IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Spdya

speedy homolog A (Xenopus laevis)

(Aliases: Spdy1,Spy1,Lm23,Gs4)

RGD: 621730
Entrez: 192209
Ensembl: ENSRNOG00000004534
UniProtKB: Q8R496

Process Predictions
Disease Predictions

Spdya biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
anatomical structure morphogenesis	GO:0009653	298	0.123
regulation of secretion	GO:0051046	224	0.118
protein complex subunit organization	GO:0071822	302	0.102
biological adhesion	GO:0022610	110	0.088
positive regulation of biosynthetic process	GO:0009891	319	0.085
positive regulation of transport	GO:0051050	245	0.075
positive regulation of cell proliferation	GO:0008284	249	0.066	Human
positive regulation of multicellular organismal process	GO:0051240	387	0.064
leukocyte activation	GO:0045321	76	0.064
regulation of response to stress	GO:0080134	126	0.063
cell adhesion	GO:0007155	110	0.058
renal system development	GO:0072001	67	0.058
tissue development	GO:0009888	252	0.053
kidney development	GO:0001822	67	0.052
protein complex assembly	GO:0006461	263	0.052
transcription from rna polymerase ii promoter	GO:0006366	252	0.050
epithelium development	GO:0060429	96	0.049
single organism reproductive process	GO:0044702	297	0.049
reproductive process	GO:0022414	372	0.045
single organism biosynthetic process	GO:0044711	342	0.044
organelle organization	GO:0006996	266	0.044	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	295	0.043
cell projection organization	GO:0030030	302	0.043
macromolecular complex subunit organization	GO:0043933	339	0.042
macromolecular complex assembly	GO:0065003	273	0.041
macromolecule localization	GO:0033036	252	0.040
regulation of nucleic acid templated transcription	GO:1903506	380	0.040
secretion by cell	GO:0032940	248	0.040
cellular component biogenesis	GO:0044085	368	0.040
apoptotic process	GO:0006915	381	0.038
neuron apoptotic process	GO:0051402	88	0.038
negative regulation of apoptotic process	GO:0043066	181	0.036
developmental growth	GO:0048589	100	0.036
cellular component assembly	GO:0022607	360	0.036
reproductive system development	GO:0061458	128	0.036
cell morphogenesis involved in differentiation	GO:0000904	119	0.035
cell type specific apoptotic process	GO:0097285	134	0.034
regulation of synaptic plasticity	GO:0048167	70	0.034
positive regulation of transcription dna templated	GO:0045893	197	0.034
neuron projection morphogenesis	GO:0048812	122	0.033
cation transport	GO:0006812	382	0.033
programmed cell death	GO:0012501	392	0.032
cellular response to growth factor stimulus	GO:0071363	162	0.032
immune system process	GO:0002376	204	0.032
positive regulation of cellular component organization	GO:0051130	200	0.031
cellular amine metabolic process	GO:0044106	38	0.031
neuron projection development	GO:0031175	273	0.031
regulation of hormone levels	GO:0010817	187	0.031
regulation of catabolic process	GO:0009894	113	0.030
proteolysis	GO:0006508	175	0.030
catabolic process	GO:0009056	351	0.030
response to peptide hormone	GO:0043434	278	0.030
cellular component morphogenesis	GO:0032989	155	0.029
regulation of vesicle mediated transport	GO:0060627	81	0.029
establishment of protein localization	GO:0045184	141	0.029
protein phosphorylation	GO:0006468	345	0.029	Mouse
embryonic skeletal system development	GO:0048706	3	0.029
cardiovascular system development	GO:0072358	134	0.028
response to growth factor	GO:0070848	189	0.028
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure	GO:0002025	1	0.028
reproduction	GO:0000003	245	0.028	Mouse
intracellular signal transduction	GO:0035556	314	0.028
response to peptide	GO:1901652	292	0.028
response to insulin	GO:0032868	133	0.027
negative regulation of cell death	GO:0060548	229	0.027
synaptic transmission	GO:0007268	235	0.027
neuron differentiation	GO:0030182	368	0.027
regulation of secretion by cell	GO:1903530	208	0.027
heart morphogenesis	GO:0003007	3	0.027
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.026
signal release	GO:0023061	145	0.026
neuron development	GO:0048666	286	0.026
cellular response to external stimulus	GO:0071496	118	0.026
negative regulation of programmed cell death	GO:0043069	183	0.026
urogenital system development	GO:0001655	78	0.025
sex differentiation	GO:0007548	113	0.025
developmental process involved in reproduction	GO:0003006	159	0.025
regulation of phosphate metabolic process	GO:0019220	349	0.025	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.025
gonad development	GO:0008406	104	0.025
cell part morphogenesis	GO:0032990	123	0.025
ovulation cycle process	GO:0022602	50	0.025
positive regulation of developmental process	GO:0051094	283	0.024
development of primary female sexual characteristics	GO:0046545	56	0.024
amine metabolic process	GO:0009308	38	0.024
multicellular organism reproduction	GO:0032504	233	0.024
retinal ganglion cell axon guidance	GO:0031290	1	0.024
multicellular organismal reproductive process	GO:0048609	233	0.024
homeostatic process	GO:0042592	331	0.024
cellular response to endogenous stimulus	GO:0071495	377	0.024
immune effector process	GO:0002252	53	0.024
protein transport	GO:0015031	132	0.024
protein complex biogenesis	GO:0070271	263	0.023
growth	GO:0040007	165	0.023
negative regulation of gene expression	GO:0010629	199	0.023
regulation of rna metabolic process	GO:0051252	391	0.023
blood vessel morphogenesis	GO:0048514	58	0.023
positive regulation of phosphorylation	GO:0042327	177	0.023	Mouse
cellular homeostasis	GO:0019725	252	0.023
multi organism reproductive process	GO:0044703	262	0.023
regulation of cell proliferation	GO:0042127	359	0.022	Human
response to reactive oxygen species	GO:0000302	120	0.022
regulation of homeostatic process	GO:0032844	101	0.022
development of primary sexual characteristics	GO:0045137	107	0.022
cellular response to peptide hormone stimulus	GO:0071375	120	0.022
cell morphogenesis	GO:0000902	142	0.021
protein oligomerization	GO:0051259	191	0.021
cell projection morphogenesis	GO:0048858	123	0.021
regulation of immune system process	GO:0002682	123	0.021
urinary bladder smooth muscle contraction	GO:0014832	4	0.021
inflammatory response	GO:0006954	150	0.020
response to mechanical stimulus	GO:0009612	134	0.020
cellular component movement	GO:0006928	248	0.020
regulation of phosphorylation	GO:0042325	248	0.020	Mouse
response to nutrient levels	GO:0031667	370	0.020
regulation of phosphorus metabolic process	GO:0051174	349	0.020	Mouse
regulation of protein localization	GO:0032880	81	0.020
sexual reproduction	GO:0019953	148	0.020
immune response	GO:0006955	104	0.020
urinary tract smooth muscle contraction	GO:0014848	4	0.020
cellular response to oxygen containing compound	GO:1901701	386	0.020
hormone transport	GO:0009914	121	0.019
response to inorganic substance	GO:0010035	377	0.019
nucleoside phosphate metabolic process	GO:0006753	283	0.019
regulation of cellular protein metabolic process	GO:0032268	267	0.019	Mouse
regulation of establishment of protein localization	GO:0070201	69	0.018
cellular ketone metabolic process	GO:0042180	51	0.018
regulation of system process	GO:0044057	208	0.018
wound healing	GO:0042060	122	0.018
cellular macromolecule localization	GO:0070727	122	0.018
organic substance catabolic process	GO:1901575	316	0.018
regulation of apoptotic process	GO:0042981	335	0.018
secretion	GO:0046903	307	0.017
positive regulation of neurogenesis	GO:0050769	165	0.017
positive regulation of protein phosphorylation	GO:0001934	135	0.017	Mouse
response to glucocorticoid	GO:0051384	223	0.017
gtp metabolic process	GO:0046039	72	0.017
regulation of cellular amino acid metabolic process	GO:0006521	2	0.017
positive regulation of response to stimulus	GO:0048584	285	0.017
regulation of defense response	GO:0031347	68	0.017
positive regulation of phosphorus metabolic process	GO:0010562	262	0.017	Mouse
gamete generation	GO:0007276	124	0.017
organophosphate metabolic process	GO:0019637	370	0.017
cellular response to lipid	GO:0071396	201	0.017
regulation of ion transport	GO:0043269	245	0.016
regulation of cell development	GO:0060284	263	0.016
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.016
regulation of hormone secretion	GO:0046883	106	0.016
vesicle mediated transport	GO:0016192	181	0.016
male gamete generation	GO:0048232	99	0.016
rna metabolic process	GO:0016070	406	0.016
response to hydrogen peroxide	GO:0042542	89	0.016
cell cell signaling	GO:0007267	335	0.016
cellular metal ion homeostasis	GO:0006875	172	0.016
positive regulation of cellular amine metabolic process	GO:0033240	3	0.016
cellular nitrogen compound catabolic process	GO:0044270	163	0.016
positive regulation of immune system process	GO:0002684	90	0.016
protein localization	GO:0008104	191	0.016
saliva secretion	GO:0046541	3	0.015
response to ketone	GO:1901654	182	0.015
axis specification	GO:0009798	4	0.015
regulation of neuron death	GO:1901214	115	0.015
nucleocytoplasmic transport	GO:0006913	48	0.015
negative regulation of response to stimulus	GO:0048585	155	0.015
fat cell proliferation	GO:0070341	2	0.015
action potential	GO:0001508	54	0.015
response to hyperoxia	GO:0055093	45	0.015
regulation of programmed cell death	GO:0043067	341	0.015
regulation of cellular amine metabolic process	GO:0033238	8	0.015
positive regulation of saliva secretion	GO:0046878	3	0.015
cellular amino acid metabolic process	GO:0006520	107	0.015
response to increased oxygen levels	GO:0036296	45	0.015
dorsal ventral axon guidance	GO:0033563	1	0.015
cell activation	GO:0001775	97	0.015
male sex differentiation	GO:0046661	64	0.015
sequestering of metal ion	GO:0051238	9	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.015
cellular response to nutrient levels	GO:0031669	60	0.015
regulation of multicellular organismal development	GO:2000026	376	0.015
spermatogenesis	GO:0007283	99	0.015
intracellular protein transport	GO:0006886	79	0.014
positive regulation of ion transport	GO:0043270	94	0.014
negative regulation of long term synaptic potentiation	GO:1900272	1	0.014
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.014
regulation of body fluid levels	GO:0050878	90	0.014
female gonad development	GO:0008585	53	0.014
regulation of response to external stimulus	GO:0032101	106	0.014
signal transduction by phosphorylation	GO:0023014	144	0.014
positive regulation of rna metabolic process	GO:0051254	203	0.014
negative regulation of innate immune response	GO:0045824	4	0.014
single organism catabolic process	GO:0044712	283	0.014
negative regulation of biosynthetic process	GO:0009890	168	0.014
regulation of protein transport	GO:0051223	68	0.014
positive regulation of nervous system development	GO:0051962	178	0.014
multicellular organism growth	GO:0035264	1	0.014
response to extracellular stimulus	GO:0009991	380	0.014
regulation of cell morphogenesis	GO:0022604	77	0.014
positive regulation of gene expression	GO:0010628	244	0.013
positive regulation of intracellular signal transduction	GO:1902533	138	0.013
carbohydrate derivative biosynthetic process	GO:1901137	124	0.013
response to metal ion	GO:0010038	253	0.013
oxoacid metabolic process	GO:0043436	290	0.013
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.013
axonogenesis	GO:0007409	71	0.013
response to hexose	GO:0009746	144	0.013
reproductive structure development	GO:0048608	128	0.013
endomembrane system organization	GO:0010256	48	0.013
positive regulation of phosphate metabolic process	GO:0045937	262	0.013	Mouse
tangential migration from the subventricular zone to the olfactory bulb	GO:0022028	1	0.013
regulation of cellular ketone metabolic process	GO:0010565	27	0.012
morphogenesis of an epithelium	GO:0002009	20	0.012
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.012
metanephros development	GO:0001656	14	0.012
detection of visible light	GO:0009584	3	0.012
regulation of rna biosynthetic process	GO:2001141	381	0.012
organic acid metabolic process	GO:0006082	292	0.012
negative regulation of secretion	GO:0051048	82	0.012
positive regulation of defense response	GO:0031349	37	0.012
hormone secretion	GO:0046879	115	0.012
nucleobase containing small molecule metabolic process	GO:0055086	316	0.012
regulation of cell differentiation	GO:0045595	320	0.012
regulation of cellular localization	GO:0060341	263	0.012
aromatic compound catabolic process	GO:0019439	168	0.012
response to cytokine	GO:0034097	215	0.012
response to transforming growth factor beta	GO:0071559	46	0.012
regulation of growth	GO:0040008	105	0.012
cell motility	GO:0048870	202	0.012
response to potassium ion	GO:0035864	9	0.012
regulation of neuronal synaptic plasticity	GO:0048168	31	0.012
cellular response to hormone stimulus	GO:0032870	247	0.012
calcium ion import	GO:0070509	22	0.012
regulation of protein modification process	GO:0031399	194	0.012	Mouse
ureteric bud development	GO:0001657	14	0.012
cellular catabolic process	GO:0044248	295	0.012
cyclic purine nucleotide metabolic process	GO:0052652	62	0.011
cellular response to nitrogen compound	GO:1901699	210	0.011
transcription dna templated	GO:0006351	377	0.011
regulation of peptide hormone secretion	GO:0090276	80	0.011
macromolecule catabolic process	GO:0009057	58	0.011
regulation of neuron differentiation	GO:0045664	208	0.011
cellular response to peptide	GO:1901653	133	0.011
cellular response to mechanical stimulus	GO:0071260	48	0.011
innate immune response	GO:0045087	35	0.011
nitrogen compound transport	GO:0071705	229	0.011
eye morphogenesis	GO:0048592	4	0.011
actin cytoskeleton organization	GO:0030036	73	0.011
odontogenesis	GO:0042476	32	0.011
positive regulation of lipid metabolic process	GO:0045834	33	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.011
rna biosynthetic process	GO:0032774	380	0.010
single fertilization	GO:0007338	3	0.010
indole containing compound metabolic process	GO:0042430	11	0.010
regulation of blood circulation	GO:1903522	110	0.010
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.010
regulation of intracellular transport	GO:0032386	65	0.010
neurological system process	GO:0050877	219	0.010
transmission of nerve impulse	GO:0019226	42	0.010
cytoplasmic transport	GO:0016482	115	0.010
regulation of inflammatory response	GO:0050727	48	0.010
rho protein signal transduction	GO:0007266	11	0.010

Spdya disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.107
disease of anatomical entity	DOID:7	0.107
eye disease	DOID:5614	0.091
eye and adnexa disease	DOID:1492	0.091
retinal disease	DOID:5679	0.091
sensory system disease	DOID:0050155	0.091
retinal degeneration	DOID:8466	0.091
musculoskeletal system disease	DOID:17	0.015
central nervous system disease	DOID:331	0.012
cardiovascular system disease	DOID:1287	0.011

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