Rattus norvegicus

142 known processes

Pkm2

pyruvate kinase, muscle

(Aliases: PKM12,Pk3)

Pkm2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
carbohydrate catabolic processGO:0016052401.000
single organism carbohydrate catabolic processGO:0044724401.000
generation of precursor metabolites and energyGO:0006091620.997
pyruvate metabolic processGO:0006090270.931
glycolytic processGO:0006096170.929
monocarboxylic acid metabolic processGO:00327871520.921
carbohydrate metabolic processGO:00059751300.885
small molecule biosynthetic processGO:00442831240.829
organic substance catabolic processGO:19015753160.777
single organism biosynthetic processGO:00447113420.764
monosaccharide metabolic processGO:0005996610.738
carbohydrate biosynthetic processGO:0016051420.697
oxoacid metabolic processGO:00434362900.695
organic acid metabolic processGO:00060822920.676
carboxylic acid metabolic processGO:00197522890.668
glucose metabolic processGO:0006006520.634
single organism catabolic processGO:00447122830.558
single organism behaviorGO:00447081300.526
single organism carbohydrate metabolic processGO:00447231180.510
protein tetramerizationGO:0051262380.475
programmed cell deathGO:00125013920.430
hexose biosynthetic processGO:0019319150.425
gluconeogenesisGO:0006094150.412
glycogen metabolic processGO:0005977230.398
regulation of apoptotic processGO:00429813350.387
regenerationGO:00310991630.385
response to campGO:0051591910.375
Rat
cofactor metabolic processGO:0051186950.372
cell cycle checkpointGO:000007520.343
catabolic processGO:00090563510.318
neuron apoptotic processGO:0051402880.314
carboxylic acid biosynthetic processGO:0046394830.313
response to insulinGO:00328681330.288
response to hexoseGO:00097461440.281
Rat
negative regulation of apoptotic processGO:00430661810.277
response to extracellular stimulusGO:00099913800.276
cellular response to nitrogen compoundGO:19016992100.275
Rat
protein homotetramerizationGO:0051289250.262
nucleobase containing small molecule metabolic processGO:00550863160.239
response to estrogenGO:00436272320.239
apoptotic processGO:00069153810.224
protein heterooligomerizationGO:0051291890.222
response to monosaccharideGO:00342841590.220
Rat
cellular response to insulin stimulusGO:0032869810.215
Rat
response to bacteriumGO:00096172000.213
response to oxidative stressGO:00069791860.207
response to heatGO:0009408600.193
Rat
response to external biotic stimulusGO:00432072210.182
response to cytokineGO:00340972150.181
energy derivation by oxidation of organic compoundsGO:0015980460.181
gland developmentGO:00487321550.180
cellular response to endogenous stimulusGO:00714953770.178
Rat
response to carbohydrateGO:00097431830.174
Rat
response to organophosphorusGO:00466831020.169
Rat
response to nutrient levelsGO:00316673700.166
organophosphate metabolic processGO:00196373700.157
cellular component assemblyGO:00226073600.156
response to peptide hormoneGO:00434342780.155
cellular response to peptide hormone stimulusGO:00713751200.150
Rat
monovalent inorganic cation transportGO:00156721720.150
response to lipopolysaccharideGO:00324961910.149
cellular response to peptideGO:19016531330.146
Rat
single organism organelle organizationGO:19025891800.143
cell type specific apoptotic processGO:00972851340.142
protein homooligomerizationGO:0051260910.142
positive regulation of apoptotic processGO:00430651540.140
response to glucoseGO:00097491360.126
Rat
neuron deathGO:00709971270.124
response to amino acidGO:0043200750.121
tissue regenerationGO:0042246360.120
cellular carbohydrate metabolic processGO:0044262720.119
liver developmentGO:0001889900.118
tissue developmentGO:00098882520.117
response to corticosteroidGO:00319602350.114
agingGO:00075682410.113
regulation of neuron apoptotic processGO:0043523830.112
negative regulation of mitotic cell cycle phase transitionGO:190199130.111
nitrogen compound transportGO:00717052290.110
organ regenerationGO:00311001010.109
cellular response to organonitrogen compoundGO:00714171970.107
Rat
mitotic dna damage checkpointGO:004477310.104
response to estradiolGO:00323551640.102
protein oligomerizationGO:00512591910.099
negative regulation of cell cycle phase transitionGO:190198840.098
response to decreased oxygen levelsGO:00362932370.097
response to alkaloidGO:00432791320.096
response to purine containing compoundGO:00140741260.095
Rat
response to glucocorticoidGO:00513842230.094
response to acid chemicalGO:00011012220.094
cellular amino acid biosynthetic processGO:0008652320.090
membrane organizationGO:0061024940.089
response to oxygen levelsGO:00704822650.089
response to peptideGO:19016522920.088
cell growthGO:00160491040.087
monosaccharide biosynthetic processGO:0046364160.087
macromolecular complex subunit organizationGO:00439333390.086
protein complex assemblyGO:00064612630.085
protein complex biogenesisGO:00702712630.084
proteolysisGO:00065081750.083
nucleotide metabolic processGO:00091172790.083
macromolecular complex assemblyGO:00650032730.083
response to other organismGO:00517072200.080
single organism cellular localizationGO:19025801020.080
cellular component biogenesisGO:00440853680.078
response to transition metal nanoparticleGO:19902671220.076
response to nutrientGO:00075842480.074
cation transportGO:00068123820.074
cell cell signalingGO:00072673350.074
positive regulation of cell deathGO:00109421840.073
response to nicotineGO:0035094510.072
negative regulation of metabolic processGO:00098923310.071
cellular response to external stimulusGO:00714961180.070
cellular cation homeostasisGO:00300031800.069
regulation of carbohydrate catabolic processGO:0043470140.068
epithelium developmentGO:0060429960.068
response to woundingGO:00096112540.066
glucan metabolic processGO:0044042230.065
response to metal ionGO:00100382530.065
Rat
cellular response to hormone stimulusGO:00328702470.065
Rat
cellular glucan metabolic processGO:0006073230.064
rna biosynthetic processGO:00327743800.063
response to molecule of bacterial originGO:00022371940.061
regulation of blood pressureGO:0008217830.059
pyridine containing compound metabolic processGO:0072524320.059
negative regulation of neuron deathGO:1901215690.058
homeostatic processGO:00425923310.057
cellular ketone metabolic processGO:0042180510.057
nucleoside phosphate metabolic processGO:00067532830.056
cellular chemical homeostasisGO:00550822470.056
purine nucleotide biosynthetic processGO:0006164830.054
blood circulationGO:00080151830.053
regulation of nervous system developmentGO:00519602640.053
regulation of programmed cell deathGO:00430673410.052
negative regulation of gene expressionGO:00106291990.051
single organism membrane organizationGO:0044802740.051
mitotic cell cycle checkpointGO:000709310.051
lactate metabolic processGO:000608930.051
regulation of cell cycleGO:0051726730.051
hexose metabolic processGO:0019318580.048
regulation of sodium ion transmembrane transporter activityGO:200064940.048
nucleic acid templated transcriptionGO:00976593790.048
behaviorGO:00076102050.047
anatomical structure morphogenesisGO:00096532980.045
growthGO:00400071650.045
cell motilityGO:00488702020.045
response to biotic stimulusGO:00096072260.045
regulation of hormone levelsGO:00108171870.044
organophosphate biosynthetic processGO:00904071430.043
dna integrity checkpointGO:003157020.042
regulation of cell differentiationGO:00455953200.042
regulation of neurogenesisGO:00507672470.041
regulation of multicellular organismal developmentGO:20000263760.041
protein heterotetramerizationGO:005129090.040
cellular macromolecule localizationGO:00707271220.040
positive regulation of programmed cell deathGO:00430681570.040
lipid metabolic processGO:00066292830.040
negative regulation of protein maturationGO:1903318470.039
regulation of mitotic cell cycle phase transitionGO:1901990110.039
negative regulation of neuron apoptotic processGO:0043524450.038
regulation of neuron differentiationGO:00456642080.037
response to starvationGO:0042594590.037
regulation of rna biosynthetic processGO:20011413810.036
syncytium formation by plasma membrane fusionGO:000076830.036
regulation of neuron deathGO:19012141150.035
response to hypoxiaGO:00016662310.035
protein nitrosylationGO:001701420.035
protein complex subunit organizationGO:00718223020.035
g protein coupled receptor signaling pathwayGO:00071862420.035
regulation of metal ion transportGO:00109591180.034
wound healingGO:00420601220.033
organelle organizationGO:00069962660.033
positive regulation of nitrogen compound metabolic processGO:00511733340.033
regulation of cell proliferationGO:00421273590.033
regulation of rna metabolic processGO:00512523910.033
mitotic cell cycle phase transitionGO:0044772200.033
regulation of cell cycle processGO:0010564310.033
negative regulation of secretionGO:0051048820.033
neurological system processGO:00508772190.032
heme biosynthetic processGO:000678340.032
positive regulation of transcription dna templatedGO:00458931970.032
positive regulation of rna biosynthetic processGO:19026801970.032
positive regulation of phosphorus metabolic processGO:00105622620.032
positive regulation of cellular component organizationGO:00511302000.032
glucan biosynthetic processGO:0009250150.032
cellular component movementGO:00069282480.032
regulation of transcription dna templatedGO:00063553740.032
g2 dna damage checkpointGO:003157210.032
muscle structure developmentGO:0061061870.031
protein processingGO:0016485680.031
neuron projection developmentGO:00311752730.031
regulation of ion transportGO:00432692450.031
transcription dna templatedGO:00063513770.031
response to hydrogen peroxideGO:0042542890.030
negative regulation of cellular metabolic processGO:00313242810.030
negative regulation of transportGO:00510511360.030
positive regulation of locomotionGO:00400171020.030
coenzyme metabolic processGO:0006732860.030
cellular response to oxygen containing compoundGO:19017013860.030
Rat
secretion by cellGO:00329402480.030
mitotic cell cycle processGO:1903047350.029
regulation of cell developmentGO:00602842630.029
regulation of cell growthGO:0001558850.029
aldehyde biosynthetic processGO:004618440.028
reproductive processGO:00224143720.028
positive regulation of rna metabolic processGO:00512542030.028
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281310.028
response to zinc ionGO:0010043390.028
hormone secretionGO:00468791150.027
positive regulation of biosynthetic processGO:00098913190.027
regulation of cellular amino acid metabolic processGO:000652120.027
positive regulation of nucleobase containing compound metabolic processGO:00459353190.027
membrane fusionGO:0061025260.027
regulation of catalytic activityGO:00507903040.027
negative regulation of cellular protein metabolic processGO:00322691060.026
cellular modified amino acid metabolic processGO:0006575610.026
cellular amino acid metabolic processGO:00065201070.026
response to inorganic substanceGO:00100353770.025
Rat
skeletal muscle tissue regenerationGO:0043403100.025
single organism reproductive processGO:00447022970.025
hormone metabolic processGO:0042445690.025
leukocyte activationGO:0045321760.025
multicellular organismal reproductive processGO:00486092330.025
multi organism reproductive processGO:00447032620.025
developmental process involved in reproductionGO:00030061590.025
secretionGO:00469033070.025
calcium ion homeostasisGO:00550741620.025
regulation of potassium ion transportGO:0043266290.024
macromolecule catabolic processGO:0009057580.024
cellular response to stressGO:00335542690.024
regulation of cellular component organizationGO:00511283680.024
regulation of phosphorus metabolic processGO:00511743490.024
organic hydroxy compound metabolic processGO:19016151150.024
response to fructoseGO:0009750100.024
mitotic cell cycleGO:0000278490.023
ion homeostasisGO:00508012120.023
mitochondrion organizationGO:0007005350.023
cation homeostasisGO:00550801950.023
positive regulation of nucleic acid templated transcriptionGO:19035081970.023
negative regulation of molecular functionGO:00440921330.023
adp metabolic processGO:004603180.023
regulation of cell cycle phase transitionGO:1901987120.023
defense responseGO:00069521940.023
regulation of growthGO:00400081050.023
cellular homeostasisGO:00197252520.023
cell cycle processGO:0022402570.023
renal system processGO:0003014400.022
ribonucleotide catabolic processGO:00092611360.022
regulation of system processGO:00440572080.022
hormone transportGO:00099141210.022
positive regulation of cellular biosynthetic processGO:00313282950.022
glutamine family amino acid biosynthetic processGO:000908420.021
regulation of cellular ketone metabolic processGO:0010565270.021
regulation of molecular functionGO:00650093980.021
regulation of membrane potentialGO:00423911100.021
response to reactive oxygen speciesGO:00003021200.021
negative regulation of macromolecule metabolic processGO:00106052600.021
intracellular transportGO:00469071850.021
cellular amine metabolic processGO:0044106380.021
smooth muscle cell proliferationGO:0048659770.020
regulation of hormone secretionGO:00468831060.020
reproductionGO:00000032450.020
neuron developmentGO:00486662860.020
regulation of nucleic acid templated transcriptionGO:19035063800.020
positive regulation of cell developmentGO:00107201760.020
positive regulation of transportGO:00510502450.019
camp metabolic processGO:0046058630.019
regulation of cellular amine metabolic processGO:003323880.019
negative regulation of cell deathGO:00605482290.019
regulation of necroptotic processGO:006054420.019
cognitionGO:0050890920.019
cytosolic calcium ion homeostasisGO:00514801400.019
negative regulation of hormone secretionGO:0046888460.019
positive regulation of cellular amine metabolic processGO:003324030.019
learning or memoryGO:0007611900.019
epithelial cell differentiationGO:0030855710.019
positive regulation of catalytic activityGO:00430851840.019
organonitrogen compound catabolic processGO:19015651790.019
circulatory system processGO:00030131830.018
regulation of hydrolase activityGO:00513361430.018
amine metabolic processGO:0009308380.018
positive regulation of multicellular organismal processGO:00512403870.018
cell cycleGO:00070491010.018
sodium ion transmembrane transportGO:0035725670.018
cellular modified amino acid biosynthetic processGO:0042398180.018
purine containing compound metabolic processGO:00725212530.018
cellular aldehyde metabolic processGO:0006081110.018
regulation of purine nucleotide metabolic processGO:19005421150.018
cell projection organizationGO:00300303020.018
actin filament depolymerizationGO:003004230.018
response to toxic substanceGO:00096361330.018
organic anion transportGO:00157111320.018
peptidyl cysteine s nitrosylationGO:001811920.017
purine nucleoside diphosphate metabolic processGO:000913590.017
oxidation reduction processGO:00551143040.017
aspartate family amino acid biosynthetic processGO:000906740.017
rna metabolic processGO:00160704060.017
regulation of protein metabolic processGO:00512462890.017
dna damage checkpointGO:000007720.017
metal ion homeostasisGO:00550651860.017
fatty acid derivative metabolic processGO:1901568380.017
immune system processGO:00023762040.017
metal ion transportGO:00300012890.017
post embryonic organ developmentGO:004856920.017
negative regulation of protein metabolic processGO:00512481140.017
regulation of actin filament depolymerizationGO:003083420.017
regulation of systemic arterial blood pressureGO:0003073300.017
heart morphogenesisGO:000300730.017
regulation of nucleotide metabolic processGO:00061401170.017
negative regulation of mitotic cell cycleGO:004593060.017
positive regulation of protein depolymerizationGO:190188130.017
developmental growthGO:00485891000.016
negative regulation of proteolysisGO:0045861410.016
syncytium formationGO:000694940.016
divalent inorganic cation homeostasisGO:00725071650.016
transmembrane transportGO:00550854120.016
regulation of cytoskeleton organizationGO:0051493490.016
regulation of cell projection organizationGO:00313441750.016
regulation of cell motilityGO:20001451310.016
negative regulation of catalytic activityGO:00430861030.016
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154170.016
regulation of cellular component movementGO:00512701500.016
cellular ion homeostasisGO:00068731840.016
protein phosphorylationGO:00064683450.016
negative regulation of secretion by cellGO:1903531720.016
negative regulation of nitrogen compound metabolic processGO:00511721610.016
regulation of locomotionGO:00400121480.016
locomotionGO:00400112370.016
inflammatory responseGO:00069541500.016
negative regulation of peptidase activityGO:0010466380.016
striated muscle cell differentiationGO:0051146390.016
hexose transportGO:0008645290.015
cellular polysaccharide biosynthetic processGO:0033692150.015
negative regulation of macromolecule biosynthetic processGO:00105581480.015
response to interleukin 6GO:0070741130.015
multicellular organism reproductionGO:00325042330.015
head developmentGO:00603222470.015
cell morphogenesis involved in neuron differentiationGO:00486671060.015
male gamete generationGO:0048232990.015
sexual reproductionGO:00199531480.015
transcription from rna polymerase ii promoterGO:00063662520.015
polysaccharide metabolic processGO:0005976250.015
neuron differentiationGO:00301823680.015
establishment of protein localizationGO:00451841410.015
regulation of transmembrane transportGO:00347621220.015
negative regulation of cellular biosynthetic processGO:00313271610.015
chemical homeostasisGO:00488782920.015
action potentialGO:0001508540.015
positive regulation of response to stimulusGO:00485842850.015
positive regulation of cellular component biogenesisGO:0044089550.015
negative regulation of nucleobase containing compound metabolic processGO:00459341530.015
organic acid biosynthetic processGO:0016053830.015
positive regulation of developmental processGO:00510942830.015
regulation of phosphate metabolic processGO:00192203490.015
regulation of secretionGO:00510462240.014
muscle cell proliferationGO:0033002840.014
regulation of neurological system processGO:0031644430.014
axis specificationGO:000979840.014
positive regulation of macromolecule biosynthetic processGO:00105572470.014
ribonucleoside catabolic processGO:00424541260.014
glycogen biosynthetic processGO:0005978150.014
gliogenesisGO:0042063930.014
regulation of renal sodium excretionGO:0035813200.014
cell migrationGO:00164771970.014
nucleotide biosynthetic processGO:0009165980.014
peptide secretionGO:0002790860.014
ribonucleotide biosynthetic processGO:0009260850.014
carboxylic acid transportGO:00469421150.014
regulation of homeostatic processGO:00328441010.014
negative regulation of growthGO:0045926370.014
regulation of synaptic transmissionGO:00508041410.014
defense response to gram negative bacteriumGO:005082930.013
organelle localizationGO:0051640550.013
macromolecule localizationGO:00330362520.013
anion transportGO:00068201780.013
regulation of peptide hormone secretionGO:0090276800.013
cellular lipid metabolic processGO:00442552080.013
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.013
response to interleukin 1GO:0070555550.013
central nervous system developmentGO:00074173110.013
negative regulation of programmed cell deathGO:00430691830.013
purine nucleoside triphosphate catabolic processGO:00091461220.013
cell cycle phase transitionGO:0044770210.013
negative regulation of cell growthGO:0030308330.013
mitotic g2 m transition checkpointGO:004481810.013
spermatogenesisGO:0007283990.013
negative regulation of cell developmentGO:0010721820.013
dicarboxylic acid catabolic processGO:004364910.013
regulation of neuron projection developmentGO:00109751610.013
small gtpase mediated signal transductionGO:0007264360.013
regulation of protein maturationGO:1903317500.013
negative regulation of cell communicationGO:00106481580.012
peptidyl amino acid modificationGO:00181931260.012
response to mechanical stimulusGO:00096121340.012
response to activityGO:0014823730.012
negative regulation of rna metabolic processGO:00512531230.012
regulation of peptidase activityGO:0052547550.012
glial cell differentiationGO:0010001650.012
cellular polysaccharide metabolic processGO:0044264230.012
response to ketoneGO:19016541820.012
cell adhesionGO:00071551100.012
negative regulation of nervous system developmentGO:0051961790.012
neural crest cell migrationGO:000175510.012
positive regulation of ion transportGO:0043270940.012
regulation of cell cycle arrestGO:007115620.012
response to cgmpGO:007030530.012
divalent metal ion transportGO:00708381320.012
positive regulation of cell differentiationGO:00455972170.012
catecholamine secretionGO:0050432330.012
regulation of synaptic plasticityGO:0048167700.012
positive regulation of cell proliferationGO:00082842490.011
carbohydrate derivative metabolic processGO:19011353460.011
fatty acid metabolic processGO:0006631990.011
ketone biosynthetic processGO:0042181130.011
ribose phosphate biosynthetic processGO:0046390870.011
localization of cellGO:00516742020.011
response to vitaminGO:00332731310.011
negative regulation of protein processingGO:0010955470.011
macroautophagyGO:001623640.011
regulation of catabolic processGO:00098941130.011
regulation of secretion by cellGO:19035302080.011
actin filament based processGO:0030029860.011
regulation of cell migrationGO:00303341280.011
regulation of cell morphogenesis involved in differentiationGO:0010769720.011
reactive oxygen species biosynthetic processGO:190340980.011
negative regulation of multicellular organismal processGO:00512412030.011
positive regulation of endothelial cell migrationGO:001059540.011
organic cyclic compound catabolic processGO:19013611750.011
reactive nitrogen species metabolic processGO:200105710.011
negative regulation of cysteine type endopeptidase activityGO:2000117180.011
pyridine nucleotide metabolic processGO:0019362280.011
molting cycleGO:004230330.011
regulation of ion homeostasisGO:2000021630.010
regulation of cellular localizationGO:00603412630.010
cellular catabolic processGO:00442482950.010
organelle fusionGO:0048284170.010
regulation of carbohydrate metabolic processGO:0006109410.010
alditol metabolic processGO:001940040.010
positive regulation of nervous system developmentGO:00519621780.010
regulation of cellular protein metabolic processGO:00322682670.010
positive regulation of cellular amino acid metabolic processGO:004576410.010
renal sodium excretionGO:0035812200.010
regulation of protein processingGO:0070613500.010
regulation of transcription from rna polymerase ii promoterGO:00063572340.010

Pkm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.029
nervous system diseaseDOID:86300.029
musculoskeletal system diseaseDOID:1700.026