Rattus norvegicus

0 known processes

Pcsk4

proprotein convertase subtilisin/kexin type 4

Pcsk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell cell signalingGO:00072673350.257
secretion by cellGO:00329402480.141
Mouse Rat
rna biosynthetic processGO:00327743800.135
regulation of nucleic acid templated transcriptionGO:19035063800.133
nitrogen compound transportGO:00717052290.124
cognitionGO:0050890920.105
regulation of transcription dna templatedGO:00063553740.103
response to nutrient levelsGO:00316673700.103
Rat
inorganic ion transmembrane transportGO:00986602290.101
regulation of blood circulationGO:19035221100.095
neurological system processGO:00508772190.092
cation transportGO:00068123820.089
inorganic cation transmembrane transportGO:00986622020.086
metal ion transportGO:00300012890.077
nucleic acid templated transcriptionGO:00976593790.072
potassium ion transportGO:0006813970.071
apoptotic processGO:00069153810.071
regulation of peptide secretionGO:0002791820.067
organic substance catabolic processGO:19015753160.067
potassium ion transmembrane transportGO:0071805710.066
cellular chemical homeostasisGO:00550822470.064
synaptic transmissionGO:00072682350.062
transcription dna templatedGO:00063513770.062
negative regulation of nucleic acid templated transcriptionGO:19035071170.061
secretionGO:00469033070.060
Mouse Rat
glutamate receptor signaling pathwayGO:0007215430.059
anatomical structure morphogenesisGO:00096532980.057
regulation of rna metabolic processGO:00512523910.056
lipid metabolic processGO:00066292830.054
hormone transportGO:00099141210.053
regulation of peptide transportGO:0090087870.052
regulation of rna biosynthetic processGO:20011413810.051
protein complex assemblyGO:00064612630.051
regulation of cell differentiationGO:00455953200.050
cellular ion homeostasisGO:00068731840.048
regulation of cellular component organizationGO:00511283680.047
acid secretionGO:0046717480.047
ion transmembrane transportGO:00342203650.046
cellular homeostasisGO:00197252520.045
signal releaseGO:00230611450.045
regulation of phosphorylationGO:00423252480.045
organophosphate metabolic processGO:00196373700.045
regulation of secretionGO:00510462240.044
Rat
response to peptide hormoneGO:00434342780.044
Rat
transmembrane transportGO:00550854120.043
peptide transportGO:0015833970.043
anion transportGO:00068201780.042
regulation of ion transportGO:00432692450.041
negative regulation of metabolic processGO:00098923310.040
homeostatic processGO:00425923310.039
regulation of membrane potentialGO:00423911100.039
rna metabolic processGO:00160704060.038
regulation of molecular functionGO:00650093980.038
positive regulation of cell deathGO:00109421840.037
positive regulation of amine transportGO:0051954260.036
cellular potassium ion transportGO:0071804720.036
regulation of apoptotic processGO:00429813350.036
g protein coupled receptor signaling pathwayGO:00071862420.036
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.035
regulation of cell developmentGO:00602842630.035
cation homeostasisGO:00550801950.035
regulation of hormone secretionGO:00468831060.035
positive regulation of developmental processGO:00510942830.035
peptide hormone secretionGO:0030072840.035
reproductive processGO:00224143720.035
Mouse
cellular divalent inorganic cation homeostasisGO:00725031620.034
response to fatty acidGO:0070542650.034
Rat
regulation of catalytic activityGO:00507903040.034
negative regulation of transcription dna templatedGO:00458921160.034
regulation of peptide hormone secretionGO:0090276800.033
regulation of multicellular organismal developmentGO:20000263760.032
regulation of intracellular signal transductionGO:19025312180.032
divalent inorganic cation transportGO:00725111340.032
macromolecular complex assemblyGO:00650032730.032
reproductionGO:00000032450.031
Mouse
sexual reproductionGO:00199531480.031
Mouse
organophosphate biosynthetic processGO:00904071430.031
response to extracellular stimulusGO:00099913800.031
Rat
regulation of phosphorus metabolic processGO:00511743490.031
insulin secretionGO:0030073690.030
response to cytokineGO:00340972150.030
Rat
negative regulation of response to stimulusGO:00485851550.030
regulation of insulin secretionGO:0050796650.030
positive regulation of cellular biosynthetic processGO:00313282950.030
transcription from rna polymerase ii promoterGO:00063662520.030
catabolic processGO:00090563510.029
programmed cell deathGO:00125013920.029
central nervous system developmentGO:00074173110.029
Rat
cellular response to endogenous stimulusGO:00714953770.029
Rat
positive regulation of nitrogen compound metabolic processGO:00511733340.029
regulation of signal transductionGO:00099663180.028
Rat
tissue developmentGO:00098882520.028
negative regulation of cellular biosynthetic processGO:00313271610.028
negative regulation of cell communicationGO:00106481580.028
response to monosaccharideGO:00342841590.028
Rat
startle responseGO:000196420.028
prepulse inhibitionGO:006013410.028
negative regulation of secretionGO:0051048820.028
peptide secretionGO:0002790860.028
ribonucleotide metabolic processGO:00092592310.027
regulation of programmed cell deathGO:00430673410.027
cyclic nucleotide metabolic processGO:0009187800.027
regulation of synaptic transmissionGO:00508041410.027
organic anion transportGO:00157111320.026
cation transmembrane transportGO:00986552630.026
cellular lipid metabolic processGO:00442552080.026
response to metal ionGO:00100382530.026
Rat
locomotionGO:00400112370.025
Rat
response to glucoseGO:00097491360.025
Rat
metal ion homeostasisGO:00550651860.025
ionotropic glutamate receptor signaling pathwayGO:0035235340.025
positive regulation of cell differentiationGO:00455972170.025
regulation of cellular localizationGO:00603412630.025
Rat
positive regulation of phosphorylationGO:00423271770.025
regulation of neurotransmitter uptakeGO:005158010.024
cell type specific apoptotic processGO:00972851340.024
regulation of response to foodGO:0032095110.024
neuron deathGO:00709971270.024
brain developmentGO:00074202470.023
Rat
circulatory system processGO:00030131830.023
chemical homeostasisGO:00488782920.023
heart processGO:0003015570.023
positive regulation of multicellular organismal processGO:00512403870.023
localization of cellGO:00516742020.023
Rat
neuron differentiationGO:00301823680.022
Fly
negative regulation of cell deathGO:00605482290.022
membrane organizationGO:0061024940.022
regulation of nucleotide metabolic processGO:00061401170.022
cellular component biogenesisGO:00440853680.022
glutamate secretionGO:0014047190.022
negative regulation of cellular metabolic processGO:00313242810.022
response to inorganic substanceGO:00100353770.021
Rat
regulation of neuron apoptotic processGO:0043523830.021
hormone secretionGO:00468791150.021
cellular response to oxygen containing compoundGO:19017013860.021
intracellular signal transductionGO:00355563140.021
negative regulation of macromolecule biosynthetic processGO:00105581480.021
negative regulation of collagen biosynthetic processGO:003296640.020
regulation of neurogenesisGO:00507672470.020
lipid transportGO:0006869610.020
purine nucleotide metabolic processGO:00061632290.020
positive regulation of cellular component organizationGO:00511302000.020
somatostatin receptor signaling pathwayGO:003816940.020
cellular cation homeostasisGO:00300031800.020
negative regulation of macromolecule metabolic processGO:00106052600.019
single organism membrane organizationGO:0044802740.019
behavioral response to nicotineGO:003509520.019
camera type eye developmentGO:0043010480.019
divalent inorganic cation homeostasisGO:00725071650.019
negative regulation of hormone secretionGO:0046888460.019
macromolecular complex subunit organizationGO:00439333390.019
reproductive system developmentGO:00614581280.019
response to hypoxiaGO:00016662310.019
response to biotic stimulusGO:00096072260.018
Rat
purine containing compound metabolic processGO:00725212530.018
regulation of phosphate metabolic processGO:00192203490.018
negative regulation of nucleobase containing compound metabolic processGO:00459341530.018
cell projection organizationGO:00300303020.018
amide transportGO:00428861050.018
positive regulation of nucleic acid templated transcriptionGO:19035081970.018
negative regulation of response to foodGO:003209670.018
regulation of transferase activityGO:00513381230.018
response to peptideGO:19016522920.018
Rat
carboxylic acid transportGO:00469421150.017
carbohydrate derivative metabolic processGO:19011353460.017
regulation of neuron deathGO:19012141150.017
positive regulation of phosphorus metabolic processGO:00105622620.017
nucleoside phosphate metabolic processGO:00067532830.017
circadian regulation of gene expressionGO:003292230.017
regulation of mapk cascadeGO:00434081160.017
organic hydroxy compound biosynthetic processGO:1901617510.017
regulation of nervous system developmentGO:00519602640.016
carboxylic acid metabolic processGO:00197522890.016
regulation of appetiteGO:003209880.016
adult locomotory behaviorGO:000834440.016
leukocyte activationGO:0045321760.016
neurotransmitter uptakeGO:000150430.016
positive regulation of glutamate secretionGO:001404980.016
negative regulation of nitrogen compound metabolic processGO:00511721610.016
ribose phosphate metabolic processGO:00196932350.016
single organism catabolic processGO:00447122830.016
organonitrogen compound biosynthetic processGO:19015661670.016
positive regulation of phosphate metabolic processGO:00459372620.015
negative regulation of rna biosynthetic processGO:19026791180.015
positive regulation of cell projection organizationGO:00313461110.015
eye developmentGO:0001654500.015
calcium ion transportGO:00068161310.015
positive regulation of apoptotic processGO:00430651540.015
cellular component assemblyGO:00226073600.015
neuron neuron synaptic transmissionGO:0007270600.015
positive regulation of rna metabolic processGO:00512542030.015
blood circulationGO:00080151830.015
response to oxygen levelsGO:00704822650.015
monocarboxylic acid transportGO:0015718520.015
cellular response to lipidGO:00713962010.015
muscle contractionGO:0006936880.014
regulation of cell proliferationGO:00421273590.014
regulation of synaptic plasticityGO:0048167700.014
mechanoreceptor differentiationGO:004249020.014
nucleobase containing small molecule metabolic processGO:00550863160.014
positive regulation of ion transportGO:0043270940.014
positive regulation of biosynthetic processGO:00098913190.014
protein complex biogenesisGO:00702712630.014
cytosolic calcium ion transportGO:0060401390.014
glycerolipid metabolic processGO:0046486670.014
regulation of transcription from rna polymerase ii promoterGO:00063572340.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178270.014
Rat
regulation of neuron projection developmentGO:00109751610.014
respiratory system developmentGO:0060541450.014
negative regulation of signalingGO:00230571570.014
single organism biosynthetic processGO:00447113420.014
fatty acid derivative metabolic processGO:1901568380.014
positive regulation of transcription dna templatedGO:00458931970.014
neuron developmentGO:00486662860.013
Fly
regulation of cell projection organizationGO:00313441750.013
negative regulation of biosynthetic processGO:00098901680.013
regulation of cyclic nucleotide metabolic processGO:0030799510.013
regulation of catabolic processGO:00098941130.013
response to carbohydrateGO:00097431830.013
Rat
positive regulation of nucleobase containing compound metabolic processGO:00459353190.013
purine ribonucleotide metabolic processGO:00091502270.013
regulation of protein metabolic processGO:00512462890.013
neuronal action potentialGO:0019228350.013
cellular metal ion homeostasisGO:00068751720.013
regulation of neuronal synaptic plasticityGO:0048168310.013
response to calcium ionGO:0051592590.013
Rat
fatty acid transportGO:0015908250.013
calcium ion homeostasisGO:00550741620.013
amine transportGO:0015837570.013
negative regulation of rna metabolic processGO:00512531230.013
organic acid metabolic processGO:00060822920.013
cellular component morphogenesisGO:00329891550.012
spermatogenesisGO:0007283990.012
Mouse
cellular response to nitrogen compoundGO:19016992100.012
positive regulation of programmed cell deathGO:00430681570.012
cytosolic calcium ion homeostasisGO:00514801400.012
response to glucocorticoidGO:00513842230.012
Rat
sequestering of metal ionGO:005123890.012
cellular response to cytokine stimulusGO:00713451270.012
amine metabolic processGO:0009308380.012
response to hexoseGO:00097461440.012
Rat
regulation of synaptic transmission glutamatergicGO:0051966260.012
positive regulation of catecholamine secretionGO:0033605130.012
synaptic transmission dopaminergicGO:0001963110.012
regulation of hormone levelsGO:00108171870.012
Rat
purine ribonucleotide catabolic processGO:00091541360.012
phospholipid biosynthetic processGO:0008654290.012
positive regulation of neurotransmitter secretionGO:000195690.012
cellular response to organonitrogen compoundGO:00714171970.012
camp metabolic processGO:0046058630.012
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.012
small gtpase mediated signal transductionGO:0007264360.012
response to acid chemicalGO:00011012220.012
Rat
lens fiber cell differentiationGO:007030630.012
organ regenerationGO:00311001010.012
respiratory gaseous exchangeGO:000758540.012
male gamete generationGO:0048232990.012
Mouse
endocytosisGO:0006897840.012
positive regulation of nervous system developmentGO:00519621780.012
regulation of secretion by cellGO:19035302080.012
Rat
metanephric tubule morphogenesisGO:007217320.011
negative regulation of molecular functionGO:00440921330.011
positive regulation of mapk cascadeGO:0043410920.011
immune system processGO:00023762040.011
regulation of neuron differentiationGO:00456642080.011
positive regulation of hormone secretionGO:0046887650.011
sensory perceptionGO:00076001010.011
response to reactive oxygen speciesGO:00003021200.011
somatostatin signaling pathwayGO:003817040.011
regulation of anatomical structure sizeGO:00900661350.011
protein localizationGO:00081041910.011
Rat
protein phosphorylationGO:00064683450.011
negative regulation of gene expressionGO:00106291990.011
positive regulation of camp metabolic processGO:0030816310.011
negative regulation of apoptotic processGO:00430661810.011
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.011
dna templated transcription initiationGO:000635240.011
cellular glucose homeostasisGO:0001678660.011
striated muscle contractionGO:0006941440.011
alcohol biosynthetic processGO:0046165380.011
negative regulation of secretion by cellGO:1903531720.011
response to ketoneGO:19016541820.011
regulation of lyase activityGO:0051339220.011
camp biosynthetic processGO:0006171470.011
action potentialGO:0001508540.011
membrane depolarizationGO:0051899320.011
regulation of cellular catabolic processGO:00313291010.011
regenerationGO:00310991630.011
positive regulation of cell communicationGO:00106472710.011
Rat
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123950.010
response to external biotic stimulusGO:00432072210.010
Rat
cellular response to external stimulusGO:00714961180.010
cellular amine metabolic processGO:0044106380.010
organic acid transportGO:00158491160.010
divalent metal ion transportGO:00708381320.010
monocarboxylic acid metabolic processGO:00327871520.010
cellular calcium ion homeostasisGO:00068741600.010
gastrulationGO:000736920.010

Pcsk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.119
disease of anatomical entityDOID:700.119
sensory system diseaseDOID:005015500.039
eye and adnexa diseaseDOID:149200.039
eye diseaseDOID:561400.039
retinal diseaseDOID:567900.039
brain diseaseDOID:93600.023
epilepsy syndromeDOID:182600.023
central nervous system diseaseDOID:33100.023
disease of metabolismDOID:001466700.023
inherited metabolic disorderDOID:65500.023