IMP: Integrative Multi-species Prediction

Rattus norvegicus

109 known processes

Eif2b1

eukaryotic translation initiation factor 2B, subunit 1 alpha

(Aliases: eIF-2a)

Entrez: 64514
RGD: 620819
Ensembl: ENSRNOG00000001039
UniProtKB: Q64270

Process Predictions
Disease Predictions

Eif2b1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of translational initiation	GO:0045947	5	0.266
translation	GO:0006412	35	0.253
ribonucleoside metabolic process	GO:0009119	174	0.117
response to peptide	GO:1901652	292	0.086
negative regulation of metabolic process	GO:0009892	331	0.076
ribonucleotide catabolic process	GO:0009261	136	0.070
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.068
ensheathment of neurons	GO:0007272	40	0.068
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.067
purine nucleotide metabolic process	GO:0006163	229	0.064
carbohydrate derivative metabolic process	GO:1901135	346	0.063
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.061
female sex differentiation	GO:0046660	59	0.059
nucleotide metabolic process	GO:0009117	279	0.059
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.059
reproductive process	GO:0022414	372	0.058
nucleobase containing small molecule metabolic process	GO:0055086	316	0.057
organophosphate metabolic process	GO:0019637	370	0.057
aging	GO:0007568	241	0.054
carbohydrate derivative catabolic process	GO:1901136	147	0.053
purine containing compound metabolic process	GO:0072521	253	0.053
purine ribonucleoside catabolic process	GO:0046130	124	0.052
response to glucose	GO:0009749	136	0.051
nucleoside phosphate metabolic process	GO:0006753	283	0.049
response to carbohydrate	GO:0009743	183	0.049
purine nucleoside catabolic process	GO:0006152	124	0.049
ribonucleotide metabolic process	GO:0009259	231	0.048
ribose phosphate metabolic process	GO:0019693	235	0.048
nucleoside catabolic process	GO:0009164	126	0.045
organonitrogen compound catabolic process	GO:1901565	179	0.044
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.044
rna biosynthetic process	GO:0032774	380	0.044
purine containing compound catabolic process	GO:0072523	138	0.044
regulation of cellular protein metabolic process	GO:0032268	267	0.043
neuronal action potential	GO:0019228	35	0.043
axon ensheathment	GO:0008366	40	0.040
regulation of translation	GO:0006417	27	0.040
development of primary sexual characteristics	GO:0045137	107	0.039
purine nucleotide catabolic process	GO:0006195	136	0.039
nucleoside triphosphate metabolic process	GO:0009141	144	0.038
positive regulation of phosphate metabolic process	GO:0045937	262	0.037
response to monosaccharide	GO:0034284	159	0.037
regulation of translation in response to stress	GO:0043555	5	0.036
organophosphate catabolic process	GO:0046434	148	0.036
aromatic compound catabolic process	GO:0019439	168	0.035
response to peptide hormone	GO:0043434	278	0.034
gonad development	GO:0008406	104	0.033
transmission of nerve impulse	GO:0019226	42	0.033
multicellular organism reproduction	GO:0032504	233	0.033
nucleobase containing compound catabolic process	GO:0034655	152	0.032
response to hexose	GO:0009746	144	0.032
sex differentiation	GO:0007548	113	0.031
regulation of nucleotide metabolic process	GO:0006140	117	0.031
regulation of phosphorus metabolic process	GO:0051174	349	0.031
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.031
development of primary female sexual characteristics	GO:0046545	56	0.031
rhythmic process	GO:0048511	156	0.030
vesicle mediated transport	GO:0016192	181	0.029
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.029
reproduction	GO:0000003	245	0.028
nucleotide catabolic process	GO:0009166	139	0.028
regulation of rna biosynthetic process	GO:2001141	381	0.028
nucleoside triphosphate catabolic process	GO:0009143	123	0.028
regulation of phosphate metabolic process	GO:0019220	349	0.027
regulation of protein metabolic process	GO:0051246	289	0.026
regulation of cell cycle	GO:0051726	73	0.026
gtp metabolic process	GO:0046039	72	0.026
cellular amine metabolic process	GO:0044106	38	0.026
multicellular organismal reproductive process	GO:0048609	233	0.025
developmental process involved in reproduction	GO:0003006	159	0.025
negative regulation of protein metabolic process	GO:0051248	114	0.025
positive regulation of phosphorus metabolic process	GO:0010562	262	0.025
female gonad development	GO:0008585	53	0.025
regulation of catalytic activity	GO:0050790	304	0.024
positive regulation of nucleotide metabolic process	GO:0045981	91	0.024
positive regulation of hydrolase activity	GO:0051345	86	0.024
regulation of purine nucleotide metabolic process	GO:1900542	115	0.023
purine ribonucleotide metabolic process	GO:0009150	227	0.023
heterocycle catabolic process	GO:0046700	167	0.023
glycosyl compound metabolic process	GO:1901657	182	0.023
apoptotic process	GO:0006915	381	0.023
purine ribonucleoside metabolic process	GO:0046128	168	0.023
nucleoside metabolic process	GO:0009116	179	0.022
organic cyclic compound catabolic process	GO:1901361	175	0.022
transcription dna templated	GO:0006351	377	0.022
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.022
ribonucleoside catabolic process	GO:0042454	126	0.022
reproductive structure development	GO:0048608	128	0.021
guanosine containing compound catabolic process	GO:1901069	71	0.021
eye morphogenesis	GO:0048592	4	0.020
negative regulation of gene expression	GO:0010629	199	0.020
positive regulation of gene expression	GO:0010628	244	0.020
translational initiation	GO:0006413	8	0.020
negative regulation of cellular metabolic process	GO:0031324	281	0.020
single organism catabolic process	GO:0044712	283	0.020
multicellular organismal signaling	GO:0035637	44	0.020
negative regulation of biosynthetic process	GO:0009890	168	0.019
regulation of nucleotide catabolic process	GO:0030811	65	0.019
ovulation cycle process	GO:0022602	50	0.019
regulation of membrane potential	GO:0042391	110	0.019
amine metabolic process	GO:0009308	38	0.019
rna metabolic process	GO:0016070	406	0.019
positive regulation of cellular catabolic process	GO:0031331	71	0.019
reproductive system development	GO:0061458	128	0.019
cellular response to stress	GO:0033554	269	0.019
action potential	GO:0001508	54	0.018
nucleic acid templated transcription	GO:0097659	379	0.018
cellular catabolic process	GO:0044248	295	0.018
organelle organization	GO:0006996	266	0.018
negative regulation of macromolecule metabolic process	GO:0010605	260	0.018
gtp catabolic process	GO:0006184	71	0.018
regulation of cell proliferation	GO:0042127	359	0.018
positive regulation of gtp catabolic process	GO:0033126	48	0.017
cellular nitrogen compound catabolic process	GO:0044270	163	0.017
cellular component assembly	GO:0022607	360	0.017
maintenance of location	GO:0051235	17	0.017
positive regulation of catalytic activity	GO:0043085	184	0.017
negative regulation of cellular protein metabolic process	GO:0032269	106	0.017
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.016
regulation of rna metabolic process	GO:0051252	391	0.016
oligodendrocyte differentiation	GO:0048709	32	0.016
positive regulation of nucleotide catabolic process	GO:0030813	53	0.016
regulation of catabolic process	GO:0009894	113	0.016
regulation of gtpase activity	GO:0043087	57	0.016
nucleoside phosphate catabolic process	GO:1901292	140	0.016
positive regulation of molecular function	GO:0044093	230	0.016
astrocyte development	GO:0014002	4	0.015
cation transport	GO:0006812	382	0.015
central nervous system development	GO:0007417	311	0.015
nitrogen compound transport	GO:0071705	229	0.015
regulation of molecular function	GO:0065009	398	0.015
organonitrogen compound biosynthetic process	GO:1901566	167	0.015
purine nucleoside metabolic process	GO:0042278	169	0.015
macromolecular complex subunit organization	GO:0043933	339	0.015
response to heat	GO:0009408	60	0.014
catabolic process	GO:0009056	351	0.014
intracellular transport	GO:0046907	185	0.014
ovulation cycle	GO:0042698	67	0.014
positive regulation of biosynthetic process	GO:0009891	319	0.014
positive regulation of gtpase activity	GO:0043547	47	0.014
oxoacid metabolic process	GO:0043436	290	0.014
histone methylation	GO:0016571	3	0.014
regulation of purine nucleotide catabolic process	GO:0033121	65	0.013
negative regulation of cell death	GO:0060548	229	0.013
glial cell differentiation	GO:0010001	65	0.013
single organism intracellular transport	GO:1902582	166	0.013
transcription from rna polymerase ii promoter	GO:0006366	252	0.012
embryo development	GO:0009790	49	0.012
regulation of nucleic acid templated transcription	GO:1903506	380	0.012
myelination	GO:0042552	39	0.012
positive regulation of cellular component organization	GO:0051130	200	0.012
single organism reproductive process	GO:0044702	297	0.012
nucleotide biosynthetic process	GO:0009165	98	0.012
regulation of gtp catabolic process	GO:0033124	58	0.012
response to acid chemical	GO:0001101	222	0.012
nucleoside monophosphate metabolic process	GO:0009123	93	0.011
negative regulation of apoptotic process	GO:0043066	181	0.011
secretion	GO:0046903	307	0.011
nucleoside phosphate biosynthetic process	GO:1901293	102	0.011
synaptic vesicle endocytosis	GO:0048488	4	0.011
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.011
regulation of synaptic vesicle endocytosis	GO:1900242	1	0.011
positive regulation of rna biosynthetic process	GO:1902680	197	0.011
glial cell development	GO:0021782	19	0.011
response to temperature stimulus	GO:0009266	94	0.010
head development	GO:0060322	247	0.010
macromolecular complex assembly	GO:0065003	273	0.010
organic substance catabolic process	GO:1901575	316	0.010
single organism cellular localization	GO:1902580	102	0.010
regulation of cellular component organization	GO:0051128	368	0.010
positive regulation of nucleoside metabolic process	GO:0045979	55	0.010
regulation of nucleoside metabolic process	GO:0009118	66	0.010

Eif2b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.031
nervous system disease	DOID:863	0.031
central nervous system disease	DOID:331	0.018
brain disease	DOID:936	0.012

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