization	GO:0010256	48	0.021
cytoplasmic transport	GO:0016482	115	0.021
establishment of synaptic vesicle localization	GO:0097480	23	0.021
hepaticobiliary system development	GO:0061008	90	0.021
secretion	GO:0046903	307	0.021
regulation of cell development	GO:0060284	263	0.021
central nervous system development	GO:0007417	311	0.021
internal protein amino acid acetylation	GO:0006475	9	0.021
morphogenesis of an epithelium	GO:0002009	20	0.021
response to external biotic stimulus	GO:0043207	221	0.021
response to peptide hormone	GO:0043434	278	0.020
signal release	GO:0023061	145	0.020
axonogenesis	GO:0007409	71	0.020
purine containing compound catabolic process	GO:0072523	138	0.020
multi multicellular organism process	GO:0044706	138	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.020
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.020
negative regulation of cell communication	GO:0010648	158	0.020
reproduction	GO:0000003	245	0.020
positive regulation of cellular biosynthetic process	GO:0031328	295	0.020
cell growth	GO:0016049	104	0.020
protein oligomerization	GO:0051259	191	0.020
nucleoside phosphate metabolic process	GO:0006753	283	0.019
response to nutrient	GO:0007584	248	0.019
regulation of cellular localization	GO:0060341	263	0.019
hormone secretion	GO:0046879	115	0.018
carboxylic acid metabolic process	GO:0019752	289	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.018
protein localization to membrane	GO:0072657	36	0.018
cytoskeleton organization	GO:0007010	111	0.018
organic substance catabolic process	GO:1901575	316	0.018
nucleobase containing small molecule metabolic process	GO:0055086	316	0.018
response to carbohydrate	GO:0009743	183	0.017
cell morphogenesis involved in differentiation	GO:0000904	119	0.017
apoptotic process	GO:0006915	381	0.017
organic acid metabolic process	GO:0006082	292	0.017
regulation of cell growth	GO:0001558	85	0.017
glycosyl compound metabolic process	GO:1901657	182	0.017
oxoacid metabolic process	GO:0043436	290	0.017
heterocycle catabolic process	GO:0046700	167	0.017
epithelium development	GO:0060429	96	0.016
regulation of protein metabolic process	GO:0051246	289	0.016
response to monosaccharide	GO:0034284	159	0.016
regulation of multicellular organismal development	GO:2000026	376	0.016
regulation of intracellular signal transduction	GO:1902531	218	0.016
defense response	GO:0006952	194	0.016
regulation of fat cell differentiation	GO:0045598	3	0.016
cell projection morphogenesis	GO:0048858	123	0.016
purine containing compound metabolic process	GO:0072521	253	0.016
negative regulation of rna biosynthetic process	GO:1902679	118	0.016
response to metal ion	GO:0010038	253	0.016
monocarboxylic acid metabolic process	GO:0032787	152	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.016
chromosome organization	GO:0051276	36	0.016
hemopoiesis	GO:0030097	34	0.016
single organism biosynthetic process	GO:0044711	342	0.016
purine nucleotide catabolic process	GO:0006195	136	0.016
hormone transport	GO:0009914	121	0.015
immune effector process	GO:0002252	53	0.015
multi organism reproductive process	GO:0044703	262	0.015
developmental growth	GO:0048589	100	0.015
sexual reproduction	GO:0019953	148	0.015
positive regulation of biosynthetic process	GO:0009891	319	0.015
axon cargo transport	GO:0008088	1	0.015
organ morphogenesis	GO:0009887	75	0.015
regulation of cell differentiation	GO:0045595	320	0.015
positive regulation of phosphate metabolic process	GO:0045937	262	0.015
nucleoside triphosphate metabolic process	GO:0009141	144	0.015
embryo development	GO:0009790	49	0.015
protein targeting to nucleus	GO:0044744	35	0.015
negative regulation of cell death	GO:0060548	229	0.015
small molecule biosynthetic process	GO:0044283	124	0.015
cellular component assembly	GO:0022607	360	0.015
microtubule cytoskeleton organization	GO:0000226	25	0.015
regulation of rna metabolic process	GO:0051252	391	0.015
negative regulation of cellular metabolic process	GO:0031324	281	0.014
ribonucleotide catabolic process	GO:0009261	136	0.014
regulation of gtpase activity	GO:0043087	57	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.014
multicellular organismal reproductive process	GO:0048609	233	0.014
regulation of rna biosynthetic process	GO:2001141	381	0.014
anterior posterior pattern specification	GO:0009952	1	0.014
lipid storage	GO:0019915	1	0.014
negative regulation of tor signaling	GO:0032007	2	0.014
regulation of phosphate metabolic process	GO:0019220	349	0.014
cellular response to nitrogen compound	GO:1901699	210	0.014
circadian regulation of gene expression	GO:0032922	3	0.014
purine ribonucleoside metabolic process	GO:0046128	168	0.014
cell part morphogenesis	GO:0032990	123	0.014
regulation of phosphorylation	GO:0042325	248	0.014
positive regulation of intracellular protein transport	GO:0090316	20	0.014
positive regulation of transcription dna templated	GO:0045893	197	0.013
single organism catabolic process	GO:0044712	283	0.013
regulation of hormone secretion	GO:0046883	106	0.013
bmp signaling pathway	GO:0030509	4	0.013
negative regulation of programmed cell death	GO:0043069	183	0.013
eye development	GO:0001654	50	0.013
jak stat cascade	GO:0007259	26	0.013
positive regulation of cell death	GO:0010942	184	0.013
cardiovascular system development	GO:0072358	134	0.013
nucleoside catabolic process	GO:0009164	126	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
regulation of growth	GO:0040008	105	0.013
monocarboxylic acid biosynthetic process	GO:0072330	48	0.013
negative regulation of metabolic process	GO:0009892	331	0.012
response to peptide	GO:1901652	292	0.012
negative regulation of gene expression	GO:0010629	199	0.012
posttranscriptional regulation of gene expression	GO:0010608	37	0.012
cellular response to stress	GO:0033554	269	0.012
hematopoietic progenitor cell differentiation	GO:0002244	2	0.012
response to molecule of bacterial origin	GO:0002237	194	0.012
cellular nitrogen compound catabolic process	GO:0044270	163	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.012
regulation of system process	GO:0044057	208	0.012
response to lipopolysaccharide	GO:0032496	191	0.012
lipid localization	GO:0010876	62	0.012
cell cycle checkpoint	GO:0000075	2	0.012
centrosome localization	GO:0051642	1	0.012
regulation of canonical wnt signaling pathway	GO:0060828	4	0.012
single organism membrane organization	GO:0044802	74	0.012
regulation of mapk cascade	GO:0043408	116	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.012
transmission of nerve impulse	GO:0019226	42	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.012
peptide secretion	GO:0002790	86	0.012
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.012
gtp metabolic process	GO:0046039	72	0.012
nuclear transport	GO:0051169	49	0.012
reproductive structure development	GO:0048608	128	0.012
regulation of nucleotide metabolic process	GO:0006140	117	0.011
regulation of protein phosphorylation	GO:0001932	183	0.011
mrna transport	GO:0051028	2	0.011
organic cyclic compound catabolic process	GO:1901361	175	0.011
cellular response to oxygen containing compound	GO:1901701	386	0.011
developmental process involved in reproduction	GO:0003006	159	0.011
regulation of hormone levels	GO:0010817	187	0.011
multicellular organism reproduction	GO:0032504	233	0.011
organonitrogen compound catabolic process	GO:1901565	179	0.011
positive regulation of apoptotic process	GO:0043065	154	0.011
smooth muscle cell proliferation	GO:0048659	77	0.011
cellular response to inorganic substance	GO:0071241	65	0.011
insulin like growth factor receptor signaling pathway	GO:0048009	3	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
nucleobase containing compound catabolic process	GO:0034655	152	0.011
sex differentiation	GO:0007548	113	0.011
regulation of catalytic activity	GO:0050790	304	0.011
heart development	GO:0007507	72	0.011
ribonucleoprotein complex biogenesis	GO:0022613	10	0.011
neuron projection morphogenesis	GO:0048812	122	0.011
positive regulation of protein modification process	GO:0031401	142	0.011
positive regulation of fatty acid transport	GO:2000193	9	0.010
regulation of muscle tissue development	GO:1901861	25	0.010
regulation of mrna splicing via spliceosome	GO:0048024	3	0.010
cerebellar purkinje cell layer development	GO:0021680	2	0.010
positive regulation of cell differentiation	GO:0045597	217	0.010
cellular response to molecule of bacterial origin	GO:0071219	56	0.010
immune system development	GO:0002520	41	0.010
homeostatic process	GO:0042592	331	0.010
regulation of lipid biosynthetic process	GO:0046890	38	0.010
regulation of phosphorus metabolic process	GO:0051174	349	0.010
transcription from rna polymerase ii promoter	GO:0006366	252	0.010
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.010
muscle cell proliferation	GO:0033002	84	0.010

Supt5h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.032
nervous system disease	DOID:863	0.032
epilepsy syndrome	DOID:1826	0.032
central nervous system disease	DOID:331	0.032
brain disease	DOID:936	0.032
electroclinical syndrome	DOID:0050701	0.032

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