IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Asb2

ankyrin repeat and SOCS box-containing 2

Ensembl: ENSRNOG00000009012
Entrez: 299266
RGD: 1306414
UniProtKB: Q5U2S6

Process Predictions
Disease Predictions

Asb2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular component biogenesis	GO:0044085	368	0.335
ion transmembrane transport	GO:0034220	365	0.263
cellular ion homeostasis	GO:0006873	184	0.251
cellular component assembly	GO:0022607	360	0.187
muscle system process	GO:0003012	115	0.165
protein complex subunit organization	GO:0071822	302	0.137
head development	GO:0060322	247	0.135
blood circulation	GO:0008015	183	0.135
transmembrane transport	GO:0055085	412	0.131
heart contraction	GO:0060047	57	0.117
response to other organism	GO:0051707	220	0.116
regulation of system process	GO:0044057	208	0.112
central nervous system development	GO:0007417	311	0.100
circulatory system process	GO:0003013	183	0.096
response to hypoxia	GO:0001666	231	0.092
organic acid metabolic process	GO:0006082	292	0.085
cellular cation homeostasis	GO:0030003	180	0.080
cellular macromolecule localization	GO:0070727	122	0.080
brain development	GO:0007420	247	0.078
positive regulation of developmental process	GO:0051094	283	0.077
response to external biotic stimulus	GO:0043207	221	0.075
intracellular signal transduction	GO:0035556	314	0.075
behavior	GO:0007610	205	0.070
divalent inorganic cation homeostasis	GO:0072507	165	0.070
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.070
heart process	GO:0003015	57	0.070
regulation of blood circulation	GO:1903522	110	0.069
calcium ion homeostasis	GO:0055074	162	0.068
striated muscle contraction	GO:0006941	44	0.067
macromolecular complex assembly	GO:0065003	273	0.065
ion homeostasis	GO:0050801	212	0.064
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.064
inorganic ion transmembrane transport	GO:0098660	229	0.063
cellular protein localization	GO:0034613	122	0.062
protein localization	GO:0008104	191	0.060
programmed cell death	GO:0012501	392	0.060
vascular process in circulatory system	GO:0003018	96	0.059
taxis	GO:0042330	67	0.058
protein complex biogenesis	GO:0070271	263	0.057
chemical homeostasis	GO:0048878	292	0.057
cellular calcium ion homeostasis	GO:0006874	160	0.056
cellular homeostasis	GO:0019725	252	0.053
regulation of phosphate metabolic process	GO:0019220	349	0.052
negative regulation of multicellular organismal process	GO:0051241	203	0.052
regulation of ion transport	GO:0043269	245	0.052
purine nucleotide metabolic process	GO:0006163	229	0.051
metal ion homeostasis	GO:0055065	186	0.050
circulatory system development	GO:0072359	134	0.050
protein complex assembly	GO:0006461	263	0.049
regulation of programmed cell death	GO:0043067	341	0.049
regulation of cell differentiation	GO:0045595	320	0.049
cation transmembrane transport	GO:0098655	263	0.048
cytosolic calcium ion homeostasis	GO:0051480	140	0.047
cellular metal ion homeostasis	GO:0006875	172	0.047
cell part morphogenesis	GO:0032990	123	0.046
regulation of multicellular organismal development	GO:2000026	376	0.046
homeostatic process	GO:0042592	331	0.046
regulation of metal ion transport	GO:0010959	118	0.046
cation transport	GO:0006812	382	0.045
nucleoside phosphate metabolic process	GO:0006753	283	0.044
organic anion transport	GO:0015711	132	0.044
regulation of muscle contraction	GO:0006937	53	0.044
regulation of catabolic process	GO:0009894	113	0.043
response to oxygen levels	GO:0070482	265	0.042
cellular chemical homeostasis	GO:0055082	247	0.042
cation homeostasis	GO:0055080	195	0.042
regulation of phosphorus metabolic process	GO:0051174	349	0.042
response to biotic stimulus	GO:0009607	226	0.041
positive regulation of cell proliferation	GO:0008284	249	0.040
positive regulation of cell differentiation	GO:0045597	217	0.040
macromolecule localization	GO:0033036	252	0.040
positive regulation of programmed cell death	GO:0043068	157	0.040
response to decreased oxygen levels	GO:0036293	237	0.039
regulation of phagocytosis engulfment	GO:0060099	4	0.039
divalent inorganic cation transport	GO:0072511	134	0.038
regulation of chemotaxis	GO:0050920	29	0.038
response to extracellular stimulus	GO:0009991	380	0.037
regulation of cellular component movement	GO:0051270	150	0.037
muscle contraction	GO:0006936	88	0.037
macromolecular complex subunit organization	GO:0043933	339	0.037
cellular component movement	GO:0006928	248	0.037
intracellular transport	GO:0046907	185	0.036
cellular response to organic cyclic compound	GO:0071407	202	0.036
response to nutrient levels	GO:0031667	370	0.035
protein oligomerization	GO:0051259	191	0.035
rna biosynthetic process	GO:0032774	380	0.034
regulation of signal transduction	GO:0009966	318	0.034
cellular ketone metabolic process	GO:0042180	51	0.034
calcium ion transport	GO:0006816	131	0.034
negative regulation of metabolic process	GO:0009892	331	0.034
neuron development	GO:0048666	286	0.033
organophosphate biosynthetic process	GO:0090407	143	0.033
cellular glucan metabolic process	GO:0006073	23	0.033
immune system process	GO:0002376	204	0.033
amine metabolic process	GO:0009308	38	0.033
nucleobase containing small molecule metabolic process	GO:0055086	316	0.032
regulation of stem cell differentiation	GO:2000736	2	0.032
response to molecule of bacterial origin	GO:0002237	194	0.032
cell projection organization	GO:0030030	302	0.032
regulation of striated muscle contraction	GO:0006942	21	0.032
cardiovascular system development	GO:0072358	134	0.032
s shaped body morphogenesis	GO:0072050	2	0.031
striated muscle cell development	GO:0055002	26	0.031
locomotion	GO:0040011	237	0.031
regulation of fat cell differentiation	GO:0045598	3	0.030
cardiac muscle cell development	GO:0055013	16	0.030
regulation of blood vessel size	GO:0050880	89	0.030
regulation of tube size	GO:0035150	89	0.030
organophosphate metabolic process	GO:0019637	370	0.030
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0014808	4	0.030
regulation of mapk cascade	GO:0043408	116	0.029
actin filament based process	GO:0030029	86	0.029
single organism biosynthetic process	GO:0044711	342	0.029
heart development	GO:0007507	72	0.029
response to estrogen	GO:0043627	232	0.029
positive regulation of phagocytosis engulfment	GO:0060100	4	0.028
regulation of cell development	GO:0060284	263	0.028
cellular amino acid metabolic process	GO:0006520	107	0.028
regulation of muscle system process	GO:0090257	79	0.028
regulation of cellular catabolic process	GO:0031329	101	0.028
positive regulation of chemotaxis	GO:0050921	23	0.027
ventricular cardiac muscle cell action potential	GO:0086005	2	0.027
nucleotide catabolic process	GO:0009166	139	0.027
regulation of actin filament based process	GO:0032970	42	0.027
regulation of cellular amine metabolic process	GO:0033238	8	0.027
regulation of neuron projection development	GO:0010975	161	0.027
muscle tissue development	GO:0060537	58	0.027	Mouse
cellular response to oxygen containing compound	GO:1901701	386	0.027
regulation of rna biosynthetic process	GO:2001141	381	0.026
cell morphogenesis involved in differentiation	GO:0000904	119	0.026
single organism carbohydrate metabolic process	GO:0044723	118	0.026
sensory perception of pain	GO:0019233	73	0.026
positive regulation of cell death	GO:0010942	184	0.026
carbohydrate metabolic process	GO:0005975	130	0.026
regulation of cell proliferation	GO:0042127	359	0.025
carboxylic acid metabolic process	GO:0019752	289	0.025
divalent metal ion transport	GO:0070838	132	0.025
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0010880	4	0.025
regulation of intracellular signal transduction	GO:1902531	218	0.025
regulation of cell projection organization	GO:0031344	175	0.025
cellular polysaccharide metabolic process	GO:0044264	23	0.025
single organism reproductive process	GO:0044702	297	0.024
synapse organization	GO:0050808	46	0.024
small gtpase mediated signal transduction	GO:0007264	36	0.024
cellular component morphogenesis	GO:0032989	155	0.024
regulation of molecular function	GO:0065009	398	0.024
cellular response to lipid	GO:0071396	201	0.024
cellular nitrogen compound catabolic process	GO:0044270	163	0.024
regulation of cell morphogenesis	GO:0022604	77	0.023
positive regulation of signaling	GO:0023056	270	0.023
ribose phosphate metabolic process	GO:0019693	235	0.023
regulation of cellular component biogenesis	GO:0044087	86	0.023
muscle cell proliferation	GO:0033002	84	0.023
purine ribonucleotide metabolic process	GO:0009150	227	0.023
cellular protein complex assembly	GO:0043623	44	0.023
ras protein signal transduction	GO:0007265	29	0.023
multicellular organismal signaling	GO:0035637	44	0.023
cardiac conduction	GO:0061337	2	0.023
defense response	GO:0006952	194	0.023
purine containing compound metabolic process	GO:0072521	253	0.022
regulation of nucleotide metabolic process	GO:0006140	117	0.022
sexual reproduction	GO:0019953	148	0.022
response to corticosteroid	GO:0031960	235	0.022
response to toxic substance	GO:0009636	133	0.022
nucleotide metabolic process	GO:0009117	279	0.022
metal ion transport	GO:0030001	289	0.022
transcription dna templated	GO:0006351	377	0.021
regulation of anatomical structure size	GO:0090066	135	0.021
immune response	GO:0006955	104	0.021
regulation of nucleic acid templated transcription	GO:1903506	380	0.021
glycogen metabolic process	GO:0005977	23	0.021
oxidation reduction process	GO:0055114	304	0.021
regulation of immune system process	GO:0002682	123	0.021
proteolysis	GO:0006508	175	0.021	Mouse
positive regulation of protein modification process	GO:0031401	142	0.021
regulation of neurogenesis	GO:0050767	247	0.020
positive regulation of gene expression	GO:0010628	244	0.020
muscle structure development	GO:0061061	87	0.020	Mouse
response to estradiol	GO:0032355	164	0.020
positive regulation of phosphorus metabolic process	GO:0010562	262	0.020
response to cytokine	GO:0034097	215	0.020
regulation of smooth muscle cell proliferation	GO:0048660	75	0.020
ossification	GO:0001503	70	0.019
cellular response to endogenous stimulus	GO:0071495	377	0.019
purine ribonucleoside metabolic process	GO:0046128	168	0.019
regulation of apoptotic process	GO:0042981	335	0.019
regulation of peptide secretion	GO:0002791	82	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.019
cardiac muscle contraction	GO:0060048	27	0.019
synaptic transmission	GO:0007268	235	0.019
neuron differentiation	GO:0030182	368	0.019
organic acid catabolic process	GO:0016054	49	0.019
cell projection morphogenesis	GO:0048858	123	0.019
smooth muscle cell proliferation	GO:0048659	77	0.019
positive regulation of cellular component organization	GO:0051130	200	0.019
membrane depolarization during action potential	GO:0086010	1	0.019
regulation of purine nucleotide metabolic process	GO:1900542	115	0.019
cell cell signaling	GO:0007267	335	0.019
single organism organelle organization	GO:1902589	180	0.019
calcium mediated signaling	GO:0019722	23	0.018
regulation of anatomical structure morphogenesis	GO:0022603	141	0.018
response to ketone	GO:1901654	182	0.018
carbohydrate derivative metabolic process	GO:1901135	346	0.018
negative regulation of cellular metabolic process	GO:0031324	281	0.018
cell migration	GO:0016477	197	0.018
regulation of cellular localization	GO:0060341	263	0.018
regulation of cellular amino acid metabolic process	GO:0006521	2	0.018
regulation of peptide hormone secretion	GO:0090276	80	0.018
cellular response to stress	GO:0033554	269	0.018
regulation of neuron death	GO:1901214	115	0.018
anion transport	GO:0006820	178	0.018
regulation of hydrolase activity	GO:0051336	143	0.018
apoptotic process	GO:0006915	381	0.018
cellular catabolic process	GO:0044248	295	0.018	Mouse
muscle organ development	GO:0007517	50	0.018	Mouse
response to wounding	GO:0009611	254	0.018
regulation of protein metabolic process	GO:0051246	289	0.018
single organism intracellular transport	GO:1902582	166	0.018
regulation of nervous system development	GO:0051960	264	0.017
single organism membrane organization	GO:0044802	74	0.017
glucan metabolic process	GO:0044042	23	0.017
sarcoplasmic reticulum calcium ion transport	GO:0070296	8	0.017
organic acid transport	GO:0015849	116	0.017
cardiocyte differentiation	GO:0035051	22	0.017
positive regulation of molecular function	GO:0044093	230	0.017
negative regulation of heart growth	GO:0061117	3	0.017
negative regulation of organ growth	GO:0046621	3	0.017
vasculogenesis	GO:0001570	3	0.017
anatomical structure morphogenesis	GO:0009653	298	0.017
regulation of neuron differentiation	GO:0045664	208	0.017
positive regulation of cell communication	GO:0010647	271	0.017
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.017
cellular amine metabolic process	GO:0044106	38	0.016
actin filament based movement	GO:0030048	16	0.016
protein transport	GO:0015031	132	0.016
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.016
organonitrogen compound biosynthetic process	GO:1901566	167	0.016
negative regulation of signal transduction	GO:0009968	83	0.016
negative regulation of developmental process	GO:0051093	125	0.016
biological adhesion	GO:0022610	110	0.016
cytoskeleton organization	GO:0007010	111	0.016
negative regulation of macromolecule metabolic process	GO:0010605	260	0.016
positive regulation of transcription dna templated	GO:0045893	197	0.016
cardiac muscle cell action potential involved in contraction	GO:0086002	2	0.015
organelle organization	GO:0006996	266	0.015
positive regulation of signal transduction	GO:0009967	175	0.015
response to acid chemical	GO:0001101	222	0.015
transmission of nerve impulse	GO:0019226	42	0.015
rho protein signal transduction	GO:0007266	11	0.015
negative regulation of neuron differentiation	GO:0045665	62	0.015
cellular modified amino acid biosynthetic process	GO:0042398	18	0.015
membrane organization	GO:0061024	94	0.015
bmp signaling pathway	GO:0030509	4	0.015
inflammatory response	GO:0006954	150	0.015
cellular response to cytokine stimulus	GO:0071345	127	0.015
positive regulation of apoptotic process	GO:0043065	154	0.015
catabolic process	GO:0009056	351	0.015	Mouse
oxoacid metabolic process	GO:0043436	290	0.015
signal release	GO:0023061	145	0.015
regulation of transferase activity	GO:0051338	123	0.014
organic substance catabolic process	GO:1901575	316	0.014	Mouse
actin cytoskeleton organization	GO:0030036	73	0.014
cytoplasmic transport	GO:0016482	115	0.014
endoplasmic reticulum to cytosol transport	GO:1903513	4	0.014
positive regulation of catabolic process	GO:0009896	78	0.014
regulation of cell adhesion	GO:0030155	52	0.014
regulation of dendrite development	GO:0050773	59	0.014
response to inorganic substance	GO:0010035	377	0.014
negative regulation of cell communication	GO:0010648	158	0.014
calcium ion transport from endoplasmic reticulum to cytosol	GO:1903514	4	0.014
regulation of cellular protein metabolic process	GO:0032268	267	0.014
positive regulation of transport	GO:0051050	245	0.014
neuron projection morphogenesis	GO:0048812	122	0.014
regulation of actin filament based movement	GO:1903115	12	0.014
negative regulation of transport	GO:0051051	136	0.014
regulation of membrane repolarization	GO:0060306	1	0.014
positive regulation of ion transport	GO:0043270	94	0.013
negative regulation of cell development	GO:0010721	82	0.013
nucleic acid templated transcription	GO:0097659	379	0.013
negative regulation of neurogenesis	GO:0050768	78	0.013
positive regulation of nucleotide metabolic process	GO:0045981	91	0.013
single organism catabolic process	GO:0044712	283	0.013
energy derivation by oxidation of organic compounds	GO:0015980	46	0.013
nucleobase containing compound catabolic process	GO:0034655	152	0.013
ribonucleoside metabolic process	GO:0009119	174	0.013
negative regulation of cell death	GO:0060548	229	0.013
muscle cell differentiation	GO:0042692	52	0.013	Mouse
ribonucleotide metabolic process	GO:0009259	231	0.013
positive regulation of cellular component biogenesis	GO:0044089	55	0.013
polysaccharide metabolic process	GO:0005976	25	0.013
rna metabolic process	GO:0016070	406	0.013
positive regulation of cellular catabolic process	GO:0031331	71	0.013
neuron projection development	GO:0031175	273	0.013
response to metal ion	GO:0010038	253	0.013
protein autophosphorylation	GO:0046777	66	0.013
regulation of bmp signaling pathway	GO:0030510	2	0.013
regulation of heart contraction	GO:0008016	48	0.013
regulation of cardiac muscle contraction	GO:0055117	17	0.013
negative regulation of biosynthetic process	GO:0009890	168	0.013
response to mechanical stimulus	GO:0009612	134	0.013
mapk cascade	GO:0000165	140	0.013
monovalent inorganic cation transport	GO:0015672	172	0.013
heterocycle catabolic process	GO:0046700	167	0.013
response to glucocorticoid	GO:0051384	223	0.012
guanosine containing compound metabolic process	GO:1901068	74	0.012
protein phosphorylation	GO:0006468	345	0.012
sequestering of metal ion	GO:0051238	9	0.012
wound healing	GO:0042060	122	0.012
erk1 and erk2 cascade	GO:0070371	48	0.012
heart growth	GO:0060419	20	0.012
cellular response to acid chemical	GO:0071229	75	0.012
cellular response to hormone stimulus	GO:0032870	247	0.012
cardiac muscle tissue development	GO:0048738	26	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.012
regulation of transcription dna templated	GO:0006355	374	0.012
negative regulation of response to stimulus	GO:0048585	155	0.012
cyclic nucleotide metabolic process	GO:0009187	80	0.012
membrane repolarization	GO:0086009	1	0.012
cellular response to abiotic stimulus	GO:0071214	85	0.012
regulation of cell growth	GO:0001558	85	0.012
gliogenesis	GO:0042063	93	0.012
regulation of canonical wnt signaling pathway	GO:0060828	4	0.012
response to lipopolysaccharide	GO:0032496	191	0.012
response to vitamin	GO:0033273	131	0.012
regulation of synapse organization	GO:0050807	19	0.012
regulation of growth	GO:0040008	105	0.012
calcium ion transmembrane transport	GO:0070588	70	0.012
nucleoside metabolic process	GO:0009116	179	0.012
single organism cellular localization	GO:1902580	102	0.012
regulation of transmembrane transporter activity	GO:0022898	49	0.011
positive regulation of biosynthetic process	GO:0009891	319	0.011
chemotaxis	GO:0006935	66	0.011
posttranscriptional regulation of gene expression	GO:0010608	37	0.011
regulation of locomotion	GO:0040012	148	0.011
regulation of cardiac muscle contraction by calcium ion signaling	GO:0010882	3	0.011
positive regulation of response to stimulus	GO:0048584	285	0.011
regulation of cellular ketone metabolic process	GO:0010565	27	0.011
actomyosin structure organization	GO:0031032	22	0.011
second messenger mediated signaling	GO:0019932	51	0.011
response to radiation	GO:0009314	137	0.011
peptide secretion	GO:0002790	86	0.011
regulation of cytoskeleton organization	GO:0051493	49	0.011
positive regulation of phosphate metabolic process	GO:0045937	262	0.011
vasodilation	GO:0042311	44	0.011
regulation of purine nucleotide catabolic process	GO:0033121	65	0.011
motor neuron axon guidance	GO:0008045	1	0.011
regulation of transmembrane transport	GO:0034762	122	0.011
regulation of catalytic activity	GO:0050790	304	0.011
negative regulation of rna metabolic process	GO:0051253	123	0.011
multicellular organismal reproductive process	GO:0048609	233	0.011
regulation of skeletal muscle tissue regeneration	GO:0043416	2	0.011
regulation of cardiac muscle cell contraction	GO:0086004	11	0.011
negative regulation of cell proliferation	GO:0008285	119	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.011
peptidyl amino acid modification	GO:0018193	126	0.011
female pregnancy	GO:0007565	122	0.011
negative regulation of nervous system development	GO:0051961	79	0.011
response to peptide hormone	GO:0043434	278	0.011
regulation of rna metabolic process	GO:0051252	391	0.011
regulation of endocytosis	GO:0030100	42	0.010
developmental process involved in reproduction	GO:0003006	159	0.010
multicellular organism growth	GO:0035264	1	0.010
spindle organization	GO:0007051	2	0.010
negative regulation of cardiac muscle tissue growth	GO:0055022	3	0.010
protein localization to organelle	GO:0033365	57	0.010
calcium ion import	GO:0070509	22	0.010
cell growth	GO:0016049	104	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.010
cellular macromolecular complex assembly	GO:0034622	58	0.010
multi organism reproductive process	GO:0044703	262	0.010
positive regulation of ion transmembrane transport	GO:0034767	24	0.010
cardiac muscle cell action potential	GO:0086001	5	0.010
regulation of protein modification process	GO:0031399	194	0.010
protein homooligomerization	GO:0051260	91	0.010
regulation of cation channel activity	GO:2001257	23	0.010
positive regulation of multicellular organismal process	GO:0051240	387	0.010
hippocampus development	GO:0021766	30	0.010
regulation of kinase activity	GO:0043549	117	0.010
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.010
sequestering of calcium ion	GO:0051208	8	0.010
response to nutrient	GO:0007584	248	0.010

Asb2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.157
disease of anatomical entity	DOID:7	0.157
cardiovascular system disease	DOID:1287	0.133
muscle tissue disease	DOID:66	0.101
cardiomyopathy	DOID:0050700	0.101
heart disease	DOID:114	0.101
intrinsic cardiomyopathy	DOID:0060036	0.101
muscular disease	DOID:0080000	0.101
myopathy	DOID:423	0.101
dilated cardiomyopathy	DOID:12930	0.042
long qt syndrome	DOID:2843	0.032
nervous system disease	DOID:863	0.026
urinary system disease	DOID:18	0.016
cancer	DOID:162	0.011
disease of cellular proliferation	DOID:14566	0.011
organ system cancer	DOID:0050686	0.011
disease of metabolism	DOID:0014667	0.010
inherited metabolic disorder	DOID:655	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network