IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Hrasls5

HRAS-like suppressor family, member 5

(Aliases: RGD1308376,MGC116140)

Entrez: 293711
RGD: 1308376
Ensembl: ENSRNOG00000023528
UniProtKB: Q4KLN5

Process Predictions
Disease Predictions

Hrasls5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
carboxylic acid metabolic process	GO:0019752	289	0.309
organic anion transport	GO:0015711	132	0.286
single organism reproductive process	GO:0044702	297	0.278
ion transmembrane transport	GO:0034220	365	0.276
hindlimb morphogenesis	GO:0035137	2	0.266
transmembrane transport	GO:0055085	412	0.240
oxoacid metabolic process	GO:0043436	290	0.190
response to extracellular stimulus	GO:0009991	380	0.187
embryonic hindlimb morphogenesis	GO:0035116	2	0.184
organic substance catabolic process	GO:1901575	316	0.167
anion transmembrane transport	GO:0098656	77	0.167
cellular response to iron iii ion	GO:0071283	3	0.153
response to indole 3 methanol	GO:0071680	2	0.148
macromolecular complex assembly	GO:0065003	273	0.138
apoptotic process	GO:0006915	381	0.134
response to organophosphorus	GO:0046683	102	0.132
response to hexose	GO:0009746	144	0.119
programmed cell death	GO:0012501	392	0.119
carboxylic acid transport	GO:0046942	115	0.119
response to purine containing compound	GO:0014074	126	0.117
response to alkaloid	GO:0043279	132	0.117
response to nutrient levels	GO:0031667	370	0.110
protein complex assembly	GO:0006461	263	0.109
response to camp	GO:0051591	91	0.105
organic acid transport	GO:0015849	116	0.104
secretion	GO:0046903	307	0.099
neuron differentiation	GO:0030182	368	0.094
cellular component assembly	GO:0022607	360	0.093
positive regulation of synaptic plasticity	GO:0031915	3	0.091
limb morphogenesis	GO:0035108	4	0.091
response to high light intensity	GO:0009644	1	0.084
positive regulation of multicellular organismal process	GO:0051240	387	0.079
prostate gland epithelium morphogenesis	GO:0060740	2	0.079
regulation of programmed cell death	GO:0043067	341	0.077
negative regulation of nervous system development	GO:0051961	79	0.077
lipid biosynthetic process	GO:0008610	128	0.074
reproductive process	GO:0022414	372	0.074
response to glucose	GO:0009749	136	0.072
reproduction	GO:0000003	245	0.070
multicellular organism reproduction	GO:0032504	233	0.070
protein complex biogenesis	GO:0070271	263	0.068
monocarboxylic acid metabolic process	GO:0032787	152	0.067
response to nutrient	GO:0007584	248	0.064
positive regulation of transport	GO:0051050	245	0.064
protein oligomerization	GO:0051259	191	0.064
catabolic process	GO:0009056	351	0.064
transformation of host cell by virus	GO:0019087	4	0.063
organic acid metabolic process	GO:0006082	292	0.059
response to carbohydrate	GO:0009743	183	0.058
protein complex subunit organization	GO:0071822	302	0.058
response to bacterium	GO:0009617	200	0.058
single organism catabolic process	GO:0044712	283	0.057
steroid biosynthetic process	GO:0006694	48	0.057
response to decreased oxygen levels	GO:0036293	237	0.054
reproductive structure development	GO:0048608	128	0.054
embryonic appendage morphogenesis	GO:0035113	4	0.053
regulation of nervous system development	GO:0051960	264	0.052
reproductive system development	GO:0061458	128	0.052
cellular response to fluid shear stress	GO:0071498	4	0.051
regulation of cellular component organization	GO:0051128	368	0.049
prostate gland morphogenesis	GO:0060512	2	0.049
nitrogen compound transport	GO:0071705	229	0.049
sexual reproduction	GO:0019953	148	0.048
response to metal ion	GO:0010038	253	0.047
positive regulation of cell proliferation	GO:0008284	249	0.047
regulation of cellular ketone metabolic process	GO:0010565	27	0.046
response to nicotine	GO:0035094	51	0.045
protein homooligomerization	GO:0051260	91	0.045
neuron projection development	GO:0031175	273	0.045
regulation of secretion by cell	GO:1903530	208	0.045
negative regulation of multicellular organismal process	GO:0051241	203	0.044
response to low density lipoprotein particle	GO:0055098	4	0.044
nucleoside triphosphate metabolic process	GO:0009141	144	0.044
cellular response to nitrogen compound	GO:1901699	210	0.043
cellular component biogenesis	GO:0044085	368	0.042
regulation of multicellular organismal development	GO:2000026	376	0.042
response to monosaccharide	GO:0034284	159	0.041
embryonic limb morphogenesis	GO:0030326	4	0.041
multi organism reproductive process	GO:0044703	262	0.041
response to corticosteroid	GO:0031960	235	0.040
cell cell signaling	GO:0007267	335	0.040
cellular response to organic cyclic compound	GO:0071407	202	0.040
response to peptide	GO:1901652	292	0.040
response to acid chemical	GO:0001101	222	0.039
cellular response to hormone stimulus	GO:0032870	247	0.039
neuron development	GO:0048666	286	0.038
cellular catabolic process	GO:0044248	295	0.038
regulation of apoptotic process	GO:0042981	335	0.038
cellular response to low density lipoprotein particle stimulus	GO:0071404	3	0.037
regulation of cell differentiation	GO:0045595	320	0.037
secretion by cell	GO:0032940	248	0.036
ovulation cycle	GO:0042698	67	0.036
collagen catabolic process	GO:0030574	2	0.036
vesicle mediated transport	GO:0016192	181	0.035
response to temperature stimulus	GO:0009266	94	0.035
regulation of neurogenesis	GO:0050767	247	0.034
response to heat	GO:0009408	60	0.034
regulation of cell adhesion	GO:0030155	52	0.034
regulation of blood circulation	GO:1903522	110	0.034
response to axon injury	GO:0048678	59	0.034
response to oxygen levels	GO:0070482	265	0.034
response to hypoxia	GO:0001666	231	0.034
positive regulation of apoptotic process	GO:0043065	154	0.033
response to ethanol	GO:0045471	162	0.033
response to retinoic acid	GO:0032526	63	0.033
multicellular organismal reproductive process	GO:0048609	233	0.033
cellular response to stress	GO:0033554	269	0.032
vitamin transport	GO:0051180	14	0.032
mesoderm development	GO:0007498	2	0.031
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.031
biological adhesion	GO:0022610	110	0.031
regulation of cell proliferation	GO:0042127	359	0.031
regulation of membrane potential	GO:0042391	110	0.030
regulation of rna biosynthetic process	GO:2001141	381	0.030
organonitrogen compound catabolic process	GO:1901565	179	0.030
response to inorganic substance	GO:0010035	377	0.030
regulation of cell development	GO:0060284	263	0.030
cell adhesion	GO:0007155	110	0.029
response to molecule of bacterial origin	GO:0002237	194	0.029
regulation of hormone levels	GO:0010817	187	0.029
regulation of catalytic activity	GO:0050790	304	0.028
choline transport	GO:0015871	4	0.028
response to estrogen	GO:0043627	232	0.027
positive regulation of programmed cell death	GO:0043068	157	0.027
cellular ketone metabolic process	GO:0042180	51	0.027
proteolysis	GO:0006508	175	0.027
neuron projection regeneration	GO:0031102	35	0.027
synaptic transmission	GO:0007268	235	0.027
rna metabolic process	GO:0016070	406	0.026
cellular lipid metabolic process	GO:0044255	208	0.026
negative regulation of programmed cell death	GO:0043069	183	0.026
gliogenesis	GO:0042063	93	0.026
insecticide metabolic process	GO:0017143	4	0.026
response to lipopolysaccharide	GO:0032496	191	0.026
regulation of neuron projection development	GO:0010975	161	0.026
single organism biosynthetic process	GO:0044711	342	0.025
cellular response to endogenous stimulus	GO:0071495	377	0.025
female gonad development	GO:0008585	53	0.025
neurological system process	GO:0050877	219	0.025
regulation of neuron differentiation	GO:0045664	208	0.024
steroid metabolic process	GO:0008202	73	0.024
response to peptide hormone	GO:0043434	278	0.024
carbohydrate homeostasis	GO:0033500	75	0.024
response to hyperoxia	GO:0055093	45	0.024
ovulation	GO:0030728	17	0.024
glycosyl compound metabolic process	GO:1901657	182	0.024
regulation of system process	GO:0044057	208	0.023
positive regulation of secretion by cell	GO:1903532	128	0.023
response to glucocorticoid	GO:0051384	223	0.023
cation transport	GO:0006812	382	0.023
embryo development	GO:0009790	49	0.023
fatty acid metabolic process	GO:0006631	99	0.023
cell projection organization	GO:0030030	302	0.023
regulation of secretion	GO:0051046	224	0.023
gamete generation	GO:0007276	124	0.023
multicellular organismal catabolic process	GO:0044243	2	0.022
central nervous system development	GO:0007417	311	0.022
response to amino acid	GO:0043200	75	0.022
anion transport	GO:0006820	178	0.022
regulation of anatomical structure size	GO:0090066	135	0.022
inorganic ion transmembrane transport	GO:0098660	229	0.022
amino acid transport	GO:0006865	70	0.022
response to other organism	GO:0051707	220	0.021
response to vitamin	GO:0033273	131	0.021
aging	GO:0007568	241	0.021
positive regulation of hormone secretion	GO:0046887	65	0.021
chemical homeostasis	GO:0048878	292	0.021
monocarboxylic acid transport	GO:0015718	52	0.021
multi multicellular organism process	GO:0044706	138	0.021
membrane organization	GO:0061024	94	0.021
positive regulation of signaling	GO:0023056	270	0.021
glial cell differentiation	GO:0010001	65	0.021
positive regulation of cell differentiation	GO:0045597	217	0.021
negative regulation of uterine smooth muscle contraction	GO:0070473	2	0.021
appendage morphogenesis	GO:0035107	4	0.020
regulation of protein serine threonine kinase activity	GO:0071900	64	0.020
nucleobase containing small molecule metabolic process	GO:0055086	316	0.020
organic hydroxy compound transport	GO:0015850	77	0.020
regulation of rna metabolic process	GO:0051252	391	0.020
regulation of protein metabolic process	GO:0051246	289	0.020
cellular response to oxygen containing compound	GO:1901701	386	0.020
regulation of cell projection organization	GO:0031344	175	0.020
positive regulation of ion transport	GO:0043270	94	0.020
neuron death	GO:0070997	127	0.019
cellular homeostasis	GO:0019725	252	0.019
cation transmembrane transport	GO:0098655	263	0.019
negative regulation of developmental process	GO:0051093	125	0.019
hormone metabolic process	GO:0042445	69	0.019
reactive oxygen species biosynthetic process	GO:1903409	8	0.019
cellular hormone metabolic process	GO:0034754	49	0.019
response to estradiol	GO:0032355	164	0.019
response to fluid shear stress	GO:0034405	16	0.018
cellular potassium ion transport	GO:0071804	72	0.018
cellular chemical homeostasis	GO:0055082	247	0.018
negative regulation of macromolecule metabolic process	GO:0010605	260	0.018
negative regulation of apoptotic process	GO:0043066	181	0.018
cellular response to metal ion	GO:0071248	55	0.018
negative regulation of neurogenesis	GO:0050768	78	0.018
development of primary sexual characteristics	GO:0045137	107	0.018
response to ketone	GO:1901654	182	0.017
negative regulation of neuron differentiation	GO:0045665	62	0.017
positive regulation of map kinase activity	GO:0043406	46	0.017
cellular amino acid metabolic process	GO:0006520	107	0.017
gonad development	GO:0008406	104	0.017
response to oxidative stress	GO:0006979	186	0.017
response to fatty acid	GO:0070542	65	0.017
small gtpase mediated signal transduction	GO:0007264	36	0.017
positive regulation of cellular biosynthetic process	GO:0031328	295	0.017
negative regulation of cell development	GO:0010721	82	0.017
positive regulation of cellular component organization	GO:0051130	200	0.017
synaptic growth at neuromuscular junction	GO:0051124	1	0.016
spermatogenesis	GO:0007283	99	0.016
regulation of molecular function	GO:0065009	398	0.016
positive regulation of cellular amine metabolic process	GO:0033240	3	0.016
insulin receptor signaling pathway	GO:0008286	24	0.016
cellular response to lipid	GO:0071396	201	0.016
negative regulation of metabolic process	GO:0009892	331	0.016
cellular response to organonitrogen compound	GO:0071417	197	0.016
hormone secretion	GO:0046879	115	0.016
developmental process involved in reproduction	GO:0003006	159	0.015
positive regulation of neurogenesis	GO:0050769	165	0.015
response to transition metal nanoparticle	GO:1990267	122	0.015
response to increased oxygen levels	GO:0036296	45	0.015
brain development	GO:0007420	247	0.015
glucose homeostasis	GO:0042593	75	0.015
regulation of blood vessel size	GO:0050880	89	0.015
positive regulation of phosphorylation	GO:0042327	177	0.015
b cell mediated immunity	GO:0019724	4	0.015
fatty acid oxidation	GO:0019395	29	0.014
neuron projection morphogenesis	GO:0048812	122	0.014
female pregnancy	GO:0007565	122	0.014
homeostatic process	GO:0042592	331	0.014
cellular response to inorganic substance	GO:0071241	65	0.014
response to activity	GO:0014823	73	0.014
peptidyl tyrosine modification	GO:0018212	72	0.014
ras protein signal transduction	GO:0007265	29	0.014
blood vessel development	GO:0001568	69	0.014
response to vitamin a	GO:0033189	36	0.014
glycerol transport	GO:0015793	2	0.014
purine nucleoside metabolic process	GO:0042278	169	0.014
monovalent inorganic cation transport	GO:0015672	172	0.014
peptidyl tyrosine phosphorylation	GO:0018108	72	0.014
wound healing	GO:0042060	122	0.013
positive regulation of catalytic activity	GO:0043085	184	0.013
regulation of hydrolase activity	GO:0051336	143	0.013
tissue development	GO:0009888	252	0.013
carboxylic acid biosynthetic process	GO:0046394	83	0.013
positive regulation of cell development	GO:0010720	176	0.013
response to progesterone	GO:0032570	48	0.013
positive regulation of developmental process	GO:0051094	283	0.013
purine containing compound metabolic process	GO:0072521	253	0.013
positive regulation of protein serine threonine kinase activity	GO:0071902	52	0.013
ovulation cycle process	GO:0022602	50	0.013
regulation of ion transport	GO:0043269	245	0.013
negative regulation of transcription regulatory region dna binding	GO:2000678	2	0.013
negative regulation of cell death	GO:0060548	229	0.013
positive regulation of kinase activity	GO:0033674	77	0.013
amide transport	GO:0042886	105	0.013
organophosphate metabolic process	GO:0019637	370	0.013
transcription dna templated	GO:0006351	377	0.013
positive regulation of hepatocyte differentiation	GO:0070368	2	0.013
ovulation from ovarian follicle	GO:0001542	7	0.012
negative regulation of transport	GO:0051051	136	0.012
anterior posterior pattern specification	GO:0009952	1	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.012
regulation of systemic arterial blood pressure by norepinephrine epinephrine	GO:0001993	2	0.012
regeneration	GO:0031099	163	0.012
blood circulation	GO:0008015	183	0.012
negative regulation of cellular metabolic process	GO:0031324	281	0.012
organic acid biosynthetic process	GO:0016053	83	0.012
heterocycle catabolic process	GO:0046700	167	0.012
positive regulation of cell death	GO:0010942	184	0.012
rhythmic process	GO:0048511	156	0.012
positive regulation of amino acid transport	GO:0051957	13	0.012
positive regulation of blood circulation	GO:1903524	65	0.012
regulation of cellular amino acid metabolic process	GO:0006521	2	0.012
male gamete generation	GO:0048232	99	0.012
glucan metabolic process	GO:0044042	23	0.012
insulin secretion	GO:0030073	69	0.012
regulation of growth	GO:0040008	105	0.012
response to reactive oxygen species	GO:0000302	120	0.012
ionotropic glutamate receptor signaling pathway	GO:0035235	34	0.012
positive regulation of lipid metabolic process	GO:0045834	33	0.012
carbohydrate derivative metabolic process	GO:1901135	346	0.011
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.011
protein heterooligomerization	GO:0051291	89	0.011
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.011
neuronal action potential	GO:0019228	35	0.011
protein phosphorylation	GO:0006468	345	0.011
lipid storage	GO:0019915	1	0.011
regulation of lipid biosynthetic process	GO:0046890	38	0.011
regulation of lipid metabolic process	GO:0019216	68	0.011
vasoconstriction	GO:0042310	54	0.011
diterpenoid metabolic process	GO:0016101	33	0.011
cellular response to carbohydrate stimulus	GO:0071322	72	0.011
negative regulation of cell communication	GO:0010648	158	0.011
response to ammonium ion	GO:0060359	71	0.011
female sex differentiation	GO:0046660	59	0.011
positive regulation of molecular function	GO:0044093	230	0.011
positive regulation of peptide secretion	GO:0002793	52	0.011
negative regulation of signaling	GO:0023057	157	0.011
reactive nitrogen species metabolic process	GO:2001057	1	0.011
anatomical structure morphogenesis	GO:0009653	298	0.011
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.011
chromosome segregation	GO:0007059	2	0.011
heart morphogenesis	GO:0003007	3	0.011
positive regulation of protein phosphorylation	GO:0001934	135	0.011
cellular response to acid chemical	GO:0071229	75	0.011
positive regulation of protein modification process	GO:0031401	142	0.011
reactive oxygen species metabolic process	GO:0072593	37	0.010
oxidation reduction process	GO:0055114	304	0.010
regulation of protein modification process	GO:0031399	194	0.010
inorganic anion transport	GO:0015698	41	0.010
regulation of platelet activation	GO:0010543	2	0.010
organic hydroxy compound metabolic process	GO:1901615	115	0.010
neuron neuron synaptic transmission	GO:0007270	60	0.010
dna metabolic process	GO:0006259	96	0.010
cellular response to molecule of bacterial origin	GO:0071219	56	0.010
cellular response to extracellular stimulus	GO:0031668	73	0.010
locomotion	GO:0040011	237	0.010
cellular response to cytokine stimulus	GO:0071345	127	0.010
divalent metal ion transport	GO:0070838	132	0.010
protein maturation	GO:0051604	68	0.010

Hrasls5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.020
disease of anatomical entity	DOID:7	0.020
connective tissue disease	DOID:65	0.020
bone disease	DOID:0080001	0.017
bone development disease	DOID:0080006	0.012
overnutrition	DOID:654	0.010
acquired metabolic disease	DOID:0060158	0.010
disease of metabolism	DOID:0014667	0.010
obesity	DOID:9970	0.010
nutrition disease	DOID:374	0.010

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