IMP: Integrative Multi-species Prediction

Rattus norvegicus

11 known processes

Mgst3

microsomal glutathione S-transferase 3

RGD: 1306373
Ensembl: ENSRNOG00000004245
Entrez: 289197
UniProtKB: D4ADS4

Process Predictions
Disease Predictions

Mgst3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular modified amino acid metabolic process	GO:0006575	61	0.575
carboxylic acid metabolic process	GO:0019752	289	0.560
organic acid metabolic process	GO:0006082	292	0.387
oxoacid metabolic process	GO:0043436	290	0.383
glutathione metabolic process	GO:0006749	15	0.273
sulfur compound metabolic process	GO:0006790	70	0.126
carboxylic acid biosynthetic process	GO:0046394	83	0.113
organic acid biosynthetic process	GO:0016053	83	0.108
cellular catabolic process	GO:0044248	295	0.100
cellular amino acid metabolic process	GO:0006520	107	0.097
aging	GO:0007568	241	0.094
tissue development	GO:0009888	252	0.088
carbohydrate metabolic process	GO:0005975	130	0.075
apoptotic process	GO:0006915	381	0.070
small molecule biosynthetic process	GO:0044283	124	0.067
cellular amide metabolic process	GO:0043603	44	0.064
peptide metabolic process	GO:0006518	32	0.064
single organism reproductive process	GO:0044702	297	0.063
positive regulation of molecular function	GO:0044093	230	0.062
multicellular organism reproduction	GO:0032504	233	0.060
glutathione biosynthetic process	GO:0006750	3	0.058
cation transmembrane transport	GO:0098655	263	0.057
regulation of molecular function	GO:0065009	398	0.056
response to inorganic substance	GO:0010035	377	0.054
cellular response to stress	GO:0033554	269	0.053
regulation of ion transport	GO:0043269	245	0.053
reproductive process	GO:0022414	372	0.052
regulation of phosphate metabolic process	GO:0019220	349	0.052
neuron apoptotic process	GO:0051402	88	0.051
multicellular organismal reproductive process	GO:0048609	233	0.051
central nervous system development	GO:0007417	311	0.049
single organism catabolic process	GO:0044712	283	0.047
cofactor metabolic process	GO:0051186	95	0.047
cellular response to oxidative stress	GO:0034599	76	0.047
reproduction	GO:0000003	245	0.047
regulation of programmed cell death	GO:0043067	341	0.047
response to wounding	GO:0009611	254	0.046
macromolecular complex assembly	GO:0065003	273	0.046
regulation of catalytic activity	GO:0050790	304	0.046
programmed cell death	GO:0012501	392	0.045
positive regulation of cell communication	GO:0010647	271	0.044
regulation of multicellular organismal development	GO:2000026	376	0.044
cellular ketone metabolic process	GO:0042180	51	0.043
regulation of signal transduction	GO:0009966	318	0.043
positive regulation of signal transduction	GO:0009967	175	0.042
single organism biosynthetic process	GO:0044711	342	0.041
cellular response to external stimulus	GO:0071496	118	0.041
ion homeostasis	GO:0050801	212	0.040
behavior	GO:0007610	205	0.040
cellular modified amino acid biosynthetic process	GO:0042398	18	0.040
macromolecular complex subunit organization	GO:0043933	339	0.038
monocarboxylic acid metabolic process	GO:0032787	152	0.038
cellular homeostasis	GO:0019725	252	0.036
positive regulation of response to stimulus	GO:0048584	285	0.036
sexual reproduction	GO:0019953	148	0.036
divalent metal ion transport	GO:0070838	132	0.035
response to glucocorticoid	GO:0051384	223	0.035
reactive oxygen species metabolic process	GO:0072593	37	0.035
response to radiation	GO:0009314	137	0.034
developmental process involved in reproduction	GO:0003006	159	0.034
anatomical structure morphogenesis	GO:0009653	298	0.034
homeostatic process	GO:0042592	331	0.034
catabolic process	GO:0009056	351	0.033
cellular calcium ion homeostasis	GO:0006874	160	0.033
cellular response to oxygen containing compound	GO:1901701	386	0.033
cellular chemical homeostasis	GO:0055082	247	0.033
small molecule catabolic process	GO:0044282	59	0.033
positive regulation of phosphorus metabolic process	GO:0010562	262	0.032
protein phosphorylation	GO:0006468	345	0.032
response to toxic substance	GO:0009636	133	0.032
response to nutrient	GO:0007584	248	0.032
oxidation reduction process	GO:0055114	304	0.032
regulation of cell differentiation	GO:0045595	320	0.031
nucleobase containing small molecule metabolic process	GO:0055086	316	0.030
response to extracellular stimulus	GO:0009991	380	0.029
neurological system process	GO:0050877	219	0.029
mechanoreceptor differentiation	GO:0042490	2	0.028
multi organism reproductive process	GO:0044703	262	0.028
single organism organelle organization	GO:1902589	180	0.028
neuron death	GO:0070997	127	0.028
regulation of apoptotic process	GO:0042981	335	0.028
cation homeostasis	GO:0055080	195	0.028
response to oxidative stress	GO:0006979	186	0.028
response to antibiotic	GO:0046677	39	0.028
epithelium development	GO:0060429	96	0.027
cellular response to reactive oxygen species	GO:0034614	55	0.027
regulation of cellular localization	GO:0060341	263	0.027
cellular response to organic cyclic compound	GO:0071407	202	0.027
response to nutrient levels	GO:0031667	370	0.026
fatty acid metabolic process	GO:0006631	99	0.026
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.026
peptidyl amino acid modification	GO:0018193	126	0.026
organic hydroxy compound metabolic process	GO:1901615	115	0.026
cellular response to endogenous stimulus	GO:0071495	377	0.025
metal ion homeostasis	GO:0055065	186	0.025
regulation of nervous system development	GO:0051960	264	0.025
brain development	GO:0007420	247	0.025
protein oligomerization	GO:0051259	191	0.025
nucleoside metabolic process	GO:0009116	179	0.025
cell type specific apoptotic process	GO:0097285	134	0.025
regulation of neuron death	GO:1901214	115	0.025
positive regulation of signaling	GO:0023056	270	0.025
negative regulation of programmed cell death	GO:0043069	183	0.024
cellular response to lipid	GO:0071396	201	0.024
response to ethanol	GO:0045471	162	0.024
negative regulation of cell death	GO:0060548	229	0.024
protein complex biogenesis	GO:0070271	263	0.024
transcription dna templated	GO:0006351	377	0.024
calcium ion transport	GO:0006816	131	0.023
organelle organization	GO:0006996	266	0.023
intracellular signal transduction	GO:0035556	314	0.023
protein complex assembly	GO:0006461	263	0.023
negative regulation of cell differentiation	GO:0045596	99	0.023
very long chain fatty acid metabolic process	GO:0000038	3	0.022
gamete generation	GO:0007276	124	0.022
rna metabolic process	GO:0016070	406	0.022
organic substance catabolic process	GO:1901575	316	0.022
response to ketone	GO:1901654	182	0.021
positive regulation of catalytic activity	GO:0043085	184	0.021
spermatogenesis	GO:0007283	99	0.021
negative regulation of metabolic process	GO:0009892	331	0.021
cellular response to nitrogen compound	GO:1901699	210	0.021
protein complex subunit organization	GO:0071822	302	0.020
divalent inorganic cation transport	GO:0072511	134	0.020
transmembrane transport	GO:0055085	412	0.020
response to transition metal nanoparticle	GO:1990267	122	0.020
cellular metal ion homeostasis	GO:0006875	172	0.020
head development	GO:0060322	247	0.020
chemical homeostasis	GO:0048878	292	0.019
regulation of cell proliferation	GO:0042127	359	0.019
cell cell signaling	GO:0007267	335	0.019
purine ribonucleotide metabolic process	GO:0009150	227	0.019
regulation of phosphorus metabolic process	GO:0051174	349	0.019
regulation of calcium ion transport	GO:0051924	77	0.019
generation of precursor metabolites and energy	GO:0006091	62	0.019
intracellular transport	GO:0046907	185	0.019
cytosolic calcium ion homeostasis	GO:0051480	140	0.019
cellular component assembly	GO:0022607	360	0.019
negative regulation of macromolecule metabolic process	GO:0010605	260	0.018
cell projection organization	GO:0030030	302	0.018
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.018
metal ion transport	GO:0030001	289	0.018
response to peptide hormone	GO:0043434	278	0.017
cellular component biogenesis	GO:0044085	368	0.017
synaptic transmission	GO:0007268	235	0.017
defense response	GO:0006952	194	0.017
lipid metabolic process	GO:0006629	283	0.017
single organism intracellular transport	GO:1902582	166	0.017
regulation of response to stress	GO:0080134	126	0.017
regulation of anatomical structure size	GO:0090066	135	0.017
negative regulation of multicellular organismal process	GO:0051241	203	0.017
response to reactive oxygen species	GO:0000302	120	0.016
ion transmembrane transport	GO:0034220	365	0.016
neuron differentiation	GO:0030182	368	0.016
single organism behavior	GO:0044708	130	0.016
regulation of cellular amine metabolic process	GO:0033238	8	0.016
positive regulation of intracellular signal transduction	GO:1902533	138	0.016
cell morphogenesis	GO:0000902	142	0.016
nicotinamide nucleotide metabolic process	GO:0046496	28	0.015
nitrogen compound transport	GO:0071705	229	0.015
regulation of metal ion transport	GO:0010959	118	0.015
regulation of system process	GO:0044057	208	0.015
multi multicellular organism process	GO:0044706	138	0.015
male gamete generation	GO:0048232	99	0.015
response to corticosteroid	GO:0031960	235	0.015
muscle contraction	GO:0006936	88	0.015
neuronal action potential	GO:0019228	35	0.015
urogenital system development	GO:0001655	78	0.015
cellular ion homeostasis	GO:0006873	184	0.015
negative regulation of innate immune response	GO:0045824	4	0.014
positive regulation of phosphate metabolic process	GO:0045937	262	0.014
muscle system process	GO:0003012	115	0.014
axon development	GO:0061564	96	0.014
positive regulation of biosynthetic process	GO:0009891	319	0.014
response to acid chemical	GO:0001101	222	0.014
cellular response to nutrient levels	GO:0031669	60	0.014
purine nucleoside metabolic process	GO:0042278	169	0.014
cellular cation homeostasis	GO:0030003	180	0.014
small gtpase mediated signal transduction	GO:0007264	36	0.014
positive regulation of multicellular organismal process	GO:0051240	387	0.014
positive regulation of phosphorylation	GO:0042327	177	0.014
regulation of cellular protein metabolic process	GO:0032268	267	0.014
sex differentiation	GO:0007548	113	0.014
regulation of membrane potential	GO:0042391	110	0.014
regulation of rna biosynthetic process	GO:2001141	381	0.014
regulation of nucleic acid templated transcription	GO:1903506	380	0.014
divalent inorganic cation homeostasis	GO:0072507	165	0.014
amine metabolic process	GO:0009308	38	0.014
regulation of phosphorylation	GO:0042325	248	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.013
reproductive structure development	GO:0048608	128	0.013
organonitrogen compound biosynthetic process	GO:1901566	167	0.013
positive regulation of neurogenesis	GO:0050769	165	0.013
negative regulation of apoptotic process	GO:0043066	181	0.013
hormone metabolic process	GO:0042445	69	0.013
aromatic amino acid family catabolic process	GO:0009074	7	0.013
cytoskeleton organization	GO:0007010	111	0.013
regulation of neurogenesis	GO:0050767	247	0.013
cellular amine metabolic process	GO:0044106	38	0.013
positive regulation of cellular biosynthetic process	GO:0031328	295	0.013
cellular component morphogenesis	GO:0032989	155	0.013
response to estrogen	GO:0043627	232	0.013
regulation of intracellular signal transduction	GO:1902531	218	0.013
regulation of cellular amino acid metabolic process	GO:0006521	2	0.012
response to peptide	GO:1901652	292	0.012
organophosphate metabolic process	GO:0019637	370	0.012
signal transduction by phosphorylation	GO:0023014	144	0.012
regulation of intracellular transport	GO:0032386	65	0.012
calcium ion homeostasis	GO:0055074	162	0.012
cellular carbohydrate metabolic process	GO:0044262	72	0.012
axis specification	GO:0009798	4	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.012
positive regulation of transporter activity	GO:0032411	14	0.012
organic anion transport	GO:0015711	132	0.012
negative regulation of neurogenesis	GO:0050768	78	0.012
carbohydrate derivative metabolic process	GO:1901135	346	0.012
positive regulation of transport	GO:0051050	245	0.012
regulation of cell projection organization	GO:0031344	175	0.012
positive regulation of kinase activity	GO:0033674	77	0.012
regulation of cell development	GO:0060284	263	0.012
inflammatory response	GO:0006954	150	0.011
negative regulation of molecular function	GO:0044092	133	0.011
cytoplasmic transport	GO:0016482	115	0.011
regulation of transcription dna templated	GO:0006355	374	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
multicellular organismal homeostasis	GO:0048871	49	0.011
lipid biosynthetic process	GO:0008610	128	0.011
response to decreased oxygen levels	GO:0036293	237	0.011
negative regulation of neuron death	GO:1901215	69	0.011
locomotion	GO:0040011	237	0.011
circulatory system process	GO:0003013	183	0.011
response to hexose	GO:0009746	144	0.011
regulation of hormone levels	GO:0010817	187	0.011
neuron development	GO:0048666	286	0.011
epithelial cell differentiation	GO:0030855	71	0.011
embryonic pattern specification	GO:0009880	1	0.011
regulation of rna metabolic process	GO:0051252	391	0.011
negative regulation of transport	GO:0051051	136	0.011
gliogenesis	GO:0042063	93	0.011
sequestering of metal ion	GO:0051238	9	0.011
protein homooligomerization	GO:0051260	91	0.011
cellular response to organonitrogen compound	GO:0071417	197	0.010
response to metal ion	GO:0010038	253	0.010
macromolecule localization	GO:0033036	252	0.010
response to hydrogen peroxide	GO:0042542	89	0.010
anterior posterior pattern specification	GO:0009952	1	0.010
response to estradiol	GO:0032355	164	0.010
tube development	GO:0035295	89	0.010
positive regulation of transmembrane transport	GO:0034764	25	0.010
transmission of nerve impulse	GO:0019226	42	0.010
oxidoreduction coenzyme metabolic process	GO:0006733	31	0.010
response to amino acid	GO:0043200	75	0.010
blood circulation	GO:0008015	183	0.010
coenzyme metabolic process	GO:0006732	86	0.010

Mgst3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
benign neoplasm	DOID:0060072	0.027
disease of cellular proliferation	DOID:14566	0.027
disease of anatomical entity	DOID:7	0.021
nervous system disease	DOID:863	0.021
organ system cancer	DOID:0050686	0.015
cancer	DOID:162	0.015
central nervous system disease	DOID:331	0.011

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