IMP: Integrative Multi-species Prediction

Rattus norvegicus

80 known processes

Nedd4

neural precursor cell expressed, developmentally down-regulated 4

(Aliases: Nedd4a)

RGD: 3157
Entrez: 25489
Ensembl: ENSRNOG00000006683
UniProtKB: Q62940

Process Predictions
Disease Predictions

Nedd4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell morphogenesis	GO:0000902	142	0.861
negative regulation of developmental process	GO:0051093	125	0.725
nucleic acid templated transcription	GO:0097659	379	0.690	Human Mouse
regulation of nucleic acid templated transcription	GO:1903506	380	0.672	Human Mouse
negative regulation of cellular metabolic process	GO:0031324	281	0.666	Human Mouse
negative regulation of nervous system development	GO:0051961	79	0.659
positive regulation of rna biosynthetic process	GO:1902680	197	0.656
neuron differentiation	GO:0030182	368	0.652
positive regulation of gene expression	GO:0010628	244	0.633
rna biosynthetic process	GO:0032774	380	0.631	Human Mouse
regulation of phosphate metabolic process	GO:0019220	349	0.606
osteoblast differentiation	GO:0001649	26	0.584
regulation of intracellular signal transduction	GO:1902531	218	0.580	Human
negative regulation of gene expression	GO:0010629	199	0.569	Human Mouse
intracellular signal transduction	GO:0035556	314	0.554	Human
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.549
negative regulation of metabolic process	GO:0009892	331	0.548	Human Mouse
regulation of osteoblast differentiation	GO:0045667	14	0.539
transcription dna templated	GO:0006351	377	0.511	Human Mouse
cell morphogenesis involved in differentiation	GO:0000904	119	0.493
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.478	Human Mouse
neuron development	GO:0048666	286	0.452
cell projection organization	GO:0030030	302	0.450
regulation of multicellular organismal development	GO:2000026	376	0.427
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.409
rna metabolic process	GO:0016070	406	0.400	Human Mouse
positive regulation of transcription dna templated	GO:0045893	197	0.400
cellular component morphogenesis	GO:0032989	155	0.394
positive regulation of catalytic activity	GO:0043085	184	0.389
negative regulation of macromolecule metabolic process	GO:0010605	260	0.384	Human Mouse
regulation of neuron projection development	GO:0010975	161	0.378
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.377	Human Mouse
negative regulation of cellular biosynthetic process	GO:0031327	161	0.372	Human Mouse
carboxylic acid metabolic process	GO:0019752	289	0.371
embryonic appendage morphogenesis	GO:0035113	4	0.363
cellular amino acid metabolic process	GO:0006520	107	0.353
protein phosphorylation	GO:0006468	345	0.340
regulation of signal transduction	GO:0009966	318	0.340	Human Mouse
regulation of cellular amine metabolic process	GO:0033238	8	0.336
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.327
positive regulation of phosphorus metabolic process	GO:0010562	262	0.326
reproduction	GO:0000003	245	0.323
cellular ketone metabolic process	GO:0042180	51	0.322
brain development	GO:0007420	247	0.319
positive regulation of intracellular signal transduction	GO:1902533	138	0.315	Human
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.314	Human Mouse
regulation of cellular component organization	GO:0051128	368	0.314
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.313	Human Mouse
amine metabolic process	GO:0009308	38	0.310
single organism behavior	GO:0044708	130	0.309
cellular response to stress	GO:0033554	269	0.308	Human
negative regulation of multicellular organismal process	GO:0051241	203	0.308
regulation of protein phosphorylation	GO:0001932	183	0.298
positive regulation of cellular component organization	GO:0051130	200	0.293	Rat
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.291
peptidyl tyrosine phosphorylation	GO:0018108	72	0.289
negative regulation of organ growth	GO:0046621	3	0.287
negative regulation of biosynthetic process	GO:0009890	168	0.277	Human Mouse
regulation of neuron differentiation	GO:0045664	208	0.274
regulation of rna biosynthetic process	GO:2001141	381	0.268	Human Mouse
cell projection morphogenesis	GO:0048858	123	0.259
positive regulation of cellular protein metabolic process	GO:0032270	167	0.255
regulation of transcription dna templated	GO:0006355	374	0.254	Human Mouse
protein complex assembly	GO:0006461	263	0.251
regulation of rna metabolic process	GO:0051252	391	0.232	Human Mouse
regulation of protein modification process	GO:0031399	194	0.232
apoptotic process	GO:0006915	381	0.231
cellular calcium ion homeostasis	GO:0006874	160	0.231
regulation of cellular amino acid metabolic process	GO:0006521	2	0.229
regulation of cell proliferation	GO:0042127	359	0.226
immune system process	GO:0002376	204	0.219
cation homeostasis	GO:0055080	195	0.218
regulation of phosphorus metabolic process	GO:0051174	349	0.217
positive regulation of cellular biosynthetic process	GO:0031328	295	0.209
growth	GO:0040007	165	0.202
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.196
reproductive process	GO:0022414	372	0.192
epithelial cell proliferation	GO:0050673	54	0.190
regulation of apoptotic process	GO:0042981	335	0.186
programmed cell death	GO:0012501	392	0.185
cellular component movement	GO:0006928	248	0.184
negative regulation of rna metabolic process	GO:0051253	123	0.182	Human Mouse
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.180
regulation of cellular protein metabolic process	GO:0032268	267	0.177
behavior	GO:0007610	205	0.177
negative regulation of growth	GO:0045926	37	0.176
regulation of protein metabolic process	GO:0051246	289	0.176	Human Mouse Rat
cellular amine metabolic process	GO:0044106	38	0.176
regulation of phosphorylation	GO:0042325	248	0.172
cell type specific apoptotic process	GO:0097285	134	0.171
positive regulation of signaling	GO:0023056	270	0.165	Human
positive regulation of rna metabolic process	GO:0051254	203	0.164
protein oligomerization	GO:0051259	191	0.159
neuron apoptotic process	GO:0051402	88	0.158
response to extracellular stimulus	GO:0009991	380	0.158
axon development	GO:0061564	96	0.158
anatomical structure morphogenesis	GO:0009653	298	0.158
central nervous system development	GO:0007417	311	0.158
negative regulation of transcription dna templated	GO:0045892	116	0.155	Human Mouse
regulation of kinase activity	GO:0043549	117	0.154
cellular ion homeostasis	GO:0006873	184	0.153
positive regulation of cellular amine metabolic process	GO:0033240	3	0.153
positive regulation of phosphate metabolic process	GO:0045937	262	0.149
regulation of growth	GO:0040008	105	0.145
receptor localization to synapse	GO:0097120	2	0.144
positive regulation of response to stimulus	GO:0048584	285	0.142	Human
regeneration	GO:0031099	163	0.140
negative regulation of osteoblast differentiation	GO:0045668	2	0.139
cellular homeostasis	GO:0019725	252	0.139
positive regulation of protein phosphorylation	GO:0001934	135	0.137
regulation of cellular ketone metabolic process	GO:0010565	27	0.136
calcium ion homeostasis	GO:0055074	162	0.134
cellular component biogenesis	GO:0044085	368	0.133
macromolecular complex assembly	GO:0065003	273	0.131
protein complex subunit organization	GO:0071822	302	0.130
positive regulation of protein metabolic process	GO:0051247	178	0.130	Human Mouse Rat
divalent inorganic cation homeostasis	GO:0072507	165	0.130
head development	GO:0060322	247	0.130
positive regulation of multicellular organismal process	GO:0051240	387	0.129
localization of cell	GO:0051674	202	0.128
positive regulation of phosphorylation	GO:0042327	177	0.128
multi organism reproductive process	GO:0044703	262	0.128
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.124	Human Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.124
positive regulation of protein modification process	GO:0031401	142	0.123
rhythmic process	GO:0048511	156	0.123
negative regulation of rna biosynthetic process	GO:1902679	118	0.123	Human Mouse
negative regulation of epithelial cell proliferation	GO:0050680	16	0.123
positive regulation of cell communication	GO:0010647	271	0.121	Human
cation transport	GO:0006812	382	0.118	Human Mouse Rat
positive regulation of cell differentiation	GO:0045597	217	0.117
cell cell signaling	GO:0007267	335	0.116	Mouse
regulation of cell differentiation	GO:0045595	320	0.116
response to nutrient levels	GO:0031667	370	0.114
regulation of molecular function	GO:0065009	398	0.113	Human Rat
negative regulation of cell development	GO:0010721	82	0.112
cytosolic calcium ion homeostasis	GO:0051480	140	0.112
single organism organelle organization	GO:1902589	180	0.112
regulation of cell growth	GO:0001558	85	0.112
auditory receptor cell differentiation	GO:0042491	2	0.112
axonogenesis	GO:0007409	71	0.111
positive regulation of biosynthetic process	GO:0009891	319	0.111
cellular metal ion homeostasis	GO:0006875	172	0.111
negative regulation of cell differentiation	GO:0045596	99	0.108
stem cell maintenance	GO:0019827	6	0.107
regulation of translation	GO:0006417	27	0.106
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.106
response to ethanol	GO:0045471	162	0.105
regulation of protein kinase activity	GO:0045859	105	0.104
regulation of transferase activity	GO:0051338	123	0.102
negative regulation of neuron differentiation	GO:0045665	62	0.100
cell cycle	GO:0007049	101	0.098
positive regulation of signal transduction	GO:0009967	175	0.097	Human
single organism reproductive process	GO:0044702	297	0.097
ion homeostasis	GO:0050801	212	0.096
ionotropic glutamate receptor signaling pathway	GO:0035235	34	0.096
metal ion homeostasis	GO:0055065	186	0.094
cellular cation homeostasis	GO:0030003	180	0.093
limb morphogenesis	GO:0035108	4	0.091
positive regulation of molecular function	GO:0044093	230	0.091
regulation of g2 m transition of mitotic cell cycle	GO:0010389	4	0.090
immune response	GO:0006955	104	0.090
regulation of cell cycle	GO:0051726	73	0.090
phasic smooth muscle contraction	GO:0014821	3	0.089
endocytosis	GO:0006897	84	0.089	Human Rat
neuron projection development	GO:0031175	273	0.088
cellular chemical homeostasis	GO:0055082	247	0.088
cellular component assembly	GO:0022607	360	0.086
peptidyl tyrosine modification	GO:0018212	72	0.086
developmental process involved in reproduction	GO:0003006	159	0.086
negative regulation of neurogenesis	GO:0050768	78	0.085
regulation of neurogenesis	GO:0050767	247	0.084
circulatory system process	GO:0003013	183	0.084
cellular protein localization	GO:0034613	122	0.083	Human
serotonin metabolic process	GO:0042428	3	0.082
protein complex biogenesis	GO:0070271	263	0.082
neuron projection morphogenesis	GO:0048812	122	0.082
regulation of organ growth	GO:0046620	13	0.080
regulation of epithelial cell proliferation	GO:0050678	49	0.078
tissue development	GO:0009888	252	0.077	Mouse
cell cycle process	GO:0022402	57	0.076
macromolecular complex subunit organization	GO:0043933	339	0.076
regulation of vesicle mediated transport	GO:0060627	81	0.076	Rat
negative regulation of muscle cell apoptotic process	GO:0010656	21	0.075
regulation of ion transport	GO:0043269	245	0.074	Human Mouse Rat
regulation of cell development	GO:0060284	263	0.074
regulation of programmed cell death	GO:0043067	341	0.073
sexual reproduction	GO:0019953	148	0.073
ossification	GO:0001503	70	0.073
regulation of developmental growth	GO:0048638	45	0.073
ribose phosphate metabolic process	GO:0019693	235	0.072
regulation of nervous system development	GO:0051960	264	0.072
gland development	GO:0048732	155	0.072
neuromuscular process	GO:0050905	2	0.071
negative regulation of signal transduction	GO:0009968	83	0.071	Mouse
chemical homeostasis	GO:0048878	292	0.070
neuron recognition	GO:0008038	9	0.069
negative regulation of cardiac muscle tissue development	GO:0055026	3	0.068
single organism carbohydrate metabolic process	GO:0044723	118	0.067
positive regulation of nervous system development	GO:0051962	178	0.066
regulation of actin filament based process	GO:0032970	42	0.066	Rat
dendrite morphogenesis	GO:0048813	43	0.066
regulation of canonical wnt signaling pathway	GO:0060828	4	0.066
vesicle mediated transport	GO:0016192	181	0.066	Human Rat
cell growth	GO:0016049	104	0.065
taxis	GO:0042330	67	0.065
cellular response to organonitrogen compound	GO:0071417	197	0.064
jak stat cascade	GO:0007259	26	0.064
negative regulation of cell proliferation	GO:0008285	119	0.063
synaptic transmission	GO:0007268	235	0.063	Mouse
regulation of ossification	GO:0030278	32	0.063
positive regulation of cellular component biogenesis	GO:0044089	55	0.063
developmental growth	GO:0048589	100	0.061
regulation of anion transport	GO:0044070	43	0.061
establishment of protein localization	GO:0045184	141	0.061	Human
response to nutrient	GO:0007584	248	0.061
regulation of protein processing	GO:0070613	50	0.060
response to radiation	GO:0009314	137	0.060	Human
mapk cascade	GO:0000165	140	0.060
embryo development	GO:0009790	49	0.059
transcription from rna polymerase ii promoter	GO:0006366	252	0.059	Human Mouse
regulation of cytoskeleton organization	GO:0051493	49	0.058
multicellular organismal reproductive process	GO:0048609	233	0.058
cellular macromolecule localization	GO:0070727	122	0.058	Human
translation	GO:0006412	35	0.057
glutamate receptor signaling pathway	GO:0007215	43	0.057
signal transduction by phosphorylation	GO:0023014	144	0.056
circulatory system development	GO:0072359	134	0.056	Mouse
organic acid metabolic process	GO:0006082	292	0.055
peptidyl amino acid modification	GO:0018193	126	0.055
locomotion	GO:0040011	237	0.055	Human
cell migration	GO:0016477	197	0.055
epithelium development	GO:0060429	96	0.054
cytoskeleton organization	GO:0007010	111	0.053
embryonic limb morphogenesis	GO:0030326	4	0.053
positive regulation of developmental process	GO:0051094	283	0.053
reproductive structure development	GO:0048608	128	0.052
cellular response to hormone stimulus	GO:0032870	247	0.052
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.051
positive regulation of neurogenesis	GO:0050769	165	0.051
dendrite development	GO:0016358	72	0.050
homeostatic process	GO:0042592	331	0.050
cytokinetic process	GO:0032506	1	0.050
axon cargo transport	GO:0008088	1	0.049
actin filament based process	GO:0030029	86	0.048
striated muscle tissue development	GO:0014706	58	0.048
negative regulation of transport	GO:0051051	136	0.048	Human Mouse Rat
macromolecule localization	GO:0033036	252	0.047	Human
positive regulation of cell proliferation	GO:0008284	249	0.047
mechanoreceptor differentiation	GO:0042490	2	0.047
cell activation	GO:0001775	97	0.047	Mouse
regulation of mapk cascade	GO:0043408	116	0.047
ovulation cycle process	GO:0022602	50	0.047
actin cytoskeleton organization	GO:0030036	73	0.047
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.046
regulation of protein polymerization	GO:0032271	19	0.046
secretion	GO:0046903	307	0.046
purine ribonucleoside metabolic process	GO:0046128	168	0.045
cellular response to abiotic stimulus	GO:0071214	85	0.045	Human
positive regulation of mapk cascade	GO:0043410	92	0.045
oxoacid metabolic process	GO:0043436	290	0.045
neuron death	GO:0070997	127	0.045
development of primary sexual characteristics	GO:0045137	107	0.044
nitrogen compound transport	GO:0071705	229	0.044
neurological system process	GO:0050877	219	0.044
regulation of catalytic activity	GO:0050790	304	0.044
protein localization	GO:0008104	191	0.044	Human
endothelial cell proliferation	GO:0001935	20	0.043
regulation of stress activated mapk cascade	GO:0032872	23	0.043
cognition	GO:0050890	92	0.043
response to bacterium	GO:0009617	200	0.043
monovalent inorganic cation transport	GO:0015672	172	0.043	Human Mouse Rat
negative regulation of cell matrix adhesion	GO:0001953	3	0.042
blood circulation	GO:0008015	183	0.042
organelle organization	GO:0006996	266	0.042
response to wounding	GO:0009611	254	0.041
heart development	GO:0007507	72	0.041	Mouse
multicellular organism reproduction	GO:0032504	233	0.041
regulation of cell projection organization	GO:0031344	175	0.041
response to corticosteroid	GO:0031960	235	0.041
axon choice point recognition	GO:0016198	2	0.040
regulation of viral transcription	GO:0046782	2	0.040
positive regulation of cell projection organization	GO:0031346	111	0.040
regulation of cellular localization	GO:0060341	263	0.040	Human
forebrain development	GO:0030900	98	0.040
negative regulation of cardiac muscle tissue growth	GO:0055022	3	0.040
cell part morphogenesis	GO:0032990	123	0.040
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.040	Human Mouse
anion transport	GO:0006820	178	0.039
glial cell differentiation	GO:0010001	65	0.039
appendage morphogenesis	GO:0035107	4	0.038
development of primary female sexual characteristics	GO:0046545	56	0.038
lymphocyte activation	GO:0046649	43	0.038	Mouse
positive regulation of neuron projection development	GO:0010976	99	0.038
response to molecule of bacterial origin	GO:0002237	194	0.037
regulation of muscle cell apoptotic process	GO:0010660	26	0.037
positive regulation of transferase activity	GO:0051347	81	0.037
cellular response to organic cyclic compound	GO:0071407	202	0.037
anterior posterior pattern specification	GO:0009952	1	0.037
learning or memory	GO:0007611	90	0.037
heart process	GO:0003015	57	0.037
negative regulation of neuron death	GO:1901215	69	0.037
cellular response to peptide hormone stimulus	GO:0071375	120	0.036
response to nicotine	GO:0035094	51	0.036
male mating behavior	GO:0060179	3	0.036
regulation of anatomical structure size	GO:0090066	135	0.036
response to mechanical stimulus	GO:0009612	134	0.036
response to glucocorticoid	GO:0051384	223	0.035
t cell proliferation	GO:0042098	19	0.035
response to peptide	GO:1901652	292	0.034
muscle tissue development	GO:0060537	58	0.034
somatic stem cell division	GO:0048103	2	0.034
positive regulation of cell development	GO:0010720	176	0.033
ion transmembrane transport	GO:0034220	365	0.033	Human Mouse Rat
t cell activation	GO:0042110	29	0.032	Mouse
lysosome localization	GO:0032418	10	0.032
response to peptide hormone	GO:0043434	278	0.032
sex differentiation	GO:0007548	113	0.032
feeding behavior	GO:0007631	53	0.032
positive regulation of hydrolase activity	GO:0051345	86	0.032
inflammatory response	GO:0006954	150	0.031
positive regulation of ion transport	GO:0043270	94	0.031
regulation of organelle organization	GO:0033043	80	0.031
muscle structure development	GO:0061061	87	0.030
ventricular cardiac muscle cell action potential	GO:0086005	2	0.030	Rat
amino acid transport	GO:0006865	70	0.030
regulation of cell cycle g2 m phase transition	GO:1902749	4	0.030
regulation of behavior	GO:0050795	61	0.030
mitotic cell cycle phase transition	GO:0044772	20	0.029
organophosphate catabolic process	GO:0046434	148	0.029
negative regulation of apoptotic process	GO:0043066	181	0.029
cell substrate adhesion	GO:0031589	29	0.029
regulation of cell morphogenesis	GO:0022604	77	0.028
regulation of actin cytoskeleton organization	GO:0032956	30	0.028
embryonic organ morphogenesis	GO:0048562	5	0.028
mrna 3 end processing	GO:0031124	1	0.028
response to estradiol	GO:0032355	164	0.028
positive regulation of axon guidance	GO:1902669	3	0.027
mitotic cell cycle process	GO:1903047	35	0.027
vasculature development	GO:0001944	70	0.027	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.027
negative regulation of molecular function	GO:0044092	133	0.027	Rat
morphogenesis of an epithelium	GO:0002009	20	0.026
developmental growth involved in morphogenesis	GO:0060560	33	0.026
stress activated protein kinase signaling cascade	GO:0031098	37	0.026
lipid metabolic process	GO:0006629	283	0.026
response to other organism	GO:0051707	220	0.026
purine ribonucleotide metabolic process	GO:0009150	227	0.026
positive regulation of kinase activity	GO:0033674	77	0.026
cardiovascular system development	GO:0072358	134	0.025	Mouse
sensory organ development	GO:0007423	74	0.025
multi multicellular organism process	GO:0044706	138	0.025
positive regulation of tyrosine phosphorylation of stat1 protein	GO:0042511	1	0.025
protein polymerization	GO:0051258	22	0.025
reproductive system development	GO:0061458	128	0.025
gonad development	GO:0008406	104	0.025
regulation of establishment of planar polarity	GO:0090175	2	0.025
negative regulation of programmed cell death	GO:0043069	183	0.025
embryonic pattern specification	GO:0009880	1	0.025
organic hydroxy compound metabolic process	GO:1901615	115	0.025
response to estrogen	GO:0043627	232	0.024
purine containing compound metabolic process	GO:0072521	253	0.024
metal ion transport	GO:0030001	289	0.024	Human Mouse Rat
negative regulation of response to stimulus	GO:0048585	155	0.024	Mouse
regulation of anatomical structure morphogenesis	GO:0022603	141	0.024
regulation of jak stat cascade	GO:0046425	21	0.024
regulation of receptor activity	GO:0010469	29	0.024
regulation of immune system process	GO:0002682	123	0.024
cell junction organization	GO:0034330	21	0.024
protein maturation	GO:0051604	68	0.024
smooth muscle cell migration	GO:0014909	36	0.024
positive regulation of ossification	GO:0045778	17	0.024
defense response	GO:0006952	194	0.024
negative regulation of cellular component organization	GO:0051129	83	0.024
organic anion transport	GO:0015711	132	0.024
posttranscriptional regulation of gene expression	GO:0010608	37	0.023
female sex differentiation	GO:0046660	59	0.023
regulation of organic acid transport	GO:0032890	35	0.023
axon midline choice point recognition	GO:0016199	2	0.023
wnt signaling pathway planar cell polarity pathway	GO:0060071	2	0.023
negative regulation of heart growth	GO:0061117	3	0.023
collateral sprouting	GO:0048668	2	0.023
positive regulation of cytoskeleton organization	GO:0051495	26	0.023
negative regulation of cellular protein metabolic process	GO:0032269	106	0.023
regulation of smooth muscle cell migration	GO:0014910	36	0.023
regulation of response to stress	GO:0080134	126	0.023
kidney development	GO:0001822	67	0.022
negative regulation of protein metabolic process	GO:0051248	114	0.022
cellular protein complex assembly	GO:0043623	44	0.022
carboxylic acid transport	GO:0046942	115	0.022
response to metal ion	GO:0010038	253	0.022
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.022	Mouse
negative regulation of peptidase activity	GO:0010466	38	0.022
regulation of metal ion transport	GO:0010959	118	0.022	Human Mouse Rat
blood vessel development	GO:0001568	69	0.022	Mouse
organic acid transport	GO:0015849	116	0.022
protein transport	GO:0015031	132	0.022	Human
negative regulation of proteolysis	GO:0045861	41	0.021
potassium ion transport	GO:0006813	97	0.021	Human Rat
organ regeneration	GO:0031100	101	0.021
small gtpase mediated signal transduction	GO:0007264	36	0.021
cellular response to oxygen containing compound	GO:1901701	386	0.021
positive regulation of protein kinase activity	GO:0045860	73	0.021
negative regulation of protein processing	GO:0010955	47	0.021
muscle system process	GO:0003012	115	0.021
apoptotic signaling pathway	GO:0097190	27	0.021
response to starvation	GO:0042594	59	0.021
cardiac muscle cell action potential involved in contraction	GO:0086002	2	0.021	Rat
positive regulation of neuron differentiation	GO:0045666	126	0.021
cellular catabolic process	GO:0044248	295	0.021	Human Mouse
adult locomotory behavior	GO:0008344	4	0.021
cellular response to peptide	GO:1901653	133	0.021
regulation of protein localization	GO:0032880	81	0.020
regulation of l glutamate transport	GO:0002036	1	0.020
synaptic growth at neuromuscular junction	GO:0051124	1	0.020
camera type eye development	GO:0043010	48	0.020
cellular carbohydrate metabolic process	GO:0044262	72	0.020
hair cell differentiation	GO:0035315	2	0.020
inner ear receptor cell differentiation	GO:0060113	2	0.020
organophosphate metabolic process	GO:0019637	370	0.019
regulation of blood pressure	GO:0008217	83	0.019
response to insulin	GO:0032868	133	0.019
activation of mapkkk activity	GO:0000185	1	0.019
inner ear development	GO:0048839	21	0.019
regulation of peptidyl tyrosine phosphorylation	GO:0050730	32	0.019
muscle cell apoptotic process	GO:0010657	30	0.019
viral transcription	GO:0019083	2	0.019
negative regulation of endothelial cell proliferation	GO:0001937	5	0.019
transmembrane transport	GO:0055085	412	0.019	Human Mouse Rat
cellular response to nitrogen compound	GO:1901699	210	0.019
regulation of membrane potential	GO:0042391	110	0.019	Human Rat
protein heterooligomerization	GO:0051291	89	0.018
cellular response to insulin stimulus	GO:0032869	81	0.018
organ morphogenesis	GO:0009887	75	0.018	Mouse
negative regulation of smooth muscle cell proliferation	GO:0048662	21	0.018
regulation of amino acid transport	GO:0051955	25	0.018
circadian rhythm	GO:0007623	88	0.018
axon regeneration	GO:0031103	28	0.018
regulation of transmembrane transport	GO:0034762	122	0.018	Human Rat
regulation of neuron death	GO:1901214	115	0.018
carbohydrate derivative biosynthetic process	GO:1901137	124	0.018
single organismal cell cell adhesion	GO:0016337	42	0.018
negative regulation of developmental growth	GO:0048640	15	0.018
muscle organ development	GO:0007517	50	0.018
cellular response to lipid	GO:0071396	201	0.017
muscle contraction	GO:0006936	88	0.017
response to lipopolysaccharide	GO:0032496	191	0.017
ovulation cycle	GO:0042698	67	0.017
multicellular organismal signaling	GO:0035637	44	0.017
synapse organization	GO:0050808	46	0.017	Mouse
negative regulation of neuron projection development	GO:0010977	46	0.017
response to cytokine	GO:0034097	215	0.017
response to inorganic substance	GO:0010035	377	0.017
positive regulation of cell cycle g2 m phase transition	GO:1902751	1	0.017
limb development	GO:0060173	5	0.017
extrinsic apoptotic signaling pathway	GO:0097191	10	0.017
neural crest cell development	GO:0014032	2	0.017
phagocytosis	GO:0006909	17	0.017
chromosome segregation	GO:0007059	2	0.017
cellular macromolecular complex assembly	GO:0034622	58	0.017
positive regulation of transport	GO:0051050	245	0.017	Human Rat
cellular modified amino acid catabolic process	GO:0042219	1	0.017
positive regulation of cell motility	GO:2000147	97	0.017
response to decreased oxygen levels	GO:0036293	237	0.017
appendage development	GO:0048736	5	0.017
regulation of system process	GO:0044057	208	0.016
mitotic cell cycle	GO:0000278	49	0.016
axon guidance	GO:0007411	24	0.016
parasympathetic nervous system development	GO:0048486	1	0.016
regulation of protein complex assembly	GO:0043254	33	0.016
cell adhesion	GO:0007155	110	0.016
bone mineralization	GO:0030282	11	0.016
response to biotic stimulus	GO:0009607	226	0.016
neural crest cell differentiation	GO:0014033	2	0.016
rna processing	GO:0006396	22	0.016
regulation of neuron apoptotic process	GO:0043523	83	0.016
asymmetric protein localization	GO:0008105	2	0.016
regulation of cell cycle process	GO:0010564	31	0.016
indole containing compound metabolic process	GO:0042430	11	0.015
regulation of heart growth	GO:0060420	12	0.015
establishment of planar polarity	GO:0001736	1	0.015
regulation of protein kinase a signaling	GO:0010738	6	0.015
response to external biotic stimulus	GO:0043207	221	0.015
nucleoside phosphate metabolic process	GO:0006753	283	0.015
cell projection assembly	GO:0030031	21	0.015
regulation of hydrolase activity	GO:0051336	143	0.015
nucleoside metabolic process	GO:0009116	179	0.015
catabolic process	GO:0009056	351	0.015	Human Mouse Rat
eye development	GO:0001654	50	0.015
exit from mitosis	GO:0010458	1	0.015
mast cell migration	GO:0097531	4	0.015
mitochondrion organization	GO:0007005	35	0.015
gliogenesis	GO:0042063	93	0.015
intracellular transport	GO:0046907	185	0.015	Human
tissue morphogenesis	GO:0048729	22	0.015

Nedd4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.039
disease of anatomical entity	DOID:7	0.039
disease of metabolism	DOID:0014667	0.018
central nervous system disease	DOID:331	0.017

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