IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Lrrc59

leucine rich repeat containing 59

(Aliases: MGC105677)

RGD: 1305092
Entrez: 287633
Ensembl: ENSRNOG00000003524
UniProtKB: Q5RJR8

Process Predictions
Disease Predictions

Lrrc59 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular biogenic amine biosynthetic process	GO:0042401	4	0.276
polyamine biosynthetic process	GO:0006596	4	0.238
macromolecular complex assembly	GO:0065003	273	0.208
regulation of nucleic acid templated transcription	GO:1903506	380	0.183
regulation of immune system process	GO:0002682	123	0.162
rna metabolic process	GO:0016070	406	0.155
positive regulation of biosynthetic process	GO:0009891	319	0.146
rna biosynthetic process	GO:0032774	380	0.129
organelle organization	GO:0006996	266	0.123
nucleic acid templated transcription	GO:0097659	379	0.122
brain development	GO:0007420	247	0.107
regulation of molecular function	GO:0065009	398	0.100
positive regulation of cellular biosynthetic process	GO:0031328	295	0.098
positive regulation of gene expression	GO:0010628	244	0.098
response to external biotic stimulus	GO:0043207	221	0.096
regulation of rna metabolic process	GO:0051252	391	0.095
immune system process	GO:0002376	204	0.092
negative regulation of gene expression	GO:0010629	199	0.090
negative regulation of developmental process	GO:0051093	125	0.088
reproductive process	GO:0022414	372	0.087
protein complex subunit organization	GO:0071822	302	0.084
regulation of cellular protein metabolic process	GO:0032268	267	0.081
regulation of cellular component organization	GO:0051128	368	0.081
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.074
negative regulation of macromolecule metabolic process	GO:0010605	260	0.073
metal ion homeostasis	GO:0055065	186	0.073
regulation of rna biosynthetic process	GO:2001141	381	0.073
positive regulation of apoptotic process	GO:0043065	154	0.070
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.069
regulation of programmed cell death	GO:0043067	341	0.069
cellular component assembly	GO:0022607	360	0.069
vesicle mediated transport	GO:0016192	181	0.067
neural crest cell development	GO:0014032	2	0.066
intracellular transport	GO:0046907	185	0.065
eye morphogenesis	GO:0048592	4	0.064
single organism organelle organization	GO:1902589	180	0.064
catabolic process	GO:0009056	351	0.063
cellular ion homeostasis	GO:0006873	184	0.061
cytoskeleton organization	GO:0007010	111	0.061
aging	GO:0007568	241	0.060
single organism reproductive process	GO:0044702	297	0.060
positive regulation of phosphorus metabolic process	GO:0010562	262	0.060
cellular response to stress	GO:0033554	269	0.060
regulation of transcription dna templated	GO:0006355	374	0.058
proteolysis	GO:0006508	175	0.058
er associated ubiquitin dependent protein catabolic process	GO:0030433	1	0.057
gland development	GO:0048732	155	0.056
head development	GO:0060322	247	0.056
amine metabolic process	GO:0009308	38	0.056
cellular component biogenesis	GO:0044085	368	0.054
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.054
cation homeostasis	GO:0055080	195	0.054
reproduction	GO:0000003	245	0.054
negative regulation of cellular biosynthetic process	GO:0031327	161	0.054
cytoplasmic transport	GO:0016482	115	0.051
alpha amino acid metabolic process	GO:1901605	71	0.051
regulation of neurogenesis	GO:0050767	247	0.051
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.050
neuron projection development	GO:0031175	273	0.050
protein complex assembly	GO:0006461	263	0.049
regulation of cell proliferation	GO:0042127	359	0.048
negative regulation of cell development	GO:0010721	82	0.048
negative regulation of metabolic process	GO:0009892	331	0.047
endoplasmic reticulum unfolded protein response	GO:0030968	2	0.047
tissue development	GO:0009888	252	0.046
hepaticobiliary system development	GO:0061008	90	0.046
regulation of leukocyte migration	GO:0002685	24	0.045
organic acid metabolic process	GO:0006082	292	0.044
cellular amino acid metabolic process	GO:0006520	107	0.044
ribose phosphate metabolic process	GO:0019693	235	0.044
regulation of cell differentiation	GO:0045595	320	0.043
apoptotic process	GO:0006915	381	0.043
negative regulation of multicellular organismal process	GO:0051241	203	0.043
carbohydrate derivative biosynthetic process	GO:1901137	124	0.043
programmed cell death	GO:0012501	392	0.043
positive regulation of rna metabolic process	GO:0051254	203	0.042
regulation of transmembrane transport	GO:0034762	122	0.042
protein complex biogenesis	GO:0070271	263	0.041
macromolecule localization	GO:0033036	252	0.041
negative regulation of biosynthetic process	GO:0009890	168	0.040
cellular chemical homeostasis	GO:0055082	247	0.040
cellular metal ion homeostasis	GO:0006875	172	0.039
neuron differentiation	GO:0030182	368	0.039
receptor mediated endocytosis	GO:0006898	42	0.039
intracellular signal transduction	GO:0035556	314	0.039
regulation of behavior	GO:0050795	61	0.038
organonitrogen compound biosynthetic process	GO:1901566	167	0.038
positive regulation of cell differentiation	GO:0045597	217	0.038
regulation of calcium ion transport	GO:0051924	77	0.037
anatomical structure morphogenesis	GO:0009653	298	0.037
regulation of ion transport	GO:0043269	245	0.036
calcium ion transport	GO:0006816	131	0.035
nucleotide metabolic process	GO:0009117	279	0.035
positive regulation of phosphate metabolic process	GO:0045937	262	0.035
nucleobase containing small molecule metabolic process	GO:0055086	316	0.035
membrane organization	GO:0061024	94	0.035
negative regulation of cell differentiation	GO:0045596	99	0.034
regulation of cellular component biogenesis	GO:0044087	86	0.034
secretion by cell	GO:0032940	248	0.034
central nervous system development	GO:0007417	311	0.034
cellular response to unfolded protein	GO:0034620	2	0.033
regulation of phosphate metabolic process	GO:0019220	349	0.033
oxoacid metabolic process	GO:0043436	290	0.033
macromolecule catabolic process	GO:0009057	58	0.033
response to hypoxia	GO:0001666	231	0.032
cellular amine metabolic process	GO:0044106	38	0.032
mitotic cell cycle	GO:0000278	49	0.032
sexual reproduction	GO:0019953	148	0.031
regulation of multicellular organismal development	GO:2000026	376	0.031
positive regulation of rna biosynthetic process	GO:1902680	197	0.031
single organism intracellular transport	GO:1902582	166	0.031
neuron development	GO:0048666	286	0.030
positive regulation of catalytic activity	GO:0043085	184	0.030
cardiovascular system development	GO:0072358	134	0.029
negative regulation of dendrite development	GO:2000171	9	0.029
multicellular organism reproduction	GO:0032504	233	0.029
homeostatic process	GO:0042592	331	0.029
multicellular organismal reproductive process	GO:0048609	233	0.029
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.029
synaptic vesicle endocytosis	GO:0048488	4	0.028
cellular cation homeostasis	GO:0030003	180	0.028
cell cycle	GO:0007049	101	0.027
maintenance of location	GO:0051235	17	0.027
chemical homeostasis	GO:0048878	292	0.027
cation transport	GO:0006812	382	0.026
cellular homeostasis	GO:0019725	252	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.025
chromatin remodeling	GO:0006338	3	0.025
response to endoplasmic reticulum stress	GO:0034976	10	0.025
positive regulation of cell migration	GO:0030335	96	0.025
regulation of response to stress	GO:0080134	126	0.024
dna metabolic process	GO:0006259	96	0.024
organophosphate metabolic process	GO:0019637	370	0.024
cellular response to cytokine stimulus	GO:0071345	127	0.024
carboxylic acid biosynthetic process	GO:0046394	83	0.024
protein polymerization	GO:0051258	22	0.024
endocytosis	GO:0006897	84	0.024
regulation of hydrolase activity	GO:0051336	143	0.024
regulation of metal ion transport	GO:0010959	118	0.024
protein localization to organelle	GO:0033365	57	0.024
organelle localization	GO:0051640	55	0.023
negative regulation of rna biosynthetic process	GO:1902679	118	0.023
extracellular matrix constituent secretion	GO:0070278	4	0.023
response to decreased oxygen levels	GO:0036293	237	0.023
inorganic cation transmembrane transport	GO:0098662	202	0.023
positive regulation of cell death	GO:0010942	184	0.023
positive regulation of immune system process	GO:0002684	90	0.023
positive regulation of cellular component biogenesis	GO:0044089	55	0.023
gamete generation	GO:0007276	124	0.022
cellular protein complex assembly	GO:0043623	44	0.022
positive regulation of hydrolase activity	GO:0051345	86	0.022
response to other organism	GO:0051707	220	0.022
divalent metal ion transport	GO:0070838	132	0.022
chromosome segregation	GO:0007059	2	0.022
regulation of cell cycle	GO:0051726	73	0.022
membrane fusion	GO:0061025	26	0.022
nucleocytoplasmic transport	GO:0006913	48	0.022
defense response	GO:0006952	194	0.022
response to cytokine	GO:0034097	215	0.022
positive regulation of programmed cell death	GO:0043068	157	0.021
positive regulation of response to stimulus	GO:0048584	285	0.021
multi organism reproductive process	GO:0044703	262	0.021
positive regulation of transcription dna templated	GO:0045893	197	0.021
carboxylic acid metabolic process	GO:0019752	289	0.020
cytoskeleton dependent cytokinesis	GO:0061640	2	0.020
developmental process involved in reproduction	GO:0003006	159	0.020
divalent inorganic cation transport	GO:0072511	134	0.020
establishment of protein localization	GO:0045184	141	0.020
positive regulation of organelle organization	GO:0010638	48	0.020
positive regulation of molecular function	GO:0044093	230	0.020
regulation of cell development	GO:0060284	263	0.020
response to amine	GO:0014075	46	0.020
positive regulation of developmental process	GO:0051094	283	0.020
ion homeostasis	GO:0050801	212	0.019
negative regulation of nervous system development	GO:0051961	79	0.019
cell morphogenesis involved in differentiation	GO:0000904	119	0.019
divalent inorganic cation homeostasis	GO:0072507	165	0.019
regulation of catabolic process	GO:0009894	113	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.019
cellular biogenic amine metabolic process	GO:0006576	30	0.019
lipid storage	GO:0019915	1	0.018
cellular catabolic process	GO:0044248	295	0.018
vesicle docking	GO:0048278	5	0.018
response to oxidative stress	GO:0006979	186	0.018
cellular component movement	GO:0006928	248	0.018
regulation of catalytic activity	GO:0050790	304	0.018
response to peptide hormone	GO:0043434	278	0.018
regulation of anatomical structure size	GO:0090066	135	0.018
regulation of nucleotide metabolic process	GO:0006140	117	0.018
regulation of cell cycle process	GO:0010564	31	0.018
organic cyclic compound catabolic process	GO:1901361	175	0.018
sequestering of metal ion	GO:0051238	9	0.018
positive regulation of protein metabolic process	GO:0051247	178	0.017
regulation of protein metabolic process	GO:0051246	289	0.017
nicotinamide nucleotide metabolic process	GO:0046496	28	0.017
er nucleus signaling pathway	GO:0006984	3	0.017
regulation of purine nucleotide metabolic process	GO:1900542	115	0.017
secretion	GO:0046903	307	0.016
spermatogenesis	GO:0007283	99	0.016
regulation of nervous system development	GO:0051960	264	0.016
regulation of cellular catabolic process	GO:0031329	101	0.016
ribonucleoside metabolic process	GO:0009119	174	0.016
eye development	GO:0001654	50	0.016
vesicle docking involved in exocytosis	GO:0006904	4	0.015
negative regulation of catalytic activity	GO:0043086	103	0.015
regulation of intracellular signal transduction	GO:1902531	218	0.015
single organism membrane organization	GO:0044802	74	0.015
response to tumor cell	GO:0002347	4	0.015
ras protein signal transduction	GO:0007265	29	0.015
single organism biosynthetic process	GO:0044711	342	0.015
nitrogen compound transport	GO:0071705	229	0.015
heterocycle catabolic process	GO:0046700	167	0.015
cellular response to oxygen containing compound	GO:1901701	386	0.015
response to oxygen levels	GO:0070482	265	0.015
positive regulation of protein phosphorylation	GO:0001934	135	0.014
positive regulation of multicellular organismal process	GO:0051240	387	0.014
carbohydrate derivative metabolic process	GO:1901135	346	0.014
positive regulation of cellular component movement	GO:0051272	102	0.014
negative regulation of neurogenesis	GO:0050768	78	0.014
reproductive structure development	GO:0048608	128	0.014
protein modification by small protein conjugation	GO:0032446	31	0.014
negative regulation of transcription dna templated	GO:0045892	116	0.014
cellular response to oxidative stress	GO:0034599	76	0.014
protein modification by small protein conjugation or removal	GO:0070647	35	0.014
glycoprotein biosynthetic process	GO:0009101	19	0.014
regulation of calcium ion transmembrane transporter activity	GO:1901019	17	0.014
spindle organization	GO:0007051	2	0.014
positive regulation of nucleotide metabolic process	GO:0045981	91	0.014
nuclear import	GO:0051170	35	0.014
sex differentiation	GO:0007548	113	0.014
cellular response to external stimulus	GO:0071496	118	0.014
protein targeting to nucleus	GO:0044744	35	0.014
anterograde axon cargo transport	GO:0008089	1	0.014
single organism carbohydrate metabolic process	GO:0044723	118	0.014
regulation of neuron differentiation	GO:0045664	208	0.014
response to inorganic substance	GO:0010035	377	0.014
cardiac ventricle development	GO:0003231	1	0.014
negative regulation of rna metabolic process	GO:0051253	123	0.013
regulation of locomotion	GO:0040012	148	0.013
response to nutrient levels	GO:0031667	370	0.013
protein import into nucleus	GO:0006606	35	0.013
cell cycle process	GO:0022402	57	0.013
single organism catabolic process	GO:0044712	283	0.013
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.013
ribonucleotide metabolic process	GO:0009259	231	0.013
male gamete generation	GO:0048232	99	0.013
microtubule organizing center organization	GO:0031023	1	0.013
nucleoside phosphate metabolic process	GO:0006753	283	0.013
nuclear transport	GO:0051169	49	0.013
organic anion transport	GO:0015711	132	0.013
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.013
endoplasmic reticulum organization	GO:0007029	1	0.013
liver development	GO:0001889	90	0.013
nucleoside triphosphate metabolic process	GO:0009141	144	0.013
tube development	GO:0035295	89	0.012
transcription dna templated	GO:0006351	377	0.012
positive regulation of cell motility	GO:2000147	97	0.012
calcium ion transport into cytosol	GO:0060402	38	0.012
calcium ion homeostasis	GO:0055074	162	0.012
protein catabolic process	GO:0030163	30	0.012
locomotion	GO:0040011	237	0.012
regulation of chemotaxis	GO:0050920	29	0.012
sequestering of calcium ion	GO:0051208	8	0.012
transcription from rna polymerase ii promoter	GO:0006366	252	0.012
maintenance of protein location	GO:0045185	7	0.012
lipid localization	GO:0010876	62	0.012
regulation of apoptotic process	GO:0042981	335	0.012
dephosphorylation	GO:0016311	98	0.012
response to wounding	GO:0009611	254	0.012
cell migration	GO:0016477	197	0.012
oxidation reduction process	GO:0055114	304	0.012
cellular calcium ion homeostasis	GO:0006874	160	0.012
chromatin assembly or disassembly	GO:0006333	1	0.012
immune effector process	GO:0002252	53	0.012
coenzyme metabolic process	GO:0006732	86	0.012
rna localization	GO:0006403	4	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.012
reproductive system development	GO:0061458	128	0.012
negative regulation of cellular metabolic process	GO:0031324	281	0.011
calcium ion transmembrane transport	GO:0070588	70	0.011
protein folding	GO:0006457	12	0.011
negative regulation of molecular function	GO:0044092	133	0.011
positive regulation of cell proliferation	GO:0008284	249	0.011
regulation of ion transmembrane transport	GO:0034765	121	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
immune response	GO:0006955	104	0.011
regulation of neuron projection development	GO:0010975	161	0.011
organophosphate biosynthetic process	GO:0090407	143	0.011
multicellular organism growth	GO:0035264	1	0.011
regulation of smooth muscle cell proliferation	GO:0048660	75	0.011
embryo development	GO:0009790	49	0.011
macromolecular complex subunit organization	GO:0043933	339	0.011
response to glucose	GO:0009749	136	0.011
innate immune response	GO:0045087	35	0.011
metal ion transport	GO:0030001	289	0.011
gtp metabolic process	GO:0046039	72	0.011
cellular macromolecular complex assembly	GO:0034622	58	0.011
negative regulation of cell death	GO:0060548	229	0.011
cytosolic calcium ion homeostasis	GO:0051480	140	0.011
regulation of signal transduction	GO:0009966	318	0.011
cellular response to nutrient levels	GO:0031669	60	0.011
synaptic transmission	GO:0007268	235	0.010
purine nucleoside metabolic process	GO:0042278	169	0.010
proteasomal protein catabolic process	GO:0010498	8	0.010
amine biosynthetic process	GO:0009309	4	0.010
branched chain amino acid transport	GO:0015803	2	0.010
regulation of cell projection organization	GO:0031344	175	0.010
cell projection organization	GO:0030030	302	0.010
chordate embryonic development	GO:0043009	18	0.010
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	27	0.010

Lrrc59 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.025
nervous system disease	DOID:863	0.025
neuropathy	DOID:870	0.021
neuromuscular disease	DOID:440	0.021
charcot marie tooth disease type 2	DOID:0050539	0.021
charcot marie tooth disease	DOID:10595	0.021
central nervous system disease	DOID:331	0.016
brain disease	DOID:936	0.014
disease of cellular proliferation	DOID:14566	0.010

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