IMP: Integrative Multi-species Prediction

Rattus norvegicus

17 known processes

Gsk3a

glycogen synthase kinase 3 alpha

RGD: 620351
Ensembl: ENSRNOG00000020417
Entrez: 50686
UniProtKB: P18265

Process Predictions
Disease Predictions

Gsk3a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
single organism behavior	GO:0044708	130	0.258	Fly
rna biosynthetic process	GO:0032774	380	0.146	Mouse
nucleic acid templated transcription	GO:0097659	379	0.139	Mouse
anterior posterior pattern specification	GO:0009952	1	0.137
monovalent inorganic cation transport	GO:0015672	172	0.117
regulation of rna biosynthetic process	GO:2001141	381	0.098	Mouse
transcription dna templated	GO:0006351	377	0.093	Mouse
protein localization	GO:0008104	191	0.082	Worm
cellular catabolic process	GO:0044248	295	0.080	Mouse Fly
regulation of multicellular organismal development	GO:2000026	376	0.079	Mouse Rat Fly
regulation of transcription dna templated	GO:0006355	374	0.072	Mouse
regulation of neuron differentiation	GO:0045664	208	0.068	Rat
cell cycle	GO:0007049	101	0.068	Worm Fly
regulation of signal transduction	GO:0009966	318	0.068	Human Mouse Rat Worm Fly
regulation of cellular component organization	GO:0051128	368	0.067	Mouse Rat Worm Fly
membrane organization	GO:0061024	94	0.066	Mouse Worm
reproductive process	GO:0022414	372	0.065	Worm Fly
central nervous system development	GO:0007417	311	0.064
regulation of rna metabolic process	GO:0051252	391	0.062	Mouse
cell projection organization	GO:0030030	302	0.062	Rat
neuron projection development	GO:0031175	273	0.059	Rat
jak stat cascade	GO:0007259	26	0.059
positive regulation of response to stimulus	GO:0048584	285	0.057	Mouse
regulation of nucleic acid templated transcription	GO:1903506	380	0.056	Mouse
response to purine containing compound	GO:0014074	126	0.055
rna metabolic process	GO:0016070	406	0.055	Mouse
chemosensory behavior	GO:0007635	2	0.054	Fly
protein phosphorylation	GO:0006468	345	0.050
response to cytokine	GO:0034097	215	0.050	Mouse
regulation of phosphorus metabolic process	GO:0051174	349	0.050	Mouse Rat Fly
endocytosis	GO:0006897	84	0.049	Worm
multicellular organismal reproductive process	GO:0048609	233	0.048	Worm Fly
regulation of intracellular signal transduction	GO:1902531	218	0.046	Mouse Rat Fly
positive regulation of neurogenesis	GO:0050769	165	0.046
neuron death	GO:0070997	127	0.046
transmembrane transport	GO:0055085	412	0.045
grooming behavior	GO:0007625	4	0.044
homeostatic process	GO:0042592	331	0.043
ion transmembrane transport	GO:0034220	365	0.041
cellular component assembly	GO:0022607	360	0.041	Fly
circadian rhythm	GO:0007623	88	0.041	Fly
positive regulation of rna biosynthetic process	GO:1902680	197	0.040	Mouse
response to nutrient levels	GO:0031667	370	0.038
regulation of cellular localization	GO:0060341	263	0.037	Mouse Worm
carboxylic acid metabolic process	GO:0019752	289	0.037
positive regulation of gene expression	GO:0010628	244	0.037	Mouse
reproduction	GO:0000003	245	0.036	Worm Fly
response to alkaloid	GO:0043279	132	0.035
neuroblast differentiation	GO:0014016	1	0.035
regulation of nervous system development	GO:0051960	264	0.035	Rat Fly
negative regulation of transcription regulatory region dna binding	GO:2000678	2	0.034
negative regulation of metabolic process	GO:0009892	331	0.034	Human Rat Fly
regulation of cellular ketone metabolic process	GO:0010565	27	0.033
positive regulation of cellular biosynthetic process	GO:0031328	295	0.033	Mouse
rhythmic process	GO:0048511	156	0.033	Fly
organic anion transport	GO:0015711	132	0.033
secretion by cell	GO:0032940	248	0.032
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.032	Mouse
transcription from rna polymerase ii promoter	GO:0006366	252	0.031	Mouse
organic acid metabolic process	GO:0006082	292	0.031
cell morphogenesis	GO:0000902	142	0.031	Rat Fly
anion transport	GO:0006820	178	0.031
cellular response to stress	GO:0033554	269	0.030	Fly
response to mechanical stimulus	GO:0009612	134	0.030	Rat
regulation of kinase activity	GO:0043549	117	0.030	Rat Fly
rhythmic synaptic transmission	GO:0060024	1	0.030
carboxylic acid transport	GO:0046942	115	0.030
regulation of cellular protein metabolic process	GO:0032268	267	0.030	Mouse Rat Fly
male sex differentiation	GO:0046661	64	0.030	Fly
axis specification	GO:0009798	4	0.030
regulation of neurogenesis	GO:0050767	247	0.029	Rat
positive regulation of biosynthetic process	GO:0009891	319	0.029	Mouse
single organism reproductive process	GO:0044702	297	0.029	Worm Fly
oxoacid metabolic process	GO:0043436	290	0.029
positive regulation of transcription dna templated	GO:0045893	197	0.029	Mouse
positive regulation of rna metabolic process	GO:0051254	203	0.028	Mouse
neuron apoptotic process	GO:0051402	88	0.028
organic substance catabolic process	GO:1901575	316	0.028	Mouse Fly
positive regulation of phosphate metabolic process	GO:0045937	262	0.028	Mouse
cation transport	GO:0006812	382	0.028
steroid metabolic process	GO:0008202	73	0.028
regulation of protein modification process	GO:0031399	194	0.027	Mouse Rat Fly
regulation of transmembrane transporter activity	GO:0022898	49	0.027
adult locomotory behavior	GO:0008344	4	0.027
regulation of cell cycle	GO:0051726	73	0.027	Worm Fly
regulation of long term neuronal synaptic plasticity	GO:0048169	15	0.027
head development	GO:0060322	247	0.027
multi organism reproductive process	GO:0044703	262	0.026	Worm Fly
purine nucleotide metabolic process	GO:0006163	229	0.026	Mouse
cell cell signaling	GO:0007267	335	0.026	Rat Fly
negative regulation of cellular metabolic process	GO:0031324	281	0.026	Rat Fly
catabolic process	GO:0009056	351	0.025	Mouse Fly
response to monosaccharide	GO:0034284	159	0.025
nitrogen compound transport	GO:0071705	229	0.025
nucleobase containing small molecule metabolic process	GO:0055086	316	0.025	Mouse
negative regulation of response to stimulus	GO:0048585	155	0.025	Human Mouse Rat Worm Fly
male mating behavior	GO:0060179	3	0.025
cell part morphogenesis	GO:0032990	123	0.025	Rat
programmed cell death	GO:0012501	392	0.025	Mouse Rat
cellular macromolecule localization	GO:0070727	122	0.024
embryonic axis specification	GO:0000578	1	0.024
protein complex assembly	GO:0006461	263	0.024
regulation of neuron death	GO:1901214	115	0.024
glial cell differentiation	GO:0010001	65	0.023
positive regulation of cell development	GO:0010720	176	0.023
synaptic vesicle endocytosis	GO:0048488	4	0.023
intracellular receptor signaling pathway	GO:0030522	35	0.023
response to nutrient	GO:0007584	248	0.023
regulation of protein phosphorylation	GO:0001932	183	0.023	Mouse Rat Fly
cellular response to hormone stimulus	GO:0032870	247	0.023	Human Mouse
cellular component morphogenesis	GO:0032989	155	0.022	Rat Fly
response to retinoic acid	GO:0032526	63	0.022
regulation of phosphate metabolic process	GO:0019220	349	0.022	Mouse Rat Fly
regulation of phosphorylation	GO:0042325	248	0.022	Mouse Rat Fly
regulation of circadian sleep wake cycle sleep	GO:0045187	18	0.021
cell growth	GO:0016049	104	0.021	Mouse
regulation of cell development	GO:0060284	263	0.021	Mouse Rat
regulation of cellular amine metabolic process	GO:0033238	8	0.021
response to acid chemical	GO:0001101	222	0.021
negative regulation of collagen biosynthetic process	GO:0032966	4	0.021
digestive system development	GO:0055123	41	0.021
neuron projection morphogenesis	GO:0048812	122	0.021	Rat
regulation of transferase activity	GO:0051338	123	0.021	Human Mouse Rat Fly
rhythmic behavior	GO:0007622	24	0.021
negative regulation of cell communication	GO:0010648	158	0.021	Human Mouse Rat Worm Fly
response to carbohydrate	GO:0009743	183	0.021
cellular amino acid metabolic process	GO:0006520	107	0.021
embryonic pattern specification	GO:0009880	1	0.020	Fly
positive regulation of neuron differentiation	GO:0045666	126	0.020
protein oligomerization	GO:0051259	191	0.020
branched chain amino acid transport	GO:0015803	2	0.020
chemical homeostasis	GO:0048878	292	0.020
organelle organization	GO:0006996	266	0.020	Mouse Worm Fly
peptide transport	GO:0015833	97	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.020	Mouse
immune system process	GO:0002376	204	0.019	Fly
cellular response to oxygen containing compound	GO:1901701	386	0.019	Human Mouse
regulation of molecular function	GO:0065009	398	0.019	Human Mouse Rat Fly
regulation of endocytosis	GO:0030100	42	0.019
positive regulation of cell differentiation	GO:0045597	217	0.019
axon development	GO:0061564	96	0.018
response to vitamin	GO:0033273	131	0.018
positive regulation of cell death	GO:0010942	184	0.018	Mouse Rat
negative regulation of developmental process	GO:0051093	125	0.018	Mouse Rat Fly
amide transport	GO:0042886	105	0.018
cell cycle checkpoint	GO:0000075	2	0.018
cellular ketone metabolic process	GO:0042180	51	0.018
neuron development	GO:0048666	286	0.018	Rat
positive regulation of molecular function	GO:0044093	230	0.018	Mouse
oxidation reduction process	GO:0055114	304	0.018
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.018	Rat
macromolecule localization	GO:0033036	252	0.017	Worm
cell morphogenesis involved in differentiation	GO:0000904	119	0.017	Rat Fly
brain development	GO:0007420	247	0.017
purine containing compound metabolic process	GO:0072521	253	0.017	Mouse
phospholipid metabolic process	GO:0006644	61	0.017
behavior	GO:0007610	205	0.017	Fly
tube development	GO:0035295	89	0.017
development of primary sexual characteristics	GO:0045137	107	0.016	Worm Fly
negative regulation of transport	GO:0051051	136	0.016	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.016	Mouse
positive regulation of developmental process	GO:0051094	283	0.016
negative regulation of cellular component organization	GO:0051129	83	0.016	Rat Fly
metal ion transport	GO:0030001	289	0.016
single organism cellular localization	GO:1902580	102	0.016	Worm
phosphatidylinositol dephosphorylation	GO:0046856	4	0.016
peptidyl amino acid modification	GO:0018193	126	0.016	Mouse Worm
macromolecular complex subunit organization	GO:0043933	339	0.016	Worm Fly
amino acid transport	GO:0006865	70	0.016
apoptotic process	GO:0006915	381	0.015	Mouse Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.015	Mouse
negative regulation of programmed cell death	GO:0043069	183	0.015
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.015	Mouse
regulation of hormone levels	GO:0010817	187	0.015
response to peptide hormone	GO:0043434	278	0.015	Human Mouse
intracellular protein transport	GO:0006886	79	0.015
cellular homeostasis	GO:0019725	252	0.015
vesicle mediated transport	GO:0016192	181	0.015	Worm
response to amphetamine	GO:0001975	25	0.015
carbohydrate derivative metabolic process	GO:1901135	346	0.015	Mouse
positive regulation of protein modification process	GO:0031401	142	0.015	Mouse
sexual reproduction	GO:0019953	148	0.014	Worm Fly
positive regulation of cell communication	GO:0010647	271	0.014	Mouse
cellular component biogenesis	GO:0044085	368	0.014	Fly
positive regulation of cellular component organization	GO:0051130	200	0.014	Mouse Fly
response to extracellular stimulus	GO:0009991	380	0.014
response to inorganic substance	GO:0010035	377	0.014	Mouse Rat
negative regulation of cell death	GO:0060548	229	0.014
regulation of cell maturation	GO:1903429	3	0.014
negative regulation of rna metabolic process	GO:0051253	123	0.014
gonad development	GO:0008406	104	0.014	Worm Fly
regulation of programmed cell death	GO:0043067	341	0.014	Mouse Rat
regulation of neuron projection development	GO:0010975	161	0.014	Rat
positive regulation of protein export from nucleus	GO:0046827	3	0.014
positive regulation of phosphorus metabolic process	GO:0010562	262	0.014	Mouse
regulation of lipid metabolic process	GO:0019216	68	0.014
regulation of phosphatidylinositol dephosphorylation	GO:0060304	1	0.013
positive regulation of signaling	GO:0023056	270	0.013	Mouse
protein targeting	GO:0006605	61	0.013
regulation of cellular catabolic process	GO:0031329	101	0.013	Fly
response to electrical stimulus	GO:0051602	56	0.013
anion transmembrane transport	GO:0098656	77	0.013
embryo development	GO:0009790	49	0.013	Worm Fly
positive regulation of cellular amine metabolic process	GO:0033240	3	0.013
organophosphate metabolic process	GO:0019637	370	0.013	Mouse
endoplasmic reticulum organization	GO:0007029	1	0.012
gamete generation	GO:0007276	124	0.012	Worm Fly
positive regulation of intracellular signal transduction	GO:1902533	138	0.012
negative regulation of cell development	GO:0010721	82	0.012	Mouse Rat
regulation of cell cycle arrest	GO:0071156	2	0.012
positive regulation of protein phosphorylation	GO:0001934	135	0.012	Mouse
synaptic transmission	GO:0007268	235	0.012	Rat Fly
ion homeostasis	GO:0050801	212	0.012
response to oxidative stress	GO:0006979	186	0.012
neurotrophin production	GO:0032898	2	0.012
nucleoside triphosphate metabolic process	GO:0009141	144	0.012
multicellular organism reproduction	GO:0032504	233	0.012	Worm Fly
synaptic growth at neuromuscular junction	GO:0051124	1	0.012	Fly
proteolysis	GO:0006508	175	0.012	Mouse Fly
retinal ganglion cell axon guidance	GO:0031290	1	0.012
regulation of embryonic development	GO:0045995	2	0.012
defense response	GO:0006952	194	0.012
amine metabolic process	GO:0009308	38	0.012
sex differentiation	GO:0007548	113	0.012	Worm Fly
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering	GO:0097113	2	0.012
multi multicellular organism process	GO:0044706	138	0.012
regulation of apoptotic process	GO:0042981	335	0.012	Mouse Rat
asymmetric stem cell division	GO:0098722	2	0.012
purine ribonucleoside metabolic process	GO:0046128	168	0.012
olfactory behavior	GO:0042048	2	0.011	Fly
membrane depolarization during cardiac muscle cell action potential	GO:0086012	1	0.011
neuromuscular synaptic transmission	GO:0007274	2	0.011
activation of mapkkk activity	GO:0000185	1	0.011
intracellular signal transduction	GO:0035556	314	0.011	Mouse Rat Fly
regulation of protein localization	GO:0032880	81	0.011	Worm
regulation of circadian sleep wake cycle	GO:0042749	18	0.011
regulation of cell differentiation	GO:0045595	320	0.011	Mouse Rat Fly
regulation of growth	GO:0040008	105	0.011	Mouse Fly
regulation of hormone secretion	GO:0046883	106	0.011
circadian behavior	GO:0048512	24	0.011
regulation of neuronal synaptic plasticity	GO:0048168	31	0.011	Rat
regulation of peptide secretion	GO:0002791	82	0.011
cellular response to insulin stimulus	GO:0032869	81	0.011	Human Mouse
regulation of circadian rhythm	GO:0042752	27	0.011	Fly
neuron differentiation	GO:0030182	368	0.011	Rat
cellular potassium ion transport	GO:0071804	72	0.011
regulation of cell projection organization	GO:0031344	175	0.011	Rat
cell cell junction organization	GO:0045216	20	0.011
positive regulation of catalytic activity	GO:0043085	184	0.011	Mouse
central nervous system neuron axonogenesis	GO:0021955	1	0.011
organic acid transport	GO:0015849	116	0.011
signal release	GO:0023061	145	0.011
response to radiation	GO:0009314	137	0.010
protein complex biogenesis	GO:0070271	263	0.010
cellular response to acid chemical	GO:0071229	75	0.010
neuron fate commitment	GO:0048663	4	0.010
response to ammonium ion	GO:0060359	71	0.010
negative regulation of innate immune response	GO:0045824	4	0.010
cellular amine metabolic process	GO:0044106	38	0.010
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.010	Mouse
inorganic ion transmembrane transport	GO:0098660	229	0.010
innate immune response	GO:0045087	35	0.010
response to camp	GO:0051591	91	0.010
macromolecule catabolic process	GO:0009057	58	0.010	Mouse Fly

Gsk3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.043
	nervous system disease	DOID:863	0	0.043

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