Rattus norvegicus

59 known processes

Nr1i2

nuclear receptor subfamily 1, group I, member 2

(Aliases: MGC108643,PXR)

Nr1i2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to biotic stimulusGO:00096072260.468
Rat
response to external biotic stimulusGO:00432072210.316
Rat
response to other organismGO:00517072200.297
Rat
regulation of telomerase activityGO:005197220.240
Rat
carboxylic acid metabolic processGO:00197522890.180
Rat
organic acid metabolic processGO:00060822920.158
Rat
vitamin d receptor signaling pathwayGO:007056110.148
Rat
oxoacid metabolic processGO:00434362900.147
Rat
chemical homeostasisGO:00488782920.134
Fly
response to lipopolysaccharideGO:00324961910.114
Rat
gonad developmentGO:00084061040.112
regulation of nervous system developmentGO:00519602640.106
Rat
single organism biosynthetic processGO:00447113420.100
Rat
oxidation reduction processGO:00551143040.100
Rat Fly
coenzyme metabolic processGO:0006732860.097
regulation of locomotionGO:00400121480.094
Rat
locomotionGO:00400112370.092
Rat
reproductionGO:00000032450.090
Rat
response to nutrient levelsGO:00316673700.089
Rat Fly
cellular response to oxygen containing compoundGO:19017013860.088
Rat
monocarboxylic acid metabolic processGO:00327871520.081
Rat
cellular response to hormone stimulusGO:00328702470.081
Zebrafish Rat
cellular amino acid metabolic processGO:00065201070.081
response to oxygen levelsGO:00704822650.078
Rat
regulation of cell developmentGO:00602842630.078
Rat
cellular chemical homeostasisGO:00550822470.077
organ regenerationGO:00311001010.075
Rat
single organism carbohydrate catabolic processGO:0044724400.074
thioester metabolic processGO:0035383280.074
insulin secretionGO:0030073690.072
Rat
negative regulation of pancreatic stellate cell proliferationGO:200023010.072
Rat
single organism reproductive processGO:00447022970.070
Rat
response to extracellular stimulusGO:00099913800.069
Rat Fly
multicellular organism reproductionGO:00325042330.069
Rat
fatty acid oxidationGO:0019395290.068
Rat
lipid oxidationGO:0034440300.066
Rat
positive regulation of phagocytosis engulfmentGO:006010040.066
Rat
organic hydroxy compound metabolic processGO:19016151150.063
Rat
neuron differentiationGO:00301823680.061
acyl coa metabolic processGO:0006637280.060
response to purine containing compoundGO:00140741260.059
Rat
positive regulation of cellular component movementGO:00512721020.059
regulation of apoptotic processGO:00429813350.057
Rat
negative regulation of cell deathGO:00605482290.057
Rat
monosaccharide metabolic processGO:0005996610.056
Fly
vitamin a metabolic processGO:000677620.055
Rat
cofactor metabolic processGO:0051186950.054
regulation of peptide hormone secretionGO:0090276800.053
Rat
lipid metabolic processGO:00066292830.052
Rat
response to bacteriumGO:00096172000.051
Rat
response to cytokineGO:00340972150.050
apoptotic processGO:00069153810.050
Rat
carbohydrate catabolic processGO:0016052400.050
positive regulation of nervous system developmentGO:00519621780.049
Rat
peptide hormone secretionGO:0030072840.048
Rat
transcription from rna polymerase ii promoterGO:00063662520.048
regulation of neurogenesisGO:00507672470.048
Rat
anatomical structure morphogenesisGO:00096532980.048
alpha amino acid metabolic processGO:1901605710.048
neuron developmentGO:00486662860.047
organic substance catabolic processGO:19015753160.046
response to carbohydrateGO:00097431830.046
Rat
response to organophosphorusGO:00466831020.042
response to monosaccharideGO:00342841590.041
Rat
catabolic processGO:00090563510.041
Human
regulation of transcription dna templatedGO:00063553740.041
reproductive processGO:00224143720.041
Rat
negative regulation of response to external stimulusGO:0032102370.040
Rat
cell motilityGO:00488702020.040
Rat
regulation of nucleic acid templated transcriptionGO:19035063800.040
regulation of response to external stimulusGO:00321011060.039
Rat
regulation of multicellular organismal developmentGO:20000263760.039
Rat
tube developmentGO:0035295890.039
Rat
regulation of cellular amino acid metabolic processGO:000652120.038
cellular response to stressGO:00335542690.038
Rat
regulation of insulin secretionGO:0050796650.038
Rat
mrna transcriptionGO:000929920.037
Rat
cell morphogenesis involved in differentiationGO:00009041190.037
negative regulation of acute inflammatory responseGO:000267440.037
Rat
establishment or maintenance of transmembrane electrochemical gradientGO:001024810.037
hormone secretionGO:00468791150.037
Rat
rhythmic processGO:00485111560.037
response to glucoseGO:00097491360.037
Rat
regulation of neuron deathGO:19012141150.036
Rat
glutamine family amino acid metabolic processGO:0009064150.036
regulation of peptide transportGO:0090087870.036
Rat
peptidyl amino acid modificationGO:00181931260.036
cellular component movementGO:00069282480.035
Rat
regulation of molecular functionGO:00650093980.035
Rat
sterol homeostasisGO:005509230.035
Fly
negative regulation of tyrosine phosphorylation of stat5 proteinGO:004252410.034
regulation of cellular ketone metabolic processGO:0010565270.034
Rat
amine metabolic processGO:0009308380.034
antibiotic transportGO:004289120.034
transcription dna templatedGO:00063513770.034
anion transmembrane transportGO:0098656770.033
peptide transportGO:0015833970.033
Rat
peptide secretionGO:0002790860.033
Rat
nitrogen cycle metabolic processGO:007194150.033
organophosphate metabolic processGO:00196373700.032
Rat
cellular carbohydrate metabolic processGO:0044262720.032
Fly
response to peptideGO:19016522920.032
Rat
amide transportGO:00428861050.032
Rat
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.031
Rat
negative regulation of cell differentiationGO:0045596990.031
negative regulation of cell proliferationGO:00082851190.031
Rat
carboxylic acid catabolic processGO:0046395490.031
small molecule biosynthetic processGO:00442831240.031
regulation of neuron projection developmentGO:00109751610.030
negative regulation of macromolecule metabolic processGO:00106052600.030
Human Rat
metal ion transportGO:00300012890.030
Rat
positive regulation of gene expressionGO:00106282440.030
Human Mouse Rat
cholesterol homeostasisGO:004263230.030
Fly
response to decreased oxygen levelsGO:00362932370.030
Rat
growthGO:00400071650.029
Rat
signal releaseGO:00230611450.029
Rat
secretion by cellGO:00329402480.029
Rat
sensory organ developmentGO:0007423740.028
glutathione transportGO:003463520.028
regulation of peptide secretionGO:0002791820.028
Rat
cellular response to endogenous stimulusGO:00714953770.027
Zebrafish Rat
cellular response to lipidGO:00713962010.027
Zebrafish Rat
negative regulation of neurogenesisGO:0050768780.027
ion transmembrane transportGO:00342203650.027
regulation of rna metabolic processGO:00512523910.027
gland developmentGO:00487321550.026
cellular amine metabolic processGO:0044106380.026
cation transportGO:00068123820.026
Rat
multicellular organismal reproductive processGO:00486092330.025
Rat
positive regulation of cell communicationGO:00106472710.025
Rat
fatty acid metabolic processGO:0006631990.025
Rat
epithelium developmentGO:0060429960.025
Rat
regulation of anatomical structure sizeGO:00900661350.025
Rat
cellular component assemblyGO:00226073600.025
reproductive structure developmentGO:00486081280.025
Rat
regulation of transcription from rna polymerase ii promoterGO:00063572340.025
salivary gland developmentGO:000743130.025
embryo implantationGO:0007566150.025
Rat
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.025
Human Rat
organic cyclic compound catabolic processGO:19013611750.025
oligopeptide transportGO:000685740.025
neuron projection developmentGO:00311752730.024
programmed cell deathGO:00125013920.024
Rat
lipid biosynthetic processGO:00086101280.024
Rat
cellular calcium ion homeostasisGO:00068741600.024
sulfur compound metabolic processGO:0006790700.024
cellular metal ion homeostasisGO:00068751720.024
negative regulation of programmed cell deathGO:00430691830.024
Rat
response to estrogenGO:00436272320.024
Rat
positive regulation of locomotionGO:00400171020.023
homeostatic processGO:00425923310.023
Fly
rna biosynthetic processGO:00327743800.023
cellular homeostasisGO:00197252520.023
regulation of cell migrationGO:00303341280.023
Rat
sodium ion transmembrane transportGO:0035725670.023
positive regulation of macromolecule biosynthetic processGO:00105572470.023
Human Rat
ion homeostasisGO:00508012120.023
single organism behaviorGO:00447081300.022
Rat
response to vitaminGO:00332731310.022
Rat
hexose metabolic processGO:0019318580.022
Fly
regulation of cell growthGO:0001558850.022
Rat
regulation of phagocytosis engulfmentGO:006009940.022
Rat
circadian regulation of gene expressionGO:003292230.021
cell cycleGO:00070491010.021
cellular cation homeostasisGO:00300031800.021
positive regulation of multicellular organismal processGO:00512403870.021
Rat
negative regulation of rna biosynthetic processGO:19026791180.021
Human Rat
regulation of dendrite developmentGO:0050773590.021
calcium ion transportGO:00068161310.021
Rat
neuron deathGO:00709971270.021
Rat
nitrogen compound transportGO:00717052290.021
Rat
regulation of fat cell differentiationGO:004559830.021
Rat
negative regulation of response to stimulusGO:00485851550.020
Rat
response to nutrientGO:00075842480.020
Rat
secretionGO:00469033070.020
Rat
localization of cellGO:00516742020.020
Rat
regulation of hormone levelsGO:00108171870.020
Rat
positive regulation of transcription dna templatedGO:00458931970.020
Human Rat
regulation of inflammatory responseGO:0050727480.020
Rat
positive regulation of response to external stimulusGO:0032103510.020
positive regulation of biosynthetic processGO:00098913190.020
Human Rat
regulation of programmed cell deathGO:00430673410.020
Rat
pyruvate metabolic processGO:0006090270.020
sodium independent organic anion transportGO:004325220.020
regulation of cellular amine metabolic processGO:003323880.020
cellular response to alcoholGO:0097306870.020
Rat
small molecule catabolic processGO:0044282590.019
cell migrationGO:00164771970.019
Rat
regulation of pancreatic stellate cell proliferationGO:200022920.019
Rat
developmental process involved in reproductionGO:00030061590.019
Rat
cell morphogenesis involved in neuron differentiationGO:00486671060.019
smooth muscle cell proliferationGO:0048659770.019
Rat
defense responseGO:00069521940.019
Rat
regulation of cellular component movementGO:00512701500.019
Rat
regulation of system processGO:00440572080.019
Rat
regulation of calcium ion transportGO:0051924770.019
Rat
cell projection organizationGO:00300303020.019
transmembrane transportGO:00550854120.019
negative regulation of signalingGO:00230571570.018
regulation of protein phosphorylationGO:00019321830.018
response to oxidative stressGO:00069791860.018
cell part morphogenesisGO:00329901230.018
organic cation transportGO:0015695110.018
behaviorGO:00076102050.018
Rat
negative regulation of developmental processGO:00510931250.017
cellular lipid metabolic processGO:00442552080.017
Rat
multi organism reproductive processGO:00447032620.017
Rat
response to woundingGO:00096112540.017
Rat
regulation of cell morphogenesisGO:0022604770.017
divalent metal ion transportGO:00708381320.017
Rat
response to estradiolGO:00323551640.017
Rat
hormone transportGO:00099141210.017
Rat
male sex differentiationGO:0046661640.017
positive regulation of molecular functionGO:00440932300.017
kidney developmentGO:0001822670.017
response to metforminGO:190155810.017
Rat
cellular divalent inorganic cation homeostasisGO:00725031620.017
glycolytic processGO:0006096170.017
regulation of hormone secretionGO:00468831060.016
Rat
regulation of cell proliferationGO:00421273590.016
Rat
steroid hormone mediated signaling pathwayGO:004340180.016
Zebrafish Rat
glucose metabolic processGO:0006006520.016
Fly
divalent inorganic cation homeostasisGO:00725071650.016
positive regulation of hormone secretionGO:0046887650.016
Rat
maintenance of locationGO:0051235170.016
carbohydrate biosynthetic processGO:0016051420.016
response to insulinGO:00328681330.016
Rat
negative regulation of cellular metabolic processGO:00313242810.016
Human Rat
carbohydrate metabolic processGO:00059751300.015
Rat Fly
adult behaviorGO:0030534160.015
Rat
regulation of microvillus organizationGO:003253010.015
activation of jak2 kinase activityGO:004297720.015
cellular amino acid biosynthetic processGO:0008652320.015
response to inorganic substanceGO:00100353770.015
Rat
placenta developmentGO:0001890220.015
Rat
response to growth factorGO:00708481890.015
regenerationGO:00310991630.015
Rat
cation homeostasisGO:00550801950.015
negative regulation of nitrogen compound metabolic processGO:00511721610.015
Human Rat
negative regulation of activation of jak2 kinase activityGO:190256910.015
positive regulation of rna metabolic processGO:00512542030.015
Human Rat
regulation of response to woundingGO:1903034690.015
Rat
cytosolic calcium ion homeostasisGO:00514801400.015
cellular response to vitamin eGO:007130630.015
Rat
dopamine transportGO:0015872180.015
lipid storageGO:001991510.015
g protein coupled receptor signaling pathwayGO:00071862420.015
positive regulation of nitrogen compound metabolic processGO:00511733340.015
Human Rat
response to hexoseGO:00097461440.015
Rat
cellular response to oxygen levelsGO:0071453600.014
Rat
negative regulation of transcription dna templatedGO:00458921160.014
Human Rat
organic acid catabolic processGO:0016054490.014
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.014
Human Rat
negative regulation of nucleic acid templated transcriptionGO:19035071170.014
Human Rat
ribonucleoside metabolic processGO:00091191740.014
positive regulation of cell developmentGO:00107201760.014
Rat
acute inflammatory responseGO:0002526580.014
Rat
cell projection morphogenesisGO:00488581230.014
calcium ion homeostasisGO:00550741620.014
regulation of dendrite morphogenesisGO:0048814330.014
positive regulation of apoptotic processGO:00430651540.014
Rat
mechanoreceptor differentiationGO:004249020.014
lipid modificationGO:0030258520.014
Rat
response to alkaloidGO:00432791320.014
Rat
sex differentiationGO:00075481130.014
positive regulation of cellular biosynthetic processGO:00313282950.014
Human Rat
cellular response to organic cyclic compoundGO:00714072020.014
Zebrafish Rat
positive regulation of signal transductionGO:00099671750.014
cardiovascular system developmentGO:00723581340.014
Rat
single organism carbohydrate metabolic processGO:00447231180.014
Fly
single organism catabolic processGO:00447122830.014
regulation of cellular protein metabolic processGO:00322682670.013
organophosphate biosynthetic processGO:00904071430.013
Rat
dendrite developmentGO:0016358720.013
response to starvationGO:0042594590.013
Rat Fly
hepaticobiliary system developmentGO:0061008900.013
positive regulation of neurogenesisGO:00507691650.013
Rat
regulation of protein metabolic processGO:00512462890.013
cell morphogenesisGO:00009021420.013
cellular modified amino acid metabolic processGO:0006575610.013
liver developmentGO:0001889900.013
cellular component morphogenesisGO:00329891550.013
carnitine transportGO:001587910.013
cellular ketone metabolic processGO:0042180510.013
Rat
negative regulation of molecular functionGO:00440921330.013
Rat
positive regulation of cytosolic calcium ion concentrationGO:00072041220.013
positive regulation of cell projection organizationGO:00313461110.013
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.013
regulation of transcription regulatory region dna bindingGO:200067740.013
Rat
regulation of cell morphogenesis involved in differentiationGO:0010769720.013
rna metabolic processGO:00160704060.013
positive regulation of peptide hormone secretionGO:0090277500.013
Rat
regulation of activation of jak2 kinase activityGO:001053410.013
cellular glucan metabolic processGO:0006073230.013
Fly
positive regulation of neuron projection developmentGO:0010976990.013
negative regulation of macromolecule biosynthetic processGO:00105581480.013
Human Rat
synaptic transmission gabaergicGO:0051932220.013
amino acid transmembrane transportGO:0003333330.013
action potentialGO:0001508540.012
regulation of acute inflammatory responseGO:0002673230.012
Rat
regulation of cell projection organizationGO:00313441750.012
blood circulationGO:00080151830.012
Rat
regulation of cell motilityGO:20001451310.012
Rat
response to vitamin eGO:0033197240.012
Rat
negative regulation of apoptotic processGO:00430661810.012
Rat
response to transition metal nanoparticleGO:19902671220.012
glucose homeostasisGO:0042593750.012
positive regulation of rna biosynthetic processGO:19026801970.012
Human Rat
inflammatory responseGO:00069541500.012
Rat
negative regulation of protein metabolic processGO:00512481140.012
mesoderm developmentGO:000749820.012
positive regulation of nucleobase containing compound metabolic processGO:00459353190.012
Human Rat
carboxylic acid biosynthetic processGO:0046394830.012
cell growthGO:00160491040.012
Rat
positive regulation of cell proliferationGO:00082842490.012
behavioral response to nicotineGO:003509520.012
Rat
positive regulation of neuron differentiationGO:00456661260.012
organelle organizationGO:00069962660.012
metal ion homeostasisGO:00550651860.012
defense response to gram negative bacteriumGO:005082930.012
muscle cell apoptotic processGO:0010657300.011
cellular catabolic processGO:00442482950.011
Human
epithelial cell differentiationGO:0030855710.011
negative regulation of cellular protein metabolic processGO:00322691060.011
positive regulation of cell migrationGO:0030335960.011
negative regulation of cellular amino acid metabolic processGO:004576300.011
negative regulation of neuron deathGO:1901215690.011
Rat
negative regulation of cellular amine metabolic processGO:003323930.011
regulation of secretion by cellGO:19035302080.011
Rat
inorganic ion transmembrane transportGO:00986602290.011
male gamete generationGO:0048232990.011
terpenoid metabolic processGO:0006721370.011
Rat
sexual reproductionGO:00199531480.011
positive regulation of cellular component organizationGO:00511302000.011
Rat
positive regulation of developmental processGO:00510942830.011
Rat
negative regulation of catalytic activityGO:00430861030.011
Rat
cellular ion homeostasisGO:00068731840.011
establishment of tissue polarityGO:000716420.011
peptidyl tyrosine modificationGO:0018212720.011
positive regulation of cell differentiationGO:00455972170.011
Rat
regulation of catalytic activityGO:00507903040.011
Rat
enzyme linked receptor protein signaling pathwayGO:00071671160.011
monosaccharide biosynthetic processGO:0046364160.011
response to molecule of bacterial originGO:00022371940.011
Rat
spermatogenesisGO:0007283990.011
negative regulation of multicellular organismal processGO:00512412030.011
Rat
regulation of lipid biosynthetic processGO:0046890380.011
maternal process involved in female pregnancyGO:0060135380.011
Rat
nucleoside metabolic processGO:00091161790.010
gliogenesisGO:0042063930.010
Rat
positive regulation of catalytic activityGO:00430851840.010
macromolecular complex assemblyGO:00650032730.010
regulation of growthGO:00400081050.010
Rat
regulation of cellular component sizeGO:0032535510.010
regulation of hydrolase activityGO:00513361430.010
circadian rhythmGO:0007623880.010
regulation of gluconeogenesisGO:000611140.010
positive regulation of response to stimulusGO:00485842850.010
axon developmentGO:0061564960.010
camera type eye developmentGO:0043010480.010
glycosyl compound metabolic processGO:19016571820.010
muscle cell proliferationGO:0033002840.010
Rat
protein complex assemblyGO:00064612630.010
regulation of cellular catabolic processGO:00313291010.010

Nr1i2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.044
disease of anatomical entityDOID:700.044
disease of metabolismDOID:001466700.019
cardiovascular system diseaseDOID:128700.017
sensory system diseaseDOID:005015500.014
vascular diseaseDOID:17800.011
artery diseaseDOID:005082800.011
inherited metabolic disorderDOID:65500.011