Rattus norvegicus

139 known processes

Akr1b1

aldo-keto reductase family 1, member B1 (aldose reductase)

(Aliases: ALR-P-I,RATALDRED,Aldr1,Akr1b3,ALDRED,Alr,Akr1b4)

Akr1b1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to oxidative stressGO:00069791860.136
regulation of apoptotic processGO:00429813350.084
carboxylic acid metabolic processGO:00197522890.079
cellular amino acid metabolic processGO:00065201070.075
intracellular signal transductionGO:00355563140.071
programmed cell deathGO:00125013920.066
catabolic processGO:00090563510.058
regulation of cell proliferationGO:00421273590.058
cellular lipid metabolic processGO:00442552080.057
Rat
cellular response to endogenous stimulusGO:00714953770.055
cellular response to stressGO:00335542690.055
organic substance catabolic processGO:19015753160.054
apoptotic processGO:00069153810.053
response to inorganic substanceGO:00100353770.053
regulation of programmed cell deathGO:00430673410.052
oxoacid metabolic processGO:00434362900.051
negative regulation of metabolic processGO:00098923310.049
regulation of intracellular signal transductionGO:19025312180.048
macromolecular complex subunit organizationGO:00439333390.047
positive regulation of nitrogen compound metabolic processGO:00511733340.046
reproductionGO:00000032450.045
response to carbohydrateGO:00097431830.043
organophosphate metabolic processGO:00196373700.042
response to estrogenGO:00436272320.042
Rat
organic acid metabolic processGO:00060822920.038
response to ketoneGO:19016541820.037
negative regulation of response to stimulusGO:00485851550.037
cell projection organizationGO:00300303020.036
agingGO:00075682410.036
regulation of rna metabolic processGO:00512523910.036
neuron projection developmentGO:00311752730.036
single organism biosynthetic processGO:00447113420.035
regulation of rna biosynthetic processGO:20011413810.035
response to reactive oxygen speciesGO:00003021200.035
protein complex assemblyGO:00064612630.034
cellular amide metabolic processGO:0043603440.034
regulation of nucleic acid templated transcriptionGO:19035063800.034
response to external biotic stimulusGO:00432072210.034
regulation of molecular functionGO:00650093980.034
transcription dna templatedGO:00063513770.033
multi organism reproductive processGO:00447032620.033
single organism carbohydrate metabolic processGO:00447231180.032
cellular ketone metabolic processGO:0042180510.032
Human
secretionGO:00469033070.032
cellular response to oxidative stressGO:0034599760.032
positive regulation of nucleobase containing compound metabolic processGO:00459353190.031
response to nutrient levelsGO:00316673700.031
protein complex subunit organizationGO:00718223020.030
negative regulation of transportGO:00510511360.030
cellular response to reactive oxygen speciesGO:0034614550.030
macromolecular complex assemblyGO:00650032730.030
regulation of cellular ketone metabolic processGO:0010565270.030
negative regulation of cell deathGO:00605482290.029
single organism reproductive processGO:00447022970.027
cellular catabolic processGO:00442482950.027
regulation of phosphate metabolic processGO:00192203490.026
regulation of cellular amino acid metabolic processGO:000652120.026
regulation of transcription dna templatedGO:00063553740.026
rna metabolic processGO:00160704060.026
positive regulation of cellular biosynthetic processGO:00313282950.025
regulation of catalytic activityGO:00507903040.025
cellular response to organonitrogen compoundGO:00714171970.025
cellular response to organic cyclic compoundGO:00714072020.025
reproductive processGO:00224143720.025
proteolysisGO:00065081750.025
cellular response to oxygen containing compoundGO:19017013860.025
regenerationGO:00310991630.025
negative regulation of programmed cell deathGO:00430691830.024
response to peptideGO:19016522920.024
response to estradiolGO:00323551640.023
regulation of signal transductionGO:00099663180.023
negative regulation of apoptotic processGO:00430661810.023
nucleobase containing small molecule metabolic processGO:00550863160.023
positive regulation of apoptotic processGO:00430651540.023
neuron developmentGO:00486662860.023
negative regulation of cell communicationGO:00106481580.023
response to hydrogen peroxideGO:0042542890.023
chemical homeostasisGO:00488782920.023
cellular amine metabolic processGO:0044106380.023
multicellular organismal reproductive processGO:00486092330.023
lipid metabolic processGO:00066292830.022
Rat
defense responseGO:00069521940.022
secretion by cellGO:00329402480.022
amine metabolic processGO:0009308380.022
nucleoside phosphate metabolic processGO:00067532830.022
small molecule biosynthetic processGO:00442831240.022
positive regulation of rna metabolic processGO:00512542030.022
central nervous system developmentGO:00074173110.022
Rat Fly
response to glucocorticoidGO:00513842230.022
neuron differentiationGO:00301823680.022
response to acid chemicalGO:00011012220.022
negative regulation of multicellular organismal processGO:00512412030.021
positive regulation of nucleic acid templated transcriptionGO:19035081970.021
response to metal ionGO:00100382530.021
protein phosphorylationGO:00064683450.021
response to radiationGO:00093141370.021
regulation of phosphorus metabolic processGO:00511743490.021
rhythmic processGO:00485111560.021
positive regulation of cell communicationGO:00106472710.021
regulation of cellular amine metabolic processGO:003323880.020
meiotic cell cycle processGO:190304630.020
chromosome segregationGO:000705920.020
positive regulation of biosynthetic processGO:00098913190.020
regulation of neurogenesisGO:00507672470.020
cellular response to hormone stimulusGO:00328702470.020
response to amino acidGO:0043200750.020
nucleic acid templated transcriptionGO:00976593790.020
cellular component biogenesisGO:00440853680.020
negative regulation of biosynthetic processGO:00098901680.020
response to peptide hormoneGO:00434342780.020
response to monosaccharideGO:00342841590.020
cellular response to nitrogen compoundGO:19016992100.020
transmembrane transportGO:00550854120.019
response to biotic stimulusGO:00096072260.019
positive regulation of rna biosynthetic processGO:19026801970.019
negative regulation of molecular functionGO:00440921330.019
negative regulation of macromolecule metabolic processGO:00106052600.019
cation transportGO:00068123820.019
positive regulation of cell deathGO:00109421840.019
response to decreased oxygen levelsGO:00362932370.019
single organism catabolic processGO:00447122830.018
positive regulation of gene expressionGO:00106282440.018
ion homeostasisGO:00508012120.018
immune system processGO:00023762040.018
organic hydroxy compound metabolic processGO:19016151150.018
regulation of response to stressGO:00801341260.018
female pregnancyGO:00075651220.018
ion transmembrane transportGO:00342203650.018
anion transportGO:00068201780.018
regulation of phosphorylationGO:00423252480.018
carbohydrate metabolic processGO:00059751300.018
response to transition metal nanoparticleGO:19902671220.017
positive regulation of transcription dna templatedGO:00458931970.017
cellular protein complex assemblyGO:0043623440.017
small gtpase mediated signal transductionGO:0007264360.017
response to vitaminGO:00332731310.017
response to extracellular stimulusGO:00099913800.017
negative regulation of cellular metabolic processGO:00313242810.017
transcription from rna polymerase ii promoterGO:00063662520.017
regulation of cellular localizationGO:00603412630.017
homeostatic processGO:00425923310.017
regulation of protein modification processGO:00313991940.017
response to alkaloidGO:00432791320.017
protein oligomerizationGO:00512591910.017
negative regulation of signal transductionGO:0009968830.017
reproductive structure developmentGO:00486081280.017
protein complex biogenesisGO:00702712630.017
positive regulation of cellular amino acid metabolic processGO:004576410.016
rna biosynthetic processGO:00327743800.016
negative regulation of neuron differentiationGO:0045665620.016
brain developmentGO:00074202470.016
Rat Fly
mitotic cell cycleGO:0000278490.016
response to bacteriumGO:00096172000.016
axis specificationGO:000979840.016
cellular homeostasisGO:00197252520.016
response to woundingGO:00096112540.016
response to hypoxiaGO:00016662310.016
multicellular organism reproductionGO:00325042330.016
response to molecule of bacterial originGO:00022371940.016
sexual reproductionGO:00199531480.016
oxidation reduction processGO:00551143040.016
negative regulation of cellular protein metabolic processGO:00322691060.016
locomotionGO:00400112370.016
negative regulation of protein metabolic processGO:00512481140.015
inorganic ion transmembrane transportGO:00986602290.015
response to ethanolGO:00454711620.015
regulation of protein metabolic processGO:00512462890.015
organic acid biosynthetic processGO:0016053830.015
cell type specific apoptotic processGO:00972851340.015
metal ion transportGO:00300012890.015
organonitrogen compound biosynthetic processGO:19015661670.015
monosaccharide metabolic processGO:0005996610.015
response to toxic substanceGO:00096361330.015
cellular response to glucocorticoid stimulusGO:0071385680.015
cellular modified amino acid metabolic processGO:0006575610.015
nucleotide metabolic processGO:00091172790.015
regulation of cellular protein metabolic processGO:00322682670.015
cellular component assemblyGO:00226073600.015
response to glucoseGO:00097491360.015
negative regulation of signalingGO:00230571570.015
regulation of hormone levelsGO:00108171870.015
Rat
positive regulation of macromolecule biosynthetic processGO:00105572470.014
purine containing compound metabolic processGO:00725212530.014
regulation of multicellular organismal developmentGO:20000263760.014
anterior posterior pattern specificationGO:000995210.014
cell cycleGO:00070491010.014
cellular response to growth factor stimulusGO:00713631620.014
carbohydrate derivative metabolic processGO:19011353460.014
Human
positive regulation of developmental processGO:00510942830.014
negative regulation of gene expressionGO:00106291990.014
regulation of protein phosphorylationGO:00019321830.014
establishment of protein localizationGO:00451841410.014
positive regulation of multicellular organismal processGO:00512403870.014
single organism behaviorGO:00447081300.014
response to cytokineGO:00340972150.014
response to growth factorGO:00708481890.014
regulation of nucleotide metabolic processGO:00061401170.014
response to nutrientGO:00075842480.014
ras protein signal transductionGO:0007265290.014
positive regulation of phosphate metabolic processGO:00459372620.014
response to corticosteroidGO:00319602350.014
response to lipopolysaccharideGO:00324961910.014
cellular response to abiotic stimulusGO:0071214850.014
cellular response to corticosteroid stimulusGO:0071384690.014
response to herbicideGO:0009635160.014
developmental process involved in reproductionGO:00030061590.013
regulation of neuron projection developmentGO:00109751610.013
telencephalon developmentGO:0021537620.013
Rat
positive regulation of programmed cell deathGO:00430681570.013
regulation of anatomical structure sizeGO:00900661350.013
intracellular transportGO:00469071850.013
negative regulation of cell proliferationGO:00082851190.013
regulation of neuron apoptotic processGO:0043523830.013
regulation of membrane potentialGO:00423911100.013
cation transmembrane transportGO:00986552630.013
peptide metabolic processGO:0006518320.013
response to other organismGO:00517072200.013
gamete generationGO:00072761240.013
regulation of transcription from rna polymerase ii promoterGO:00063572340.013
cellular response to peptideGO:19016531330.013
metal ion homeostasisGO:00550651860.013
regulation of secretionGO:00510462240.012
spindle organizationGO:000705120.012
positive regulation of signalingGO:00230562700.012
gonad developmentGO:00084061040.012
regulation of ion transportGO:00432692450.012
positive regulation of molecular functionGO:00440932300.012
cellular response to lipidGO:00713962010.012
positive regulation of phosphorus metabolic processGO:00105622620.012
regulation of secretion by cellGO:19035302080.012
vascular process in circulatory systemGO:0003018960.012
response to oxygen levelsGO:00704822650.012
mitotic spindle organizationGO:000705220.012
reactive oxygen species metabolic processGO:0072593370.012
gliogenesisGO:0042063930.012
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.012
positive regulation of cellular amine metabolic processGO:003324030.012
reproductive system developmentGO:00614581280.012
g protein coupled receptor signaling pathwayGO:00071862420.012
circulatory system processGO:00030131830.012
cellular response to steroid hormone stimulusGO:0071383930.012
negative regulation of catalytic activityGO:00430861030.012
positive regulation of cellular protein metabolic processGO:00322701670.012
positive regulation of protein modification processGO:00314011420.012
spermatogenesisGO:0007283990.011
positive regulation of cell differentiationGO:00455972170.011
behaviorGO:00076102050.011
sulfur compound metabolic processGO:0006790700.011
organelle organizationGO:00069962660.011
synaptic growth at neuromuscular junctionGO:005112410.011
vesicle mediated transportGO:00161921810.011
response to hexoseGO:00097461440.011
cation homeostasisGO:00550801950.011
cellular response to external stimulusGO:00714961180.011
blood circulationGO:00080151830.011
hexose metabolic processGO:0019318580.011
cellular divalent inorganic cation homeostasisGO:00725031620.011
neuron apoptotic processGO:0051402880.011
ribonucleotide metabolic processGO:00092592310.011
regulation of protein kinase activityGO:00458591050.011
regulation of nervous system developmentGO:00519602640.011
divalent inorganic cation homeostasisGO:00725071650.011
regulation of hydrolase activityGO:00513361430.011
monocarboxylic acid metabolic processGO:00327871520.011
cellular component movementGO:00069282480.011
regulation of neuron differentiationGO:00456642080.011
response to light stimulusGO:0009416520.011
apoptotic signaling pathwayGO:0097190270.011
regulation of cell developmentGO:00602842630.011
cellular chemical homeostasisGO:00550822470.011
positive regulation of signal transductionGO:00099671750.011
regulation of cell differentiationGO:00455953200.011
immune responseGO:00069551040.010
organophosphate biosynthetic processGO:00904071430.010
protein transportGO:00150311320.010
positive regulation of catalytic activityGO:00430851840.010
alcohol metabolic processGO:0006066770.010
organic anion transportGO:00157111320.010
negative regulation of protein modification processGO:0031400520.010
regulation of catabolic processGO:00098941130.010
single organism cellular localizationGO:19025801020.010
macromolecule localizationGO:00330362520.010
wound healingGO:00420601220.010
regulation of cell migrationGO:00303341280.010
single organism carbohydrate catabolic processGO:0044724400.010
regulation of kinase activityGO:00435491170.010

Akr1b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.020
musculoskeletal system diseaseDOID:1700.020
nervous system diseaseDOID:86300.013
cardiovascular system diseaseDOID:128700.012
central nervous system diseaseDOID:33100.010