Rattus norvegicus

92 known processes

Pcsk9

proprotein convertase subtilisin/kexin type 9

(Aliases: Narc1,PC9,NARC-1)

Pcsk9 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to nutrient levelsGO:00316673700.164
positive regulation of response to stimulusGO:00485842850.126
apoptotic processGO:00069153810.125
response to woundingGO:00096112540.098
response to peptide hormoneGO:00434342780.098
cellular response to organonitrogen compoundGO:00714171970.090
cellular response to organic cyclic compoundGO:00714072020.087
response to ketoneGO:19016541820.083
response to extracellular stimulusGO:00099913800.081
cellular response to endogenous stimulusGO:00714953770.080
regulation of multicellular organismal developmentGO:20000263760.075
response to hexoseGO:00097461440.075
response to nutrientGO:00075842480.071
response to monosaccharideGO:00342841590.071
homeostatic processGO:00425923310.066
chemical homeostasisGO:00488782920.066
regulation of cell proliferationGO:00421273590.064
response to oxygen levelsGO:00704822650.064
organic substance catabolic processGO:19015753160.063
lipid metabolic processGO:00066292830.061
cellular component biogenesisGO:00440853680.060
inflammatory responseGO:00069541500.060
carbohydrate derivative metabolic processGO:19011353460.060
response to carbohydrateGO:00097431830.059
organic acid metabolic processGO:00060822920.058
cellular response to oxygen containing compoundGO:19017013860.058
programmed cell deathGO:00125013920.056
response to decreased oxygen levelsGO:00362932370.051
metal ion transportGO:00300012890.051
nucleobase containing small molecule metabolic processGO:00550863160.049
response to bacteriumGO:00096172000.049
wound healingGO:00420601220.048
response to estradiolGO:00323551640.048
response to corticosteroidGO:00319602350.048
cellular response to hormone stimulusGO:00328702470.048
oxoacid metabolic processGO:00434362900.047
regulation of system processGO:00440572080.047
response to hypoxiaGO:00016662310.047
carboxylic acid metabolic processGO:00197522890.047
proteolysisGO:00065081750.046
response to inorganic substanceGO:00100353770.045
single organism reproductive processGO:00447022970.044
cellular component assemblyGO:00226073600.044
positive regulation of cell motilityGO:2000147970.044
response to glucoseGO:00097491360.043
regulation of immune system processGO:00026821230.043
reproductive processGO:00224143720.042
monocarboxylic acid metabolic processGO:00327871520.042
positive regulation of multicellular organismal processGO:00512403870.041
intracellular transportGO:00469071850.040
catabolic processGO:00090563510.040
intracellular signal transductionGO:00355563140.040
response to acid chemicalGO:00011012220.040
cellular response to lipidGO:00713962010.039
regulation of apoptotic processGO:00429813350.039
transmembrane transportGO:00550854120.038
organ regenerationGO:00311001010.038
positive regulation of cell proliferationGO:00082842490.038
regulation of cellular protein metabolic processGO:00322682670.038
cellular response to alcoholGO:0097306870.037
response to vitaminGO:00332731310.037
ion homeostasisGO:00508012120.037
regulation of programmed cell deathGO:00430673410.037
regulation of transcription dna templatedGO:00063553740.036
regulation of protein metabolic processGO:00512462890.036
response to peptideGO:19016522920.036
single organism biosynthetic processGO:00447113420.036
regenerationGO:00310991630.035
regulation of response to external stimulusGO:00321011060.035
cellular homeostasisGO:00197252520.035
fatty acid metabolic processGO:0006631990.035
negative regulation of cellular metabolic processGO:00313242810.035
negative regulation of macromolecule metabolic processGO:00106052600.035
gland developmentGO:00487321550.034
cellular response to nitrogen compoundGO:19016992100.034
negative regulation of metabolic processGO:00098923310.034
defense responseGO:00069521940.033
cation transportGO:00068123820.033
single organism catabolic processGO:00447122830.033
macromolecule localizationGO:00330362520.033
rna biosynthetic processGO:00327743800.033
negative regulation of response to stimulusGO:00485851550.032
regulation of response to stressGO:00801341260.032
glucose homeostasisGO:0042593750.032
ion transmembrane transportGO:00342203650.032
positive regulation of cellular biosynthetic processGO:00313282950.032
cellular response to corticosteroid stimulusGO:0071384690.032
response to glucocorticoidGO:00513842230.032
neurological system processGO:00508772190.031
immune responseGO:00069551040.031
positive regulation of apoptotic processGO:00430651540.031
cell motilityGO:00488702020.031
positive regulation of transcription dna templatedGO:00458931970.031
immune system processGO:00023762040.031
negative regulation of cell proliferationGO:00082851190.031
cellular component movementGO:00069282480.030
negative regulation of multicellular organismal processGO:00512412030.030
response to metal ionGO:00100382530.030
positive regulation of gene expressionGO:00106282440.030
regulation of catalytic activityGO:00507903040.029
coagulationGO:0050817280.029
regulation of cellular component organizationGO:00511283680.029
cellular chemical homeostasisGO:00550822470.029
regulation of cellular ketone metabolic processGO:0010565270.029
localization of cellGO:00516742020.029
regulation of signal transductionGO:00099663180.029
negative regulation of nucleobase containing compound metabolic processGO:00459341530.029
negative regulation of cell deathGO:00605482290.029
nucleic acid templated transcriptionGO:00976593790.028
cellular response to stressGO:00335542690.028
circulatory system processGO:00030131830.028
reproductive system developmentGO:00614581280.027
divalent metal ion transportGO:00708381320.027
brain developmentGO:00074202470.027
response to estrogenGO:00436272320.027
regulation of body fluid levelsGO:0050878900.027
sensory perceptionGO:00076001010.027
response to molecule of bacterial originGO:00022371940.027
response to other organismGO:00517072200.027
positive regulation of nitrogen compound metabolic processGO:00511733340.027
carbohydrate homeostasisGO:0033500750.027
purine ribonucleotide metabolic processGO:00091502270.026
anatomical structure morphogenesisGO:00096532980.026
reproductionGO:00000032450.026
central nervous system developmentGO:00074173110.026
positive regulation of nucleobase containing compound metabolic processGO:00459353190.026
agingGO:00075682410.026
rhythmic processGO:00485111560.026
positive regulation of cellular component movementGO:00512721020.025
positive regulation of molecular functionGO:00440932300.025
cellular catabolic processGO:00442482950.025
nitrogen compound transportGO:00717052290.025
secretionGO:00469033070.025
anion transportGO:00068201780.024
cellular ketone metabolic processGO:0042180510.024
purine containing compound metabolic processGO:00725212530.024
negative regulation of nitrogen compound metabolic processGO:00511721610.024
positive regulation of rna biosynthetic processGO:19026801970.024
circadian rhythmGO:0007623880.024
rna metabolic processGO:00160704060.024
action potentialGO:0001508540.024
single organism intracellular transportGO:19025821660.024
divalent inorganic cation transportGO:00725111340.024
tissue developmentGO:00098882520.024
positive regulation of nucleic acid templated transcriptionGO:19035081970.024
positive regulation of cell migrationGO:0030335960.024
regulation of rna metabolic processGO:00512523910.024
cellular response to steroid hormone stimulusGO:0071383930.024
positive regulation of cell communicationGO:00106472710.024
signal releaseGO:00230611450.023
positive regulation of biosynthetic processGO:00098913190.023
regulation of defense responseGO:0031347680.023
organophosphate metabolic processGO:00196373700.023
positive regulation of phosphorylationGO:00423271770.023
regulation of nucleic acid templated transcriptionGO:19035063800.023
nucleoside phosphate metabolic processGO:00067532830.023
cytoplasmic transportGO:00164821150.023
protein phosphorylationGO:00064683450.023
developmental growthGO:00485891000.023
cation homeostasisGO:00550801950.022
calcium ion transportGO:00068161310.022
transcription from rna polymerase ii promoterGO:00063662520.022
positive regulation of blood coagulationGO:003019440.022
nucleotide metabolic processGO:00091172790.022
positive regulation of immune system processGO:0002684900.022
protein localizationGO:00081041910.022
cellular response to glucocorticoid stimulusGO:0071385680.022
positive regulation of rna metabolic processGO:00512542030.022
positive regulation of cellular component organizationGO:00511302000.022
cardiovascular system developmentGO:00723581340.022
regulation of rna biosynthetic processGO:20011413810.022
transmission of nerve impulseGO:0019226420.022
positive regulation of protein metabolic processGO:00512471780.021
negative regulation of apoptotic processGO:00430661810.021
neuron projection developmentGO:00311752730.021
multicellular organismal signalingGO:0035637440.021
inorganic ion transmembrane transportGO:00986602290.021
regulation of cell differentiationGO:00455953200.021
regulation of metal ion transportGO:00109591180.021
positive regulation of signal transductionGO:00099671750.021
regulation of cell motilityGO:20001451310.021
cellular response to hexose stimulusGO:0071331650.021
regulation of phosphorylationGO:00423252480.021
response to ethanolGO:00454711620.021
ribonucleotide metabolic processGO:00092592310.021
amide transportGO:00428861050.020
protein maturationGO:0051604680.020
establishment of protein localizationGO:00451841410.020
organic acid biosynthetic processGO:0016053830.020
regulation of cellular amine metabolic processGO:003323880.020
regulation of ion transportGO:00432692450.020
regulation of anatomical structure morphogenesisGO:00226031410.020
macromolecular complex subunit organizationGO:00439333390.020
response to cytokineGO:00340972150.020
regulation of cell developmentGO:00602842630.020
positive regulation of transportGO:00510502450.020
organelle organizationGO:00069962660.020
negative regulation of protein metabolic processGO:00512481140.020
response to insulinGO:00328681330.020
cellular component morphogenesisGO:00329891550.020
response to oxidative stressGO:00069791860.020
cellular response to peptideGO:19016531330.019
regulation of anatomical structure sizeGO:00900661350.019
female pregnancyGO:00075651220.019
response to reactive oxygen speciesGO:00003021200.019
fibrinolysisGO:004273020.019
multicellular organismal reproductive processGO:00486092330.019
cellular response to abiotic stimulusGO:0071214850.019
regulation of cellular component movementGO:00512701500.019
regulation of calcium ion transportGO:0051924770.019
hepatocyte proliferationGO:007257430.019
angiogenesisGO:0001525530.019
cellular protein localizationGO:00346131220.019
positive regulation of cell differentiationGO:00455972170.019
positive regulation of phosphorus metabolic processGO:00105622620.019
response to starvationGO:0042594590.019
regulation of fibrinolysisGO:005191720.019
myelinationGO:0042552390.018
regulation of secretion by cellGO:19035302080.018
positive regulation of macromolecule biosynthetic processGO:00105572470.018
cell growthGO:00160491040.018
blood circulationGO:00080151830.018
transcription dna templatedGO:00063513770.018
response to biotic stimulusGO:00096072260.018
purine nucleotide metabolic processGO:00061632290.018
response to radiationGO:00093141370.018
plasminogen activationGO:003163920.018
cellular amino acid metabolic processGO:00065201070.018
multi multicellular organism processGO:00447061380.018
extracellular matrix constituent secretionGO:007027840.018
protein complex subunit organizationGO:00718223020.018
cell projection organizationGO:00300303020.018
negative regulation of cellular biosynthetic processGO:00313271610.018
developmental process involved in reproductionGO:00030061590.018
negative regulation of molecular functionGO:00440921330.017
positive regulation of signalingGO:00230562700.017
regulation of peptide transportGO:0090087870.017
behaviorGO:00076102050.017
cellular amine metabolic processGO:0044106380.017
glycosyl compound metabolic processGO:19016571820.017
regulation of phosphate metabolic processGO:00192203490.017
cation transmembrane transportGO:00986552630.017
regulation of insulin secretionGO:0050796650.017
cellular metal ion homeostasisGO:00068751720.017
ribose phosphate metabolic processGO:00196932350.017
response to campGO:0051591910.017
nucleoside metabolic processGO:00091161790.017
regulation of phosphorus metabolic processGO:00511743490.017
carbohydrate derivative catabolic processGO:19011361470.017
vesicle mediated transportGO:00161921810.017
macromolecular complex assemblyGO:00650032730.017
hemostasisGO:0007599260.017
regulation of inflammatory responseGO:0050727480.017
regulation of neuron differentiationGO:00456642080.016
peptide secretionGO:0002790860.016
single organism organelle organizationGO:19025891800.016
negative regulation of programmed cell deathGO:00430691830.016
neuron differentiationGO:00301823680.016
regulation of cellular amino acid metabolic processGO:000652120.016
blood vessel morphogenesisGO:0048514580.016
regulation of neurogenesisGO:00507672470.016
response to external biotic stimulusGO:00432072210.016
cell adhesionGO:00071551100.016
positive regulation of phosphate metabolic processGO:00459372620.016
regulation of cell projection organizationGO:00313441750.016
purine nucleoside triphosphate catabolic processGO:00091461220.016
amine metabolic processGO:0009308380.016
organic hydroxy compound metabolic processGO:19016151150.016
secretion by cellGO:00329402480.016
positive regulation of cell deathGO:00109421840.016
positive regulation of catalytic activityGO:00430851840.016
synaptic transmissionGO:00072682350.016
response to organophosphorusGO:00466831020.016
regulation of protein maturationGO:1903317500.016
regulation of peptide secretionGO:0002791820.016
multi organism reproductive processGO:00447032620.016
cell migrationGO:00164771970.016
regulation of membrane potentialGO:00423911100.016
smooth muscle cell proliferationGO:0048659770.016
multicellular organism reproductionGO:00325042330.016
ribonucleoside metabolic processGO:00091191740.015
growthGO:00400071650.015
monovalent inorganic cation transportGO:00156721720.015
regulation of peptide hormone secretionGO:0090276800.015
circulatory system developmentGO:00723591340.015
peptide transportGO:0015833970.015
positive regulation of developmental processGO:00510942830.015
purine nucleotide catabolic processGO:00061951360.015
positive regulation of extracellular matrix organizationGO:190305540.015
single organism cellular localizationGO:19025801020.015
mesoderm developmentGO:000749820.015
regulation of molecular functionGO:00650093980.015
protein oligomerizationGO:00512591910.015
regulation of plasminogen activationGO:001075520.015
regulation of immune responseGO:0050776550.015
regulation of hydrolase activityGO:00513361430.015
regulation of hormone levelsGO:00108171870.015
regulation of homeostatic processGO:00328441010.015
head developmentGO:00603222470.015
regulation of growthGO:00400081050.015
locomotionGO:00400112370.015
protein processingGO:0016485680.015
urogenital system developmentGO:0001655780.015
lipid localizationGO:0010876620.014
positive regulation of cellular amine metabolic processGO:003324030.014
small molecule catabolic processGO:0044282590.014
positive regulation of programmed cell deathGO:00430681570.014
cellular response to peptide hormone stimulusGO:00713751200.014
regulation of protein processingGO:0070613500.014
small molecule biosynthetic processGO:00442831240.014
purine ribonucleoside metabolic processGO:00461281680.014
organic cyclic compound catabolic processGO:19013611750.014
response to activityGO:0014823730.014
cell morphogenesis involved in differentiationGO:00009041190.014
small gtpase mediated signal transductionGO:0007264360.014
calcium ion homeostasisGO:00550741620.014
cardiac conductionGO:006133720.014
positive regulation of response to external stimulusGO:0032103510.014
cell cell signalingGO:00072673350.014
regulation of response to woundingGO:1903034690.014
muscle structure developmentGO:0061061870.014
sterol homeostasisGO:005509230.014
cellular ion homeostasisGO:00068731840.014
immune effector processGO:0002252530.014
purine nucleoside metabolic processGO:00422781690.014
regulation of secretionGO:00510462240.014
neuron developmentGO:00486662860.014
negative regulation of phosphate metabolic processGO:0045936800.014
negative regulation of cell communicationGO:00106481580.014
ras protein signal transductionGO:0007265290.014
regulation of nervous system developmentGO:00519602640.014
cellular cation homeostasisGO:00300031800.014
regulation of protein phosphorylationGO:00019321830.014
endocytosisGO:0006897840.014
lipid transportGO:0006869610.014
epithelium developmentGO:0060429960.014
renal system developmentGO:0072001670.014
nucleobase containing compound catabolic processGO:00346551520.013
cellular calcium ion homeostasisGO:00068741600.013
bile acid biosynthetic processGO:000669930.013
purine nucleoside catabolic processGO:00061521240.013
nucleotide catabolic processGO:00091661390.013
lipid oxidationGO:0034440300.013
negative regulation of innate immune responseGO:004582440.013
response to purine containing compoundGO:00140741260.013
cellular response to carbohydrate stimulusGO:0071322720.013
gap junction assemblyGO:001626420.013
cholesterol homeostasisGO:004263230.013
anion transmembrane transportGO:0098656770.013
metal ion homeostasisGO:00550651860.013
axis specificationGO:000979840.013
regulation of cell growthGO:0001558850.013
cell morphogenesisGO:00009021420.013
nucleoside phosphate catabolic processGO:19012921400.013
response to growth factorGO:00708481890.013
regulation of neuron projection developmentGO:00109751610.013
regulation of intracellular signal transductionGO:19025312180.013
regulation of smooth muscle cell proliferationGO:0048660750.013
positive regulation of homeostatic processGO:0032846490.013
neuronal action potentialGO:0019228350.013
muscle cell proliferationGO:0033002840.013
positive regulation of cellular amino acid metabolic processGO:004576410.013
single organism behaviorGO:00447081300.013
regulation of cell migrationGO:00303341280.013
ribonucleotide catabolic processGO:00092611360.013
cellular response to glucose stimulusGO:0071333650.012
cell part morphogenesisGO:00329901230.012
regulation of protein modification processGO:00313991940.012
cellular response to growth factor stimulusGO:00713631620.012
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.012
peptide hormone secretionGO:0030072840.012
blood coagulationGO:0007596260.012
regulation of catabolic processGO:00098941130.012
kidney developmentGO:0001822670.012
coenzyme metabolic processGO:0006732860.012
b cell mediated immunityGO:001972440.012
positive regulation of protein modification processGO:00314011420.012
erythrocyte differentiationGO:003021810.012
purine nucleoside triphosphate metabolic processGO:00091441410.012
cellular lipid metabolic processGO:00442552080.012
organophosphate catabolic processGO:00464341480.012
negative regulation of cellular protein metabolic processGO:00322691060.012
oxidation reduction processGO:00551143040.012
regulation of canonical wnt signaling pathwayGO:006082840.012
purine ribonucleoside catabolic processGO:00461301240.012
purine containing compound catabolic processGO:00725231380.012
hormone transportGO:00099141210.012
regulation of transcription from rna polymerase ii promoterGO:00063572340.012
cellular response to external stimulusGO:00714961180.012
negative regulation of gene expressionGO:00106291990.012
protein transportGO:00150311320.012
nucleoside triphosphate catabolic processGO:00091431230.012
vasculature developmentGO:0001944700.012
negative regulation of biosynthetic processGO:00098901680.011
cellular glucose homeostasisGO:0001678660.011
divalent inorganic cation homeostasisGO:00725071650.011
spermatogenesisGO:0007283990.011
liver developmentGO:0001889900.011
negative regulation of catalytic activityGO:00430861030.011
positive regulation of cell developmentGO:00107201760.011
regulation of cellular localizationGO:00603412630.011
ribonucleoside triphosphate catabolic processGO:00092031220.011
axon ensheathmentGO:0008366400.011
anatomical structure formation involved in morphogenesisGO:0048646830.011
insulin secretionGO:0030073690.011
positive regulation of cell projection organizationGO:00313461110.011
positive regulation of nervous system developmentGO:00519621780.011
positive regulation of neurogenesisGO:00507691650.011
cell communication involved in cardiac conductionGO:008606520.011
positive regulation of isotype switchingGO:004583010.011
positive regulation of protein phosphorylationGO:00019341350.011
cellular response to oxygen levelsGO:0071453600.011
cell activationGO:0001775970.011
negative regulation of fibrinolysisGO:005191820.011
forebrain developmentGO:0030900980.011
response to lipopolysaccharideGO:00324961910.011
regulation of extracellular matrix constituent secretionGO:000333020.011
positive regulation of neuron projection developmentGO:0010976990.011
protein complex assemblyGO:00064612630.011
regulation of intracellular transportGO:0032386650.011
purine ribonucleoside triphosphate catabolic processGO:00092071220.011
establishment of tissue polarityGO:000716420.011
cellular divalent inorganic cation homeostasisGO:00725031620.011
negative regulation of response to external stimulusGO:0032102370.011
cellular response to cytokine stimulusGO:00713451270.011
cellular response to monosaccharide stimulusGO:0071326670.011
regulation of transferase activityGO:00513381230.011
positive regulation of extracellular matrix constituent secretionGO:000333120.011
immunoglobulin mediated immune responseGO:001606440.011
membrane organizationGO:0061024940.011
positive regulation of serotonin secretionGO:001406410.011
positive regulation of hydrolase activityGO:0051345860.011
protein homooligomerizationGO:0051260910.011
purine ribonucleoside triphosphate metabolic processGO:00092051400.011
dendrite developmentGO:0016358720.011
ribonucleoside triphosphate metabolic processGO:00091991410.011
positive regulation of neuron differentiationGO:00456661260.011
nuclear transportGO:0051169490.011
macroautophagyGO:001623640.011
gamete generationGO:00072761240.011
hepaticobiliary system developmentGO:0061008900.011
cellular response to oxidative stressGO:0034599760.011
reactive oxygen species metabolic processGO:0072593370.010
negative regulation of transportGO:00510511360.010
defense response to gram negative bacteriumGO:005082930.010
monocarboxylic acid biosynthetic processGO:0072330480.010
intracellular protein transportGO:0006886790.010
embryonic pattern specificationGO:000988010.010
negative regulation of protein maturationGO:1903318470.010
organic anion transportGO:00157111320.010
positive regulation of hemostasisGO:190004840.010
carboxylic acid transportGO:00469421150.010
negative regulation of signalingGO:00230571570.010
lipid storageGO:001991510.010
organonitrogen compound catabolic processGO:19015651790.010
g protein coupled receptor signaling pathwayGO:00071862420.010
organic acid transportGO:00158491160.010
regulation of reactive oxygen species metabolic processGO:2000377260.010
multicellular organism growthGO:003526410.010

Pcsk9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:65500.020
disease of metabolismDOID:001466700.020
disease of anatomical entityDOID:700.020
nervous system diseaseDOID:86300.020
musculoskeletal system diseaseDOID:1700.012
sensory system diseaseDOID:005015500.012