IMP: Integrative Multi-species Prediction

Rattus norvegicus

40 known processes

Socs1

suppressor of cytokine signaling 1

(Aliases: Socs-1,Cish1)

RGD: 69272
Entrez: 252971
Ensembl: ENSRNOG00000002568
UniProtKB: G3V6B4

Process Predictions
Disease Predictions

Socs1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
nucleic acid templated transcription	GO:0097659	379	0.182
transcription dna templated	GO:0006351	377	0.168
rna biosynthetic process	GO:0032774	380	0.117
regulation of nucleic acid templated transcription	GO:1903506	380	0.108
regulation of rna biosynthetic process	GO:2001141	381	0.099
homeostatic process	GO:0042592	331	0.088
regulation of transcription dna templated	GO:0006355	374	0.083
inorganic cation transmembrane transport	GO:0098662	202	0.079
transmembrane transport	GO:0055085	412	0.075
ion transmembrane transport	GO:0034220	365	0.073
regulation of rna metabolic process	GO:0051252	391	0.071
regulation of secretion	GO:0051046	224	0.064	Mouse
response to corticosteroid	GO:0031960	235	0.063	Rat
amino acid transport	GO:0006865	70	0.061
cellular response to nitrogen compound	GO:1901699	210	0.060	Mouse
protein complex subunit organization	GO:0071822	302	0.060
positive regulation of gene expression	GO:0010628	244	0.059
transcription from rna polymerase ii promoter	GO:0006366	252	0.057
anion transport	GO:0006820	178	0.055
secretion	GO:0046903	307	0.055	Mouse
rna metabolic process	GO:0016070	406	0.054
positive regulation of transcription dna templated	GO:0045893	197	0.052
response to nutrient levels	GO:0031667	370	0.048	Rat
regulation of secretion by cell	GO:1903530	208	0.046	Mouse
protein complex assembly	GO:0006461	263	0.045
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.045
positive regulation of transport	GO:0051050	245	0.044
macromolecule localization	GO:0033036	252	0.044	Mouse
nitrogen compound transport	GO:0071705	229	0.044
positive regulation of cell differentiation	GO:0045597	217	0.043
macromolecular complex subunit organization	GO:0043933	339	0.042
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.042
regeneration	GO:0031099	163	0.041
negative regulation of transport	GO:0051051	136	0.040
response to glucocorticoid	GO:0051384	223	0.039	Rat
cell cell signaling	GO:0007267	335	0.039
cation transmembrane transport	GO:0098655	263	0.038
carboxylic acid transport	GO:0046942	115	0.038
regulation of molecular function	GO:0065009	398	0.037	Mouse
inorganic ion transmembrane transport	GO:0098660	229	0.036
secretion by cell	GO:0032940	248	0.035	Mouse
cellular component biogenesis	GO:0044085	368	0.035
programmed cell death	GO:0012501	392	0.034
signal release	GO:0023061	145	0.033
cellular component assembly	GO:0022607	360	0.033
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.033
positive regulation of multicellular organismal process	GO:0051240	387	0.033
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.033
chemical homeostasis	GO:0048878	292	0.032
cellular response to oxygen containing compound	GO:1901701	386	0.032	Mouse
organic acid transport	GO:0015849	116	0.032
organic anion transport	GO:0015711	132	0.032
positive regulation of secretion	GO:0051047	140	0.031
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.031
negative regulation of cellular biosynthetic process	GO:0031327	161	0.031
regulation of apoptotic process	GO:0042981	335	0.031
regulation of cellular localization	GO:0060341	263	0.031	Mouse
response to ketone	GO:1901654	182	0.030
monovalent inorganic cation transport	GO:0015672	172	0.030
response to wounding	GO:0009611	254	0.029
response to growth factor	GO:0070848	189	0.029
negative regulation of apoptotic process	GO:0043066	181	0.029
positive regulation of biosynthetic process	GO:0009891	319	0.029
positive regulation of rna biosynthetic process	GO:1902680	197	0.029
response to mechanical stimulus	GO:0009612	134	0.028
negative regulation of programmed cell death	GO:0043069	183	0.028
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.028
inflammatory response	GO:0006954	150	0.027
aging	GO:0007568	241	0.027	Rat
cellular chemical homeostasis	GO:0055082	247	0.026
cation transport	GO:0006812	382	0.026
lipid transport	GO:0006869	61	0.026
regulation of metal ion transport	GO:0010959	118	0.026
macromolecular complex assembly	GO:0065003	273	0.026
negative regulation of biosynthetic process	GO:0009890	168	0.025
negative regulation of signaling	GO:0023057	157	0.025	Zebrafish Mouse
metal ion transport	GO:0030001	289	0.025
positive regulation of cell proliferation	GO:0008284	249	0.025
regulation of cell projection organization	GO:0031344	175	0.025
carbohydrate derivative metabolic process	GO:1901135	346	0.025
cell type specific apoptotic process	GO:0097285	134	0.024
regulation of hormone levels	GO:0010817	187	0.024
response to cytokine	GO:0034097	215	0.024
response to biotic stimulus	GO:0009607	226	0.023
nucleobase containing small molecule metabolic process	GO:0055086	316	0.023
protein oligomerization	GO:0051259	191	0.023
cellular response to growth factor stimulus	GO:0071363	162	0.023
response to peptide	GO:1901652	292	0.023
negative regulation of metabolic process	GO:0009892	331	0.023	Mouse
single organism biosynthetic process	GO:0044711	342	0.022
lipid metabolic process	GO:0006629	283	0.022
positive regulation of molecular function	GO:0044093	230	0.022	Mouse
positive regulation of cell death	GO:0010942	184	0.022
regulation of phosphorus metabolic process	GO:0051174	349	0.022	Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.022
negative regulation of cell communication	GO:0010648	158	0.021	Zebrafish Mouse
cellular response to cytokine stimulus	GO:0071345	127	0.021	Zebrafish Mouse Rat
positive regulation of secretion by cell	GO:1903532	128	0.021
response to hypoxia	GO:0001666	231	0.021	Rat
regulation of cellular component organization	GO:0051128	368	0.021
organophosphate metabolic process	GO:0019637	370	0.021
positive regulation of rna metabolic process	GO:0051254	203	0.021
reproductive process	GO:0022414	372	0.021
protein complex biogenesis	GO:0070271	263	0.020
cellular response to external stimulus	GO:0071496	118	0.020
positive regulation of developmental process	GO:0051094	283	0.020
vasculature development	GO:0001944	70	0.019
negative regulation of cellular metabolic process	GO:0031324	281	0.019	Mouse
cellular response to endogenous stimulus	GO:0071495	377	0.019	Mouse
regulation of neuron apoptotic process	GO:0043523	83	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.019
circulatory system process	GO:0003013	183	0.018
acid secretion	GO:0046717	48	0.018
regulation of transmembrane transport	GO:0034762	122	0.018
nucleoside phosphate metabolic process	GO:0006753	283	0.017
response to oxygen levels	GO:0070482	265	0.017	Rat
regulation of protein metabolic process	GO:0051246	289	0.017	Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.017
growth	GO:0040007	165	0.017
peptide secretion	GO:0002790	86	0.017
learning or memory	GO:0007611	90	0.017
nucleotide metabolic process	GO:0009117	279	0.016
response to decreased oxygen levels	GO:0036293	237	0.016	Rat
response to extracellular stimulus	GO:0009991	380	0.016	Rat
amine metabolic process	GO:0009308	38	0.016
regulation of membrane potential	GO:0042391	110	0.016
response to bacterium	GO:0009617	200	0.016
negative regulation of gene expression	GO:0010629	199	0.016
negative regulation of rna biosynthetic process	GO:1902679	118	0.016
purine nucleotide metabolic process	GO:0006163	229	0.016
response to external biotic stimulus	GO:0043207	221	0.016
protein localization	GO:0008104	191	0.016	Mouse
response to toxic substance	GO:0009636	133	0.016
positive regulation of apoptotic process	GO:0043065	154	0.015
oxoacid metabolic process	GO:0043436	290	0.015
regulation of intracellular signal transduction	GO:1902531	218	0.015	Zebrafish Mouse
positive regulation of signaling	GO:0023056	270	0.015	Mouse
response to insulin	GO:0032868	133	0.015	Mouse Rat
response to hexose	GO:0009746	144	0.015
defense response	GO:0006952	194	0.015	Zebrafish
neuron apoptotic process	GO:0051402	88	0.015
response to carbohydrate	GO:0009743	183	0.015
circulatory system development	GO:0072359	134	0.015
cellular response to stress	GO:0033554	269	0.015
positive regulation of programmed cell death	GO:0043068	157	0.015
cellular cation homeostasis	GO:0030003	180	0.015
glial cell differentiation	GO:0010001	65	0.015
regulation of cellular catabolic process	GO:0031329	101	0.015
multicellular organism growth	GO:0035264	1	0.015
hormone metabolic process	GO:0042445	69	0.015
carbohydrate derivative biosynthetic process	GO:1901137	124	0.014
cellular response to drug	GO:0035690	30	0.014
regulation of neuron differentiation	GO:0045664	208	0.014
cellular response to extracellular stimulus	GO:0031668	73	0.014
regulation of cell differentiation	GO:0045595	320	0.014
positive regulation of hormone secretion	GO:0046887	65	0.014
regulation of ion transport	GO:0043269	245	0.014
central nervous system development	GO:0007417	311	0.014
blood circulation	GO:0008015	183	0.014
muscle system process	GO:0003012	115	0.014
dicarboxylic acid transport	GO:0006835	34	0.014
regulation of neurogenesis	GO:0050767	247	0.014
ribose phosphate metabolic process	GO:0019693	235	0.014
cardiovascular system development	GO:0072358	134	0.014
positive regulation of cellular amine metabolic process	GO:0033240	3	0.014
aromatic compound catabolic process	GO:0019439	168	0.014
regulation of anatomical structure morphogenesis	GO:0022603	141	0.014
regulation of multicellular organismal development	GO:2000026	376	0.014
organic substance catabolic process	GO:1901575	316	0.014
cellular amino acid metabolic process	GO:0006520	107	0.014
multicellular organism reproduction	GO:0032504	233	0.014
positive regulation of growth	GO:0045927	55	0.014
negative regulation of cell death	GO:0060548	229	0.014
dna metabolic process	GO:0006259	96	0.013
response to peptide hormone	GO:0043434	278	0.013
positive regulation of nucleotide metabolic process	GO:0045981	91	0.013
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.013
response to glucose	GO:0009749	136	0.013
glycosyl compound metabolic process	GO:1901657	182	0.013
cellular calcium ion homeostasis	GO:0006874	160	0.013
response to axon injury	GO:0048678	59	0.013
divalent inorganic cation transport	GO:0072511	134	0.013
positive regulation of ion transport	GO:0043270	94	0.013
regulation of blood pressure	GO:0008217	83	0.013
regulation of leukocyte activation	GO:0002694	45	0.013
organonitrogen compound biosynthetic process	GO:1901566	167	0.013
regulation of hormone secretion	GO:0046883	106	0.013
appendage morphogenesis	GO:0035107	4	0.012
lipid localization	GO:0010876	62	0.012
response to lipopolysaccharide	GO:0032496	191	0.012
regulation of anion transport	GO:0044070	43	0.012
regulation of cellular amino acid metabolic process	GO:0006521	2	0.012
response to alkaloid	GO:0043279	132	0.012
cell projection organization	GO:0030030	302	0.012
metal ion homeostasis	GO:0055065	186	0.012
regulation of cell proliferation	GO:0042127	359	0.012
nucleoside phosphate biosynthetic process	GO:1901293	102	0.012
cellular catabolic process	GO:0044248	295	0.012
multicellular organismal reproductive process	GO:0048609	233	0.012
positive regulation of phosphorus metabolic process	GO:0010562	262	0.012	Mouse
cellular amine metabolic process	GO:0044106	38	0.012
ras protein signal transduction	GO:0007265	29	0.012
positive regulation of cell projection organization	GO:0031346	111	0.012
sexual reproduction	GO:0019953	148	0.012
positive regulation of protein metabolic process	GO:0051247	178	0.012	Mouse
regulation of nucleotide metabolic process	GO:0006140	117	0.012
brain development	GO:0007420	247	0.012
development of primary sexual characteristics	GO:0045137	107	0.012
transmission of nerve impulse	GO:0019226	42	0.012
neuron death	GO:0070997	127	0.011
motor neuron axon guidance	GO:0008045	1	0.011
proteolysis	GO:0006508	175	0.011
divalent inorganic cation homeostasis	GO:0072507	165	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
multi organism reproductive process	GO:0044703	262	0.011
single organism behavior	GO:0044708	130	0.011
immune system process	GO:0002376	204	0.011	Zebrafish
organic hydroxy compound metabolic process	GO:1901615	115	0.011
nucleotide biosynthetic process	GO:0009165	98	0.011
monosaccharide metabolic process	GO:0005996	61	0.011
regulation of synaptic transmission	GO:0050804	141	0.011
establishment of protein localization	GO:0045184	141	0.011	Mouse
single organism organelle organization	GO:1902589	180	0.011
negative regulation of response to stimulus	GO:0048585	155	0.011	Zebrafish Mouse
positive regulation of cellular component organization	GO:0051130	200	0.011
negative regulation of ion transport	GO:0043271	51	0.011
action potential	GO:0001508	54	0.011
negative regulation of transcription dna templated	GO:0045892	116	0.011
negative regulation of rna metabolic process	GO:0051253	123	0.011
synaptic growth at neuromuscular junction	GO:0051124	1	0.011
cell activation	GO:0001775	97	0.011
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	3	0.011
sensory perception of pain	GO:0019233	73	0.011
head development	GO:0060322	247	0.011
regulation of signal transduction	GO:0009966	318	0.011	Zebrafish Mouse
regulation of establishment of protein localization	GO:0070201	69	0.011	Mouse
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	4	0.011
regulation of peptide secretion	GO:0002791	82	0.011
regulation of neuronal synaptic plasticity	GO:0048168	31	0.011
synaptic transmission	GO:0007268	235	0.011
hemopoiesis	GO:0030097	34	0.011	Zebrafish
response to radiation	GO:0009314	137	0.011	Rat
regulation of interleukin 6 production	GO:0032675	12	0.010
potassium ion transport	GO:0006813	97	0.010
regulation of cell morphogenesis	GO:0022604	77	0.010
cellular response to insulin stimulus	GO:0032869	81	0.010	Mouse
cyclic nucleotide biosynthetic process	GO:0009190	63	0.010
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.010
regulation of programmed cell death	GO:0043067	341	0.010
heterocycle catabolic process	GO:0046700	167	0.010
membrane organization	GO:0061024	94	0.010
immune system development	GO:0002520	41	0.010	Zebrafish
regulation of growth	GO:0040008	105	0.010
response to estrogen	GO:0043627	232	0.010
organ formation	GO:0048645	3	0.010
cell growth	GO:0016049	104	0.010
cellular response to organic cyclic compound	GO:0071407	202	0.010
hormone transport	GO:0009914	121	0.010
regulation of peptide transport	GO:0090087	87	0.010

Socs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.017
musculoskeletal system disease	DOID:17	0.017
inherited metabolic disorder	DOID:655	0.012
disease of metabolism	DOID:0014667	0.012
connective tissue disease	DOID:65	0.011

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