Rattus norvegicus

10 known processes

Spp2

secreted phosphoprotein 2

(Aliases: MGC108864)

Spp2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of serine type endopeptidase activityGO:190000410.697
positive regulation of extracellular matrix constituent secretionGO:000333120.648
regulation of serine type peptidase activityGO:190257110.461
positive regulation of extracellular matrix organizationGO:190305540.390
response to vitamin b6GO:003451610.339
apoptotic processGO:00069153810.317
regulation of programmed cell deathGO:00430673410.307
regulation of extracellular matrix constituent secretionGO:000333020.307
regulation of apoptotic processGO:00429813350.301
response to peptideGO:19016522920.287
negative regulation of serine type peptidase activityGO:190257210.263
regulation of hydrolase activityGO:00513361430.253
cation transportGO:00068123820.244
cofactor metabolic processGO:0051186950.234
regulation of cellular localizationGO:00603412630.222
response to campGO:0051591910.220
regulation of serine type endopeptidase activityGO:190000310.219
response to organophosphorusGO:00466831020.213
negative regulation of metabolic processGO:00098923310.209
nicotinamide nucleotide metabolic processGO:0046496280.208
response to peptide hormoneGO:00434342780.207
cell cell signalingGO:00072673350.206
negative regulation of cellular metabolic processGO:00313242810.202
positive regulation of secretionGO:00510471400.197
response to cytokineGO:00340972150.197
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.192
response to estrogenGO:00436272320.180
carboxylic acid metabolic processGO:00197522890.176
response to extracellular stimulusGO:00099913800.176
regulation of cellular component organizationGO:00511283680.175
regulation of amine transportGO:0051952540.172
regulation of secretionGO:00510462240.169
amine transportGO:0015837570.169
response to mineralocorticoidGO:0051385490.169
regulation of ion transportGO:00432692450.166
negative regulation of macromolecule metabolic processGO:00106052600.164
behaviorGO:00076102050.154
response to nutrient levelsGO:00316673700.149
cellular response to oxygen containing compoundGO:19017013860.144
response to chromateGO:004668730.143
regenerationGO:00310991630.140
programmed cell deathGO:00125013920.138
extracellular matrix constituent secretionGO:007027840.137
response to platinum ionGO:007054140.134
cellular ion homeostasisGO:00068731840.133
coenzyme metabolic processGO:0006732860.131
regulation of catalytic activityGO:00507903040.131
positive regulation of coagulationGO:005082050.130
positive regulation of multicellular organismal processGO:00512403870.130
positive regulation of transportGO:00510502450.127
cellular lipid metabolic processGO:00442552080.125
brain renin angiotensin systemGO:000203530.120
positive regulation of cellular component organizationGO:00511302000.117
oxoacid metabolic processGO:00434362900.113
organic acid metabolic processGO:00060822920.113
response to triglycerideGO:003401430.112
divalent metal ion transportGO:00708381320.111
nitrogen compound transportGO:00717052290.111
organic substance catabolic processGO:19015753160.107
feeding behaviorGO:0007631530.105
response to corticosteroidGO:00319602350.105
homeostatic processGO:00425923310.103
organic hydroxy compound transportGO:0015850770.101
response to inorganic substanceGO:00100353770.098
regulation of calcium ion transportGO:0051924770.098
response to methanolGO:003398610.096
fructose metabolic processGO:000600010.094
catecholamine secretionGO:0050432330.094
negative regulation of gene expressionGO:00106291990.093
response to glucocorticoidGO:00513842230.093
cellular sodium ion homeostasisGO:000688340.093
secretion by cellGO:00329402480.092
regulation of secretion by cellGO:19035302080.091
proteolysisGO:00065081750.090
single organism catabolic processGO:00447122830.087
organonitrogen compound catabolic processGO:19015651790.086
locomotionGO:00400112370.086
renal sodium excretionGO:0035812200.086
reproductive processGO:00224143720.084
negative regulation of protein metabolic processGO:00512481140.083
aromatic amino acid family catabolic processGO:000907470.082
regulation of cell growthGO:0001558850.081
renin angiotensin regulation of aldosterone productionGO:000201830.080
oxidation reduction processGO:00551143040.079
response to oxygen levelsGO:00704822650.078
cellular metal ion homeostasisGO:00068751720.077
cellular homeostasisGO:00197252520.076
response to decreased oxygen levelsGO:00362932370.076
positive regulation of blood coagulationGO:003019440.075
regulation of molecular functionGO:00650093980.075
metal ion transportGO:00300012890.074
g protein coupled receptor signaling pathwayGO:00071862420.074
muscle system processGO:00030121150.074
positive regulation of homeostatic processGO:0032846490.074
tonic smooth muscle contractionGO:001482040.073
regulation of homeostatic processGO:00328441010.073
single organism biosynthetic processGO:00447113420.073
negative regulation of molecular functionGO:00440921330.072
chemical homeostasisGO:00488782920.071
positive regulation of hydrolase activityGO:0051345860.071
lipid metabolic processGO:00066292830.070
divalent inorganic cation transportGO:00725111340.070
renal system processGO:0003014400.070
memoryGO:0007613540.069
multi multicellular organism processGO:00447061380.069
response to transition metal nanoparticleGO:19902671220.068
negative regulation of cellular protein metabolic processGO:00322691060.068
synaptic transmissionGO:00072682350.067
cellular amino acid metabolic processGO:00065201070.066
response to purine containing compoundGO:00140741260.066
angiotensin mediated drinking behaviorGO:000305120.066
cardiac muscle cell developmentGO:0055013160.065
calcium ion transportGO:00068161310.065
carbohydrate metabolic processGO:00059751300.064
single organism intracellular transportGO:19025821660.063
cellular response to organonitrogen compoundGO:00714171970.061
monoamine transportGO:0015844430.061
alpha amino acid metabolic processGO:1901605710.061
response to hexoseGO:00097461440.060
cell projection organizationGO:00300303020.059
aromatic amino acid family metabolic processGO:000907290.059
sterol transportGO:001591860.058
response to muscle activity involved in regulation of muscle adaptationGO:001487320.057
plasminogen activationGO:003163920.057
regulation of cellular ketone metabolic processGO:0010565270.057
regulation of protein maturationGO:1903317500.057
positive regulation of biosynthetic processGO:00098913190.056
macromolecular complex subunit organizationGO:00439333390.056
negative regulation of protein processingGO:0010955470.056
gland developmentGO:00487321550.055
organ regenerationGO:00311001010.055
negative regulation of peptidase activityGO:0010466380.055
catenin import into nucleusGO:003541110.054
response to acid chemicalGO:00011012220.054
response to glucoseGO:00097491360.054
cellular amine metabolic processGO:0044106380.054
cellular component biogenesisGO:00440853680.053
regulation of protein processingGO:0070613500.053
protein complex biogenesisGO:00702712630.052
regulation of blood circulationGO:19035221100.052
blood circulationGO:00080151830.052
protein phosphorylationGO:00064683450.052
heart developmentGO:0007507720.051
cellular component assemblyGO:00226073600.051
regulation of growthGO:00400081050.051
regulation of catecholamine secretionGO:0050433320.050
cellular ketone metabolic processGO:0042180510.050
negative regulation of vasculature developmentGO:1901343110.050
regulation of anatomical structure sizeGO:00900661350.050
amine metabolic processGO:0009308380.050
negative regulation of protein maturationGO:1903318470.050
negative regulation of endothelial cell proliferationGO:000193750.050
monocarboxylic acid metabolic processGO:00327871520.050
organophosphate metabolic processGO:00196373700.050
regulation of multicellular organismal developmentGO:20000263760.049
peptide hormone secretionGO:0030072840.049
anatomical structure morphogenesisGO:00096532980.049
norepinephrine secretionGO:0048243160.049
ion homeostasisGO:00508012120.048
positive regulation of secretion by cellGO:19035321280.048
transmission of nerve impulseGO:0019226420.048
smooth muscle contractionGO:0006939370.048
multi organism reproductive processGO:00447032620.047
carboxylic acid catabolic processGO:0046395490.046
growthGO:00400071650.045
protein processingGO:0016485680.045
protein oligomerizationGO:00512591910.045
protein maturationGO:0051604680.045
protein complex subunit organizationGO:00718223020.045
nuclear transportGO:0051169490.044
signal transduction by phosphorylationGO:00230141440.044
single organism behaviorGO:00447081300.044
vasoconstrictionGO:0042310540.044
regulation of renal sodium excretionGO:0035813200.043
positive regulation of catalytic activityGO:00430851840.043
cellular response to nitrogen compoundGO:19016992100.043
response to hypoxiaGO:00016662310.043
intracellular transportGO:00469071850.043
store operated calcium entryGO:000211520.043
response to metal ionGO:00100382530.042
response to corticosteroneGO:0051412400.042
regulation of hemostasisGO:190004690.042
catecholamine transportGO:0051937370.042
regulation of synaptic transmissionGO:00508041410.041
monosaccharide metabolic processGO:0005996610.041
positive regulation of hemostasisGO:190004840.041
negative regulation of signalingGO:00230571570.041
fibrinolysisGO:004273020.041
carbohydrate derivative metabolic processGO:19011353460.041
organic acid biosynthetic processGO:0016053830.041
agingGO:00075682410.040
cholesterol transportGO:003030150.040
circulatory system processGO:00030131830.040
regulation of cell proliferationGO:00421273590.040
reactive nitrogen species metabolic processGO:200105710.040
intracellular signal transductionGO:00355563140.040
regulation of system processGO:00440572080.040
positive regulation of nitrogen compound metabolic processGO:00511733340.039
hormone transportGO:00099141210.039
vesicle mediated transportGO:00161921810.039
response to nutrientGO:00075842480.038
defense responseGO:00069521940.038
organic cyclic compound catabolic processGO:19013611750.038
cardiovascular system developmentGO:00723581340.038
cellular chemical homeostasisGO:00550822470.037
regulation of reactive oxygen species metabolic processGO:2000377260.037
small molecule catabolic processGO:0044282590.037
regulation of reactive oxygen species biosynthetic processGO:190342650.037
regulation of body fluid levelsGO:0050878900.036
macromolecular complex assemblyGO:00650032730.036
regulation of metal ion transportGO:00109591180.036
organonitrogen compound biosynthetic processGO:19015661670.036
negative regulation of response to stimulusGO:00485851550.036
negative regulation of cell proliferationGO:00082851190.036
muscle cell differentiationGO:0042692520.036
regulation of neuronal synaptic plasticityGO:0048168310.036
cellular response to peptide hormone stimulusGO:00713751200.035
inflammatory responseGO:00069541500.035
regulation of protein metabolic processGO:00512462890.035
response to lead ionGO:0010288330.035
circadian sleep wake cycleGO:0042745230.035
multicellular organismal signalingGO:0035637440.035
liver developmentGO:0001889900.035
synaptic vesicle amine transportGO:001584230.034
neurological system processGO:00508772190.034
positive regulation of cell deathGO:00109421840.034
protein complex assemblyGO:00064612630.033
regulation of blood pressureGO:0008217830.033
hexose metabolic processGO:0019318580.033
cytoplasmic transportGO:00164821150.033
positive regulation of cell proliferationGO:00082842490.033
metal ion homeostasisGO:00550651860.033
positive regulation of nucleobase containing compound metabolic processGO:00459353190.033
cellular response to external stimulusGO:00714961180.032
cellular response to organic cyclic compoundGO:00714072020.032
ribonucleotide catabolic processGO:00092611360.032
positive regulation of cellular biosynthetic processGO:00313282950.032
circulatory system developmentGO:00723591340.032
negative regulation of epithelial cell proliferationGO:0050680160.032
regulation of muscle system processGO:0090257790.031
cellular cation homeostasisGO:00300031800.031
regulation of tube sizeGO:0035150890.031
cellular catabolic processGO:00442482950.030
central nervous system developmentGO:00074173110.030
female pregnancyGO:00075651220.030
anion transportGO:00068201780.030
response to other organismGO:00517072200.029
reactive oxygen species biosynthetic processGO:190340980.029
regulation of peptidase activityGO:0052547550.029
nucleotide metabolic processGO:00091172790.029
response to alkaloidGO:00432791320.029
response to estradiolGO:00323551640.028
regulation of norepinephrine secretionGO:0014061150.028
response to external biotic stimulusGO:00432072210.028
fatty acid metabolic processGO:0006631990.028
nucleoside phosphate metabolic processGO:00067532830.028
cellular response to stressGO:00335542690.028
dicarboxylic acid metabolic processGO:0043648420.028
negative regulation of endopeptidase activityGO:0010951360.028
positive regulation of programmed cell deathGO:00430681570.027
positive regulation of reactive oxygen species metabolic processGO:2000379160.027
neuron differentiationGO:00301823680.027
cellular response to campGO:0071320260.027
regulation of phosphorus metabolic processGO:00511743490.026
muscle structure developmentGO:0061061870.026
negative regulation of cell deathGO:00605482290.026
transmembrane transportGO:00550854120.026
regulation of cell developmentGO:00602842630.026
negative regulation of developmental processGO:00510931250.026
cell growthGO:00160491040.026
amide transportGO:00428861050.025
aromatic compound catabolic processGO:00194391680.025
cardiac cell developmentGO:0055006160.025
rhythmic behaviorGO:0007622240.025
regulation of neuron projection developmentGO:00109751610.025
regulation of systemic arterial blood pressureGO:0003073300.025
response to ketoneGO:19016541820.025
positive regulation of phospholipase activityGO:0010518100.025
negative regulation of catalytic activityGO:00430861030.025
positive regulation of molecular functionGO:00440932300.025
single organism carbohydrate metabolic processGO:00447231180.025
cellular response to endogenous stimulusGO:00714953770.024
negative regulation of proteolysisGO:0045861410.024
regulation of proteolysisGO:0030162660.024
regulation of vasculature developmentGO:1901342440.024
cellular amino acid biosynthetic processGO:0008652320.024
negative regulation of calcium ion importGO:009028120.024
mapk cascadeGO:00001651400.024
negative regulation of angiogenesisGO:0016525100.024
artery smooth muscle contractionGO:001482440.024
negative regulation of programmed cell deathGO:00430691830.024
heterocycle catabolic processGO:00467001670.024
norepinephrine transportGO:0015874180.024
erk1 and erk2 cascadeGO:0070371480.024
carboxylic acid biosynthetic processGO:0046394830.023
neuron projection developmentGO:00311752730.023
isoquinoline alkaloid metabolic processGO:003307620.023
purine nucleotide catabolic processGO:00061951360.023
single organism reproductive processGO:00447022970.023
response to vitaminGO:00332731310.023
regulation of phosphate metabolic processGO:00192203490.023
ribonucleoside triphosphate catabolic processGO:00092031220.022
circadian sleep wake cycle processGO:0022410210.022
carbohydrate catabolic processGO:0016052400.022
cellular nitrogen compound catabolic processGO:00442701630.022
circadian sleep wake cycle sleepGO:0050802210.022
urea cycleGO:000005050.022
regulation of circadian sleep wake cycleGO:0042749180.022
positive regulation of renal sodium excretionGO:0035815100.022
regulation of response to external stimulusGO:00321011060.022
extracellular matrix organizationGO:0030198130.022
regulation of circadian sleep wake cycle sleepGO:0045187180.022
response to woundingGO:00096112540.022
catabolic processGO:00090563510.022
uterine smooth muscle contractionGO:0070471100.021
forebrain developmentGO:0030900980.021
response to carbohydrateGO:00097431830.021
cellular response to insulin stimulusGO:0032869810.021
indole containing compound metabolic processGO:0042430110.021
response to activityGO:0014823730.021
steroid metabolic processGO:0008202730.021
response to mercury ionGO:0046689150.021
regulation of behaviorGO:0050795610.021
negative regulation of nervous system developmentGO:0051961790.020
regulation of cellular amine metabolic processGO:003323880.020
regulation of phospholipase activityGO:0010517120.020
cellular response to mechanical stimulusGO:0071260480.020
positive regulation of nitric oxide biosynthetic processGO:0045429140.020
regulation of cellular amino acid metabolic processGO:000652120.020
purine nucleoside triphosphate metabolic processGO:00091441410.020
sensory perceptionGO:00076001010.020
intracellular protein transportGO:0006886790.020
protein homooligomerizationGO:0051260910.020
hepaticobiliary system developmentGO:0061008900.020
sleepGO:0030431300.020
rna metabolic processGO:00160704060.020
negative regulation of transportGO:00510511360.020
regulation of response to woundingGO:1903034690.020
calcium ion homeostasisGO:00550741620.019
vascular process in circulatory systemGO:0003018960.019
negative regulation of phosphate metabolic processGO:0045936800.019
organelle organizationGO:00069962660.019
acute inflammatory responseGO:0002526580.019
organophosphate catabolic processGO:00464341480.019
circadian rhythmGO:0007623880.019
positive regulation of blood pressureGO:0045777310.019
regulation of plasminogen activationGO:001075520.019
response to molecule of bacterial originGO:00022371940.018
regulation of long term neuronal synaptic plasticityGO:0048169150.018
purine ribonucleotide metabolic processGO:00091502270.018
response to foodGO:0032094270.018
negative regulation of phosphorus metabolic processGO:0010563800.018
purine ribonucleotide catabolic processGO:00091541360.018
regulation of cellular protein metabolic processGO:00322682670.018
cellular response to interleukin 6GO:007135490.018
cellular response to peptideGO:19016531330.018
negative regulation of cell communicationGO:00106481580.018
response to monosaccharideGO:00342841590.018
carboxylic acid transportGO:00469421150.018
response to biotic stimulusGO:00096072260.018
regulation of ion homeostasisGO:2000021630.017
nucleocytoplasmic transportGO:0006913480.017
cellular macromolecule localizationGO:00707271220.017
excretionGO:0007588240.017
positive regulation of reactive oxygen species biosynthetic processGO:190342820.017
positive regulation of cell projection organizationGO:00313461110.017
response to interferon gammaGO:0034341200.017
cell migrationGO:00164771970.017
sulfur compound metabolic processGO:0006790700.017
response to ammonium ionGO:0060359710.017
regulation of transmembrane transportGO:00347621220.017
cation homeostasisGO:00550801950.017
regulation of cell projection organizationGO:00313441750.017
response to vitamin aGO:0033189360.017
divalent inorganic cation homeostasisGO:00725071650.017
regulation of nervous system developmentGO:00519602640.017
regulation of systemic arterial blood pressure mediated by a chemical signalGO:0003044130.017
response to nicotineGO:0035094510.017
regulation of lipase activityGO:0060191150.017
negative regulation of fibrinolysisGO:005191820.017
alpha amino acid catabolic processGO:1901606200.017
muscle contractionGO:0006936880.017
regulation of excretionGO:0044062210.016
cognitionGO:0050890920.016
response to amphetamineGO:0001975250.016
peptide transportGO:0015833970.016
physiological muscle hypertrophyGO:0003298130.016
negative regulation of blood vessel morphogenesisGO:2000181100.016
response to mechanical stimulusGO:00096121340.016
regulation of phosphorylationGO:00423252480.016
nad metabolic processGO:0019674150.016
regulation of rna biosynthetic processGO:20011413810.016
cellular protein localizationGO:00346131220.016
brain developmentGO:00074202470.016
purine ribonucleoside catabolic processGO:00461301240.016
epithelial cell proliferationGO:0050673540.016
regulation of phospholipase c activityGO:190027490.016
response to amino acidGO:0043200750.016
positive regulation of macromolecule biosynthetic processGO:00105572470.016
regulation of angiogenesisGO:0045765390.016
lipid modificationGO:0030258520.016
developmental growthGO:00485891000.016
tissue developmentGO:00098882520.016
response to fluorideGO:190261730.015
positive regulation of cytosolic calcium ion concentrationGO:00072041220.015
cytoskeleton organizationGO:00070101110.015
positive regulation of apoptotic processGO:00430651540.015
regulation of cell differentiationGO:00455953200.015
neuron developmentGO:00486662860.015
regulation of epithelial cell proliferationGO:0050678490.015
cellular divalent inorganic cation homeostasisGO:00725031620.015
secretionGO:00469033070.015
secretion by tissueGO:0032941370.015
regulation of defecationGO:200029210.015
endocrine processGO:0050886320.015
carbohydrate homeostasisGO:0033500750.015
single organism nuclear importGO:1902593350.015
regulation of fibrinolysisGO:005191720.015
purine containing compound metabolic processGO:00725212530.015
cell adhesionGO:00071551100.015
localization of cellGO:00516742020.015
ribonucleoside metabolic processGO:00091191740.015
purine ribonucleoside metabolic processGO:00461281680.015
sodium ion homeostasisGO:0055078230.015
purine nucleotide metabolic processGO:00061632290.015
rhythmic processGO:00485111560.015
response to toxic substanceGO:00096361330.015
pyridine nucleotide metabolic processGO:0019362280.015
alpha amino acid biosynthetic processGO:1901607230.015
oxidoreduction coenzyme metabolic processGO:0006733310.014
regulation of neurological system processGO:0031644430.014
positive regulation of amino acid transportGO:0051957130.014
nucleoside metabolic processGO:00091161790.014
nucleoside triphosphate metabolic processGO:00091411440.014
nucleoside phosphate catabolic processGO:19012921400.014
negative regulation of multicellular organismal processGO:00512412030.014
positive regulation of calcium ion transportGO:0051928360.014
purine ribonucleoside triphosphate metabolic processGO:00092051400.014
regulation of nitric oxide biosynthetic processGO:0045428200.014
regulation of blood vessel sizeGO:0050880890.014
immune system processGO:00023762040.014
protein targetingGO:0006605610.014
positive regulation of catabolic processGO:0009896780.014
negative regulation of wound healingGO:006104580.014
response to starvationGO:0042594590.014
positive regulation of phosphorus metabolic processGO:00105622620.014
detection of abiotic stimulusGO:0009582130.014
glucose metabolic processGO:0006006520.014
positive regulation of blood circulationGO:1903524650.014
regulation of circadian rhythmGO:0042752270.014
response to insulinGO:00328681330.013
protein localization to nucleusGO:0034504390.013
biological adhesionGO:00226101100.013
angiogenesisGO:0001525530.013
insulin secretionGO:0030073690.013
axon developmentGO:0061564960.013
hormone secretionGO:00468791150.013
establishment of protein localizationGO:00451841410.013
lipid transportGO:0006869610.013
regulation of anatomical structure morphogenesisGO:00226031410.013
cellular response to abiotic stimulusGO:0071214850.013
regulation of signal transductionGO:00099663180.013
activation of phospholipase c activityGO:000720270.013
cellular response to lipidGO:00713962010.013
negative regulation of apoptotic processGO:00430661810.013
response to vitamin kGO:003257140.013
regulation of cellular component biogenesisGO:0044087860.013
positive regulation of neuron differentiationGO:00456661260.013
cellular biogenic amine metabolic processGO:0006576300.013
organic acid catabolic processGO:0016054490.013
regulation of nucleoside metabolic processGO:0009118660.013
single organism organelle organizationGO:19025891800.013
negative regulation of cellular biosynthetic processGO:00313271610.013
phospholipid metabolic processGO:0006644610.013
response to cocaineGO:0042220390.013
reactive oxygen species metabolic processGO:0072593370.013
learning or memoryGO:0007611900.013
ribose phosphate metabolic processGO:00196932350.013
negative regulation of hydrolase activityGO:0051346520.013
head developmentGO:00603222470.012
smooth muscle cell proliferationGO:0048659770.012
regulation of neuron differentiationGO:00456642080.012
telencephalon developmentGO:0021537620.012
positive regulation of ion transportGO:0043270940.012
cardiocyte differentiationGO:0035051220.012
nucleobase containing small molecule metabolic processGO:00550863160.012
pyridine containing compound metabolic processGO:0072524320.012
cellular component movementGO:00069282480.012

Spp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
vascular diseaseDOID:17800.039
artery diseaseDOID:005082800.039
disease of anatomical entityDOID:700.039
cardiovascular system diseaseDOID:128700.039
disease of metabolismDOID:001466700.031
inherited metabolic disorderDOID:65500.023
acquired metabolic diseaseDOID:006015800.015
musculoskeletal system diseaseDOID:1700.014