IMP: Integrative Multi-species Prediction

Rattus norvegicus

415 known processes

Ptgs2

prostaglandin-endoperoxide synthase 2

(Aliases: Cox2,COX-2)

Entrez: 29527
Ensembl: ENSRNOG00000002525
RGD: 620349
UniProtKB: P35355

Process Predictions
Disease Predictions

Ptgs2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to glucocorticoid	GO:0051384	223	0.854
cellular response to peptide	GO:1901653	133	0.706
response to nutrient	GO:0007584	248	0.689
multi multicellular organism process	GO:0044706	138	0.671
response to corticosteroid	GO:0031960	235	0.643
single organism reproductive process	GO:0044702	297	0.609
response to peptide	GO:1901652	292	0.608
cellular response to peptide hormone stimulus	GO:0071375	120	0.562
response to vitamin d	GO:0033280	34	0.545
cellular response to endogenous stimulus	GO:0071495	377	0.518
response to purine containing compound	GO:0014074	126	0.463
response to extracellular stimulus	GO:0009991	380	0.442
response to peptide hormone	GO:0043434	278	0.439
reproductive process	GO:0022414	372	0.420
behavior	GO:0007610	205	0.409
cellular response to oxygen containing compound	GO:1901701	386	0.406
cellular response to organic cyclic compound	GO:0071407	202	0.367
positive regulation of cellular component movement	GO:0051272	102	0.362
response to nutrient levels	GO:0031667	370	0.352
response to camp	GO:0051591	91	0.344
response to heat	GO:0009408	60	0.343
positive regulation of cell motility	GO:2000147	97	0.328
response to vitamin	GO:0033273	131	0.320
cellular response to insulin stimulus	GO:0032869	81	0.295
carboxylic acid metabolic process	GO:0019752	289	0.283
response to organophosphorus	GO:0046683	102	0.282
response to inorganic substance	GO:0010035	377	0.282
regulation of programmed cell death	GO:0043067	341	0.279
cellular response to hormone stimulus	GO:0032870	247	0.276
intracellular signal transduction	GO:0035556	314	0.264
reproduction	GO:0000003	245	0.259
response to estradiol	GO:0032355	164	0.256
regulation of neuron differentiation	GO:0045664	208	0.255
response to insulin	GO:0032868	133	0.252
response to hydrogen peroxide	GO:0042542	89	0.251
regulation of cellular component movement	GO:0051270	150	0.245
positive regulation of fever generation	GO:0031622	5	0.243
response to dexamethasone	GO:0071548	49	0.236
cellular component movement	GO:0006928	248	0.232
negative regulation of cell death	GO:0060548	229	0.229
aging	GO:0007568	241	0.229	Rat
cellular response to cytokine stimulus	GO:0071345	127	0.226
positive regulation of transport	GO:0051050	245	0.215
negative regulation of signaling	GO:0023057	157	0.211
positive regulation of cell migration	GO:0030335	96	0.208
response to estrogen	GO:0043627	232	0.207
cellular response to interleukin 1	GO:0071347	37	0.201
response to oxidative stress	GO:0006979	186	0.201
regulation of signal transduction	GO:0009966	318	0.200
myeloid leukocyte migration	GO:0097529	20	0.196
positive regulation of developmental process	GO:0051094	283	0.194
cellular response to organonitrogen compound	GO:0071417	197	0.192
response to antibiotic	GO:0046677	39	0.188
response to growth factor	GO:0070848	189	0.188
response to lipopolysaccharide	GO:0032496	191	0.187
regulation of cell proliferation	GO:0042127	359	0.186
regulation of nucleic acid templated transcription	GO:1903506	380	0.185
cellular response to reactive oxygen species	GO:0034614	55	0.182
cell cycle	GO:0007049	101	0.181
cellular response to stress	GO:0033554	269	0.179	Human
positive regulation of cellular biosynthetic process	GO:0031328	295	0.178
regulation of system process	GO:0044057	208	0.175
transcription dna templated	GO:0006351	377	0.173
negative regulation of gene expression	GO:0010629	199	0.170
anatomical structure morphogenesis	GO:0009653	298	0.169
multicellular organism reproduction	GO:0032504	233	0.165
multi organism reproductive process	GO:0044703	262	0.164
regulation of cell differentiation	GO:0045595	320	0.163	Mouse
single organism behavior	GO:0044708	130	0.162
response to potassium ion	GO:0035864	9	0.161
cellular response to lipid	GO:0071396	201	0.160
response to alkaloid	GO:0043279	132	0.159
positive regulation of signaling	GO:0023056	270	0.158
regulation of rna metabolic process	GO:0051252	391	0.158
apoptotic process	GO:0006915	381	0.155
positive regulation of intracellular protein transport	GO:0090316	20	0.155
negative regulation of metabolic process	GO:0009892	331	0.154
positive regulation of response to stimulus	GO:0048584	285	0.154
cell growth	GO:0016049	104	0.149
response to carbohydrate	GO:0009743	183	0.149
response to cytokine	GO:0034097	215	0.148
cellular component morphogenesis	GO:0032989	155	0.147
response to reactive oxygen species	GO:0000302	120	0.146
negative regulation of cellular metabolic process	GO:0031324	281	0.145
placenta development	GO:0001890	22	0.144
response to decreased oxygen levels	GO:0036293	237	0.144	Human
regulation of nervous system development	GO:0051960	264	0.143
developmental process involved in reproduction	GO:0003006	159	0.143
response to temperature stimulus	GO:0009266	94	0.141
multicellular organismal reproductive process	GO:0048609	233	0.140
positive regulation of locomotion	GO:0040017	102	0.138
nucleic acid templated transcription	GO:0097659	379	0.136
regulation of ossification	GO:0030278	32	0.136
regulation of rna biosynthetic process	GO:2001141	381	0.133
gonad development	GO:0008406	104	0.132
cellular response to corticosteroid stimulus	GO:0071384	69	0.131
regulation of transcription dna templated	GO:0006355	374	0.130
acute phase response	GO:0006953	20	0.129
regulation of cellular protein metabolic process	GO:0032268	267	0.128
cellular response to external stimulus	GO:0071496	118	0.127
organ morphogenesis	GO:0009887	75	0.126
regulation of neurogenesis	GO:0050767	247	0.126
response to mechanical stimulus	GO:0009612	134	0.124
cellular ketone metabolic process	GO:0042180	51	0.122
response to wounding	GO:0009611	254	0.122
regulation of cell development	GO:0060284	263	0.121
neurological system process	GO:0050877	219	0.118
rna metabolic process	GO:0016070	406	0.118
cellular response to molecule of bacterial origin	GO:0071219	56	0.117
cellular response to nitrogen compound	GO:1901699	210	0.117
regulation of chemotaxis	GO:0050920	29	0.117
response to interleukin 1	GO:0070555	55	0.117
female pregnancy	GO:0007565	122	0.114
regulation of neuron projection development	GO:0010975	161	0.114
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.114
central nervous system development	GO:0007417	311	0.114
metal ion transport	GO:0030001	289	0.114
positive regulation of transcription factor import into nucleus	GO:0042993	4	0.113
response to toxic substance	GO:0009636	133	0.113
regulation of intracellular signal transduction	GO:1902531	218	0.111
reproductive system development	GO:0061458	128	0.108
regulation of cellular component organization	GO:0051128	368	0.107
positive regulation of cellular amine metabolic process	GO:0033240	3	0.104
neuron development	GO:0048666	286	0.103
negative regulation of protein metabolic process	GO:0051248	114	0.102
cell motility	GO:0048870	202	0.101
growth	GO:0040007	165	0.099
negative regulation of apoptotic process	GO:0043066	181	0.098
taxis	GO:0042330	67	0.097
cellular response to ketone	GO:1901655	51	0.097
secretion	GO:0046903	307	0.097	Rat
stress activated protein kinase signaling cascade	GO:0031098	37	0.097
cellular response to growth factor stimulus	GO:0071363	162	0.096
cellular response to alcohol	GO:0097306	87	0.096
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.095
response to biotic stimulus	GO:0009607	226	0.095
regulation of hormone levels	GO:0010817	187	0.095	Rat
female gonad development	GO:0008585	53	0.094
response to hexose	GO:0009746	144	0.093
calcium ion homeostasis	GO:0055074	162	0.093
organic acid metabolic process	GO:0006082	292	0.093
neuron projection development	GO:0031175	273	0.093
regulation of phosphorylation	GO:0042325	248	0.091
programmed cell death	GO:0012501	392	0.090
tissue development	GO:0009888	252	0.088
cellular response to oxidative stress	GO:0034599	76	0.088
negative regulation of cell communication	GO:0010648	158	0.087
regulation of cellular ketone metabolic process	GO:0010565	27	0.086
response to metal ion	GO:0010038	253	0.086
regulation of cell migration	GO:0030334	128	0.084
regulation of protein metabolic process	GO:0051246	289	0.084
cellular homeostasis	GO:0019725	252	0.084
regulation of multicellular organismal development	GO:2000026	376	0.082
cellular response to steroid hormone stimulus	GO:0071383	93	0.082
negative regulation of macromolecule metabolic process	GO:0010605	260	0.081
maternal process involved in female pregnancy	GO:0060135	38	0.081
response to acid chemical	GO:0001101	222	0.081
negative regulation of cellular protein metabolic process	GO:0032269	106	0.081
sodium ion transport	GO:0006814	82	0.078
regulation of molecular function	GO:0065009	398	0.077
macromolecular complex subunit organization	GO:0043933	339	0.077
negative regulation of cellular biosynthetic process	GO:0031327	161	0.077
positive regulation of erk1 and erk2 cascade	GO:0070374	29	0.076
positive regulation of cell communication	GO:0010647	271	0.076
neuron differentiation	GO:0030182	368	0.075
positive regulation of cell proliferation	GO:0008284	249	0.074
response to ethanol	GO:0045471	162	0.074
rna biosynthetic process	GO:0032774	380	0.074
positive regulation of nucleocytoplasmic transport	GO:0046824	17	0.073
oxoacid metabolic process	GO:0043436	290	0.072
mapk cascade	GO:0000165	140	0.071
cation homeostasis	GO:0055080	195	0.071
secretion by cell	GO:0032940	248	0.071	Rat
response to oxygen levels	GO:0070482	265	0.071	Human
response to molecule of bacterial origin	GO:0002237	194	0.070
response to ketone	GO:1901654	182	0.069	Rat
positive regulation of biosynthetic process	GO:0009891	319	0.069
regulation of immune system process	GO:0002682	123	0.068
single organism catabolic process	GO:0044712	283	0.068
cellular amine metabolic process	GO:0044106	38	0.068
negative regulation of biosynthetic process	GO:0009890	168	0.066
cellular response to lipopolysaccharide	GO:0071222	55	0.066
response to monosaccharide	GO:0034284	159	0.066
negative regulation of gluconeogenesis	GO:0045721	1	0.065
cellular response to glucocorticoid stimulus	GO:0071385	68	0.065
cell projection organization	GO:0030030	302	0.065
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.065
cellular cation homeostasis	GO:0030003	180	0.064
transmembrane transport	GO:0055085	412	0.062
chemical homeostasis	GO:0048878	292	0.062
cardiovascular system development	GO:0072358	134	0.061
regulation of erk1 and erk2 cascade	GO:0070372	41	0.060
blood circulation	GO:0008015	183	0.060
regulation of cellular amino acid metabolic process	GO:0006521	2	0.060
cellular chemical homeostasis	GO:0055082	247	0.059
macromolecule localization	GO:0033036	252	0.059
response to bacterium	GO:0009617	200	0.059
macromolecular complex assembly	GO:0065003	273	0.058
localization of cell	GO:0051674	202	0.058
reproductive structure development	GO:0048608	128	0.058
regulation of apoptotic process	GO:0042981	335	0.057
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.057
gastrulation	GO:0007369	2	0.057
regulation of phosphate metabolic process	GO:0019220	349	0.057
circulatory system process	GO:0003013	183	0.056
response to radiation	GO:0009314	137	0.056
regeneration	GO:0031099	163	0.056
negative regulation of rna biosynthetic process	GO:1902679	118	0.056
cellular response to biotic stimulus	GO:0071216	59	0.056
organelle organization	GO:0006996	266	0.056
nucleocytoplasmic transport	GO:0006913	48	0.056
negative regulation of programmed cell death	GO:0043069	183	0.055
regulation of behavior	GO:0050795	61	0.055
positive regulation of cellular component organization	GO:0051130	200	0.055
negative regulation of cell proliferation	GO:0008285	119	0.055
protein complex assembly	GO:0006461	263	0.055
blood vessel development	GO:0001568	69	0.055
developmental growth	GO:0048589	100	0.054
regulation of homeostatic process	GO:0032844	101	0.054
regulation of cellular localization	GO:0060341	263	0.054
cellular calcium ion homeostasis	GO:0006874	160	0.053
regulation of organelle organization	GO:0033043	80	0.053
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.052
formation of primary germ layer	GO:0001704	1	0.052
stress activated mapk cascade	GO:0051403	35	0.051
regulation of cellular amine metabolic process	GO:0033238	8	0.050
homeostatic process	GO:0042592	331	0.050
muscle cell proliferation	GO:0033002	84	0.050
positive regulation of rna metabolic process	GO:0051254	203	0.050
erk1 and erk2 cascade	GO:0070371	48	0.049
positive regulation of multicellular organismal process	GO:0051240	387	0.049
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.048
mesoderm formation	GO:0001707	1	0.048
protein complex biogenesis	GO:0070271	263	0.048
positive regulation of chemotaxis	GO:0050921	23	0.048
muscle system process	GO:0003012	115	0.048
regulation of jnk cascade	GO:0046328	19	0.047
cytokine mediated signaling pathway	GO:0019221	43	0.047
regulation of protein transport	GO:0051223	68	0.047
single organism intracellular transport	GO:1902582	166	0.047
embryo implantation	GO:0007566	15	0.046
gamete generation	GO:0007276	124	0.046
metal ion homeostasis	GO:0055065	186	0.046
regulation of hydrolase activity	GO:0051336	143	0.046
cell morphogenesis	GO:0000902	142	0.045
transcription from rna polymerase ii promoter	GO:0006366	252	0.045
response to hypoxia	GO:0001666	231	0.045	Human
regulation of protein maturation	GO:1903317	50	0.045
cellular response to extracellular stimulus	GO:0031668	73	0.045
negative regulation of neuron apoptotic process	GO:0043524	45	0.044
epithelium development	GO:0060429	96	0.044	Mouse
cognition	GO:0050890	92	0.044
sexual reproduction	GO:0019953	148	0.043
leukocyte chemotaxis	GO:0030595	22	0.043
chemotaxis	GO:0006935	66	0.043
rhythmic process	GO:0048511	156	0.043
cellular response to tumor necrosis factor	GO:0071356	46	0.043
leukocyte migration	GO:0050900	38	0.043
oxidation reduction process	GO:0055114	304	0.043
response to amine	GO:0014075	46	0.043
regulation of protein processing	GO:0070613	50	0.042
development of primary sexual characteristics	GO:0045137	107	0.042
negative regulation of cellular carbohydrate metabolic process	GO:0010677	7	0.042
positive regulation of rna biosynthetic process	GO:1902680	197	0.042
head development	GO:0060322	247	0.042
negative regulation of developmental process	GO:0051093	125	0.041
negative regulation of molecular function	GO:0044092	133	0.041
learning or memory	GO:0007611	90	0.041
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.041
regulation of cell motility	GO:2000145	131	0.041
protein complex subunit organization	GO:0071822	302	0.041
brain development	GO:0007420	247	0.041
cellular response to oxygen levels	GO:0071453	60	0.040	Human
positive regulation of phosphate metabolic process	GO:0045937	262	0.040
glucose homeostasis	GO:0042593	75	0.040
regulation of cellular catabolic process	GO:0031329	101	0.040
reactive oxygen species metabolic process	GO:0072593	37	0.040
regulation of phosphorus metabolic process	GO:0051174	349	0.040
cellular response to abiotic stimulus	GO:0071214	85	0.039
response to amphetamine	GO:0001975	25	0.039
g protein coupled receptor signaling pathway	GO:0007186	242	0.039
carbohydrate homeostasis	GO:0033500	75	0.039
response to insecticide	GO:0017085	21	0.039
positive regulation of leukocyte migration	GO:0002687	21	0.039
inflammatory response	GO:0006954	150	0.039
protein phosphorylation	GO:0006468	345	0.039
positive regulation of response to external stimulus	GO:0032103	51	0.039
axon development	GO:0061564	96	0.039
jnk cascade	GO:0007254	28	0.038
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.038
maintenance of location	GO:0051235	17	0.038
neuron death	GO:0070997	127	0.038
positive regulation of gene expression	GO:0010628	244	0.038
positive regulation of cellular protein metabolic process	GO:0032270	167	0.038
cellular metal ion homeostasis	GO:0006875	172	0.038
cellular response to atp	GO:0071318	5	0.038
single organism nuclear import	GO:1902593	35	0.038
ovulation cycle process	GO:0022602	50	0.037
positive regulation of cell differentiation	GO:0045597	217	0.037	Mouse
positive regulation of phosphorylation	GO:0042327	177	0.037
cellular ion homeostasis	GO:0006873	184	0.037
reactive oxygen species biosynthetic process	GO:1903409	8	0.037
gland development	GO:0048732	155	0.037
positive regulation of neurogenesis	GO:0050769	165	0.037
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.036
negative regulation of transcription dna templated	GO:0045892	116	0.036
neuromuscular process	GO:0050905	2	0.036
signal transduction by phosphorylation	GO:0023014	144	0.036
positive regulation of protein kinase b signaling	GO:0051897	10	0.035
response to ammonium ion	GO:0060359	71	0.035
protein import	GO:0017038	37	0.035
regulation of acute inflammatory response	GO:0002673	23	0.035
response to tumor necrosis factor	GO:0034612	56	0.035
intracellular transport	GO:0046907	185	0.035
cellular response to drug	GO:0035690	30	0.034
regulation of secretion by cell	GO:1903530	208	0.034	Rat
regulation of leukocyte migration	GO:0002685	24	0.034
cellular response to interferon gamma	GO:0071346	14	0.034
cellular component assembly	GO:0022607	360	0.034
muscle structure development	GO:0061061	87	0.034
immune system process	GO:0002376	204	0.034
digestive system development	GO:0055123	41	0.034
positive regulation of immune system process	GO:0002684	90	0.034
locomotion	GO:0040011	237	0.033
pyruvate metabolic process	GO:0006090	27	0.033
acute inflammatory response	GO:0002526	58	0.033
development of primary female sexual characteristics	GO:0046545	56	0.033
regulation of establishment of protein localization	GO:0070201	69	0.033
nuclear transport	GO:0051169	49	0.033
divalent inorganic cation homeostasis	GO:0072507	165	0.033
response to glucose	GO:0009749	136	0.033
positive regulation of nervous system development	GO:0051962	178	0.033
negative regulation of protein maturation	GO:1903318	47	0.033
negative regulation of peptidase activity	GO:0010466	38	0.033
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.032
cellular response to nutrient levels	GO:0031669	60	0.032
single organism biosynthetic process	GO:0044711	342	0.032
amine metabolic process	GO:0009308	38	0.032
purine containing compound metabolic process	GO:0072521	253	0.032
response to corticosterone	GO:0051412	40	0.032	Rat
regulation of blood circulation	GO:1903522	110	0.032
cell migration	GO:0016477	197	0.032
positive regulation of neuron differentiation	GO:0045666	126	0.031
single organism organelle organization	GO:1902589	180	0.031
cellular amino acid metabolic process	GO:0006520	107	0.031
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.031
ion homeostasis	GO:0050801	212	0.031
cell chemotaxis	GO:0060326	31	0.031
protein processing	GO:0016485	68	0.031
response to cold	GO:0009409	29	0.030
vesicle mediated transport	GO:0016192	181	0.030
regulation of cell growth	GO:0001558	85	0.030
mesoderm development	GO:0007498	2	0.030
protein targeting to nucleus	GO:0044744	35	0.030
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.030
cytoplasmic transport	GO:0016482	115	0.030
positive regulation of intracellular signal transduction	GO:1902533	138	0.030
negative regulation of neuron death	GO:1901215	69	0.030
reactive nitrogen species metabolic process	GO:2001057	1	0.030
female sex differentiation	GO:0046660	59	0.030
positive regulation of homeostatic process	GO:0032846	49	0.030
fever generation	GO:0001660	9	0.029
organonitrogen compound catabolic process	GO:1901565	179	0.029
dibenzo p dioxin metabolic process	GO:0018894	10	0.029
muscle contraction	GO:0006936	88	0.029
carboxylic acid biosynthetic process	GO:0046394	83	0.029
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.029
establishment of protein localization	GO:0045184	141	0.029
negative regulation of endopeptidase activity	GO:0010951	36	0.029
response to other organism	GO:0051707	220	0.028
memory	GO:0007613	54	0.028
mitotic cell cycle	GO:0000278	49	0.028
response to activity	GO:0014823	73	0.028
regulation of nucleocytoplasmic transport	GO:0046822	28	0.028
regulation of peptide transport	GO:0090087	87	0.028
response to low density lipoprotein particle	GO:0055098	4	0.028
cellular response to nutrient	GO:0031670	30	0.028
divalent inorganic cation transport	GO:0072511	134	0.028
regulation of neuron death	GO:1901214	115	0.028
endoplasmic reticulum to cytosol transport	GO:1903513	4	0.028
negative regulation of multicellular organismal process	GO:0051241	203	0.028
sequestering of metal ion	GO:0051238	9	0.028
positive regulation of keratinocyte migration	GO:0051549	2	0.028
peptidyl amino acid modification	GO:0018193	126	0.028
regulation of protein localization	GO:0032880	81	0.027
carbohydrate derivative metabolic process	GO:1901135	346	0.027
ras protein signal transduction	GO:0007265	29	0.027
small gtpase mediated signal transduction	GO:0007264	36	0.027
decidualization	GO:0046697	14	0.027
protein localization	GO:0008104	191	0.027
sex differentiation	GO:0007548	113	0.027
response to external biotic stimulus	GO:0043207	221	0.027
cation transport	GO:0006812	382	0.027
regulation of cell projection organization	GO:0031344	175	0.027
actin filament based process	GO:0030029	86	0.027
central nervous system neuron axonogenesis	GO:0021955	1	0.027
cellular response to dexamethasone stimulus	GO:0071549	36	0.027
gliogenesis	GO:0042063	93	0.027
steroid metabolic process	GO:0008202	73	0.026
response to calcium ion	GO:0051592	59	0.026
regulation of anatomical structure morphogenesis	GO:0022603	141	0.026
positive regulation of ion transport	GO:0043270	94	0.026
organic substance catabolic process	GO:1901575	316	0.025
positive regulation of cell development	GO:0010720	176	0.025
cellular catabolic process	GO:0044248	295	0.025
cellular hormone metabolic process	GO:0034754	49	0.025
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.025
positive regulation of nf kappab import into nucleus	GO:0042346	2	0.025
wound healing	GO:0042060	122	0.025
regulation of locomotion	GO:0040012	148	0.025
regulation of catabolic process	GO:0009894	113	0.025
regulation of heat generation	GO:0031650	8	0.024
regulation of angiogenesis	GO:0045765	39	0.024
ossification	GO:0001503	70	0.024
positive regulation of cell death	GO:0010942	184	0.024
cellular response to low density lipoprotein particle stimulus	GO:0071404	3	0.024
negative regulation of protein processing	GO:0010955	47	0.024
cellular macromolecular complex assembly	GO:0034622	58	0.024
anion transport	GO:0006820	178	0.024
organic anion transport	GO:0015711	132	0.024
heart morphogenesis	GO:0003007	3	0.024
cellular response to hypoxia	GO:0071456	51	0.024	Human
tube development	GO:0035295	89	0.023
response to transforming growth factor beta	GO:0071559	46	0.023
regulation of mapk cascade	GO:0043408	116	0.023
sequestering of calcium ion	GO:0051208	8	0.023
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.023
nuclear import	GO:0051170	35	0.023
positive regulation of protein transport	GO:0051222	41	0.023
regulation of leukocyte chemotaxis	GO:0002688	12	0.023
mesoderm morphogenesis	GO:0048332	1	0.023
catabolic process	GO:0009056	351	0.023
positive regulation of leukocyte chemotaxis	GO:0002690	10	0.023
regulation of cell cycle	GO:0051726	73	0.023
positive regulation of organelle organization	GO:0010638	48	0.023
hormone metabolic process	GO:0042445	69	0.023
retina morphogenesis in camera type eye	GO:0060042	1	0.023
positive regulation of signal transduction	GO:0009967	175	0.023
heart contraction	GO:0060047	57	0.023
monocarboxylic acid metabolic process	GO:0032787	152	0.023
regulation of monocyte chemotaxis	GO:0090025	3	0.022
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.022
positive regulation of fat cell differentiation	GO:0045600	2	0.022	Mouse
cellular response to hydrogen peroxide	GO:0070301	42	0.022
generation of precursor metabolites and energy	GO:0006091	62	0.022
carbohydrate catabolic process	GO:0016052	40	0.022
dephosphorylation	GO:0016311	98	0.022
ribonucleotide catabolic process	GO:0009261	136	0.022
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.022
response to fibroblast growth factor	GO:0071774	29	0.022
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.021
regulation of stress activated mapk cascade	GO:0032872	23	0.021
regulation of catalytic activity	GO:0050790	304	0.021
positive regulation of cell growth	GO:0030307	44	0.021
response to electrical stimulus	GO:0051602	56	0.021
cytosolic calcium ion homeostasis	GO:0051480	140	0.021
ovulation	GO:0030728	17	0.021
establishment of protein localization to organelle	GO:0072594	44	0.021
response to retinoic acid	GO:0032526	63	0.021
peptidyl tyrosine phosphorylation	GO:0018108	72	0.021
regulation of protein phosphorylation	GO:0001932	183	0.021
regulation of metal ion transport	GO:0010959	118	0.021
proteolysis	GO:0006508	175	0.021
multicellular organismal signaling	GO:0035637	44	0.021
positive regulation of neuron projection development	GO:0010976	99	0.021
positive regulation of behavior	GO:0048520	38	0.020
response to nicotine	GO:0035094	51	0.020
neuron apoptotic process	GO:0051402	88	0.020
response to light stimulus	GO:0009416	52	0.020
dna metabolic process	GO:0006259	96	0.020
tissue regeneration	GO:0042246	36	0.020
chemosensory behavior	GO:0007635	2	0.020
positive regulation of nitric oxide biosynthetic process	GO:0045429	14	0.020
regulation of ion transport	GO:0043269	245	0.020
response to osmotic stress	GO:0006970	42	0.020
regulation of protein complex assembly	GO:0043254	33	0.020
protein maturation	GO:0051604	68	0.020
cellular response to acid chemical	GO:0071229	75	0.020
anterior posterior pattern specification	GO:0009952	1	0.020
peptide hormone secretion	GO:0030072	84	0.020
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.020
hormone transport	GO:0009914	121	0.020	Rat
organ regeneration	GO:0031100	101	0.019
endocytosis	GO:0006897	84	0.019
negative regulation of cell differentiation	GO:0045596	99	0.019
response to amino acid	GO:0043200	75	0.019
cellular response to hexose stimulus	GO:0071331	65	0.019
regulation of protein targeting	GO:1903533	28	0.019
monovalent inorganic cation transport	GO:0015672	172	0.019
jak stat cascade	GO:0007259	26	0.019
regulation of protein modification process	GO:0031399	194	0.019
heart process	GO:0003015	57	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.019
neuron projection morphogenesis	GO:0048812	122	0.019
digestive tract development	GO:0048565	39	0.019
embryo development	GO:0009790	49	0.019

Ptgs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.030
disease of cellular proliferation	DOID:14566	0.030
disease of metabolism	DOID:0014667	0.020

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