IMP: Integrative Multi-species Prediction

Rattus norvegicus

139 known processes

Akr1b1

aldo-keto reductase family 1, member B1 (aldose reductase)

(Aliases: ALR-P-I,RATALDRED,Aldr1,Akr1b3,ALDRED,Alr,Akr1b4)

RGD: 2092
Ensembl: ENSRNOG00000009513
Entrez: 24192
UniProtKB: P07943

Process Predictions
Disease Predictions

Akr1b1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to oxidative stress	GO:0006979	186	0.136
regulation of apoptotic process	GO:0042981	335	0.084
carboxylic acid metabolic process	GO:0019752	289	0.079
cellular amino acid metabolic process	GO:0006520	107	0.075
intracellular signal transduction	GO:0035556	314	0.071
programmed cell death	GO:0012501	392	0.066
catabolic process	GO:0009056	351	0.058
regulation of cell proliferation	GO:0042127	359	0.058
cellular lipid metabolic process	GO:0044255	208	0.057	Rat
cellular response to endogenous stimulus	GO:0071495	377	0.055
cellular response to stress	GO:0033554	269	0.055
organic substance catabolic process	GO:1901575	316	0.054
apoptotic process	GO:0006915	381	0.053
response to inorganic substance	GO:0010035	377	0.053
regulation of programmed cell death	GO:0043067	341	0.052
oxoacid metabolic process	GO:0043436	290	0.051
negative regulation of metabolic process	GO:0009892	331	0.049
regulation of intracellular signal transduction	GO:1902531	218	0.048
macromolecular complex subunit organization	GO:0043933	339	0.047
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.046
reproduction	GO:0000003	245	0.045
response to carbohydrate	GO:0009743	183	0.043
organophosphate metabolic process	GO:0019637	370	0.042
response to estrogen	GO:0043627	232	0.042	Rat
organic acid metabolic process	GO:0006082	292	0.038
response to ketone	GO:1901654	182	0.037
negative regulation of response to stimulus	GO:0048585	155	0.037
cell projection organization	GO:0030030	302	0.036
aging	GO:0007568	241	0.036
regulation of rna metabolic process	GO:0051252	391	0.036
neuron projection development	GO:0031175	273	0.036
single organism biosynthetic process	GO:0044711	342	0.035
regulation of rna biosynthetic process	GO:2001141	381	0.035
response to reactive oxygen species	GO:0000302	120	0.035
protein complex assembly	GO:0006461	263	0.034
cellular amide metabolic process	GO:0043603	44	0.034
regulation of nucleic acid templated transcription	GO:1903506	380	0.034
response to external biotic stimulus	GO:0043207	221	0.034
regulation of molecular function	GO:0065009	398	0.034
transcription dna templated	GO:0006351	377	0.033
multi organism reproductive process	GO:0044703	262	0.033
single organism carbohydrate metabolic process	GO:0044723	118	0.032
cellular ketone metabolic process	GO:0042180	51	0.032	Human
secretion	GO:0046903	307	0.032
cellular response to oxidative stress	GO:0034599	76	0.032
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.031
response to nutrient levels	GO:0031667	370	0.031
protein complex subunit organization	GO:0071822	302	0.030
negative regulation of transport	GO:0051051	136	0.030
cellular response to reactive oxygen species	GO:0034614	55	0.030
macromolecular complex assembly	GO:0065003	273	0.030
regulation of cellular ketone metabolic process	GO:0010565	27	0.030
negative regulation of cell death	GO:0060548	229	0.029
single organism reproductive process	GO:0044702	297	0.027
cellular catabolic process	GO:0044248	295	0.027
regulation of phosphate metabolic process	GO:0019220	349	0.026
regulation of cellular amino acid metabolic process	GO:0006521	2	0.026
regulation of transcription dna templated	GO:0006355	374	0.026
rna metabolic process	GO:0016070	406	0.026
positive regulation of cellular biosynthetic process	GO:0031328	295	0.025
regulation of catalytic activity	GO:0050790	304	0.025
cellular response to organonitrogen compound	GO:0071417	197	0.025
cellular response to organic cyclic compound	GO:0071407	202	0.025
reproductive process	GO:0022414	372	0.025
proteolysis	GO:0006508	175	0.025
cellular response to oxygen containing compound	GO:1901701	386	0.025
regeneration	GO:0031099	163	0.025
negative regulation of programmed cell death	GO:0043069	183	0.024
response to peptide	GO:1901652	292	0.024
response to estradiol	GO:0032355	164	0.023
regulation of signal transduction	GO:0009966	318	0.023
negative regulation of apoptotic process	GO:0043066	181	0.023
nucleobase containing small molecule metabolic process	GO:0055086	316	0.023
positive regulation of apoptotic process	GO:0043065	154	0.023
neuron development	GO:0048666	286	0.023
negative regulation of cell communication	GO:0010648	158	0.023
response to hydrogen peroxide	GO:0042542	89	0.023
chemical homeostasis	GO:0048878	292	0.023
cellular amine metabolic process	GO:0044106	38	0.023
multicellular organismal reproductive process	GO:0048609	233	0.023
lipid metabolic process	GO:0006629	283	0.022	Rat
defense response	GO:0006952	194	0.022
secretion by cell	GO:0032940	248	0.022
amine metabolic process	GO:0009308	38	0.022
nucleoside phosphate metabolic process	GO:0006753	283	0.022
small molecule biosynthetic process	GO:0044283	124	0.022
positive regulation of rna metabolic process	GO:0051254	203	0.022
central nervous system development	GO:0007417	311	0.022	Rat Fly
response to glucocorticoid	GO:0051384	223	0.022
neuron differentiation	GO:0030182	368	0.022
response to acid chemical	GO:0001101	222	0.022
negative regulation of multicellular organismal process	GO:0051241	203	0.021
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.021
response to metal ion	GO:0010038	253	0.021
protein phosphorylation	GO:0006468	345	0.021
response to radiation	GO:0009314	137	0.021
regulation of phosphorus metabolic process	GO:0051174	349	0.021
rhythmic process	GO:0048511	156	0.021
positive regulation of cell communication	GO:0010647	271	0.021
regulation of cellular amine metabolic process	GO:0033238	8	0.020
meiotic cell cycle process	GO:1903046	3	0.020
chromosome segregation	GO:0007059	2	0.020
positive regulation of biosynthetic process	GO:0009891	319	0.020
regulation of neurogenesis	GO:0050767	247	0.020
cellular response to hormone stimulus	GO:0032870	247	0.020
response to amino acid	GO:0043200	75	0.020
nucleic acid templated transcription	GO:0097659	379	0.020
cellular component biogenesis	GO:0044085	368	0.020
negative regulation of biosynthetic process	GO:0009890	168	0.020
response to peptide hormone	GO:0043434	278	0.020
response to monosaccharide	GO:0034284	159	0.020
cellular response to nitrogen compound	GO:1901699	210	0.020
transmembrane transport	GO:0055085	412	0.019
response to biotic stimulus	GO:0009607	226	0.019
positive regulation of rna biosynthetic process	GO:1902680	197	0.019
negative regulation of molecular function	GO:0044092	133	0.019
negative regulation of macromolecule metabolic process	GO:0010605	260	0.019
cation transport	GO:0006812	382	0.019
positive regulation of cell death	GO:0010942	184	0.019
response to decreased oxygen levels	GO:0036293	237	0.019
single organism catabolic process	GO:0044712	283	0.018
positive regulation of gene expression	GO:0010628	244	0.018
ion homeostasis	GO:0050801	212	0.018
immune system process	GO:0002376	204	0.018
organic hydroxy compound metabolic process	GO:1901615	115	0.018
regulation of response to stress	GO:0080134	126	0.018
female pregnancy	GO:0007565	122	0.018
ion transmembrane transport	GO:0034220	365	0.018
anion transport	GO:0006820	178	0.018
regulation of phosphorylation	GO:0042325	248	0.018
carbohydrate metabolic process	GO:0005975	130	0.018
response to transition metal nanoparticle	GO:1990267	122	0.017
positive regulation of transcription dna templated	GO:0045893	197	0.017
cellular protein complex assembly	GO:0043623	44	0.017
small gtpase mediated signal transduction	GO:0007264	36	0.017
response to vitamin	GO:0033273	131	0.017
response to extracellular stimulus	GO:0009991	380	0.017
negative regulation of cellular metabolic process	GO:0031324	281	0.017
transcription from rna polymerase ii promoter	GO:0006366	252	0.017
regulation of cellular localization	GO:0060341	263	0.017
homeostatic process	GO:0042592	331	0.017
regulation of protein modification process	GO:0031399	194	0.017
response to alkaloid	GO:0043279	132	0.017
protein oligomerization	GO:0051259	191	0.017
negative regulation of signal transduction	GO:0009968	83	0.017
reproductive structure development	GO:0048608	128	0.017
protein complex biogenesis	GO:0070271	263	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.016
rna biosynthetic process	GO:0032774	380	0.016
negative regulation of neuron differentiation	GO:0045665	62	0.016
brain development	GO:0007420	247	0.016	Rat Fly
mitotic cell cycle	GO:0000278	49	0.016
response to bacterium	GO:0009617	200	0.016
axis specification	GO:0009798	4	0.016
cellular homeostasis	GO:0019725	252	0.016
response to wounding	GO:0009611	254	0.016
response to hypoxia	GO:0001666	231	0.016
multicellular organism reproduction	GO:0032504	233	0.016
response to molecule of bacterial origin	GO:0002237	194	0.016
sexual reproduction	GO:0019953	148	0.016
oxidation reduction process	GO:0055114	304	0.016
negative regulation of cellular protein metabolic process	GO:0032269	106	0.016
locomotion	GO:0040011	237	0.016
negative regulation of protein metabolic process	GO:0051248	114	0.015
inorganic ion transmembrane transport	GO:0098660	229	0.015
response to ethanol	GO:0045471	162	0.015
regulation of protein metabolic process	GO:0051246	289	0.015
organic acid biosynthetic process	GO:0016053	83	0.015
cell type specific apoptotic process	GO:0097285	134	0.015
metal ion transport	GO:0030001	289	0.015
organonitrogen compound biosynthetic process	GO:1901566	167	0.015
monosaccharide metabolic process	GO:0005996	61	0.015
response to toxic substance	GO:0009636	133	0.015
cellular response to glucocorticoid stimulus	GO:0071385	68	0.015
cellular modified amino acid metabolic process	GO:0006575	61	0.015
nucleotide metabolic process	GO:0009117	279	0.015
regulation of cellular protein metabolic process	GO:0032268	267	0.015
cellular component assembly	GO:0022607	360	0.015
response to glucose	GO:0009749	136	0.015
negative regulation of signaling	GO:0023057	157	0.015
regulation of hormone levels	GO:0010817	187	0.015	Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.014
purine containing compound metabolic process	GO:0072521	253	0.014
regulation of multicellular organismal development	GO:2000026	376	0.014
anterior posterior pattern specification	GO:0009952	1	0.014
cell cycle	GO:0007049	101	0.014
cellular response to growth factor stimulus	GO:0071363	162	0.014
carbohydrate derivative metabolic process	GO:1901135	346	0.014	Human
positive regulation of developmental process	GO:0051094	283	0.014
negative regulation of gene expression	GO:0010629	199	0.014
regulation of protein phosphorylation	GO:0001932	183	0.014
establishment of protein localization	GO:0045184	141	0.014
positive regulation of multicellular organismal process	GO:0051240	387	0.014
single organism behavior	GO:0044708	130	0.014
response to cytokine	GO:0034097	215	0.014
response to growth factor	GO:0070848	189	0.014
regulation of nucleotide metabolic process	GO:0006140	117	0.014
response to nutrient	GO:0007584	248	0.014
ras protein signal transduction	GO:0007265	29	0.014
positive regulation of phosphate metabolic process	GO:0045937	262	0.014
response to corticosteroid	GO:0031960	235	0.014
response to lipopolysaccharide	GO:0032496	191	0.014
cellular response to abiotic stimulus	GO:0071214	85	0.014
cellular response to corticosteroid stimulus	GO:0071384	69	0.014
response to herbicide	GO:0009635	16	0.014
developmental process involved in reproduction	GO:0003006	159	0.013
regulation of neuron projection development	GO:0010975	161	0.013
telencephalon development	GO:0021537	62	0.013	Rat
positive regulation of programmed cell death	GO:0043068	157	0.013
regulation of anatomical structure size	GO:0090066	135	0.013
intracellular transport	GO:0046907	185	0.013
negative regulation of cell proliferation	GO:0008285	119	0.013
regulation of neuron apoptotic process	GO:0043523	83	0.013
regulation of membrane potential	GO:0042391	110	0.013
cation transmembrane transport	GO:0098655	263	0.013
peptide metabolic process	GO:0006518	32	0.013
response to other organism	GO:0051707	220	0.013
gamete generation	GO:0007276	124	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.013
cellular response to peptide	GO:1901653	133	0.013
metal ion homeostasis	GO:0055065	186	0.013
regulation of secretion	GO:0051046	224	0.012
spindle organization	GO:0007051	2	0.012
positive regulation of signaling	GO:0023056	270	0.012
gonad development	GO:0008406	104	0.012
regulation of ion transport	GO:0043269	245	0.012
positive regulation of molecular function	GO:0044093	230	0.012
cellular response to lipid	GO:0071396	201	0.012
positive regulation of phosphorus metabolic process	GO:0010562	262	0.012
regulation of secretion by cell	GO:1903530	208	0.012
vascular process in circulatory system	GO:0003018	96	0.012
response to oxygen levels	GO:0070482	265	0.012
mitotic spindle organization	GO:0007052	2	0.012
reactive oxygen species metabolic process	GO:0072593	37	0.012
gliogenesis	GO:0042063	93	0.012
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	4	0.012
positive regulation of cellular amine metabolic process	GO:0033240	3	0.012
reproductive system development	GO:0061458	128	0.012
g protein coupled receptor signaling pathway	GO:0007186	242	0.012
circulatory system process	GO:0003013	183	0.012
cellular response to steroid hormone stimulus	GO:0071383	93	0.012
negative regulation of catalytic activity	GO:0043086	103	0.012
positive regulation of cellular protein metabolic process	GO:0032270	167	0.012
positive regulation of protein modification process	GO:0031401	142	0.012
spermatogenesis	GO:0007283	99	0.011
positive regulation of cell differentiation	GO:0045597	217	0.011
behavior	GO:0007610	205	0.011
sulfur compound metabolic process	GO:0006790	70	0.011
organelle organization	GO:0006996	266	0.011
synaptic growth at neuromuscular junction	GO:0051124	1	0.011
vesicle mediated transport	GO:0016192	181	0.011
response to hexose	GO:0009746	144	0.011
cation homeostasis	GO:0055080	195	0.011
cellular response to external stimulus	GO:0071496	118	0.011
blood circulation	GO:0008015	183	0.011
hexose metabolic process	GO:0019318	58	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.011
neuron apoptotic process	GO:0051402	88	0.011
ribonucleotide metabolic process	GO:0009259	231	0.011
regulation of protein kinase activity	GO:0045859	105	0.011
regulation of nervous system development	GO:0051960	264	0.011
divalent inorganic cation homeostasis	GO:0072507	165	0.011
regulation of hydrolase activity	GO:0051336	143	0.011
monocarboxylic acid metabolic process	GO:0032787	152	0.011
cellular component movement	GO:0006928	248	0.011
regulation of neuron differentiation	GO:0045664	208	0.011
response to light stimulus	GO:0009416	52	0.011
apoptotic signaling pathway	GO:0097190	27	0.011
regulation of cell development	GO:0060284	263	0.011
cellular chemical homeostasis	GO:0055082	247	0.011
positive regulation of signal transduction	GO:0009967	175	0.011
regulation of cell differentiation	GO:0045595	320	0.011
immune response	GO:0006955	104	0.010
organophosphate biosynthetic process	GO:0090407	143	0.010
protein transport	GO:0015031	132	0.010
positive regulation of catalytic activity	GO:0043085	184	0.010
alcohol metabolic process	GO:0006066	77	0.010
organic anion transport	GO:0015711	132	0.010
negative regulation of protein modification process	GO:0031400	52	0.010
regulation of catabolic process	GO:0009894	113	0.010
single organism cellular localization	GO:1902580	102	0.010
macromolecule localization	GO:0033036	252	0.010
wound healing	GO:0042060	122	0.010
regulation of cell migration	GO:0030334	128	0.010
single organism carbohydrate catabolic process	GO:0044724	40	0.010
regulation of kinase activity	GO:0043549	117	0.010

Akr1b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.020
musculoskeletal system disease	DOID:17	0.020
nervous system disease	DOID:863	0.013
cardiovascular system disease	DOID:1287	0.012
central nervous system disease	DOID:331	0.010

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