Rattus norvegicus

89 known processes

Bhlhe40

basic helix-loop-helix family, member e40

(Aliases: Sharp2,Bhlhb2,Stra14,Stra13,Dec1,SHARP-2)

Bhlhe40 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of transcription dna templatedGO:00063553740.203
rna metabolic processGO:00160704060.188
regulation of nucleic acid templated transcriptionGO:19035063800.166
nucleic acid templated transcriptionGO:00976593790.151
regulation of rna biosynthetic processGO:20011413810.147
regulation of rna metabolic processGO:00512523910.147
regulation of intracellular signal transductionGO:19025312180.136
apoptotic processGO:00069153810.123
neuron differentiationGO:00301823680.122
regulation of programmed cell deathGO:00430673410.119
regulation of neurogenesisGO:00507672470.118
protein phosphorylationGO:00064683450.117
cellular response to endogenous stimulusGO:00714953770.112
response to extracellular stimulusGO:00099913800.109
negative regulation of nitrogen compound metabolic processGO:00511721610.107
regulation of protein metabolic processGO:00512462890.104
programmed cell deathGO:00125013920.102
cellular response to stressGO:00335542690.094
cellular response to hormone stimulusGO:00328702470.090
rna biosynthetic processGO:00327743800.087
regulation of transcription from rna polymerase ii promoterGO:00063572340.086
intracellular signal transductionGO:00355563140.085
dna metabolic processGO:0006259960.083
response to decreased oxygen levelsGO:00362932370.082
transcription dna templatedGO:00063513770.081
response to metal ionGO:00100382530.080
protein complex biogenesisGO:00702712630.079
negative regulation of metabolic processGO:00098923310.078
negative regulation of macromolecule biosynthetic processGO:00105581480.077
negative regulation of macromolecule metabolic processGO:00106052600.077
regulation of multicellular organismal developmentGO:20000263760.076
response to molecule of bacterial originGO:00022371940.073
regulation of apoptotic processGO:00429813350.072
regulation of cell differentiationGO:00455953200.072
positive regulation of multicellular organismal processGO:00512403870.071
response to biotic stimulusGO:00096072260.070
transcription from rna polymerase ii promoterGO:00063662520.069
regulation of cellular component organizationGO:00511283680.068
cellular component assemblyGO:00226073600.067
negative regulation of cellular biosynthetic processGO:00313271610.066
regulation of cell developmentGO:00602842630.065
regulation of phosphate metabolic processGO:00192203490.064
protein complex assemblyGO:00064612630.064
carboxylic acid metabolic processGO:00197522890.064
response to glucocorticoidGO:00513842230.064
positive regulation of biosynthetic processGO:00098913190.064
neuron developmentGO:00486662860.060
positive regulation of cell differentiationGO:00455972170.060
cell projection organizationGO:00300303020.059
cellular response to oxygen containing compoundGO:19017013860.059
organic acid metabolic processGO:00060822920.059
negative regulation of apoptotic processGO:00430661810.058
response to nutrient levelsGO:00316673700.058
negative regulation of nucleobase containing compound metabolic processGO:00459341530.057
regulation of protein modification processGO:00313991940.057
macromolecular complex assemblyGO:00650032730.057
regulation of cellular protein metabolic processGO:00322682670.057
positive regulation of rna biosynthetic processGO:19026801970.056
negative regulation of cell deathGO:00605482290.056
response to acid chemicalGO:00011012220.056
cellular component biogenesisGO:00440853680.055
response to external biotic stimulusGO:00432072210.054
regulation of catalytic activityGO:00507903040.054
cellular ketone metabolic processGO:0042180510.053
response to inorganic substanceGO:00100353770.053
response to radiationGO:00093141370.053
regulation of cell proliferationGO:00421273590.052
regulation of molecular functionGO:00650093980.051
Human
response to peptideGO:19016522920.051
positive regulation of nitrogen compound metabolic processGO:00511733340.051
cellular amino acid metabolic processGO:00065201070.051
positive regulation of cellular biosynthetic processGO:00313282950.051
reproductive processGO:00224143720.050
response to nutrientGO:00075842480.050
organic substance catabolic processGO:19015753160.049
negative regulation of biosynthetic processGO:00098901680.049
protein complex subunit organizationGO:00718223020.048
negative regulation of cell communicationGO:00106481580.047
single organism biosynthetic processGO:00447113420.047
negative regulation of cellular metabolic processGO:00313242810.047
neuron projection developmentGO:00311752730.047
regulation of nervous system developmentGO:00519602640.046
regulation of signal transductionGO:00099663180.046
catabolic processGO:00090563510.046
regulation of proteasomal protein catabolic processGO:006113640.046
response to estrogenGO:00436272320.046
response to estradiolGO:00323551640.046
circulatory system processGO:00030131830.045
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.045
response to other organismGO:00517072200.045
positive regulation of cellular component organizationGO:00511302000.044
positive regulation of rna metabolic processGO:00512542030.044
response to woundingGO:00096112540.044
response to oxidative stressGO:00069791860.044
anatomical structure morphogenesisGO:00096532980.043
response to ketoneGO:19016541820.043
response to hypoxiaGO:00016662310.043
cellular response to lipidGO:00713962010.043
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.042
response to insulinGO:00328681330.042
positive regulation of phosphate metabolic processGO:00459372620.042
macromolecular complex subunit organizationGO:00439333390.041
response to corticosteroidGO:00319602350.041
single organism reproductive processGO:00447022970.041
cellular response to nitrogen compoundGO:19016992100.040
positive regulation of macromolecule biosynthetic processGO:00105572470.040
response to interleukin 1GO:0070555550.039
response to bacteriumGO:00096172000.039
regulation of neuron differentiationGO:00456642080.039
signal transduction by phosphorylationGO:00230141440.039
cellular response to molecule of bacterial originGO:0071219560.038
tissue developmentGO:00098882520.038
macromolecule localizationGO:00330362520.038
secretionGO:00469033070.038
regulation of phosphorylationGO:00423252480.037
positive regulation of nucleobase containing compound metabolic processGO:00459353190.037
cellular response to oxidative stressGO:0034599760.037
chemical homeostasisGO:00488782920.037
regulation of immune system processGO:00026821230.037
inactivation of mapk activityGO:000018820.037
vesicle mediated transportGO:00161921810.036
positive regulation of transportGO:00510502450.036
negative regulation of response to stimulusGO:00485851550.036
neuron deathGO:00709971270.036
regulation of system processGO:00440572080.036
negative regulation of cell differentiationGO:0045596990.036
negative regulation of neuron deathGO:1901215690.035
central nervous system developmentGO:00074173110.035
positive regulation of nucleic acid templated transcriptionGO:19035081970.035
secretion by cellGO:00329402480.035
regulation of neuron projection developmentGO:00109751610.034
organophosphate metabolic processGO:00196373700.034
negative regulation of cellular protein metabolic processGO:00322691060.034
positive regulation of gene expressionGO:00106282440.034
protein dephosphorylationGO:0006470380.033
cellular homeostasisGO:00197252520.033
negative regulation of rna metabolic processGO:00512531230.033
multi organism reproductive processGO:00447032620.033
enzyme linked receptor protein signaling pathwayGO:00071671160.033
response to monosaccharideGO:00342841590.032
cation transportGO:00068123820.032
carbohydrate metabolic processGO:00059751300.032
immune system processGO:00023762040.032
positive regulation of transcription dna templatedGO:00458931970.032
regulation of cellular ketone metabolic processGO:0010565270.032
cellular cation homeostasisGO:00300031800.031
positive regulation of developmental processGO:00510942830.031
negative regulation of developmental processGO:00510931250.031
cellular ion homeostasisGO:00068731840.031
regulation of protein phosphorylationGO:00019321830.031
oxoacid metabolic processGO:00434362900.031
regulation of cellular amine metabolic processGO:003323880.031
regulation of neuron deathGO:19012141150.031
negative regulation of gene expressionGO:00106291990.030
positive regulation of cell communicationGO:00106472710.030
cellular response to follicle stimulating hormone stimulusGO:0071372130.030
positive regulation of immune system processGO:0002684900.030
transmembrane transportGO:00550854120.029
positive regulation of nervous system developmentGO:00519621780.029
negative regulation of programmed cell deathGO:00430691830.029
response to oxygen levelsGO:00704822650.029
cellular component morphogenesisGO:00329891550.029
response to cytokineGO:00340972150.029
positive regulation of fat cell differentiationGO:004560020.029
blood circulationGO:00080151830.029
regulation of ossificationGO:0030278320.028
response to lipopolysaccharideGO:00324961910.028
locomotor rhythmGO:004547510.028
Zebrafish
response to hydrogen peroxideGO:0042542890.028
synaptic transmissionGO:00072682350.028
positive regulation of phosphorus metabolic processGO:00105622620.028
negative regulation of transcription dna templatedGO:00458921160.027
amine metabolic processGO:0009308380.027
ion homeostasisGO:00508012120.027
regenerationGO:00310991630.027
small gtpase mediated signal transductionGO:0007264360.027
nitrogen compound transportGO:00717052290.027
negative regulation of signalingGO:00230571570.027
cellular response to growth factor stimulusGO:00713631620.027
regulation of kinase activityGO:00435491170.027
regulation of response to stressGO:00801341260.027
cellular response to organic cyclic compoundGO:00714072020.026
cellular response to external stimulusGO:00714961180.026
negative regulation of neuron apoptotic processGO:0043524450.026
response to reactive oxygen speciesGO:00003021200.026
mapk cascadeGO:00001651400.026
positive regulation of signalingGO:00230562700.026
monosaccharide metabolic processGO:0005996610.026
cellular amine metabolic processGO:0044106380.026
regulation of cell projection organizationGO:00313441750.026
homeostatic processGO:00425923310.026
positive regulation of response to stimulusGO:00485842850.025
head developmentGO:00603222470.025
myeloid leukocyte differentiationGO:0002573200.025
protein oligomerizationGO:00512591910.025
regulation of cellular amino acid metabolic processGO:000652120.024
regulation of catabolic processGO:00098941130.024
circadian regulation of gene expressionGO:003292230.024
Human Zebrafish Mouse
response to glucoseGO:00097491360.024
cellular catabolic processGO:00442482950.024
positive regulation of neurogenesisGO:00507691650.024
response to hexoseGO:00097461440.024
response to peptide hormoneGO:00434342780.024
intracellular transportGO:00469071850.024
regulation of metanephros developmentGO:007221540.024
regulation of synaptic transmissionGO:00508041410.024
negative regulation of neurogenesisGO:0050768780.024
negative regulation of protein metabolic processGO:00512481140.024
organic anion transportGO:00157111320.024
cellular response to steroid hormone stimulusGO:0071383930.023
negative regulation of rna biosynthetic processGO:19026791180.023
response to ethanolGO:00454711620.023
positive regulation of cellular amine metabolic processGO:003324030.023
single organism carbohydrate metabolic processGO:00447231180.023
negative regulation of nervous system developmentGO:0051961790.023
alpha amino acid metabolic processGO:1901605710.022
response to transition metal nanoparticleGO:19902671220.022
negative regulation of molecular functionGO:00440921330.022
Human
positive regulation of phosphorylationGO:00423271770.022
dephosphorylationGO:0016311980.022
regulation of secretionGO:00510462240.022
cell cell signalingGO:00072673350.022
regulation of p38mapk cascadeGO:190074410.022
cell type specific apoptotic processGO:00972851340.022
cellular response to organonitrogen compoundGO:00714171970.021
positive regulation of cell deathGO:00109421840.021
heart morphogenesisGO:000300730.021
single organism catabolic processGO:00447122830.021
positive regulation of protein modification processGO:00314011420.021
multi multicellular organism processGO:00447061380.021
developmental growthGO:00485891000.021
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.021
regulation of transferase activityGO:00513381230.021
nucleobase containing small molecule metabolic processGO:00550863160.021
cell morphogenesisGO:00009021420.020
regulation of cellular localizationGO:00603412630.020
heart contractionGO:0060047570.020
nucleotide metabolic processGO:00091172790.020
negative regulation of catalytic activityGO:00430861030.020
positive regulation of cell projection organizationGO:00313461110.020
immune system developmentGO:0002520410.020
nucleoside phosphate metabolic processGO:00067532830.020
brain developmentGO:00074202470.020
negative regulation of multicellular organismal processGO:00512412030.020
metal ion homeostasisGO:00550651860.019
regulation of phosphorus metabolic processGO:00511743490.019
peptide transportGO:0015833970.019
ras protein signal transductionGO:0007265290.019
positive regulation of cellular protein metabolic processGO:00322701670.019
agingGO:00075682410.019
response to alkaloidGO:00432791320.019
cellular macromolecule localizationGO:00707271220.019
regulation of membrane potentialGO:00423911100.019
cellular response to lipopolysaccharideGO:0071222550.019
regulation of osteoblast differentiationGO:0045667140.019
cellular metal ion homeostasisGO:00068751720.019
regulation of myeloid cell differentiationGO:0045637120.019
behaviorGO:00076102050.019
Zebrafish
regulation of map kinase activityGO:0043405530.019
bmp signaling pathwayGO:003050940.018
positive regulation of cell developmentGO:00107201760.018
regulation of fat cell differentiationGO:004559830.018
response to organophosphorusGO:00466831020.018
chromosome segregationGO:000705920.018
cell cycleGO:00070491010.018
amide transportGO:00428861050.018
multicellular organismal reproductive processGO:00486092330.018
organelle organizationGO:00069962660.018
anion transportGO:00068201780.018
proteolysisGO:00065081750.018
coenzyme metabolic processGO:0006732860.018
regulation of blood circulationGO:19035221100.018
response to axon injuryGO:0048678590.018
cellular response to interleukin 1GO:0071347370.017
cellular chemical homeostasisGO:00550822470.017
carbohydrate derivative metabolic processGO:19011353460.017
positive regulation of protein metabolic processGO:00512471780.017
peptidyl amino acid modificationGO:00181931260.017
cellular divalent inorganic cation homeostasisGO:00725031620.017
multicellular organism growthGO:003526410.017
cell projection morphogenesisGO:00488581230.017
reproductionGO:00000032450.017
circulatory system developmentGO:00723591340.017
positive regulation of ion transportGO:0043270940.017
positive regulation of neuron projection developmentGO:0010976990.017
response to vitaminGO:00332731310.017
cation homeostasisGO:00550801950.017
heart developmentGO:0007507720.016
circadian rhythmGO:0007623880.016
regulation of homeostatic processGO:00328441010.016
cellular response to cytokine stimulusGO:00713451270.016
regulation of cell adhesionGO:0030155520.016
positive regulation of cell migrationGO:0030335960.016
single organism intracellular transportGO:19025821660.016
cellular response to biotic stimulusGO:0071216590.016
regulation of ion transportGO:00432692450.016
vascular process in circulatory systemGO:0003018960.016
ion transmembrane transportGO:00342203650.016
spindle organizationGO:000705120.016
regulation of hormone levelsGO:00108171870.016
positive regulation of mesenchymal cell proliferationGO:000205340.016
negative regulation of innate immune responseGO:004582440.016
wound healingGO:00420601220.015
regulation of hormone secretionGO:00468831060.015
single organism organelle organizationGO:19025891800.015
actin filament based processGO:0030029860.015
growthGO:00400071650.015
cellular calcium ion homeostasisGO:00068741600.015
protein localizationGO:00081041910.015
regulation of dna metabolic processGO:0051052600.015
protein heterooligomerizationGO:0051291890.015
dendrite developmentGO:0016358720.015
biological adhesionGO:00226101100.015
response to toxic substanceGO:00096361330.015
positive regulation of smooth muscle cell proliferationGO:0048661510.015
negative regulation of neuron differentiationGO:0045665620.015
regulation of hydrolase activityGO:00513361430.015
cellular response to peptide hormone stimulusGO:00713751200.015
protein transportGO:00150311320.015
organic acid transportGO:00158491160.015
female pregnancyGO:00075651220.015
gastrulationGO:000736920.015
regulation of cell morphogenesisGO:0022604770.015
response to growth factorGO:00708481890.015
muscle cell proliferationGO:0033002840.015
hormone transportGO:00099141210.015
positive regulation of cellular catabolic processGO:0031331710.015
cellular amino acid biosynthetic processGO:0008652320.015
ossificationGO:0001503700.015
cellular response to peptideGO:19016531330.015
protein autophosphorylationGO:0046777660.014
cellular response to transforming growth factor beta stimulusGO:0071560410.014
transforming growth factor beta receptor signaling pathwayGO:0007179180.014
divalent inorganic cation homeostasisGO:00725071650.014
gliogenesisGO:0042063930.014
negative regulation of phosphorylationGO:0042326570.014
localization of cellGO:00516742020.014
negative regulation of phosphate metabolic processGO:0045936800.014
organic hydroxy compound metabolic processGO:19016151150.014
lipid metabolic processGO:00066292830.014
neurological system processGO:00508772190.014
regulation of cellular catabolic processGO:00313291010.014
collateral sproutingGO:004866820.014
reproductive structure developmentGO:00486081280.014
cell growthGO:00160491040.014
positive regulation of cellular amino acid metabolic processGO:004576410.014
positive regulation of protein phosphorylationGO:00019341350.014
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.014
response to purine containing compoundGO:00140741260.014
gland developmentGO:00487321550.014
cytoplasmic transportGO:00164821150.014
positive regulation of molecular functionGO:00440932300.014
cellular response to acid chemicalGO:0071229750.014
response to carbohydrateGO:00097431830.014
g protein coupled receptor signaling pathwayGO:00071862420.014
purine ribonucleotide metabolic processGO:00091502270.014
regulation of protein serine threonine kinase activityGO:0071900640.014
calcium ion homeostasisGO:00550741620.014
positive regulation of catalytic activityGO:00430851840.014
positive regulation of cell proliferationGO:00082842490.014
placenta developmentGO:0001890220.014
regulation of protein localizationGO:0032880810.014
regulation of protein kinase activityGO:00458591050.014
rhythmic processGO:00485111560.013
purine containing compound metabolic processGO:00725212530.013
cell adhesionGO:00071551100.013
ribonucleotide metabolic processGO:00092592310.013
positive regulation of neuron differentiationGO:00456661260.013
positive regulation of transforming growth factor beta3 productionGO:003291620.013
organonitrogen compound catabolic processGO:19015651790.013
hexose metabolic processGO:0019318580.013
negative regulation of cell developmentGO:0010721820.013
response to campGO:0051591910.013
carboxylic acid biosynthetic processGO:0046394830.013
positive regulation of catabolic processGO:0009896780.013
metal ion transportGO:00300012890.013
regulation of tube sizeGO:0035150890.013
mammary gland epithelium developmentGO:006118010.013
amide biosynthetic processGO:0043604100.013
embryonic pattern specificationGO:000988010.013
hormone secretionGO:00468791150.013
cellular response to insulin stimulusGO:0032869810.013
cellular response to nutrient levelsGO:0031669600.013
action potentialGO:0001508540.013
establishment of protein localizationGO:00451841410.013
response to calcium ionGO:0051592590.013
p38mapk cascadeGO:003806610.013
muscle system processGO:00030121150.013
cellular response to gonadotropin stimulusGO:0071371170.013
axis specificationGO:000979840.013
alpha amino acid biosynthetic processGO:1901607230.012
glycogen metabolic processGO:0005977230.012
forebrain developmentGO:0030900980.012
positive regulation of protein kinase activityGO:0045860730.012
positive regulation of programmed cell deathGO:00430681570.012
cell cycle checkpointGO:000007520.012
lipid transportGO:0006869610.012
regulation of protein transportGO:0051223680.012
cytosolic calcium ion homeostasisGO:00514801400.012
regulation of cell migrationGO:00303341280.012
cellular response to extracellular stimulusGO:0031668730.012
cellular component movementGO:00069282480.012
cellular response to oxygen levelsGO:0071453600.012
response to dexamethasoneGO:0071548490.012
response to amino acidGO:0043200750.012
heart processGO:0003015570.012
cardiovascular system developmentGO:00723581340.012
lipid storageGO:001991510.012
negative regulation of phosphorus metabolic processGO:0010563800.012
macromolecule catabolic processGO:0009057580.012
multicellular organism reproductionGO:00325042330.012
regulation of bmp signaling pathwayGO:003051020.012
sensory organ developmentGO:0007423740.012
regulation of neuron apoptotic processGO:0043523830.012
ribose phosphate metabolic processGO:00196932350.012
cytoskeleton dependent cytokinesisGO:006164020.012
negative regulation of protein modification processGO:0031400520.012
regulation of proteasomal ubiquitin dependent protein catabolic processGO:003243430.012
negative regulation of mitotic cell cycle phase transitionGO:190199130.012
cellular response to alcoholGO:0097306870.012
glucose metabolic processGO:0006006520.011
regulation of response to external stimulusGO:00321011060.011
nucleoside metabolic processGO:00091161790.011
neuron projection morphogenesisGO:00488121220.011
positive regulation of immunoglobulin productionGO:000263940.011
cell motilityGO:00488702020.011
lipid localizationGO:0010876620.011
regulation of cellular component movementGO:00512701500.011
peptide hormone secretionGO:0030072840.011
cofactor metabolic processGO:0051186950.011
negative regulation of cell cycle phase transitionGO:190198840.011
gamete generationGO:00072761240.011
eye developmentGO:0001654500.011
purine nucleotide metabolic processGO:00061632290.011
cardiac chamber developmentGO:000320510.011
heterocycle catabolic processGO:00467001670.011
regulation of erk1 and erk2 cascadeGO:0070372410.011
regulation of dendrite developmentGO:0050773590.011
negative regulation of osteoblast differentiationGO:004566820.011
small molecule biosynthetic processGO:00442831240.011
osteoblast differentiationGO:0001649260.011
regulation of peptide transportGO:0090087870.011
cardiac ventricle developmentGO:000323110.011
positive regulation of apoptotic processGO:00430651540.011
epithelial cell differentiationGO:0030855710.011
smooth muscle cell proliferationGO:0048659770.011
regulation of nucleotide metabolic processGO:00061401170.011
purine containing compound catabolic processGO:00725231380.011
positive regulation of response to external stimulusGO:0032103510.011
positive regulation of cellular component movementGO:00512721020.011
cellular response to abiotic stimulusGO:0071214850.011
positive regulation of peptide secretionGO:0002793520.011
single organism carbohydrate catabolic processGO:0044724400.011
multicellular organismal signalingGO:0035637440.010
monocarboxylic acid metabolic processGO:00327871520.010
regulation of secretion by cellGO:19035302080.010
sexual reproductionGO:00199531480.010
cell cell signaling involved in cell fate commitmentGO:004516820.010
cellular modified amino acid metabolic processGO:0006575610.010
negative regulation of signal transductionGO:0009968830.010
defense response to gram negative bacteriumGO:005082930.010
positive regulation of isotype switchingGO:004583010.010
rho protein signal transductionGO:0007266110.010
regulation of anatomical structure sizeGO:00900661350.010
regulation of blood vessel sizeGO:0050880890.010
calcium ion transportGO:00068161310.010
formation of primary germ layerGO:000170410.010
developmental process involved in reproductionGO:00030061590.010
negative regulation of nucleic acid templated transcriptionGO:19035071170.010
nucleobase containing compound catabolic processGO:00346551520.010
maintenance of locationGO:0051235170.010
cytokine productionGO:0001816610.010
mesoderm developmentGO:000749820.010
regulation of stem cell differentiationGO:200073620.010
monovalent inorganic cation transportGO:00156721720.010

Bhlhe40 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.020
disease of anatomical entityDOID:700.020
disease of metabolismDOID:001466700.017
inherited metabolic disorderDOID:65500.017
musculoskeletal system diseaseDOID:1700.017