IMP: Integrative Multi-species Prediction

Rattus norvegicus

31 known processes

Gtf2h1

general transcription factor IIH, polypeptide 1

Entrez: 361580
Ensembl: ENSRNOG00000012360
RGD: 1308225
UniProtKB: D3ZYG3

Process Predictions
Disease Predictions

Gtf2h1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.045
catabolic process	GO:0009056	351	0.039
rna biosynthetic process	GO:0032774	380	0.039
organic acid metabolic process	GO:0006082	292	0.037
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.034
protein complex subunit organization	GO:0071822	302	0.032
regulation of nucleic acid templated transcription	GO:1903506	380	0.030
programmed cell death	GO:0012501	392	0.029
single organism reproductive process	GO:0044702	297	0.029
positive regulation of cellular biosynthetic process	GO:0031328	295	0.029
oxoacid metabolic process	GO:0043436	290	0.029
carboxylic acid metabolic process	GO:0019752	289	0.027
regulation of transcription dna templated	GO:0006355	374	0.026
macromolecular complex assembly	GO:0065003	273	0.025
positive regulation of biosynthetic process	GO:0009891	319	0.025
regulation of cellular ketone metabolic process	GO:0010565	27	0.025
intracellular signal transduction	GO:0035556	314	0.024
fatty acid metabolic process	GO:0006631	99	0.024
organic substance catabolic process	GO:1901575	316	0.023
cellular response to endogenous stimulus	GO:0071495	377	0.023
positive regulation of gene expression	GO:0010628	244	0.022
cellular ketone metabolic process	GO:0042180	51	0.021
cation transport	GO:0006812	382	0.021
regulation of programmed cell death	GO:0043067	341	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.021
regulation of cellular amino acid metabolic process	GO:0006521	2	0.021
development of primary sexual characteristics	GO:0045137	107	0.021
locomotion	GO:0040011	237	0.020
regulation of multicellular organismal development	GO:2000026	376	0.020
reproduction	GO:0000003	245	0.020
positive regulation of cell death	GO:0010942	184	0.020
positive regulation of cell differentiation	GO:0045597	217	0.019
chromosome segregation	GO:0007059	2	0.019
positive regulation of multicellular organismal process	GO:0051240	387	0.019
ion transmembrane transport	GO:0034220	365	0.019
cellular amine metabolic process	GO:0044106	38	0.018
regulation of rna metabolic process	GO:0051252	391	0.018
regulation of cell proliferation	GO:0042127	359	0.018
amine metabolic process	GO:0009308	38	0.018
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.018
positive regulation of cell development	GO:0010720	176	0.018
homeostatic process	GO:0042592	331	0.018
positive regulation of cell communication	GO:0010647	271	0.018
cellular amino acid metabolic process	GO:0006520	107	0.018
anatomical structure morphogenesis	GO:0009653	298	0.018
macromolecule localization	GO:0033036	252	0.018
transmembrane transport	GO:0055085	412	0.018
cellular component morphogenesis	GO:0032989	155	0.017
response to hexose	GO:0009746	144	0.017
response to carbohydrate	GO:0009743	183	0.017
intracellular transport	GO:0046907	185	0.017
negative regulation of metabolic process	GO:0009892	331	0.017
positive regulation of developmental process	GO:0051094	283	0.017
cellular component biogenesis	GO:0044085	368	0.016
neuron projection development	GO:0031175	273	0.016
cellular response to stress	GO:0033554	269	0.016
chemical homeostasis	GO:0048878	292	0.016
multicellular organism reproduction	GO:0032504	233	0.016
positive regulation of rna biosynthetic process	GO:1902680	197	0.016
reproductive process	GO:0022414	372	0.016
cellular catabolic process	GO:0044248	295	0.016
protein phosphorylation	GO:0006468	345	0.015
nucleic acid templated transcription	GO:0097659	379	0.015
regulation of cellular amine metabolic process	GO:0033238	8	0.015
negative regulation of macromolecule metabolic process	GO:0010605	260	0.015
reproductive structure development	GO:0048608	128	0.015
cellular lipid metabolic process	GO:0044255	208	0.015
response to metal ion	GO:0010038	253	0.015
regulation of rna biosynthetic process	GO:2001141	381	0.015
regulation of apoptotic process	GO:0042981	335	0.015
response to glucose	GO:0009749	136	0.015
lipid metabolic process	GO:0006629	283	0.015
apoptotic process	GO:0006915	381	0.015
regulation of phosphate metabolic process	GO:0019220	349	0.014
developmental process involved in reproduction	GO:0003006	159	0.014
positive regulation of cellular amine metabolic process	GO:0033240	3	0.014
reproductive system development	GO:0061458	128	0.014
rna metabolic process	GO:0016070	406	0.014
organelle organization	GO:0006996	266	0.014
anion transport	GO:0006820	178	0.014
positive regulation of molecular function	GO:0044093	230	0.014
positive regulation of protein metabolic process	GO:0051247	178	0.014
positive regulation of rna metabolic process	GO:0051254	203	0.014
sex differentiation	GO:0007548	113	0.014
multicellular organismal reproductive process	GO:0048609	233	0.014
small gtpase mediated signal transduction	GO:0007264	36	0.014
cell projection organization	GO:0030030	302	0.014
synaptic transmission	GO:0007268	235	0.013
cell cycle checkpoint	GO:0000075	2	0.013
single organism catabolic process	GO:0044712	283	0.013
regulation of neuron differentiation	GO:0045664	208	0.013
response to cytokine	GO:0034097	215	0.013
protein complex biogenesis	GO:0070271	263	0.013
metal ion transport	GO:0030001	289	0.013
protein complex assembly	GO:0006461	263	0.013
regulation of cell differentiation	GO:0045595	320	0.013
response to corticosteroid	GO:0031960	235	0.013
cellular response to cytokine stimulus	GO:0071345	127	0.013
synaptic growth at neuromuscular junction	GO:0051124	1	0.013
response to inorganic substance	GO:0010035	377	0.013
regulation of hormone levels	GO:0010817	187	0.013
cell cell signaling	GO:0007267	335	0.013
negative regulation of cellular metabolic process	GO:0031324	281	0.013
regulation of neuron projection development	GO:0010975	161	0.012
regulation of phosphorus metabolic process	GO:0051174	349	0.012
regulation of cellular protein metabolic process	GO:0032268	267	0.012
multi organism reproductive process	GO:0044703	262	0.012
small molecule biosynthetic process	GO:0044283	124	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.012
response to glucocorticoid	GO:0051384	223	0.012
cell cycle	GO:0007049	101	0.012
regulation of hormone secretion	GO:0046883	106	0.012
positive regulation of transcription dna templated	GO:0045893	197	0.012
inorganic ion transmembrane transport	GO:0098660	229	0.012
neuron differentiation	GO:0030182	368	0.012
regulation of molecular function	GO:0065009	398	0.012
cell growth	GO:0016049	104	0.012
cellular homeostasis	GO:0019725	252	0.011
single organism carbohydrate metabolic process	GO:0044723	118	0.011
response to ketone	GO:1901654	182	0.011
positive regulation of phosphate metabolic process	GO:0045937	262	0.011
regulation of cellular component organization	GO:0051128	368	0.011
monocarboxylic acid metabolic process	GO:0032787	152	0.011
signal release	GO:0023061	145	0.011
protein oligomerization	GO:0051259	191	0.011
positive regulation of response to stimulus	GO:0048584	285	0.011
glucose metabolic process	GO:0006006	52	0.011
cellular component assembly	GO:0022607	360	0.011
organic cyclic compound catabolic process	GO:1901361	175	0.011
dna metabolic process	GO:0006259	96	0.011
positive regulation of programmed cell death	GO:0043068	157	0.011
response to toxic substance	GO:0009636	133	0.011
central nervous system development	GO:0007417	311	0.011
bmp signaling pathway	GO:0030509	4	0.011
protein localization	GO:0008104	191	0.011
neuron development	GO:0048666	286	0.010
myosin filament assembly	GO:0031034	1	0.010
nucleoside phosphate metabolic process	GO:0006753	283	0.010
ribose phosphate metabolic process	GO:0019693	235	0.010
localization of cell	GO:0051674	202	0.010
gonad development	GO:0008406	104	0.010
response to growth factor	GO:0070848	189	0.010
response to peptide	GO:1901652	292	0.010

Gtf2h1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.016
disease of anatomical entity	DOID:7	0.016
central nervous system disease	DOID:331	0.013
disease of metabolism	DOID:0014667	0.011

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