IMP: Integrative Multi-species Prediction

Rattus norvegicus

48 known processes

Hsd17b2

hydroxysteroid (17-beta) dehydrogenase 2

Entrez: 79243
RGD: 621803
Ensembl: ENSRNOG00000013982
UniProtKB: Q62730

Process Predictions
Disease Predictions

Hsd17b2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to nutrient	GO:0007584	248	0.801	Rat
organic acid metabolic process	GO:0006082	292	0.559	Rat
response to corticosteroid	GO:0031960	235	0.506	Rat
oxoacid metabolic process	GO:0043436	290	0.479	Rat
monocarboxylic acid metabolic process	GO:0032787	152	0.459	Rat
response to peptide hormone	GO:0043434	278	0.450	Rat
organic acid biosynthetic process	GO:0016053	83	0.441	Rat
response to extracellular stimulus	GO:0009991	380	0.437	Rat
liver development	GO:0001889	90	0.424	Rat
response to glucocorticoid	GO:0051384	223	0.389	Rat
response to estrogen	GO:0043627	232	0.369	Rat
response to nutrient levels	GO:0031667	370	0.347	Rat
response to vitamin	GO:0033273	131	0.235
carboxylic acid metabolic process	GO:0019752	289	0.232	Rat
carboxylic acid biosynthetic process	GO:0046394	83	0.224	Rat
response to transition metal nanoparticle	GO:1990267	122	0.224
response to peptide	GO:1901652	292	0.200	Rat
response to acid chemical	GO:0001101	222	0.188	Human
gland development	GO:0048732	155	0.170	Rat
cellular lipid metabolic process	GO:0044255	208	0.166	Rat
response to camp	GO:0051591	91	0.156
cellular response to hormone stimulus	GO:0032870	247	0.156
response to inorganic substance	GO:0010035	377	0.147
single organism reproductive process	GO:0044702	297	0.144	Mouse
response to metal ion	GO:0010038	253	0.136
cellular amino acid metabolic process	GO:0006520	107	0.134
cellular response to endogenous stimulus	GO:0071495	377	0.129
regulation of hormone levels	GO:0010817	187	0.124
response to toxic substance	GO:0009636	133	0.121	Rat
intestinal absorption	GO:0050892	3	0.113
cellular response to lipid	GO:0071396	201	0.100
cellular response to peptide hormone stimulus	GO:0071375	120	0.095
multi organism reproductive process	GO:0044703	262	0.088	Rat
lipid metabolic process	GO:0006629	283	0.081
monocarboxylic acid biosynthetic process	GO:0072330	48	0.080	Rat
cellular response to external stimulus	GO:0071496	118	0.079
cellular ketone metabolic process	GO:0042180	51	0.076
cellular response to organic cyclic compound	GO:0071407	202	0.073
regeneration	GO:0031099	163	0.072
cellular response to steroid hormone stimulus	GO:0071383	93	0.072
response to carbohydrate	GO:0009743	183	0.071
cellular response to nitrogen compound	GO:1901699	210	0.071
cellular response to corticosteroid stimulus	GO:0071384	69	0.070
cellular response to oxygen containing compound	GO:1901701	386	0.070
hepaticobiliary system development	GO:0061008	90	0.069	Rat
regulation of cellular ketone metabolic process	GO:0010565	27	0.066
response to acetate	GO:0010034	3	0.066
cellular hormone metabolic process	GO:0034754	49	0.065
response to organophosphorus	GO:0046683	102	0.065
response to estradiol	GO:0032355	164	0.063	Rat
macromolecular complex subunit organization	GO:0043933	339	0.062
response to food	GO:0032094	27	0.061	Rat
response to xenobiotic stimulus	GO:0009410	23	0.060
response to decreased oxygen levels	GO:0036293	237	0.059	Rat
response to insulin	GO:0032868	133	0.059	Rat
multi multicellular organism process	GO:0044706	138	0.058	Rat
organ regeneration	GO:0031100	101	0.058
multicellular organism reproduction	GO:0032504	233	0.058
response to oxygen levels	GO:0070482	265	0.056	Rat
cellular response to organonitrogen compound	GO:0071417	197	0.054
cellular component assembly	GO:0022607	360	0.054
cellular component biogenesis	GO:0044085	368	0.052
cellular response to glucocorticoid stimulus	GO:0071385	68	0.050
catabolic process	GO:0009056	351	0.050
organic anion transport	GO:0015711	132	0.050
response to hypoxia	GO:0001666	231	0.049	Rat
cellular response to insulin stimulus	GO:0032869	81	0.049
amine metabolic process	GO:0009308	38	0.048
lipid biosynthetic process	GO:0008610	128	0.048
response to purine containing compound	GO:0014074	126	0.048
single organism catabolic process	GO:0044712	283	0.047
response to vitamin b6	GO:0034516	1	0.045
response to retinoic acid	GO:0032526	63	0.044	Human
response to vitamin a	GO:0033189	36	0.044
negative regulation of serine type endopeptidase activity	GO:1900004	1	0.043
reproductive process	GO:0022414	372	0.043	Mouse Rat
cofactor metabolic process	GO:0051186	95	0.043
pyruvate metabolic process	GO:0006090	27	0.043
response to amino acid	GO:0043200	75	0.042
protein complex biogenesis	GO:0070271	263	0.042
anion transport	GO:0006820	178	0.040
fatty acid oxidation	GO:0019395	29	0.040
chemical homeostasis	GO:0048878	292	0.039
oxidation reduction process	GO:0055114	304	0.038
response to herbicide	GO:0009635	16	0.038
coenzyme metabolic process	GO:0006732	86	0.038
cellular amine metabolic process	GO:0044106	38	0.037
anatomical structure morphogenesis	GO:0009653	298	0.037
protein complex subunit organization	GO:0071822	302	0.037
isoprenoid metabolic process	GO:0006720	45	0.036	Rat
cellular response to peptide	GO:1901653	133	0.036
regulation of cellular amino acid metabolic process	GO:0006521	2	0.036
single organism biosynthetic process	GO:0044711	342	0.036
response to oxidative stress	GO:0006979	186	0.035
aging	GO:0007568	241	0.035
cellular response to stress	GO:0033554	269	0.035
response to mechanical stimulus	GO:0009612	134	0.035
c21 steroid hormone metabolic process	GO:0008207	14	0.034
response to fungicide	GO:0060992	20	0.034
programmed cell death	GO:0012501	392	0.034
c21 steroid hormone biosynthetic process	GO:0006700	10	0.033
diterpenoid metabolic process	GO:0016101	33	0.033	Rat
positive regulation of multicellular organismal process	GO:0051240	387	0.033
steroid metabolic process	GO:0008202	73	0.032
monocarboxylic acid transport	GO:0015718	52	0.032
phthalate metabolic process	GO:0018963	8	0.031
circadian rhythm	GO:0007623	88	0.031
lipid localization	GO:0010876	62	0.031
cellular catabolic process	GO:0044248	295	0.031
cellular response to camp	GO:0071320	26	0.030
response to interleukin 1	GO:0070555	55	0.030
fatty acid metabolic process	GO:0006631	99	0.030
regulation of growth	GO:0040008	105	0.030
estrogen biosynthetic process	GO:0006703	6	0.029
response to other organism	GO:0051707	220	0.029
vasodilation	GO:0042311	44	0.028
response to triglyceride	GO:0034014	3	0.028
regulation of programmed cell death	GO:0043067	341	0.028
response to ketone	GO:1901654	182	0.028	Rat
regulation of cellular amine metabolic process	GO:0033238	8	0.028
acylglycerol metabolic process	GO:0006639	21	0.027
positive regulation of cellular amine metabolic process	GO:0033240	3	0.027
response to zinc ion	GO:0010043	39	0.027
multicellular organismal reproductive process	GO:0048609	233	0.027
response to ionizing radiation	GO:0010212	59	0.027
hepatocyte differentiation	GO:0070365	8	0.025
protein complex assembly	GO:0006461	263	0.025
homeostatic process	GO:0042592	331	0.025
negative regulation of gene expression	GO:0010629	199	0.025
reproductive system development	GO:0061458	128	0.025	Mouse
regulation of rna biosynthetic process	GO:2001141	381	0.025
lipid transport	GO:0006869	61	0.025
response to testosterone	GO:0033574	55	0.025
response to lead ion	GO:0010288	33	0.024
carbohydrate metabolic process	GO:0005975	130	0.024
regulation of anatomical structure size	GO:0090066	135	0.024
response to external biotic stimulus	GO:0043207	221	0.024
cellular response to interferon gamma	GO:0071346	14	0.024
response to monosaccharide	GO:0034284	159	0.024
androgen biosynthetic process	GO:0006702	10	0.024
developmental growth	GO:0048589	100	0.024
progesterone metabolic process	GO:0042448	8	0.024
spermatogenesis	GO:0007283	99	0.024
anion transmembrane transport	GO:0098656	77	0.024
organophosphate metabolic process	GO:0019637	370	0.024
response to cadmium ion	GO:0046686	35	0.024	Rat
organic substance catabolic process	GO:1901575	316	0.024
cardiac chamber development	GO:0003205	1	0.024
negative regulation of molecular function	GO:0044092	133	0.023
cellular response to metal ion	GO:0071248	55	0.023
carbohydrate derivative metabolic process	GO:1901135	346	0.023
nucleobase containing small molecule metabolic process	GO:0055086	316	0.023
single organism carbohydrate metabolic process	GO:0044723	118	0.023
cellular response to vitamin e	GO:0071306	3	0.023
transmission of nerve impulse	GO:0019226	42	0.023
hormone metabolic process	GO:0042445	69	0.023
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.023
negative regulation of transcription dna templated	GO:0045892	116	0.023
response to bacterium	GO:0009617	200	0.022
neutral lipid metabolic process	GO:0006638	21	0.022
growth	GO:0040007	165	0.022
terpenoid metabolic process	GO:0006721	37	0.022	Rat
response to insecticide	GO:0017085	21	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.022
reproduction	GO:0000003	245	0.021
circulatory system process	GO:0003013	183	0.021	Rat
protein maturation	GO:0051604	68	0.021
cellular response to ketone	GO:1901655	51	0.021
regulation of molecular function	GO:0065009	398	0.020
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	3	0.020
extracellular matrix constituent secretion	GO:0070278	4	0.020
neuron differentiation	GO:0030182	368	0.020
proteolysis	GO:0006508	175	0.020
regulation of extracellular matrix constituent secretion	GO:0003330	2	0.020
cellular response to gonadotropin stimulus	GO:0071371	17	0.020
cellular homeostasis	GO:0019725	252	0.020
aromatic compound catabolic process	GO:0019439	168	0.020
response to corticosterone	GO:0051412	40	0.019	Rat
cellular response to interleukin 1	GO:0071347	37	0.019
carboxylic acid transport	GO:0046942	115	0.019
response to cytokine	GO:0034097	215	0.019
cellular modified amino acid metabolic process	GO:0006575	61	0.019
heart morphogenesis	GO:0003007	3	0.019
regulation of catalytic activity	GO:0050790	304	0.019
protein processing	GO:0016485	68	0.019
head development	GO:0060322	247	0.019	Rat
response to reactive oxygen species	GO:0000302	120	0.018
sulfur compound metabolic process	GO:0006790	70	0.018
reproductive structure development	GO:0048608	128	0.018	Mouse
sexual reproduction	GO:0019953	148	0.018
negative regulation of metabolic process	GO:0009892	331	0.018
neurological system process	GO:0050877	219	0.018
tissue development	GO:0009888	252	0.018	Rat
positive regulation of cellular biosynthetic process	GO:0031328	295	0.018
catenin import into nucleus	GO:0035411	1	0.018
negative regulation of cellular metabolic process	GO:0031324	281	0.017
nitrogen compound transport	GO:0071705	229	0.017
cellular response to xenobiotic stimulus	GO:0071466	19	0.017
regulation of cellular component organization	GO:0051128	368	0.017
developmental process involved in reproduction	GO:0003006	159	0.017	Mouse
amide transport	GO:0042886	105	0.017
positive regulation of catalytic activity	GO:0043085	184	0.017
regulation of blood pressure	GO:0008217	83	0.017	Rat
behavior	GO:0007610	205	0.016
response to lipopolysaccharide	GO:0032496	191	0.016
rhythmic process	GO:0048511	156	0.016
hexose metabolic process	GO:0019318	58	0.016
pancreatic stellate cell proliferation	GO:0072343	2	0.016
macromolecular complex assembly	GO:0065003	273	0.016
reactive nitrogen species metabolic process	GO:2001057	1	0.016
smooth muscle cell proliferation	GO:0048659	77	0.016
regulation of multicellular organismal development	GO:2000026	376	0.016
vitamin d receptor signaling pathway	GO:0070561	1	0.016
response to mercury ion	GO:0046689	15	0.016
sterol homeostasis	GO:0055092	3	0.016
transcription dna templated	GO:0006351	377	0.016
lipid catabolic process	GO:0016042	46	0.016
ion homeostasis	GO:0050801	212	0.016
negative regulation of transcription regulatory region dna binding	GO:2000678	2	0.016
regulation of nucleic acid templated transcription	GO:1903506	380	0.016
response to hyperoxia	GO:0055093	45	0.016
negative regulation of apoptotic process	GO:0043066	181	0.015
insecticide metabolic process	GO:0017143	4	0.015
negative regulation of catalytic activity	GO:0043086	103	0.015
lipid oxidation	GO:0034440	30	0.015
glycosyl compound metabolic process	GO:1901657	182	0.015
regulation of serine type endopeptidase activity	GO:1900003	1	0.015
placenta development	GO:0001890	22	0.015	Mouse
regulation of ion transport	GO:0043269	245	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.015
cellular response to oxidative stress	GO:0034599	76	0.015
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.015
regulation of apoptotic process	GO:0042981	335	0.014
central nervous system development	GO:0007417	311	0.014	Rat
bmp signaling pathway	GO:0030509	4	0.014
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.014
cholesterol homeostasis	GO:0042632	3	0.014
cellular response to inorganic substance	GO:0071241	65	0.014
regulation of protein maturation	GO:1903317	50	0.014
multicellular organismal signaling	GO:0035637	44	0.014
neuron projection development	GO:0031175	273	0.014
regulation of phagocytosis engulfment	GO:0060099	4	0.014
glial cell differentiation	GO:0010001	65	0.014
rhythmic behavior	GO:0007622	24	0.014
response to glucose	GO:0009749	136	0.014
negative regulation of rna metabolic process	GO:0051253	123	0.014
response to hexose	GO:0009746	144	0.014
gamete generation	GO:0007276	124	0.014
response to chromate	GO:0046687	3	0.014
positive regulation of biosynthetic process	GO:0009891	319	0.014
regulation of neuron differentiation	GO:0045664	208	0.014
positive regulation of phagocytosis engulfment	GO:0060100	4	0.013
brain renin angiotensin system	GO:0002035	3	0.013
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
positive regulation of signaling	GO:0023056	270	0.013
response to hydrogen peroxide	GO:0042542	89	0.013
regulation of peptide secretion	GO:0002791	82	0.013
negative regulation of programmed cell death	GO:0043069	183	0.013
regulation of tube size	GO:0035150	89	0.013
organic hydroxy compound metabolic process	GO:1901615	115	0.013
response to vitamin d	GO:0033280	34	0.013
negative regulation of serine type peptidase activity	GO:1902572	1	0.013
protein oligomerization	GO:0051259	191	0.013
negative regulation of protein metabolic process	GO:0051248	114	0.013
response to activity	GO:0014823	73	0.013
nucleotide metabolic process	GO:0009117	279	0.013
response to vitamin e	GO:0033197	24	0.013
negative regulation of peptidase activity	GO:0010466	38	0.013
locomotion	GO:0040011	237	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
positive regulation of developmental process	GO:0051094	283	0.013
cell projection organization	GO:0030030	302	0.013
regulation of blood circulation	GO:1903522	110	0.012
chromosome segregation	GO:0007059	2	0.012
single organism carbohydrate catabolic process	GO:0044724	40	0.012
regulation of nervous system development	GO:0051960	264	0.012
digestive system development	GO:0055123	41	0.012
purine nucleoside metabolic process	GO:0042278	169	0.012
xenobiotic metabolic process	GO:0006805	19	0.012
regulation of neuronal synaptic plasticity	GO:0048168	31	0.012
pyridine containing compound metabolic process	GO:0072524	32	0.012
vitamin a metabolic process	GO:0006776	2	0.012
regulation of protein processing	GO:0070613	50	0.012
response to methanol	GO:0033986	1	0.012
positive regulation of transport	GO:0051050	245	0.012
antibiotic transport	GO:0042891	2	0.012
chemosensory behavior	GO:0007635	2	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.012
phenylpropanoid catabolic process	GO:0046271	3	0.012
heterocycle catabolic process	GO:0046700	167	0.012
response to temperature stimulus	GO:0009266	94	0.012
secretion	GO:0046903	307	0.012
inorganic anion transport	GO:0015698	41	0.012
carbohydrate catabolic process	GO:0016052	40	0.012
telencephalon development	GO:0021537	62	0.012
positive regulation of protein metabolic process	GO:0051247	178	0.011
isoprenoid biosynthetic process	GO:0008299	12	0.011	Rat
lipid storage	GO:0019915	1	0.011
response to interferon gamma	GO:0034341	20	0.011
sulfur compound biosynthetic process	GO:0044272	19	0.011
circadian behavior	GO:0048512	24	0.011
apoptotic process	GO:0006915	381	0.011
small molecule biosynthetic process	GO:0044283	124	0.011	Rat
regulation of serine type peptidase activity	GO:1902571	1	0.011
response to calcium ion	GO:0051592	59	0.011
phosphatidylethanolamine metabolic process	GO:0046337	1	0.011
biphenyl metabolic process	GO:0018879	10	0.011
positive regulation of extracellular matrix constituent secretion	GO:0003331	2	0.011
organic cyclic compound catabolic process	GO:1901361	175	0.011
axis specification	GO:0009798	4	0.011
regulation of pancreatic stellate cell proliferation	GO:2000229	2	0.011
monosaccharide metabolic process	GO:0005996	61	0.011
positive regulation of molecular function	GO:0044093	230	0.011
rna metabolic process	GO:0016070	406	0.011
neural crest cell differentiation	GO:0014033	2	0.011
cellular response to mechanical stimulus	GO:0071260	48	0.011
cellular ion homeostasis	GO:0006873	184	0.011
rna biosynthetic process	GO:0032774	380	0.011
dibenzo p dioxin metabolic process	GO:0018894	10	0.011
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.011
cellular response to abiotic stimulus	GO:0071214	85	0.011
response to muscle activity involved in regulation of muscle adaptation	GO:0014873	2	0.011
positive regulation of extracellular matrix organization	GO:1903055	4	0.011
regulation of transcription dna templated	GO:0006355	374	0.011
positive regulation of growth	GO:0045927	55	0.011
neuron development	GO:0048666	286	0.011
purine ribonucleoside metabolic process	GO:0046128	168	0.011
inflammatory response	GO:0006954	150	0.011
circadian sleep wake cycle	GO:0042745	23	0.011
cellular response to fluid shear stress	GO:0071498	4	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.010
nicotinamide nucleotide metabolic process	GO:0046496	28	0.010
protein localization to organelle	GO:0033365	57	0.010
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.010
response to molecule of bacterial origin	GO:0002237	194	0.010
odontogenesis	GO:0042476	32	0.010
defense response	GO:0006952	194	0.010
regulation of hydrolase activity	GO:0051336	143	0.010
regulation of sodium ion transmembrane transporter activity	GO:2000649	4	0.010
male gamete generation	GO:0048232	99	0.010
positive regulation of fatty acid oxidation	GO:0046321	6	0.010
positive regulation of fibroblast proliferation	GO:0048146	15	0.010
toxin transport	GO:1901998	3	0.010
androgen metabolic process	GO:0008209	14	0.010
positive regulation of cell projection organization	GO:0031346	111	0.010
brain development	GO:0007420	247	0.010	Rat
wound healing	GO:0042060	122	0.010

Hsd17b2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.052
inherited metabolic disorder	DOID:655	0.031
steroid inherited metabolic disorder	DOID:1701	0.031
congenital adrenal hyperplasia	DOID:0050811	0.031
lipid metabolism disorder	DOID:3146	0.031
acquired metabolic disease	DOID:0060158	0.014
disease of anatomical entity	DOID:7	0.013
connective tissue disease	DOID:65	0.013
musculoskeletal system disease	DOID:17	0.013
artery disease	DOID:0050828	0.012
vascular disease	DOID:178	0.012
cardiovascular system disease	DOID:1287	0.012
disease of cellular proliferation	DOID:14566	0.011
cancer	DOID:162	0.011

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