Rattus norvegicus

415 known processes

Ptgs2

prostaglandin-endoperoxide synthase 2

(Aliases: Cox2,COX-2)

Ptgs2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to glucocorticoidGO:00513842230.854
cellular response to peptideGO:19016531330.706
response to nutrientGO:00075842480.689
multi multicellular organism processGO:00447061380.671
response to corticosteroidGO:00319602350.643
single organism reproductive processGO:00447022970.609
response to peptideGO:19016522920.608
cellular response to peptide hormone stimulusGO:00713751200.562
response to vitamin dGO:0033280340.545
cellular response to endogenous stimulusGO:00714953770.518
response to purine containing compoundGO:00140741260.463
response to extracellular stimulusGO:00099913800.442
response to peptide hormoneGO:00434342780.439
reproductive processGO:00224143720.420
behaviorGO:00076102050.409
cellular response to oxygen containing compoundGO:19017013860.406
cellular response to organic cyclic compoundGO:00714072020.367
positive regulation of cellular component movementGO:00512721020.362
response to nutrient levelsGO:00316673700.352
response to campGO:0051591910.344
response to heatGO:0009408600.343
positive regulation of cell motilityGO:2000147970.328
response to vitaminGO:00332731310.320
cellular response to insulin stimulusGO:0032869810.295
carboxylic acid metabolic processGO:00197522890.283
response to organophosphorusGO:00466831020.282
response to inorganic substanceGO:00100353770.282
regulation of programmed cell deathGO:00430673410.279
cellular response to hormone stimulusGO:00328702470.276
intracellular signal transductionGO:00355563140.264
reproductionGO:00000032450.259
response to estradiolGO:00323551640.256
regulation of neuron differentiationGO:00456642080.255
response to insulinGO:00328681330.252
response to hydrogen peroxideGO:0042542890.251
regulation of cellular component movementGO:00512701500.245
positive regulation of fever generationGO:003162250.243
response to dexamethasoneGO:0071548490.236
cellular component movementGO:00069282480.232
negative regulation of cell deathGO:00605482290.229
agingGO:00075682410.229
Rat
cellular response to cytokine stimulusGO:00713451270.226
positive regulation of transportGO:00510502450.215
negative regulation of signalingGO:00230571570.211
positive regulation of cell migrationGO:0030335960.208
response to estrogenGO:00436272320.207
cellular response to interleukin 1GO:0071347370.201
response to oxidative stressGO:00069791860.201
regulation of signal transductionGO:00099663180.200
myeloid leukocyte migrationGO:0097529200.196
positive regulation of developmental processGO:00510942830.194
cellular response to organonitrogen compoundGO:00714171970.192
response to antibioticGO:0046677390.188
response to growth factorGO:00708481890.188
response to lipopolysaccharideGO:00324961910.187
regulation of cell proliferationGO:00421273590.186
regulation of nucleic acid templated transcriptionGO:19035063800.185
cellular response to reactive oxygen speciesGO:0034614550.182
cell cycleGO:00070491010.181
cellular response to stressGO:00335542690.179
Human
positive regulation of cellular biosynthetic processGO:00313282950.178
regulation of system processGO:00440572080.175
transcription dna templatedGO:00063513770.173
negative regulation of gene expressionGO:00106291990.170
anatomical structure morphogenesisGO:00096532980.169
multicellular organism reproductionGO:00325042330.165
multi organism reproductive processGO:00447032620.164
regulation of cell differentiationGO:00455953200.163
Mouse
single organism behaviorGO:00447081300.162
response to potassium ionGO:003586490.161
cellular response to lipidGO:00713962010.160
response to alkaloidGO:00432791320.159
positive regulation of signalingGO:00230562700.158
regulation of rna metabolic processGO:00512523910.158
apoptotic processGO:00069153810.155
positive regulation of intracellular protein transportGO:0090316200.155
negative regulation of metabolic processGO:00098923310.154
positive regulation of response to stimulusGO:00485842850.154
cell growthGO:00160491040.149
response to carbohydrateGO:00097431830.149
response to cytokineGO:00340972150.148
cellular component morphogenesisGO:00329891550.147
response to reactive oxygen speciesGO:00003021200.146
negative regulation of cellular metabolic processGO:00313242810.145
placenta developmentGO:0001890220.144
response to decreased oxygen levelsGO:00362932370.144
Human
regulation of nervous system developmentGO:00519602640.143
developmental process involved in reproductionGO:00030061590.143
response to temperature stimulusGO:0009266940.141
multicellular organismal reproductive processGO:00486092330.140
positive regulation of locomotionGO:00400171020.138
nucleic acid templated transcriptionGO:00976593790.136
regulation of ossificationGO:0030278320.136
regulation of rna biosynthetic processGO:20011413810.133
gonad developmentGO:00084061040.132
cellular response to corticosteroid stimulusGO:0071384690.131
regulation of transcription dna templatedGO:00063553740.130
acute phase responseGO:0006953200.129
regulation of cellular protein metabolic processGO:00322682670.128
cellular response to external stimulusGO:00714961180.127
organ morphogenesisGO:0009887750.126
regulation of neurogenesisGO:00507672470.126
response to mechanical stimulusGO:00096121340.124
cellular ketone metabolic processGO:0042180510.122
response to woundingGO:00096112540.122
regulation of cell developmentGO:00602842630.121
neurological system processGO:00508772190.118
rna metabolic processGO:00160704060.118
cellular response to molecule of bacterial originGO:0071219560.117
cellular response to nitrogen compoundGO:19016992100.117
regulation of chemotaxisGO:0050920290.117
response to interleukin 1GO:0070555550.117
female pregnancyGO:00075651220.114
regulation of neuron projection developmentGO:00109751610.114
positive regulation of cellular amino acid metabolic processGO:004576410.114
central nervous system developmentGO:00074173110.114
metal ion transportGO:00300012890.114
positive regulation of transcription factor import into nucleusGO:004299340.113
response to toxic substanceGO:00096361330.113
regulation of intracellular signal transductionGO:19025312180.111
reproductive system developmentGO:00614581280.108
regulation of cellular component organizationGO:00511283680.107
positive regulation of cellular amine metabolic processGO:003324030.104
neuron developmentGO:00486662860.103
negative regulation of protein metabolic processGO:00512481140.102
cell motilityGO:00488702020.101
growthGO:00400071650.099
negative regulation of apoptotic processGO:00430661810.098
taxisGO:0042330670.097
cellular response to ketoneGO:1901655510.097
secretionGO:00469033070.097
Rat
stress activated protein kinase signaling cascadeGO:0031098370.097
cellular response to growth factor stimulusGO:00713631620.096
cellular response to alcoholGO:0097306870.096
regulation of transcription from rna polymerase ii promoterGO:00063572340.095
response to biotic stimulusGO:00096072260.095
regulation of hormone levelsGO:00108171870.095
Rat
female gonad developmentGO:0008585530.094
response to hexoseGO:00097461440.093
calcium ion homeostasisGO:00550741620.093
organic acid metabolic processGO:00060822920.093
neuron projection developmentGO:00311752730.093
regulation of phosphorylationGO:00423252480.091
programmed cell deathGO:00125013920.090
tissue developmentGO:00098882520.088
cellular response to oxidative stressGO:0034599760.088
negative regulation of cell communicationGO:00106481580.087
regulation of cellular ketone metabolic processGO:0010565270.086
response to metal ionGO:00100382530.086
regulation of cell migrationGO:00303341280.084
regulation of protein metabolic processGO:00512462890.084
cellular homeostasisGO:00197252520.084
regulation of multicellular organismal developmentGO:20000263760.082
cellular response to steroid hormone stimulusGO:0071383930.082
negative regulation of macromolecule metabolic processGO:00106052600.081
maternal process involved in female pregnancyGO:0060135380.081
response to acid chemicalGO:00011012220.081
negative regulation of cellular protein metabolic processGO:00322691060.081
sodium ion transportGO:0006814820.078
regulation of molecular functionGO:00650093980.077
macromolecular complex subunit organizationGO:00439333390.077
negative regulation of cellular biosynthetic processGO:00313271610.077
positive regulation of erk1 and erk2 cascadeGO:0070374290.076
positive regulation of cell communicationGO:00106472710.076
neuron differentiationGO:00301823680.075
positive regulation of cell proliferationGO:00082842490.074
response to ethanolGO:00454711620.074
rna biosynthetic processGO:00327743800.074
positive regulation of nucleocytoplasmic transportGO:0046824170.073
oxoacid metabolic processGO:00434362900.072
mapk cascadeGO:00001651400.071
cation homeostasisGO:00550801950.071
secretion by cellGO:00329402480.071
Rat
response to oxygen levelsGO:00704822650.071
Human
response to molecule of bacterial originGO:00022371940.070
response to ketoneGO:19016541820.069
Rat
positive regulation of biosynthetic processGO:00098913190.069
regulation of immune system processGO:00026821230.068
single organism catabolic processGO:00447122830.068
cellular amine metabolic processGO:0044106380.068
negative regulation of biosynthetic processGO:00098901680.066
cellular response to lipopolysaccharideGO:0071222550.066
response to monosaccharideGO:00342841590.066
negative regulation of gluconeogenesisGO:004572110.065
cellular response to glucocorticoid stimulusGO:0071385680.065
cell projection organizationGO:00300303020.065
positive regulation of nitrogen compound metabolic processGO:00511733340.065
cellular cation homeostasisGO:00300031800.064
transmembrane transportGO:00550854120.062
chemical homeostasisGO:00488782920.062
cardiovascular system developmentGO:00723581340.061
regulation of erk1 and erk2 cascadeGO:0070372410.060
blood circulationGO:00080151830.060
regulation of cellular amino acid metabolic processGO:000652120.060
cellular chemical homeostasisGO:00550822470.059
macromolecule localizationGO:00330362520.059
response to bacteriumGO:00096172000.059
macromolecular complex assemblyGO:00650032730.058
localization of cellGO:00516742020.058
reproductive structure developmentGO:00486081280.058
regulation of apoptotic processGO:00429813350.057
positive regulation of macromolecule biosynthetic processGO:00105572470.057
gastrulationGO:000736920.057
regulation of phosphate metabolic processGO:00192203490.057
circulatory system processGO:00030131830.056
response to radiationGO:00093141370.056
regenerationGO:00310991630.056
negative regulation of rna biosynthetic processGO:19026791180.056
cellular response to biotic stimulusGO:0071216590.056
organelle organizationGO:00069962660.056
nucleocytoplasmic transportGO:0006913480.056
negative regulation of programmed cell deathGO:00430691830.055
regulation of behaviorGO:0050795610.055
positive regulation of cellular component organizationGO:00511302000.055
negative regulation of cell proliferationGO:00082851190.055
protein complex assemblyGO:00064612630.055
blood vessel developmentGO:0001568690.055
developmental growthGO:00485891000.054
regulation of homeostatic processGO:00328441010.054
regulation of cellular localizationGO:00603412630.054
cellular calcium ion homeostasisGO:00068741600.053
regulation of organelle organizationGO:0033043800.053
positive regulation of nucleobase containing compound metabolic processGO:00459353190.052
formation of primary germ layerGO:000170410.052
stress activated mapk cascadeGO:0051403350.051
regulation of cellular amine metabolic processGO:003323880.050
homeostatic processGO:00425923310.050
muscle cell proliferationGO:0033002840.050
positive regulation of rna metabolic processGO:00512542030.050
erk1 and erk2 cascadeGO:0070371480.049
positive regulation of multicellular organismal processGO:00512403870.049
cellular divalent inorganic cation homeostasisGO:00725031620.048
mesoderm formationGO:000170710.048
protein complex biogenesisGO:00702712630.048
positive regulation of chemotaxisGO:0050921230.048
muscle system processGO:00030121150.048
regulation of jnk cascadeGO:0046328190.047
cytokine mediated signaling pathwayGO:0019221430.047
regulation of protein transportGO:0051223680.047
single organism intracellular transportGO:19025821660.047
embryo implantationGO:0007566150.046
gamete generationGO:00072761240.046
metal ion homeostasisGO:00550651860.046
regulation of hydrolase activityGO:00513361430.046
cell morphogenesisGO:00009021420.045
transcription from rna polymerase ii promoterGO:00063662520.045
response to hypoxiaGO:00016662310.045
Human
regulation of protein maturationGO:1903317500.045
cellular response to extracellular stimulusGO:0031668730.045
negative regulation of neuron apoptotic processGO:0043524450.044
epithelium developmentGO:0060429960.044
Mouse
cognitionGO:0050890920.044
sexual reproductionGO:00199531480.043
leukocyte chemotaxisGO:0030595220.043
chemotaxisGO:0006935660.043
rhythmic processGO:00485111560.043
cellular response to tumor necrosis factorGO:0071356460.043
leukocyte migrationGO:0050900380.043
oxidation reduction processGO:00551143040.043
response to amineGO:0014075460.043
regulation of protein processingGO:0070613500.042
development of primary sexual characteristicsGO:00451371070.042
negative regulation of cellular carbohydrate metabolic processGO:001067770.042
positive regulation of rna biosynthetic processGO:19026801970.042
head developmentGO:00603222470.042
negative regulation of developmental processGO:00510931250.041
negative regulation of molecular functionGO:00440921330.041
learning or memoryGO:0007611900.041
negative regulation of macromolecule biosynthetic processGO:00105581480.041
regulation of cell motilityGO:20001451310.041
protein complex subunit organizationGO:00718223020.041
brain developmentGO:00074202470.041
cellular response to oxygen levelsGO:0071453600.040
Human
positive regulation of phosphate metabolic processGO:00459372620.040
glucose homeostasisGO:0042593750.040
regulation of cellular catabolic processGO:00313291010.040
reactive oxygen species metabolic processGO:0072593370.040
regulation of phosphorus metabolic processGO:00511743490.040
cellular response to abiotic stimulusGO:0071214850.039
response to amphetamineGO:0001975250.039
g protein coupled receptor signaling pathwayGO:00071862420.039
carbohydrate homeostasisGO:0033500750.039
response to insecticideGO:0017085210.039
positive regulation of leukocyte migrationGO:0002687210.039
inflammatory responseGO:00069541500.039
protein phosphorylationGO:00064683450.039
positive regulation of response to external stimulusGO:0032103510.039
axon developmentGO:0061564960.039
jnk cascadeGO:0007254280.038
positive regulation of cytosolic calcium ion concentrationGO:00072041220.038
maintenance of locationGO:0051235170.038
neuron deathGO:00709971270.038
positive regulation of gene expressionGO:00106282440.038
positive regulation of cellular protein metabolic processGO:00322701670.038
cellular metal ion homeostasisGO:00068751720.038
cellular response to atpGO:007131850.038
single organism nuclear importGO:1902593350.038
ovulation cycle processGO:0022602500.037
positive regulation of cell differentiationGO:00455972170.037
Mouse
positive regulation of phosphorylationGO:00423271770.037
cellular ion homeostasisGO:00068731840.037
reactive oxygen species biosynthetic processGO:190340980.037
gland developmentGO:00487321550.037
positive regulation of neurogenesisGO:00507691650.037
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.036
negative regulation of transcription dna templatedGO:00458921160.036
neuromuscular processGO:005090520.036
signal transduction by phosphorylationGO:00230141440.036
positive regulation of protein kinase b signalingGO:0051897100.035
response to ammonium ionGO:0060359710.035
protein importGO:0017038370.035
regulation of acute inflammatory responseGO:0002673230.035
response to tumor necrosis factorGO:0034612560.035
intracellular transportGO:00469071850.035
cellular response to drugGO:0035690300.034
regulation of secretion by cellGO:19035302080.034
Rat
regulation of leukocyte migrationGO:0002685240.034
cellular response to interferon gammaGO:0071346140.034
cellular component assemblyGO:00226073600.034
muscle structure developmentGO:0061061870.034
immune system processGO:00023762040.034
digestive system developmentGO:0055123410.034
positive regulation of immune system processGO:0002684900.034
locomotionGO:00400112370.033
pyruvate metabolic processGO:0006090270.033
acute inflammatory responseGO:0002526580.033
development of primary female sexual characteristicsGO:0046545560.033
regulation of establishment of protein localizationGO:0070201690.033
nuclear transportGO:0051169490.033
divalent inorganic cation homeostasisGO:00725071650.033
response to glucoseGO:00097491360.033
positive regulation of nervous system developmentGO:00519621780.033
negative regulation of protein maturationGO:1903318470.033
negative regulation of peptidase activityGO:0010466380.033
negative regulation of nitrogen compound metabolic processGO:00511721610.032
cellular response to nutrient levelsGO:0031669600.032
single organism biosynthetic processGO:00447113420.032
amine metabolic processGO:0009308380.032
purine containing compound metabolic processGO:00725212530.032
response to corticosteroneGO:0051412400.032
Rat
regulation of blood circulationGO:19035221100.032
cell migrationGO:00164771970.032
positive regulation of neuron differentiationGO:00456661260.031
single organism organelle organizationGO:19025891800.031
cellular amino acid metabolic processGO:00065201070.031
anatomical structure formation involved in morphogenesisGO:0048646830.031
ion homeostasisGO:00508012120.031
cell chemotaxisGO:0060326310.031
protein processingGO:0016485680.031
response to coldGO:0009409290.030
vesicle mediated transportGO:00161921810.030
regulation of cell growthGO:0001558850.030
mesoderm developmentGO:000749820.030
protein targeting to nucleusGO:0044744350.030
cell morphogenesis involved in neuron differentiationGO:00486671060.030
cytoplasmic transportGO:00164821150.030
positive regulation of intracellular signal transductionGO:19025331380.030
negative regulation of neuron deathGO:1901215690.030
reactive nitrogen species metabolic processGO:200105710.030
female sex differentiationGO:0046660590.030
positive regulation of homeostatic processGO:0032846490.030
fever generationGO:000166090.029
organonitrogen compound catabolic processGO:19015651790.029
dibenzo p dioxin metabolic processGO:0018894100.029
muscle contractionGO:0006936880.029
carboxylic acid biosynthetic processGO:0046394830.029
regulation of reactive oxygen species biosynthetic processGO:190342650.029
establishment of protein localizationGO:00451841410.029
negative regulation of endopeptidase activityGO:0010951360.029
response to other organismGO:00517072200.028
memoryGO:0007613540.028
mitotic cell cycleGO:0000278490.028
response to activityGO:0014823730.028
regulation of nucleocytoplasmic transportGO:0046822280.028
regulation of peptide transportGO:0090087870.028
response to low density lipoprotein particleGO:005509840.028
cellular response to nutrientGO:0031670300.028
divalent inorganic cation transportGO:00725111340.028
regulation of neuron deathGO:19012141150.028
endoplasmic reticulum to cytosol transportGO:190351340.028
negative regulation of multicellular organismal processGO:00512412030.028
sequestering of metal ionGO:005123890.028
positive regulation of keratinocyte migrationGO:005154920.028
peptidyl amino acid modificationGO:00181931260.028
regulation of protein localizationGO:0032880810.027
carbohydrate derivative metabolic processGO:19011353460.027
ras protein signal transductionGO:0007265290.027
small gtpase mediated signal transductionGO:0007264360.027
decidualizationGO:0046697140.027
protein localizationGO:00081041910.027
sex differentiationGO:00075481130.027
response to external biotic stimulusGO:00432072210.027
cation transportGO:00068123820.027
regulation of cell projection organizationGO:00313441750.027
actin filament based processGO:0030029860.027
central nervous system neuron axonogenesisGO:002195510.027
cellular response to dexamethasone stimulusGO:0071549360.027
gliogenesisGO:0042063930.027
steroid metabolic processGO:0008202730.026
response to calcium ionGO:0051592590.026
regulation of anatomical structure morphogenesisGO:00226031410.026
positive regulation of ion transportGO:0043270940.026
organic substance catabolic processGO:19015753160.025
positive regulation of cell developmentGO:00107201760.025
cellular catabolic processGO:00442482950.025
cellular hormone metabolic processGO:0034754490.025
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.025
positive regulation of nf kappab import into nucleusGO:004234620.025
wound healingGO:00420601220.025
regulation of locomotionGO:00400121480.025
regulation of catabolic processGO:00098941130.025
regulation of heat generationGO:003165080.024
regulation of angiogenesisGO:0045765390.024
ossificationGO:0001503700.024
positive regulation of cell deathGO:00109421840.024
cellular response to low density lipoprotein particle stimulusGO:007140430.024
negative regulation of protein processingGO:0010955470.024
cellular macromolecular complex assemblyGO:0034622580.024
anion transportGO:00068201780.024
organic anion transportGO:00157111320.024
heart morphogenesisGO:000300730.024
cellular response to hypoxiaGO:0071456510.024
Human
tube developmentGO:0035295890.023
response to transforming growth factor betaGO:0071559460.023
regulation of mapk cascadeGO:00434081160.023
sequestering of calcium ionGO:005120880.023
positive regulation of reactive oxygen species biosynthetic processGO:190342820.023
nuclear importGO:0051170350.023
positive regulation of protein transportGO:0051222410.023
regulation of leukocyte chemotaxisGO:0002688120.023
mesoderm morphogenesisGO:004833210.023
catabolic processGO:00090563510.023
positive regulation of leukocyte chemotaxisGO:0002690100.023
regulation of cell cycleGO:0051726730.023
positive regulation of organelle organizationGO:0010638480.023
hormone metabolic processGO:0042445690.023
retina morphogenesis in camera type eyeGO:006004210.023
positive regulation of signal transductionGO:00099671750.023
heart contractionGO:0060047570.023
monocarboxylic acid metabolic processGO:00327871520.023
regulation of monocyte chemotaxisGO:009002530.022
cellular response to transforming growth factor beta stimulusGO:0071560410.022
positive regulation of fat cell differentiationGO:004560020.022
Mouse
cellular response to hydrogen peroxideGO:0070301420.022
generation of precursor metabolites and energyGO:0006091620.022
carbohydrate catabolic processGO:0016052400.022
dephosphorylationGO:0016311980.022
ribonucleotide catabolic processGO:00092611360.022
enzyme linked receptor protein signaling pathwayGO:00071671160.022
response to fibroblast growth factorGO:0071774290.022
negative regulation of nucleobase containing compound metabolic processGO:00459341530.021
regulation of stress activated mapk cascadeGO:0032872230.021
regulation of catalytic activityGO:00507903040.021
positive regulation of cell growthGO:0030307440.021
response to electrical stimulusGO:0051602560.021
cytosolic calcium ion homeostasisGO:00514801400.021
ovulationGO:0030728170.021
establishment of protein localization to organelleGO:0072594440.021
response to retinoic acidGO:0032526630.021
peptidyl tyrosine phosphorylationGO:0018108720.021
regulation of protein phosphorylationGO:00019321830.021
regulation of metal ion transportGO:00109591180.021
proteolysisGO:00065081750.021
multicellular organismal signalingGO:0035637440.021
positive regulation of neuron projection developmentGO:0010976990.021
positive regulation of behaviorGO:0048520380.020
response to nicotineGO:0035094510.020
neuron apoptotic processGO:0051402880.020
response to light stimulusGO:0009416520.020
dna metabolic processGO:0006259960.020
tissue regenerationGO:0042246360.020
chemosensory behaviorGO:000763520.020
positive regulation of nitric oxide biosynthetic processGO:0045429140.020
regulation of ion transportGO:00432692450.020
response to osmotic stressGO:0006970420.020
regulation of protein complex assemblyGO:0043254330.020
protein maturationGO:0051604680.020
cellular response to acid chemicalGO:0071229750.020
anterior posterior pattern specificationGO:000995210.020
peptide hormone secretionGO:0030072840.020
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.020
hormone transportGO:00099141210.020
Rat
organ regenerationGO:00311001010.019
endocytosisGO:0006897840.019
negative regulation of cell differentiationGO:0045596990.019
response to amino acidGO:0043200750.019
cellular response to hexose stimulusGO:0071331650.019
regulation of protein targetingGO:1903533280.019
monovalent inorganic cation transportGO:00156721720.019
jak stat cascadeGO:0007259260.019
regulation of protein modification processGO:00313991940.019
heart processGO:0003015570.019
negative regulation of nucleic acid templated transcriptionGO:19035071170.019
neuron projection morphogenesisGO:00488121220.019
digestive tract developmentGO:0048565390.019
embryo developmentGO:0009790490.019

Ptgs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.030
disease of cellular proliferationDOID:1456600.030
disease of metabolismDOID:001466700.020