Rattus norvegicus

40 known processes

Phlda1

pleckstrin homology-like domain, family A, member 1

(Aliases: Tdag)

Phlda1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of apoptotic processGO:00429813350.377
regulation of programmed cell deathGO:00430673410.284
positive regulation of cell deathGO:00109421840.271
programmed cell deathGO:00125013920.248
apoptotic processGO:00069153810.228
cell morphogenesis involved in neuron differentiationGO:00486671060.206
regulation of cellular component organizationGO:00511283680.198
regulation of molecular functionGO:00650093980.174
negative regulation of macromolecule metabolic processGO:00106052600.173
negative regulation of apoptotic processGO:00430661810.159
response to temperature stimulusGO:0009266940.153
positive regulation of programmed cell deathGO:00430681570.152
response to oxygen levelsGO:00704822650.144
regulation of nucleic acid templated transcriptionGO:19035063800.141
rna biosynthetic processGO:00327743800.138
regulation of transcription dna templatedGO:00063553740.137
multi organism reproductive processGO:00447032620.137
intracellular signal transductionGO:00355563140.132
nucleic acid templated transcriptionGO:00976593790.130
negative regulation of metabolic processGO:00098923310.129
negative regulation of macromolecule biosynthetic processGO:00105581480.119
response to decreased oxygen levelsGO:00362932370.117
neuron differentiationGO:00301823680.115
regulation of cell differentiationGO:00455953200.114
response to other organismGO:00517072200.114
positive regulation of cell differentiationGO:00455972170.110
regulation of rna biosynthetic processGO:20011413810.109
organelle organizationGO:00069962660.109
regulation of phosphate metabolic processGO:00192203490.109
response to glucocorticoidGO:00513842230.108
regulation of cellular protein metabolic processGO:00322682670.107
response to hypoxiaGO:00016662310.107
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.105
negative regulation of programmed cell deathGO:00430691830.100
response to estradiolGO:00323551640.098
single organism organelle organizationGO:19025891800.098
response to oxidative stressGO:00069791860.096
negative regulation of gene expressionGO:00106291990.093
response to molecule of bacterial originGO:00022371940.091
response to biotic stimulusGO:00096072260.090
reproductive processGO:00224143720.090
regulation of rna metabolic processGO:00512523910.089
regulation of cell developmentGO:00602842630.085
response to peptideGO:19016522920.084
regulation of intracellular signal transductionGO:19025312180.083
rna metabolic processGO:00160704060.080
response to external biotic stimulusGO:00432072210.080
transcription dna templatedGO:00063513770.079
response to insulinGO:00328681330.078
positive regulation of cellular component organizationGO:00511302000.078
negative regulation of cell deathGO:00605482290.078
regulation of cell proliferationGO:00421273590.078
negative regulation of nucleic acid templated transcriptionGO:19035071170.075
energy derivation by oxidation of organic compoundsGO:0015980460.075
central nervous system developmentGO:00074173110.074
axon developmentGO:0061564960.073
cellular response to stressGO:00335542690.073
positive regulation of response to stimulusGO:00485842850.072
regulation of protein metabolic processGO:00512462890.072
brain developmentGO:00074202470.072
enzyme linked receptor protein signaling pathwayGO:00071671160.071
neuron projection developmentGO:00311752730.070
negative regulation of cellular biosynthetic processGO:00313271610.070
carbohydrate derivative metabolic processGO:19011353460.070
cellular amino acid metabolic processGO:00065201070.069
response to lipopolysaccharideGO:00324961910.069
regulation of catalytic activityGO:00507903040.068
cell projection organizationGO:00300303020.067
regulation of ossificationGO:0030278320.067
response to corticosteroidGO:00319602350.066
regulation of organelle organizationGO:0033043800.066
regulation of nervous system developmentGO:00519602640.065
carboxylic acid metabolic processGO:00197522890.064
response to acid chemicalGO:00011012220.064
negative regulation of rna metabolic processGO:00512531230.064
response to extracellular stimulusGO:00099913800.063
protein phosphorylationGO:00064683450.063
negative regulation of cellular metabolic processGO:00313242810.062
response to bacteriumGO:00096172000.062
positive regulation of nitrogen compound metabolic processGO:00511733340.062
response to estrogenGO:00436272320.061
cellular ketone metabolic processGO:0042180510.061
positive regulation of rna metabolic processGO:00512542030.061
response to peptide hormoneGO:00434342780.061
cation transportGO:00068123820.059
response to inorganic substanceGO:00100353770.059
cellular response to oxygen containing compoundGO:19017013860.058
muscle system processGO:00030121150.058
tissue developmentGO:00098882520.058
positive regulation of cell communicationGO:00106472710.058
neuron projection morphogenesisGO:00488121220.057
regulation of transcription from rna polymerase ii promoterGO:00063572340.057
response to hydrogen peroxideGO:0042542890.057
oxoacid metabolic processGO:00434362900.057
positive regulation of neurogenesisGO:00507691650.057
regenerationGO:00310991630.055
negative regulation of response to stimulusGO:00485851550.054
catabolic processGO:00090563510.054
cellular lipid metabolic processGO:00442552080.054
forebrain developmentGO:0030900980.053
cell type specific apoptotic processGO:00972851340.053
positive regulation of cellular protein metabolic processGO:00322701670.052
macromolecular complex subunit organizationGO:00439333390.052
cellular component morphogenesisGO:00329891550.051
regulation of protein modification processGO:00313991940.051
anatomical structure morphogenesisGO:00096532980.051
protein complex subunit organizationGO:00718223020.051
negative regulation of transcription dna templatedGO:00458921160.050
negative regulation of biosynthetic processGO:00098901680.050
response to metal ionGO:00100382530.050
response to ketoneGO:19016541820.050
organic acid metabolic processGO:00060822920.049
regulation of signal transductionGO:00099663180.049
regulation of cellular ketone metabolic processGO:0010565270.049
negative regulation of multicellular organismal processGO:00512412030.048
regulation of neurogenesisGO:00507672470.048
response to nutrientGO:00075842480.048
negative regulation of developmental processGO:00510931250.048
cellular component biogenesisGO:00440853680.048
transcription from rna polymerase ii promoterGO:00063662520.047
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.047
positive regulation of molecular functionGO:00440932300.047
positive regulation of rna biosynthetic processGO:19026801970.047
response to woundingGO:00096112540.047
anion transportGO:00068201780.047
positive regulation of nervous system developmentGO:00519621780.046
response to cytokineGO:00340972150.046
cell morphogenesisGO:00009021420.045
single organism catabolic processGO:00447122830.045
regulation of phosphorus metabolic processGO:00511743490.044
cellular component assemblyGO:00226073600.044
cytoskeleton organizationGO:00070101110.044
response to purine containing compoundGO:00140741260.043
positive regulation of developmental processGO:00510942830.042
negative regulation of nitrogen compound metabolic processGO:00511721610.041
regulation of multicellular organismal developmentGO:20000263760.041
generation of precursor metabolites and energyGO:0006091620.041
cellular homeostasisGO:00197252520.040
single organism reproductive processGO:00447022970.040
proteolysisGO:00065081750.040
response to growth factorGO:00708481890.039
head developmentGO:00603222470.039
macromolecular complex assemblyGO:00650032730.039
regulation of cell cycleGO:0051726730.039
negative regulation of nervous system developmentGO:0051961790.039
nucleoside metabolic processGO:00091161790.038
cellular component movementGO:00069282480.038
negative regulation of cell communicationGO:00106481580.038
agingGO:00075682410.038
oxidation reduction processGO:00551143040.038
neurological system processGO:00508772190.038
positive regulation of apoptotic processGO:00430651540.037
response to campGO:0051591910.037
multicellular organismal reproductive processGO:00486092330.037
establishment of protein localizationGO:00451841410.037
regulation of system processGO:00440572080.037
multi multicellular organism processGO:00447061380.037
positive regulation of transportGO:00510502450.037
cellular response to peptide hormone stimulusGO:00713751200.036
sodium ion transportGO:0006814820.036
female pregnancyGO:00075651220.035
synaptic transmissionGO:00072682350.035
response to heatGO:0009408600.035
positive regulation of cell proliferationGO:00082842490.035
positive regulation of biosynthetic processGO:00098913190.035
negative regulation of cellular component organizationGO:0051129830.035
locomotionGO:00400112370.035
negative regulation of protein metabolic processGO:00512481140.035
regulation of cellular amino acid metabolic processGO:000652120.034
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.034
cell cell signalingGO:00072673350.034
organ regenerationGO:00311001010.034
positive regulation of nucleobase containing compound metabolic processGO:00459353190.034
response to radiationGO:00093141370.033
protein complex biogenesisGO:00702712630.033
positive regulation of phosphate metabolic processGO:00459372620.033
heart processGO:0003015570.033
monovalent inorganic cation transportGO:00156721720.032
nucleotide metabolic processGO:00091172790.032
positive regulation of multicellular organismal processGO:00512403870.032
regulation of neuron differentiationGO:00456642080.032
positive regulation of cellular biosynthetic processGO:00313282950.032
gland developmentGO:00487321550.032
secretion by cellGO:00329402480.032
positive regulation of phosphorus metabolic processGO:00105622620.032
response to mechanical stimulusGO:00096121340.032
dephosphorylationGO:0016311980.032
regulation of phosphorylationGO:00423252480.031
regulation of cytoskeleton organizationGO:0051493490.031
organophosphate metabolic processGO:00196373700.031
reproductionGO:00000032450.031
transmembrane transportGO:00550854120.031
organic anion transportGO:00157111320.031
cellular response to endogenous stimulusGO:00714953770.031
response to ethanolGO:00454711620.031
behaviorGO:00076102050.031
regulation of response to stressGO:00801341260.031
regulation of protein phosphorylationGO:00019321830.031
response to ammonium ionGO:0060359710.030
positive regulation of secretionGO:00510471400.030
negative regulation of signalingGO:00230571570.030
signal transduction by phosphorylationGO:00230141440.030
homeostatic processGO:00425923310.030
macromolecule localizationGO:00330362520.030
cellular amine metabolic processGO:0044106380.030
cellular chemical homeostasisGO:00550822470.030
lipid metabolic processGO:00066292830.030
organic substance catabolic processGO:19015753160.030
ion transmembrane transportGO:00342203650.030
response to mineralocorticoidGO:0051385490.030
positive regulation of cellular amine metabolic processGO:003324030.029
neuron developmentGO:00486662860.029
nucleoside phosphate metabolic processGO:00067532830.029
cellular response to hormone stimulusGO:00328702470.028
chemical homeostasisGO:00488782920.028
cell morphogenesis involved in differentiationGO:00009041190.028
regulation of neuron projection developmentGO:00109751610.028
regulation of cellular component movementGO:00512701500.028
regulation of hydrolase activityGO:00513361430.028
regulation of transferase activityGO:00513381230.028
negative regulation of rna biosynthetic processGO:19026791180.027
positive regulation of protein modification processGO:00314011420.027
vesicle mediated transportGO:00161921810.027
cellular response to lipidGO:00713962010.027
peptidyl amino acid modificationGO:00181931260.027
cell projection morphogenesisGO:00488581230.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.027
membrane organizationGO:0061024940.027
carbohydrate catabolic processGO:0016052400.027
response to transition metal nanoparticleGO:19902671220.027
regulation of ion transportGO:00432692450.027
cell cycleGO:00070491010.026
positive regulation of cell developmentGO:00107201760.026
cellular catabolic processGO:00442482950.026
cellular metal ion homeostasisGO:00068751720.026
positive regulation of cell motilityGO:2000147970.026
positive regulation of catalytic activityGO:00430851840.026
negative regulation of nucleobase containing compound metabolic processGO:00459341530.026
regulation of fat cell differentiationGO:004559830.026
positive regulation of signal transductionGO:00099671750.026
cellular response to external stimulusGO:00714961180.026
positive regulation of cell migrationGO:0030335960.026
purine ribonucleotide metabolic processGO:00091502270.026
ossificationGO:0001503700.025
positive regulation of phosphorylationGO:00423271770.025
aromatic compound catabolic processGO:00194391680.025
sensory perceptionGO:00076001010.025
single organism membrane organizationGO:0044802740.025
negative regulation of cell proliferationGO:00082851190.025
positive regulation of cellular amino acid metabolic processGO:004576410.025
negative regulation of cellular protein metabolic processGO:00322691060.025
ribonucleoside metabolic processGO:00091191740.025
purine ribonucleotide catabolic processGO:00091541360.025
cellular response to insulin stimulusGO:0032869810.024
wound healingGO:00420601220.024
amine metabolic processGO:0009308380.024
glycosyl compound metabolic processGO:19016571820.024
regulation of synaptic transmissionGO:00508041410.024
anterior posterior pattern specificationGO:000995210.024
salivary gland developmentGO:000743130.024
response to nutrient levelsGO:00316673700.024
nucleoside catabolic processGO:00091641260.024
multicellular organism growthGO:003526410.024
ion homeostasisGO:00508012120.024
axis specificationGO:000979840.023
positive regulation of transcription dna templatedGO:00458931970.023
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.023
response to monosaccharideGO:00342841590.023
positive regulation of macromolecule biosynthetic processGO:00105572470.023
regulation of cellular catabolic processGO:00313291010.023
reactive oxygen species metabolic processGO:0072593370.023
intracellular transportGO:00469071850.023
organonitrogen compound catabolic processGO:19015651790.023
purine nucleoside triphosphate metabolic processGO:00091441410.023
response to reactive oxygen speciesGO:00003021200.023
positive regulation of secretion by cellGO:19035321280.022
organic cyclic compound catabolic processGO:19013611750.022
cellular response to growth factor stimulusGO:00713631620.022
cellular calcium ion homeostasisGO:00068741600.022
regulation of cellular amine metabolic processGO:003323880.022
heart contractionGO:0060047570.022
mapk cascadeGO:00001651400.022
dna metabolic processGO:0006259960.022
regulation of cell projection organizationGO:00313441750.022
apoptotic signaling pathwayGO:0097190270.022
purine nucleoside metabolic processGO:00422781690.022
negative regulation of cell cycle phase transitionGO:190198840.021
positive regulation of protein metabolic processGO:00512471780.021
nucleobase containing small molecule metabolic processGO:00550863160.021
protein complex assemblyGO:00064612630.021
regulation of vesicle mediated transportGO:0060627810.021
biological adhesionGO:00226101100.021
olfactory learningGO:000835510.021
regulation of cell growthGO:0001558850.021
positive regulation of protein phosphorylationGO:00019341350.021
nucleoside triphosphate metabolic processGO:00091411440.021
cell motilityGO:00488702020.020
negative regulation of transportGO:00510511360.020
regulation of kinase activityGO:00435491170.020
developmental growthGO:00485891000.020
response to hexoseGO:00097461440.020
organophosphate catabolic processGO:00464341480.020
purine ribonucleoside triphosphate metabolic processGO:00092051400.020
neuron deathGO:00709971270.020
cellular ion homeostasisGO:00068731840.020
cellular response to lipopolysaccharideGO:0071222550.020
single organism intracellular transportGO:19025821660.020
positive regulation of signalingGO:00230562700.020
response to carbohydrateGO:00097431830.020
growthGO:00400071650.020
metal ion transportGO:00300012890.020
positive regulation of neuron differentiationGO:00456661260.020
cell migrationGO:00164771970.020
endocytosisGO:0006897840.020
ribonucleoside triphosphate metabolic processGO:00091991410.020
positive regulation of mitochondrion organizationGO:001082240.020
reproductive structure developmentGO:00486081280.020
small gtpase mediated signal transductionGO:0007264360.020
positive regulation of gene expressionGO:00106282440.020
metal ion homeostasisGO:00550651860.020
axonogenesisGO:0007409710.020
carbohydrate derivative biosynthetic processGO:19011371240.019
carboxylic acid transportGO:00469421150.019
learning or memoryGO:0007611900.019
carbohydrate metabolic processGO:00059751300.019
purine containing compound metabolic processGO:00725212530.019
hepaticobiliary system developmentGO:0061008900.019
positive regulation of locomotionGO:00400171020.019
ras protein signal transductionGO:0007265290.019
cell part morphogenesisGO:00329901230.019
purine ribonucleoside metabolic processGO:00461281680.019
nucleobase containing compound catabolic processGO:00346551520.019
cation homeostasisGO:00550801950.019
organic acid transportGO:00158491160.018
regulation of neuron deathGO:19012141150.018
negative regulation of mitotic cell cycle phase transitionGO:190199130.018
gastrulationGO:000736920.018
ribonucleoside catabolic processGO:00424541260.018
cellular response to peptideGO:19016531330.018
purine ribonucleoside monophosphate metabolic processGO:0009167840.018
positive regulation of organelle organizationGO:0010638480.018
cell adhesionGO:00071551100.018
regulation of proteolysisGO:0030162660.018
sensory organ developmentGO:0007423740.018
negative regulation of signal transductionGO:0009968830.018
regulation of metal ion transportGO:00109591180.018
intestinal absorptionGO:005089230.018
gliogenesisGO:0042063930.018
regulation of lipid metabolic processGO:0019216680.018
single organism carbohydrate metabolic processGO:00447231180.017
response to tumor necrosis factorGO:0034612560.017
renal system developmentGO:0072001670.017
response to retinoic acidGO:0032526630.017
regulation of protein kinase activityGO:00458591050.017
multicellular organism reproductionGO:00325042330.017
response to alkaloidGO:00432791320.017
reactive oxygen species biosynthetic processGO:190340980.017
nitrogen compound transportGO:00717052290.017
regulation of growthGO:00400081050.017
regulation of mapk cascadeGO:00434081160.017
ribonucleotide catabolic processGO:00092611360.017
protein maturationGO:0051604680.017
protein processingGO:0016485680.017
negative regulation of molecular functionGO:00440921330.017
localization of cellGO:00516742020.017
carbohydrate derivative catabolic processGO:19011361470.017
regulation of reactive oxygen species metabolic processGO:2000377260.017
cellular carbohydrate metabolic processGO:0044262720.017
positive regulation of fat cell differentiationGO:004560020.017
regulation of response to woundingGO:1903034690.016
response to vitaminGO:00332731310.016
regulation of protein localizationGO:0032880810.016
anatomical structure formation involved in morphogenesisGO:0048646830.016
response to interleukin 1GO:0070555550.016
taxisGO:0042330670.016
salivary gland morphogenesisGO:000743510.016
response to progesteroneGO:0032570480.016
purine nucleotide metabolic processGO:00061632290.016
regulation of membrane potentialGO:00423911100.016
glial cell differentiationGO:0010001650.016
positive regulation of hydrolase activityGO:0051345860.016
regulation of muscle system processGO:0090257790.016
developmental process involved in reproductionGO:00030061590.016
rhythmic processGO:00485111560.016
secretionGO:00469033070.016
locomotor rhythmGO:004547510.016
positive regulation of cellular component movementGO:00512721020.016
protein transportGO:00150311320.016
ribonucleotide metabolic processGO:00092592310.016
telencephalon developmentGO:0021537620.016
cytosolic calcium ion homeostasisGO:00514801400.016
regulation of hormone levelsGO:00108171870.016
cellular macromolecule localizationGO:00707271220.016
cellular response to oxygen levelsGO:0071453600.016
negative regulation of cell developmentGO:0010721820.015
atp metabolic processGO:0046034720.015
positive regulation of nucleoside metabolic processGO:0045979550.015
ribose phosphate metabolic processGO:00196932350.015
purine nucleoside monophosphate metabolic processGO:0009126840.015
endocrine system developmentGO:0035270300.015
negative regulation of cell differentiationGO:0045596990.015
ribonucleoside monophosphate metabolic processGO:0009161880.015
tube developmentGO:0035295890.015
calcium ion homeostasisGO:00550741620.015
response to coldGO:0009409290.015
defense responseGO:00069521940.015
negative regulation of osteoblast differentiationGO:004566820.015
response to glucoseGO:00097491360.015
regulation of tube sizeGO:0035150890.015
response to activityGO:0014823730.015
cellular response to cytokine stimulusGO:00713451270.015
single organism behaviorGO:00447081300.015
positive regulation of smooth muscle cell proliferationGO:0048661510.015
single organism biosynthetic processGO:00447113420.015
glycosyl compound catabolic processGO:19016581260.014
inorganic ion transmembrane transportGO:00986602290.014
regulation of smooth muscle cell proliferationGO:0048660750.014
sexual reproductionGO:00199531480.014
regulation of cellular response to stressGO:0080135490.014
single organism cell adhesionGO:0098602460.014
negative regulation of phosphorus metabolic processGO:0010563800.014
positive regulation of neuron projection developmentGO:0010976990.014
intrinsic apoptotic signaling pathway in response to dna damageGO:000863010.014
regulation of locomotionGO:00400121480.014
cellular response to abiotic stimulusGO:0071214850.014
embryonic pattern specificationGO:000988010.014
endomembrane system organizationGO:0010256480.014
cognitionGO:0050890920.014
retina morphogenesis in camera type eyeGO:006004210.014
mesonephric epithelium developmentGO:0072163140.014
amide transportGO:00428861050.014
regulation of secretion by cellGO:19035302080.014
cell growthGO:00160491040.014
potassium ion transportGO:0006813970.014
kidney developmentGO:0001822670.013
cellular response to biotic stimulusGO:0071216590.013
mitotic cell cycle checkpointGO:000709310.013
regulation of catabolic processGO:00098941130.013
cellular protein localizationGO:00346131220.013
cellular nitrogen compound catabolic processGO:00442701630.013
response to amino acidGO:0043200750.013
purine containing compound catabolic processGO:00725231380.013
muscle cell proliferationGO:0033002840.013
regulation of homotypic cell cell adhesionGO:003411040.013
cell cycle processGO:0022402570.013
cellular response to organonitrogen compoundGO:00714171970.013
regulation of protein serine threonine kinase activityGO:0071900640.013
divalent inorganic cation transportGO:00725111340.013
ribose phosphate biosynthetic processGO:0046390870.013
purine ribonucleoside catabolic processGO:00461301240.013
activation of cysteine type endopeptidase activityGO:009720240.013
cellular cation homeostasisGO:00300031800.013
regulation of immunoglobulin productionGO:000263740.013
nucleoside triphosphate catabolic processGO:00091431230.013
circulatory system developmentGO:00723591340.013
peptidyl tyrosine phosphorylationGO:0018108720.013
positive regulation of nucleotide metabolic processGO:0045981910.013
negative regulation of catalytic activityGO:00430861030.013
phospholipid metabolic processGO:0006644610.012
negative regulation of growthGO:0045926370.012
amino acid transportGO:0006865700.012
regulation of homeostatic processGO:00328441010.012
positive regulation of cellular catabolic processGO:0031331710.012
single organism cellular localizationGO:19025801020.012
regulation of protein transportGO:0051223680.012
regulation of response to external stimulusGO:00321011060.012
nucleotide catabolic processGO:00091661390.012
embryo developmentGO:0009790490.012
positive regulation of immunoglobulin productionGO:000263940.012
lipid modificationGO:0030258520.012
polysaccharide metabolic processGO:0005976250.012
regulation of ion transmembrane transportGO:00347651210.012
regulation of cell motilityGO:20001451310.012
dendrite developmentGO:0016358720.012
protein oligomerizationGO:00512591910.012
positive regulation of cytosolic calcium ion concentrationGO:00072041220.012
positive regulation of intracellular signal transductionGO:19025331380.012
response to uv cGO:001022520.012
response to organophosphorusGO:00466831020.012
negative regulation of neurogenesisGO:0050768780.012
synaptic growth at neuromuscular junctionGO:005112410.012
regulation of nucleotide metabolic processGO:00061401170.012
regulation of transcription regulatory region dna bindingGO:200067740.012
negative regulation of neuron deathGO:1901215690.012
positive regulation of cell morphogenesis involved in differentiationGO:0010770410.012
cellular divalent inorganic cation homeostasisGO:00725031620.012
gonad developmentGO:00084061040.012
apoptotic mitochondrial changesGO:0008637100.012
positive regulation of purine nucleotide catabolic processGO:0033123530.012
bmp signaling pathwayGO:003050940.012
chemotaxisGO:0006935660.011
positive regulation of mesenchymal cell proliferationGO:000205340.011

Phlda1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.017
nervous system diseaseDOID:86300.017
connective tissue diseaseDOID:6500.014
musculoskeletal system diseaseDOID:1700.014
disease of metabolismDOID:001466700.013