IMP: Integrative Multi-species Prediction

Rattus norvegicus

61 known processes

Ptf1a

pancreas specific transcription factor, 1a

Entrez: 117034
RGD: 621709
Ensembl: ENSRNOG00000016902
UniProtKB: Q64305

Process Predictions
Disease Predictions

Ptf1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of multicellular organismal process	GO:0051240	387	0.141	Rat
regulation of cell proliferation	GO:0042127	359	0.136	Rat
regulation of neurogenesis	GO:0050767	247	0.132	Rat
retina morphogenesis in camera type eye	GO:0060042	1	0.111	Mouse
positive regulation of biosynthetic process	GO:0009891	319	0.106	Zebrafish Mouse Rat
response to nutrient	GO:0007584	248	0.106
response to extracellular stimulus	GO:0009991	380	0.097
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.091
single organism biosynthetic process	GO:0044711	342	0.088
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.083	Zebrafish Mouse Rat
intracellular signal transduction	GO:0035556	314	0.081
programmed cell death	GO:0012501	392	0.078	Rat
secretion by cell	GO:0032940	248	0.078
lipid metabolic process	GO:0006629	283	0.078
cellular ion homeostasis	GO:0006873	184	0.077
organophosphate metabolic process	GO:0019637	370	0.076
cellular metal ion homeostasis	GO:0006875	172	0.076
cation homeostasis	GO:0055080	195	0.073
response to cytokine	GO:0034097	215	0.072
tissue development	GO:0009888	252	0.068	Human Mouse Rat
regulation of cellular localization	GO:0060341	263	0.066
organophosphate catabolic process	GO:0046434	148	0.065
brain development	GO:0007420	247	0.064	Human Mouse Rat
neuron differentiation	GO:0030182	368	0.064	Mouse Rat
organonitrogen compound biosynthetic process	GO:1901566	167	0.063
anatomical structure morphogenesis	GO:0009653	298	0.062	Zebrafish Mouse Rat
response to nutrient levels	GO:0031667	370	0.061
regulation of cell development	GO:0060284	263	0.060	Rat
regulation of signal transduction	GO:0009966	318	0.058
regulation of catalytic activity	GO:0050790	304	0.058
regulation of secretion	GO:0051046	224	0.057
divalent inorganic cation transport	GO:0072511	134	0.056
secretion	GO:0046903	307	0.050
regulation of multicellular organismal development	GO:2000026	376	0.050	Mouse Rat
response to tumor necrosis factor	GO:0034612	56	0.050
cellular homeostasis	GO:0019725	252	0.050	Rat
positive regulation of rna metabolic process	GO:0051254	203	0.049	Zebrafish Mouse Rat
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.046	Zebrafish Mouse Rat
neurological system process	GO:0050877	219	0.046
regulation of nucleic acid templated transcription	GO:1903506	380	0.046
regulation of blood vessel size	GO:0050880	89	0.044
regulation of hormone levels	GO:0010817	187	0.043
response to molecule of bacterial origin	GO:0002237	194	0.042
single organism reproductive process	GO:0044702	297	0.042
ion homeostasis	GO:0050801	212	0.042
regulation of cellular component organization	GO:0051128	368	0.041
muscle contraction	GO:0006936	88	0.041
purine nucleotide metabolic process	GO:0006163	229	0.040
g protein coupled receptor signaling pathway	GO:0007186	242	0.040
positive regulation of rna biosynthetic process	GO:1902680	197	0.040	Zebrafish Mouse Rat
calcium ion homeostasis	GO:0055074	162	0.040
metal ion transport	GO:0030001	289	0.039
sensory perception	GO:0007600	101	0.039
cellular response to endogenous stimulus	GO:0071495	377	0.038	Worm
small gtpase mediated signal transduction	GO:0007264	36	0.037
localization of cell	GO:0051674	202	0.037
ras protein signal transduction	GO:0007265	29	0.037
reproduction	GO:0000003	245	0.036
apoptotic process	GO:0006915	381	0.035	Rat
carbohydrate derivative metabolic process	GO:1901135	346	0.035
divalent inorganic cation homeostasis	GO:0072507	165	0.034
catabolic process	GO:0009056	351	0.034
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.033
camera type eye development	GO:0043010	48	0.033	Mouse Rat
single organism catabolic process	GO:0044712	283	0.033
neuron development	GO:0048666	286	0.032
cell projection organization	GO:0030030	302	0.031
cellular amino acid metabolic process	GO:0006520	107	0.031
positive regulation of catalytic activity	GO:0043085	184	0.031
regulation of rna biosynthetic process	GO:2001141	381	0.031
cellular catabolic process	GO:0044248	295	0.030
nucleotide metabolic process	GO:0009117	279	0.030
regulation of molecular function	GO:0065009	398	0.030
negative regulation of metabolic process	GO:0009892	331	0.030
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.030
regulation of nervous system development	GO:0051960	264	0.029	Rat
positive regulation of programmed cell death	GO:0043068	157	0.029
metal ion homeostasis	GO:0055065	186	0.029
cellular calcium ion homeostasis	GO:0006874	160	0.029
nucleobase containing small molecule metabolic process	GO:0055086	316	0.029
reproductive process	GO:0022414	372	0.029
peptidyl tyrosine phosphorylation	GO:0018108	72	0.028
hormone secretion	GO:0046879	115	0.028
macromolecule localization	GO:0033036	252	0.028
peptide secretion	GO:0002790	86	0.028
rna metabolic process	GO:0016070	406	0.027
protein complex subunit organization	GO:0071822	302	0.027
heart morphogenesis	GO:0003007	3	0.027
response to peptide hormone	GO:0043434	278	0.027	Worm
salivary gland morphogenesis	GO:0007435	1	0.027
response to decreased oxygen levels	GO:0036293	237	0.027
regulation of phosphorus metabolic process	GO:0051174	349	0.027
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.026	Zebrafish Mouse Rat
carbohydrate derivative catabolic process	GO:1901136	147	0.026
regulation of metal ion transport	GO:0010959	118	0.026
ribose phosphate metabolic process	GO:0019693	235	0.026
cell motility	GO:0048870	202	0.026
regulation of phosphate metabolic process	GO:0019220	349	0.025
cellular response to oxygen containing compound	GO:1901701	386	0.025	Rat Worm
negative regulation of cellular metabolic process	GO:0031324	281	0.025
regulation of neuron projection development	GO:0010975	161	0.025
nucleoside phosphate catabolic process	GO:1901292	140	0.024
tissue morphogenesis	GO:0048729	22	0.024	Mouse
neuron projection development	GO:0031175	273	0.024
peptide transport	GO:0015833	97	0.024
growth	GO:0040007	165	0.024
positive regulation of cell death	GO:0010942	184	0.024
regeneration	GO:0031099	163	0.023
cellular ketone metabolic process	GO:0042180	51	0.023
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.023
positive regulation of secretion by cell	GO:1903532	128	0.023
hormone transport	GO:0009914	121	0.023
locomotion	GO:0040011	237	0.023	Worm
nucleoside metabolic process	GO:0009116	179	0.023
inflammatory response	GO:0006954	150	0.022
glycoprotein biosynthetic process	GO:0009101	19	0.022
cyclic nucleotide biosynthetic process	GO:0009190	63	0.022
cellular response to tumor necrosis factor	GO:0071356	46	0.022
cellular component movement	GO:0006928	248	0.022
organonitrogen compound catabolic process	GO:1901565	179	0.022
detection of stimulus	GO:0051606	24	0.022
positive regulation of molecular function	GO:0044093	230	0.022
head development	GO:0060322	247	0.022	Human Mouse Rat
positive regulation of cell development	GO:0010720	176	0.022	Rat
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.021	Mouse Rat
purine ribonucleoside catabolic process	GO:0046130	124	0.021
purine nucleotide catabolic process	GO:0006195	136	0.021
response to food	GO:0032094	27	0.021
cell growth	GO:0016049	104	0.021
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.021
salivary gland development	GO:0007431	3	0.021
cellular chemical homeostasis	GO:0055082	247	0.021	Rat
organic cyclic compound catabolic process	GO:1901361	175	0.021
protein secretion	GO:0009306	34	0.020
nucleoside triphosphate metabolic process	GO:0009141	144	0.020
multicellular organism reproduction	GO:0032504	233	0.020
purine ribonucleoside metabolic process	GO:0046128	168	0.020
hormone metabolic process	GO:0042445	69	0.020
negative regulation of neurogenesis	GO:0050768	78	0.020
oxoacid metabolic process	GO:0043436	290	0.020
positive regulation of developmental process	GO:0051094	283	0.020	Rat
positive regulation of transport	GO:0051050	245	0.020
liver development	GO:0001889	90	0.020
regulation of gtpase activity	GO:0043087	57	0.020
oxidation reduction process	GO:0055114	304	0.020
positive regulation of phosphorus metabolic process	GO:0010562	262	0.020
axis specification	GO:0009798	4	0.020
response to oxygen levels	GO:0070482	265	0.019
regulation of rna metabolic process	GO:0051252	391	0.019
reproductive system development	GO:0061458	128	0.019
nucleoside phosphate metabolic process	GO:0006753	283	0.019
response to hypoxia	GO:0001666	231	0.019
divalent metal ion transport	GO:0070838	132	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.019
cellular response to nitrogen compound	GO:1901699	210	0.019	Worm
regulation of transcription dna templated	GO:0006355	374	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.019
positive regulation of nervous system development	GO:0051962	178	0.019	Rat
homeostatic process	GO:0042592	331	0.018	Rat
striated muscle contraction	GO:0006941	44	0.018
amide transport	GO:0042886	105	0.018
regulation of anatomical structure size	GO:0090066	135	0.018
regulation of programmed cell death	GO:0043067	341	0.018	Rat
cation transport	GO:0006812	382	0.018
glycosyl compound catabolic process	GO:1901658	126	0.018
cellular cation homeostasis	GO:0030003	180	0.018
response to wounding	GO:0009611	254	0.018
multicellular organismal reproductive process	GO:0048609	233	0.018
chemical homeostasis	GO:0048878	292	0.018	Rat
small molecule catabolic process	GO:0044282	59	0.018
regulation of hormone secretion	GO:0046883	106	0.018
protein phosphorylation	GO:0006468	345	0.018
cellular response to abiotic stimulus	GO:0071214	85	0.018
sensory perception of light stimulus	GO:0050953	3	0.017
central nervous system development	GO:0007417	311	0.017	Human Mouse Rat
nucleoside catabolic process	GO:0009164	126	0.017
heart process	GO:0003015	57	0.017
epithelial cell proliferation	GO:0050673	54	0.017	Rat
organophosphate biosynthetic process	GO:0090407	143	0.017
development of primary sexual characteristics	GO:0045137	107	0.017
regulation of cellular protein metabolic process	GO:0032268	267	0.017
regulation of cell differentiation	GO:0045595	320	0.017	Rat
positive regulation of transferase activity	GO:0051347	81	0.017
regulation of intracellular signal transduction	GO:1902531	218	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.017	Mouse Rat
negative regulation of cellular component organization	GO:0051129	83	0.017
positive regulation of transcription dna templated	GO:0045893	197	0.017	Zebrafish Mouse Rat
peptidyl amino acid modification	GO:0018193	126	0.017
cellular potassium ion transport	GO:0071804	72	0.017
glycosyl compound metabolic process	GO:1901657	182	0.016
positive regulation of intracellular signal transduction	GO:1902533	138	0.016
carbohydrate derivative biosynthetic process	GO:1901137	124	0.016
embryonic pattern specification	GO:0009880	1	0.016
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.016	Mouse
potassium ion transmembrane transport	GO:0071805	71	0.016
negative regulation of transport	GO:0051051	136	0.016
positive regulation of cell proliferation	GO:0008284	249	0.016	Rat
regulation of purine nucleotide metabolic process	GO:1900542	115	0.016
transcription from rna polymerase ii promoter	GO:0006366	252	0.016	Mouse Rat
regulation of phosphorylation	GO:0042325	248	0.016
spermatogenesis	GO:0007283	99	0.016
purine containing compound metabolic process	GO:0072521	253	0.016
regulation of ion transmembrane transport	GO:0034765	121	0.016
regulation of transferase activity	GO:0051338	123	0.016
organ regeneration	GO:0031100	101	0.016
organelle organization	GO:0006996	266	0.016
regulation of potassium ion transport	GO:0043266	29	0.016
monovalent inorganic cation homeostasis	GO:0055067	36	0.015
cell cell signaling	GO:0007267	335	0.015
regulation of cell projection organization	GO:0031344	175	0.015
establishment of protein localization	GO:0045184	141	0.015
s shaped body morphogenesis	GO:0072050	2	0.015
ribonucleoside metabolic process	GO:0009119	174	0.015
regulation of protein modification process	GO:0031399	194	0.015
regulation of homeostatic process	GO:0032844	101	0.015
negative regulation of transcription dna templated	GO:0045892	116	0.015
negative regulation of developmental process	GO:0051093	125	0.015
developmental growth	GO:0048589	100	0.015
purine containing compound catabolic process	GO:0072523	138	0.015
chemotaxis	GO:0006935	66	0.015
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.015
regulation of cellular amino acid metabolic process	GO:0006521	2	0.015
cellular amine metabolic process	GO:0044106	38	0.015
single organism organelle organization	GO:1902589	180	0.015
actin filament based process	GO:0030029	86	0.015
cytosolic calcium ion homeostasis	GO:0051480	140	0.015
calcium ion transport	GO:0006816	131	0.015
male gamete generation	GO:0048232	99	0.015
response to radiation	GO:0009314	137	0.015
regulation of nucleotide catabolic process	GO:0030811	65	0.015
nucleoside triphosphate catabolic process	GO:0009143	123	0.015
regulation of cellular ketone metabolic process	GO:0010565	27	0.015
cytoplasmic transport	GO:0016482	115	0.015	Rat
negative regulation of rna metabolic process	GO:0051253	123	0.014
regulation of protein phosphorylation	GO:0001932	183	0.014
transmission of nerve impulse	GO:0019226	42	0.014
positive regulation of protein modification process	GO:0031401	142	0.014
regulation of system process	GO:0044057	208	0.014
circadian rhythm	GO:0007623	88	0.014
proteolysis	GO:0006508	175	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.014
regulation of nucleoside metabolic process	GO:0009118	66	0.014
circulatory system development	GO:0072359	134	0.014
response to metal ion	GO:0010038	253	0.014
regulation of purine nucleotide catabolic process	GO:0033121	65	0.014
multi organism reproductive process	GO:0044703	262	0.014
organic acid metabolic process	GO:0006082	292	0.013
blood circulation	GO:0008015	183	0.013
regulation of protein secretion	GO:0050708	28	0.013
regulation of angiogenesis	GO:0045765	39	0.013
macromolecular complex subunit organization	GO:0043933	339	0.013
regulation of insulin secretion	GO:0050796	65	0.013
response to transition metal nanoparticle	GO:1990267	122	0.013
male sex differentiation	GO:0046661	64	0.013
negative regulation of multicellular organismal process	GO:0051241	203	0.013
immune system process	GO:0002376	204	0.013
positive regulation of neuron differentiation	GO:0045666	126	0.013	Rat
cell cycle	GO:0007049	101	0.013
regulation of organelle organization	GO:0033043	80	0.013
cellular protein localization	GO:0034613	122	0.013
organic substance catabolic process	GO:1901575	316	0.013
rho protein signal transduction	GO:0007266	11	0.013
organic acid biosynthetic process	GO:0016053	83	0.013
negative regulation of secretion	GO:0051048	82	0.013
peptide hormone secretion	GO:0030072	84	0.013
response to peptide	GO:1901652	292	0.013	Worm
gonad development	GO:0008406	104	0.013
response to growth factor	GO:0070848	189	0.013	Rat
regulation of kinase activity	GO:0043549	117	0.013
multicellular organismal signaling	GO:0035637	44	0.013
response to purine containing compound	GO:0014074	126	0.013
nucleobase containing compound catabolic process	GO:0034655	152	0.013
nucleotide catabolic process	GO:0009166	139	0.013
ribonucleotide metabolic process	GO:0009259	231	0.012
positive regulation of phosphate metabolic process	GO:0045937	262	0.012
membrane organization	GO:0061024	94	0.012
insulin secretion	GO:0030073	69	0.012
regulation of cellular amine metabolic process	GO:0033238	8	0.012
positive regulation of cell differentiation	GO:0045597	217	0.012	Rat
guanosine containing compound catabolic process	GO:1901069	71	0.012
circulatory system process	GO:0003013	183	0.012
regulation of cellular catabolic process	GO:0031329	101	0.012
tissue remodeling	GO:0048771	40	0.012
positive regulation of neurogenesis	GO:0050769	165	0.012	Rat
purine nucleotide biosynthetic process	GO:0006164	83	0.012
positive regulation of phosphorylation	GO:0042327	177	0.012
gtp metabolic process	GO:0046039	72	0.012
calcium ion transmembrane transport	GO:0070588	70	0.012
cellular nitrogen compound catabolic process	GO:0044270	163	0.012
phospholipid metabolic process	GO:0006644	61	0.012
alpha amino acid biosynthetic process	GO:1901607	23	0.012
positive regulation of cellular catabolic process	GO:0031331	71	0.012
carboxylic acid metabolic process	GO:0019752	289	0.012
signal release	GO:0023061	145	0.012
positive regulation of microtubule polymerization or depolymerization	GO:0031112	7	0.012
eye morphogenesis	GO:0048592	4	0.012	Mouse
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	3	0.012
microtubule based process	GO:0007017	36	0.012
nucleic acid templated transcription	GO:0097659	379	0.012
visual perception	GO:0007601	3	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	48	0.011
sex differentiation	GO:0007548	113	0.011
cardiac muscle contraction	GO:0060048	27	0.011
response to acid chemical	GO:0001101	222	0.011
negative regulation of macromolecule metabolic process	GO:0010605	260	0.011
potassium ion transport	GO:0006813	97	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
regulation of cell growth	GO:0001558	85	0.011
metanephric glomerulus development	GO:0072224	3	0.011
response to light stimulus	GO:0009416	52	0.011
negative regulation of cell development	GO:0010721	82	0.011
cellular response to mechanical stimulus	GO:0071260	48	0.011
positive regulation of cellular amine metabolic process	GO:0033240	3	0.011
cellular component biogenesis	GO:0044085	368	0.011
lung development	GO:0030324	43	0.011
cellular carbohydrate metabolic process	GO:0044262	72	0.011
retina development in camera type eye	GO:0060041	27	0.011	Mouse Rat
regulation of actin filament based process	GO:0032970	42	0.011
regulation of anatomical structure morphogenesis	GO:0022603	141	0.011
gamete generation	GO:0007276	124	0.011
positive regulation of neuron death	GO:1901216	43	0.011
positive regulation of apoptotic process	GO:0043065	154	0.011
positive regulation of gene expression	GO:0010628	244	0.011	Zebrafish Mouse Rat
negative regulation of intracellular estrogen receptor signaling pathway	GO:0033147	2	0.011
carbohydrate metabolic process	GO:0005975	130	0.011
behavior	GO:0007610	205	0.011
metanephric comma shaped body morphogenesis	GO:0072278	2	0.011
microtubule cytoskeleton organization	GO:0000226	25	0.011
regulation of calcium ion transport	GO:0051924	77	0.011
response to hyperoxia	GO:0055093	45	0.011
response to starvation	GO:0042594	59	0.010
positive regulation of appetite	GO:0032100	2	0.010
negative regulation of biosynthetic process	GO:0009890	168	0.010
amine metabolic process	GO:0009308	38	0.010
jak stat cascade	GO:0007259	26	0.010
micturition	GO:0060073	4	0.010
nucleoside phosphate biosynthetic process	GO:1901293	102	0.010
muscle system process	GO:0003012	115	0.010
regulation of vasculature development	GO:1901342	44	0.010
cellular response to stress	GO:0033554	269	0.010
renal system development	GO:0072001	67	0.010
cellular response to growth factor stimulus	GO:0071363	162	0.010	Rat
cellular response to steroid hormone stimulus	GO:0071383	93	0.010
aging	GO:0007568	241	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.010
mapk cascade	GO:0000165	140	0.010
olfactory behavior	GO:0042048	2	0.010
response to temperature stimulus	GO:0009266	94	0.010
defense response to gram negative bacterium	GO:0050829	3	0.010

Ptf1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.018
urinary system disease	DOID:18	0.014
disease of anatomical entity	DOID:7	0.014
kidney disease	DOID:557	0.014
renal tubular transport disease	DOID:447	0.014

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