IMP: Integrative Multi-species Prediction

Rattus norvegicus

94 known processes

Cand1

cullin-associated and neddylation-dissociated 1

(Aliases: Tip120A,Tip120)

Entrez: 117152
RGD: 620479
Ensembl: ENSRNOG00000007834
UniProtKB: P97536

Process Predictions
Disease Predictions

Cand1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
rna metabolic process	GO:0016070	406	0.648
rna biosynthetic process	GO:0032774	380	0.440
macromolecular complex subunit organization	GO:0043933	339	0.395
mitotic spindle organization	GO:0007052	2	0.387
regulation of nucleic acid templated transcription	GO:1903506	380	0.344
reproductive process	GO:0022414	372	0.338
cytoskeleton organization	GO:0007010	111	0.337
spindle organization	GO:0007051	2	0.325
cell morphogenesis	GO:0000902	142	0.283
organelle organization	GO:0006996	266	0.262
nucleic acid templated transcription	GO:0097659	379	0.260
single organism reproductive process	GO:0044702	297	0.257
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.253
dna packaging	GO:0006323	4	0.232
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.225
reproduction	GO:0000003	245	0.211
cell cycle	GO:0007049	101	0.207
organic acid metabolic process	GO:0006082	292	0.201
protein complex subunit organization	GO:0071822	302	0.195
mrna metabolic process	GO:0016071	20	0.195
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.187
regulation of molecular function	GO:0065009	398	0.185
regulation of rna metabolic process	GO:0051252	391	0.180
negative regulation of metabolic process	GO:0009892	331	0.177
ubiquitin dependent protein catabolic process	GO:0006511	14	0.174
apoptotic process	GO:0006915	381	0.169
regulation of rna biosynthetic process	GO:2001141	381	0.165
regulation of cellular component organization	GO:0051128	368	0.164
response to oxygen levels	GO:0070482	265	0.163
transcription dna templated	GO:0006351	377	0.157
chromatin assembly or disassembly	GO:0006333	1	0.143
cellular component assembly	GO:0022607	360	0.143
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.139
negative regulation of cellular metabolic process	GO:0031324	281	0.136
alternative mrna splicing via spliceosome	GO:0000380	4	0.130
vesicle mediated transport	GO:0016192	181	0.127
neuron projection development	GO:0031175	273	0.127
negative regulation of rna biosynthetic process	GO:1902679	118	0.121
negative regulation of gene expression	GO:0010629	199	0.121
anatomical structure morphogenesis	GO:0009653	298	0.120
cellular component biogenesis	GO:0044085	368	0.111
regulation of cellular localization	GO:0060341	263	0.108
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.107
positive regulation of signaling	GO:0023056	270	0.101
multi organism reproductive process	GO:0044703	262	0.101
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.096
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	10	0.095
regulation of transcription dna templated	GO:0006355	374	0.095
regulation of hormone secretion	GO:0046883	106	0.093
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	1	0.092
transcription from rna polymerase ii promoter	GO:0006366	252	0.092
locomotion	GO:0040011	237	0.092
negative regulation of rna metabolic process	GO:0051253	123	0.091
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.090
bmp signaling pathway	GO:0030509	4	0.089
response to nutrient	GO:0007584	248	0.088
negative regulation of biosynthetic process	GO:0009890	168	0.088
macromolecular complex assembly	GO:0065003	273	0.087
intracellular transport	GO:0046907	185	0.079
protein complex biogenesis	GO:0070271	263	0.077
response to extracellular stimulus	GO:0009991	380	0.077
oxoacid metabolic process	GO:0043436	290	0.077
positive regulation of response to stimulus	GO:0048584	285	0.076
cell cycle process	GO:0022402	57	0.076
central nervous system development	GO:0007417	311	0.075
dendrite development	GO:0016358	72	0.075
endocytosis	GO:0006897	84	0.073
response to nutrient levels	GO:0031667	370	0.073
neuron differentiation	GO:0030182	368	0.073
regulation of catalytic activity	GO:0050790	304	0.072
regulation of intracellular signal transduction	GO:1902531	218	0.069
neuron development	GO:0048666	286	0.069
negative regulation of cell death	GO:0060548	229	0.068
defense response	GO:0006952	194	0.067
cellular response to stress	GO:0033554	269	0.067
cellular homeostasis	GO:0019725	252	0.067
single organism organelle organization	GO:1902589	180	0.066
regulation of phosphate metabolic process	GO:0019220	349	0.063
cellular catabolic process	GO:0044248	295	0.063
macromolecule catabolic process	GO:0009057	58	0.063
nucleosome organization	GO:0034728	1	0.062
cellular component morphogenesis	GO:0032989	155	0.060
sexual reproduction	GO:0019953	148	0.060
regulation of peptide transport	GO:0090087	87	0.057
cell morphogenesis involved in differentiation	GO:0000904	119	0.057
proteolysis	GO:0006508	175	0.057
double strand break repair	GO:0006302	1	0.057
positive regulation of gene expression	GO:0010628	244	0.056
cellular amino acid metabolic process	GO:0006520	107	0.056
regulation of cellular response to stress	GO:0080135	49	0.056
negative regulation of transcription dna templated	GO:0045892	116	0.054
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.054
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.054
cell projection organization	GO:0030030	302	0.053
regulation of signal transduction	GO:0009966	318	0.051
intracellular signal transduction	GO:0035556	314	0.051
protein catabolic process	GO:0030163	30	0.051
protein complex assembly	GO:0006461	263	0.050
cellular protein localization	GO:0034613	122	0.049
regulation of apoptotic process	GO:0042981	335	0.049
regulation of cellular protein metabolic process	GO:0032268	267	0.049
establishment of protein localization	GO:0045184	141	0.048
regulation of hormone levels	GO:0010817	187	0.047
ossification	GO:0001503	70	0.047
organic substance catabolic process	GO:1901575	316	0.047
single organism intracellular transport	GO:1902582	166	0.046
mrna processing	GO:0006397	14	0.046
regulation of phosphorylation	GO:0042325	248	0.045
negative regulation of macromolecule metabolic process	GO:0010605	260	0.045
cellular response to growth factor stimulus	GO:0071363	162	0.045
cellular component movement	GO:0006928	248	0.044
microtubule based process	GO:0007017	36	0.044
developmental process involved in reproduction	GO:0003006	159	0.044
sensory organ development	GO:0007423	74	0.043
multicellular organismal reproductive process	GO:0048609	233	0.043
multi multicellular organism process	GO:0044706	138	0.043
response to hypoxia	GO:0001666	231	0.042
positive regulation of protein modification process	GO:0031401	142	0.041
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.041
neuron projection morphogenesis	GO:0048812	122	0.041
response to growth factor	GO:0070848	189	0.040
embryo development	GO:0009790	49	0.040
rna processing	GO:0006396	22	0.040
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	7	0.040
reproductive structure development	GO:0048608	128	0.039
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.039
modification dependent macromolecule catabolic process	GO:0043632	14	0.039
mrna stabilization	GO:0048255	2	0.039
cellular macromolecule catabolic process	GO:0044265	29	0.038
er associated ubiquitin dependent protein catabolic process	GO:0030433	1	0.038
chromatin organization	GO:0006325	34	0.038
gamete generation	GO:0007276	124	0.038
regulation of phosphorus metabolic process	GO:0051174	349	0.037
negative regulation of programmed cell death	GO:0043069	183	0.037
regulation of programmed cell death	GO:0043067	341	0.037
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.037
neurological system process	GO:0050877	219	0.036
behavior	GO:0007610	205	0.036
catabolic process	GO:0009056	351	0.035
transmembrane transport	GO:0055085	412	0.035
negative regulation of cellular biosynthetic process	GO:0031327	161	0.035
regulation of protein modification process	GO:0031399	194	0.035
response to inorganic substance	GO:0010035	377	0.035
response to decreased oxygen levels	GO:0036293	237	0.034
multicellular organism reproduction	GO:0032504	233	0.034
response to estrogen	GO:0043627	232	0.034
macromolecule localization	GO:0033036	252	0.034
negative regulation of signaling	GO:0023057	157	0.033
cell part morphogenesis	GO:0032990	123	0.033
programmed cell death	GO:0012501	392	0.033
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	27	0.033
homeostatic process	GO:0042592	331	0.032
positive regulation of cell communication	GO:0010647	271	0.032
cellular response to endogenous stimulus	GO:0071495	377	0.032
regulation of organelle organization	GO:0033043	80	0.031
regulation of protein metabolic process	GO:0051246	289	0.031
chromosome segregation	GO:0007059	2	0.031
proteasomal protein catabolic process	GO:0010498	8	0.030
cell motility	GO:0048870	202	0.030
cellular response to organic cyclic compound	GO:0071407	202	0.030
signal transduction by phosphorylation	GO:0023014	144	0.030
organ morphogenesis	GO:0009887	75	0.029
regulation of neurogenesis	GO:0050767	247	0.029
learning	GO:0007612	33	0.029
peptidyl tyrosine phosphorylation	GO:0018108	72	0.029
carboxylic acid metabolic process	GO:0019752	289	0.029
regulation of peptide hormone secretion	GO:0090276	80	0.029
immune response	GO:0006955	104	0.029
cellular response to cytokine stimulus	GO:0071345	127	0.029
negative regulation of intracellular signal transduction	GO:1902532	38	0.028
mitotic cell cycle	GO:0000278	49	0.028
dna metabolic process	GO:0006259	96	0.028
positive regulation of cellular protein metabolic process	GO:0032270	167	0.028
mrna 3 end processing	GO:0031124	1	0.028
protein transport	GO:0015031	132	0.027
monocarboxylic acid metabolic process	GO:0032787	152	0.027
osteoblast differentiation	GO:0001649	26	0.027
fertilization	GO:0009566	3	0.027
positive regulation of phosphorylation	GO:0042327	177	0.027
protein phosphorylation	GO:0006468	345	0.026
cytoplasmic transport	GO:0016482	115	0.026
secretion	GO:0046903	307	0.026
protein localization to organelle	GO:0033365	57	0.026
cellular response to nitrogen compound	GO:1901699	210	0.026
positive regulation of neuron differentiation	GO:0045666	126	0.026
regulation of multicellular organismal development	GO:2000026	376	0.026
adult locomotory behavior	GO:0008344	4	0.026
positive regulation of neuron projection development	GO:0010976	99	0.026
hormone secretion	GO:0046879	115	0.025
response to metal ion	GO:0010038	253	0.025
head development	GO:0060322	247	0.025
positive regulation of neurogenesis	GO:0050769	165	0.024
response to other organism	GO:0051707	220	0.024
modification dependent protein catabolic process	GO:0019941	14	0.024
signal release	GO:0023061	145	0.024
cell migration	GO:0016477	197	0.024
chromosome localization	GO:0050000	1	0.024
regulation of cellular amino acid metabolic process	GO:0006521	2	0.024
amine metabolic process	GO:0009308	38	0.024
axon development	GO:0061564	96	0.024
localization of cell	GO:0051674	202	0.024
negative regulation of apoptotic process	GO:0043066	181	0.023
regulation of gene expression epigenetic	GO:0040029	10	0.023
sex differentiation	GO:0007548	113	0.023
secretion by cell	GO:0032940	248	0.023
regulation of cellular ketone metabolic process	GO:0010565	27	0.023
cellular protein catabolic process	GO:0044257	19	0.023
cellular process involved in reproduction in multicellular organism	GO:0022412	35	0.023
positive regulation of apoptotic process	GO:0043065	154	0.022
cell cell signaling	GO:0007267	335	0.022
centrosome cycle	GO:0007098	1	0.022
negative regulation of cell communication	GO:0010648	158	0.022
chemosensory behavior	GO:0007635	2	0.022
positive regulation of signal transduction	GO:0009967	175	0.022
cognition	GO:0050890	92	0.021
mesenchyme development	GO:0060485	9	0.021
response to light stimulus	GO:0009416	52	0.021
tissue development	GO:0009888	252	0.021
carboxylic acid biosynthetic process	GO:0046394	83	0.021
regulation of cellular amine metabolic process	GO:0033238	8	0.021
brain development	GO:0007420	247	0.021
response to external biotic stimulus	GO:0043207	221	0.021
mitotic cell cycle process	GO:1903047	35	0.021
wound healing	GO:0042060	122	0.021
regulation of intracellular transport	GO:0032386	65	0.021
lymphocyte activation involved in immune response	GO:0002285	3	0.021
response to transforming growth factor beta	GO:0071559	46	0.021
cellular amine metabolic process	GO:0044106	38	0.020
positive regulation of protein phosphorylation	GO:0001934	135	0.020
cellular macromolecule localization	GO:0070727	122	0.020
glycosyl compound metabolic process	GO:1901657	182	0.020
positive regulation of protein metabolic process	GO:0051247	178	0.020
rhythmic process	GO:0048511	156	0.020
single fertilization	GO:0007338	3	0.020
positive regulation of phosphorus metabolic process	GO:0010562	262	0.019
mitotic nuclear division	GO:0007067	15	0.019
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.019
regulation of dendrite morphogenesis	GO:0048814	33	0.019
positive regulation of cell death	GO:0010942	184	0.019
nitrogen compound transport	GO:0071705	229	0.019
protein maturation	GO:0051604	68	0.019
purine containing compound metabolic process	GO:0072521	253	0.019
learning or memory	GO:0007611	90	0.019
response to toxic substance	GO:0009636	133	0.019
negative regulation of cell proliferation	GO:0008285	119	0.018
negative regulation of response to stimulus	GO:0048585	155	0.018
regulation of alternative mrna splicing via spliceosome	GO:0000381	2	0.018
positive regulation of transport	GO:0051050	245	0.018
actin filament based process	GO:0030029	86	0.018
cellular chemical homeostasis	GO:0055082	247	0.018
cellular response to extracellular stimulus	GO:0031668	73	0.018
positive regulation of programmed cell death	GO:0043068	157	0.018
inflammatory response	GO:0006954	150	0.018
protein localization	GO:0008104	191	0.018
retinal cell programmed cell death	GO:0046666	1	0.018
regulation of nervous system development	GO:0051960	264	0.018
negative regulation of developmental process	GO:0051093	125	0.017
positive regulation of hydrolase activity	GO:0051345	86	0.017
signal transduction involved in regulation of gene expression	GO:0023019	4	0.017
nucleobase containing small molecule metabolic process	GO:0055086	316	0.017
blood vessel development	GO:0001568	69	0.017
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.017
positive regulation of cellular amine metabolic process	GO:0033240	3	0.017
negative regulation of signal transduction	GO:0009968	83	0.017
cell type specific apoptotic process	GO:0097285	134	0.017
positive regulation of cell differentiation	GO:0045597	217	0.017
organelle assembly	GO:0070925	22	0.017
olfactory behavior	GO:0042048	2	0.017
chromosome organization	GO:0051276	36	0.017
associative learning	GO:0008306	19	0.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.017
positive regulation of cellular component biogenesis	GO:0044089	55	0.016
cation homeostasis	GO:0055080	195	0.016
regulation of establishment of protein localization	GO:0070201	69	0.016
regulation of anatomical structure morphogenesis	GO:0022603	141	0.016
insulin secretion	GO:0030073	69	0.016
peptide secretion	GO:0002790	86	0.016
sperm egg recognition	GO:0035036	1	0.016
peptide transport	GO:0015833	97	0.016
toxin transport	GO:1901998	3	0.016
cell projection morphogenesis	GO:0048858	123	0.016
regulation of cell differentiation	GO:0045595	320	0.016
cellular response to dna damage stimulus	GO:0006974	19	0.015
negative regulation of circadian rhythm	GO:0042754	5	0.015
reproductive system development	GO:0061458	128	0.015
eye development	GO:0001654	50	0.015
cellular response to hypoxia	GO:0071456	51	0.015
organelle fission	GO:0048285	25	0.015
regulation of mrna splicing via spliceosome	GO:0048024	3	0.015
carbohydrate metabolic process	GO:0005975	130	0.015
chemotaxis	GO:0006935	66	0.015
ion homeostasis	GO:0050801	212	0.015
regulation of mrna stability	GO:0043488	3	0.015
protein import into nucleus	GO:0006606	35	0.015
regulation of cell morphogenesis	GO:0022604	77	0.015
cellular response to oxygen containing compound	GO:1901701	386	0.015
transforming growth factor beta3 production	GO:0032907	2	0.014
protein homooligomerization	GO:0051260	91	0.014
cellular metal ion homeostasis	GO:0006875	172	0.014
axis specification	GO:0009798	4	0.014
regulation of homeostatic process	GO:0032844	101	0.014
regulation of peptide secretion	GO:0002791	82	0.014
response to biotic stimulus	GO:0009607	226	0.014
eye morphogenesis	GO:0048592	4	0.014
positive regulation of bone mineralization	GO:0030501	4	0.014
cellular response to external stimulus	GO:0071496	118	0.013
cellular response to nutrient levels	GO:0031669	60	0.013
positive regulation of molecular function	GO:0044093	230	0.013
binding of sperm to zona pellucida	GO:0007339	1	0.013
regulation of insulin secretion	GO:0050796	65	0.013
leukocyte activation involved in immune response	GO:0002366	16	0.013
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.013
positive regulation of cellular component organization	GO:0051130	200	0.013
response to vitamin	GO:0033273	131	0.013
peptide hormone secretion	GO:0030072	84	0.013
regulation of cell growth	GO:0001558	85	0.013
cellular cation homeostasis	GO:0030003	180	0.012
protein oligomerization	GO:0051259	191	0.012
regulation of response to stress	GO:0080134	126	0.012
positive regulation of catalytic activity	GO:0043085	184	0.012
regulation of bmp signaling pathway	GO:0030510	2	0.012
regulation of nucleocytoplasmic transport	GO:0046822	28	0.012
amide transport	GO:0042886	105	0.012
hormone transport	GO:0009914	121	0.012
response to oxidative stress	GO:0006979	186	0.012
nuclear transport	GO:0051169	49	0.012
establishment of protein localization to organelle	GO:0072594	44	0.012
histone modification	GO:0016570	30	0.012
rna stabilization	GO:0043489	2	0.012
dna conformation change	GO:0071103	10	0.012
response to reactive oxygen species	GO:0000302	120	0.012
growth	GO:0040007	165	0.012
negative regulation of neuron death	GO:1901215	69	0.012
positive regulation of cell projection organization	GO:0031346	111	0.011
positive regulation of phosphate metabolic process	GO:0045937	262	0.011
gonad development	GO:0008406	104	0.011
ncrna processing	GO:0034470	3	0.011
negative regulation of multicellular organismal process	GO:0051241	203	0.011
regulation of neuron differentiation	GO:0045664	208	0.011
regulation of cell development	GO:0060284	263	0.011
positive regulation of cellular biosynthetic process	GO:0031328	295	0.011
chromatin modification	GO:0016568	33	0.011
intracellular protein transport	GO:0006886	79	0.011
metaphase plate congression	GO:0051310	1	0.011
protein modification by small protein conjugation or removal	GO:0070647	35	0.011
positive regulation of intracellular signal transduction	GO:1902533	138	0.011
cation transmembrane transport	GO:0098655	263	0.011
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.011
rna splicing via transesterification reactions	GO:0000375	7	0.011
mapk cascade	GO:0000165	140	0.010
cellular macromolecular complex assembly	GO:0034622	58	0.010
positive regulation of leukocyte degranulation	GO:0043302	4	0.010
negative regulation of neuron apoptotic process	GO:0043524	45	0.010
cellular protein complex assembly	GO:0043623	44	0.010
response to monosaccharide	GO:0034284	159	0.010
lipid metabolic process	GO:0006629	283	0.010
regulation of cell cycle	GO:0051726	73	0.010
single organism behavior	GO:0044708	130	0.010
cellular ion homeostasis	GO:0006873	184	0.010
nucleobase containing compound catabolic process	GO:0034655	152	0.010

Cand1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.035
nervous system disease	DOID:863	0.035
central nervous system disease	DOID:331	0.021

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network