Rattus norvegicus

0 known processes

Tox

thymocyte selection-associated high mobility group box

Tox biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
intracellular signal transductionGO:00355563140.089
Rat
cellular component movementGO:00069282480.087
transcription dna templatedGO:00063513770.087
Rat
neuron developmentGO:00486662860.086
neuron differentiationGO:00301823680.079
neuron projection developmentGO:00311752730.078
response to inorganic substanceGO:00100353770.076
positive regulation of cell proliferationGO:00082842490.068
anatomical structure morphogenesisGO:00096532980.068
cell projection organizationGO:00300303020.066
regulation of cell proliferationGO:00421273590.061
regulation of neuron projection developmentGO:00109751610.059
positive regulation of multicellular organismal processGO:00512403870.057
regulation of transcription dna templatedGO:00063553740.056
Rat
reproductive processGO:00224143720.056
Rat
regulation of multicellular organismal developmentGO:20000263760.055
regulation of cell developmentGO:00602842630.054
cellular response to oxygen containing compoundGO:19017013860.054
regulation of signal transductionGO:00099663180.052
central nervous system developmentGO:00074173110.051
organophosphate metabolic processGO:00196373700.051
rna metabolic processGO:00160704060.049
Rat
regulation of neurogenesisGO:00507672470.049
regulation of nervous system developmentGO:00519602640.048
regulation of neuron differentiationGO:00456642080.048
rna biosynthetic processGO:00327743800.047
Rat
regulation of phosphorus metabolic processGO:00511743490.047
regulation of cell differentiationGO:00455953200.046
positive regulation of nitrogen compound metabolic processGO:00511733340.046
Rat
transcription from rna polymerase ii promoterGO:00063662520.046
Rat
regulation of cell projection organizationGO:00313441750.045
regulation of nucleic acid templated transcriptionGO:19035063800.045
Rat
positive regulation of cell differentiationGO:00455972170.044
locomotionGO:00400112370.043
nucleotide metabolic processGO:00091172790.043
metal ion transportGO:00300012890.043
brain developmentGO:00074202470.043
cellular response to endogenous stimulusGO:00714953770.043
cell motilityGO:00488702020.043
response to woundingGO:00096112540.042
positive regulation of developmental processGO:00510942830.042
negative regulation of response to stimulusGO:00485851550.042
positive regulation of macromolecule biosynthetic processGO:00105572470.041
Rat
multicellular organism reproductionGO:00325042330.041
nucleoside phosphate metabolic processGO:00067532830.041
positive regulation of nervous system developmentGO:00519621780.040
chemical homeostasisGO:00488782920.040
purine nucleoside metabolic processGO:00422781690.040
single organism catabolic processGO:00447122830.039
positive regulation of cell communicationGO:00106472710.039
cell morphogenesis involved in neuron differentiationGO:00486671060.038
nucleic acid templated transcriptionGO:00976593790.038
Rat
multi organism reproductive processGO:00447032620.038
cellular response to stressGO:00335542690.038
regulation of phosphate metabolic processGO:00192203490.038
purine containing compound metabolic processGO:00725212530.037
positive regulation of cellular biosynthetic processGO:00313282950.037
Rat
regulation of rna biosynthetic processGO:20011413810.036
Rat
carbohydrate derivative metabolic processGO:19011353460.036
axon developmentGO:0061564960.036
ribonucleotide metabolic processGO:00092592310.036
positive regulation of phosphorus metabolic processGO:00105622620.035
tissue developmentGO:00098882520.035
positive regulation of neurogenesisGO:00507691650.035
regulation of molecular functionGO:00650093980.035
cell migrationGO:00164771970.035
single organism biosynthetic processGO:00447113420.035
organic substance catabolic processGO:19015753160.035
positive regulation of cell developmentGO:00107201760.035
regulation of rna metabolic processGO:00512523910.035
Rat
response to mechanical stimulusGO:00096121340.035
positive regulation of nucleobase containing compound metabolic processGO:00459353190.033
Rat
regulation of cellular component organizationGO:00511283680.033
purine nucleotide metabolic processGO:00061632290.033
head developmentGO:00603222470.033
response to estrogenGO:00436272320.033
lipid metabolic processGO:00066292830.033
positive regulation of phosphate metabolic processGO:00459372620.032
cellular component biogenesisGO:00440853680.032
protein phosphorylationGO:00064683450.032
positive regulation of cellular component movementGO:00512721020.032
ribose phosphate metabolic processGO:00196932350.031
localization of cellGO:00516742020.031
regulation of catalytic activityGO:00507903040.031
positive regulation of response to stimulusGO:00485842850.030
small gtpase mediated signal transductionGO:0007264360.030
cellular response to hormone stimulusGO:00328702470.030
carboxylic acid metabolic processGO:00197522890.030
cell morphogenesis involved in differentiationGO:00009041190.030
negative regulation of multicellular organismal processGO:00512412030.030
regulation of transcription from rna polymerase ii promoterGO:00063572340.030
Rat
purine ribonucleotide metabolic processGO:00091502270.029
g protein coupled receptor signaling pathwayGO:00071862420.029
agingGO:00075682410.029
catabolic processGO:00090563510.029
purine ribonucleoside triphosphate catabolic processGO:00092071220.029
cell part morphogenesisGO:00329901230.029
ion transmembrane transportGO:00342203650.029
reproductionGO:00000032450.029
protein complex subunit organizationGO:00718223020.028
neuron projection morphogenesisGO:00488121220.028
regulation of cellular localizationGO:00603412630.028
ras protein signal transductionGO:0007265290.028
ribonucleotide catabolic processGO:00092611360.028
positive regulation of signalingGO:00230562700.028
positive regulation of biosynthetic processGO:00098913190.028
Rat
regulation of programmed cell deathGO:00430673410.028
cellular response to organic cyclic compoundGO:00714072020.028
apoptotic processGO:00069153810.027
cation transportGO:00068123820.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.027
Rat
single organism reproductive processGO:00447022970.027
Rat
cellular catabolic processGO:00442482950.027
positive regulation of cellular component organizationGO:00511302000.027
developmental growthGO:00485891000.026
negative regulation of metabolic processGO:00098923310.026
glycosyl compound metabolic processGO:19016571820.026
growthGO:00400071650.026
purine ribonucleotide catabolic processGO:00091541360.026
response to acid chemicalGO:00011012220.026
positive regulation of catalytic activityGO:00430851840.026
positive regulation of molecular functionGO:00440932300.026
cellular response to lipidGO:00713962010.026
multicellular organismal reproductive processGO:00486092330.026
cellular chemical homeostasisGO:00550822470.026
negative regulation of signalingGO:00230571570.026
programmed cell deathGO:00125013920.025
positive regulation of transportGO:00510502450.025
regulation of hydrolase activityGO:00513361430.025
cellular amine metabolic processGO:0044106380.025
amine metabolic processGO:0009308380.025
cellular homeostasisGO:00197252520.025
cellular amino acid metabolic processGO:00065201070.025
negative regulation of cell communicationGO:00106481580.025
organic acid metabolic processGO:00060822920.025
nitrogen compound transportGO:00717052290.025
cellular nitrogen compound catabolic processGO:00442701630.024
regulation of intracellular signal transductionGO:19025312180.024
positive regulation of rna biosynthetic processGO:19026801970.024
Rat
female pregnancyGO:00075651220.024
response to extracellular stimulusGO:00099913800.024
developmental process involved in reproductionGO:00030061590.024
Rat
regulation of catabolic processGO:00098941130.024
nucleoside phosphate catabolic processGO:19012921400.024
aromatic compound catabolic processGO:00194391680.024
secretionGO:00469033070.024
circulatory system developmentGO:00723591340.023
multi multicellular organism processGO:00447061380.023
positive regulation of rna metabolic processGO:00512542030.023
Rat
cellular component assemblyGO:00226073600.023
positive regulation of signal transductionGO:00099671750.023
response to vitaminGO:00332731310.023
regulation of phosphorylationGO:00423252480.022
positive regulation of gene expressionGO:00106282440.022
Rat
nucleobase containing small molecule metabolic processGO:00550863160.022
homeostatic processGO:00425923310.022
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.022
Rat
nucleoside triphosphate metabolic processGO:00091411440.022
regulation of cellular amine metabolic processGO:003323880.022
regulation of cellular ketone metabolic processGO:0010565270.022
heart morphogenesisGO:000300730.022
cellular metal ion homeostasisGO:00068751720.022
response to molecule of bacterial originGO:00022371940.022
response to peptideGO:19016522920.021
cation transmembrane transportGO:00986552630.021
regulation of secretion by cellGO:19035302080.021
positive regulation of cell migrationGO:0030335960.021
regulation of cellular amino acid metabolic processGO:000652120.021
single organism cellular localizationGO:19025801020.021
ion homeostasisGO:00508012120.021
response to nutrient levelsGO:00316673700.021
negative regulation of cell deathGO:00605482290.020
neuron deathGO:00709971270.020
positive regulation of cell projection organizationGO:00313461110.020
cation homeostasisGO:00550801950.020
cellular cation homeostasisGO:00300031800.020
response to peptide hormoneGO:00434342780.020
cellular ion homeostasisGO:00068731840.020
organonitrogen compound catabolic processGO:19015651790.020
macromolecular complex assemblyGO:00650032730.020
gliogenesisGO:0042063930.020
positive regulation of cellular amine metabolic processGO:003324030.020
nucleotide catabolic processGO:00091661390.020
enzyme linked receptor protein signaling pathwayGO:00071671160.020
positive regulation of purine nucleotide metabolic processGO:1900544910.020
intracellular transportGO:00469071850.020
calcium ion homeostasisGO:00550741620.020
response to growth factorGO:00708481890.020
regulation of cellular component movementGO:00512701500.020
purine nucleoside triphosphate metabolic processGO:00091441410.020
protein localizationGO:00081041910.019
cellular lipid metabolic processGO:00442552080.019
purine ribonucleoside triphosphate metabolic processGO:00092051400.019
positive regulation of neuron differentiationGO:00456661260.019
gland developmentGO:00487321550.019
anterior posterior pattern specificationGO:000995210.019
positive regulation of nucleotide metabolic processGO:0045981910.019
maintenance of locationGO:0051235170.019
regulation of membrane potentialGO:00423911100.019
regulation of secretionGO:00510462240.019
organic cyclic compound catabolic processGO:19013611750.019
cellular component morphogenesisGO:00329891550.019
carbohydrate derivative catabolic processGO:19011361470.019
positive regulation of neuron projection developmentGO:0010976990.019
carbohydrate metabolic processGO:00059751300.019
regulation of canonical wnt signaling pathwayGO:006082840.019
reproductive system developmentGO:00614581280.019
Rat
purine containing compound catabolic processGO:00725231380.019
regulation of system processGO:00440572080.019
neuron apoptotic processGO:0051402880.019
rhythmic processGO:00485111560.018
defense responseGO:00069521940.018
biological adhesionGO:00226101100.018
regulation of cell motilityGO:20001451310.018
cellular response to growth factor stimulusGO:00713631620.018
cytoplasmic transportGO:00164821150.018
ribonucleoside triphosphate catabolic processGO:00092031220.018
positive regulation of cellular amino acid metabolic processGO:004576410.018
oxoacid metabolic processGO:00434362900.018
negative regulation of nucleobase containing compound metabolic processGO:00459341530.018
axis specificationGO:000979840.018
cellular response to nitrogen compoundGO:19016992100.018
organophosphate catabolic processGO:00464341480.018
cardiac chamber developmentGO:000320510.018
nucleoside triphosphate catabolic processGO:00091431230.018
regulation of neuron apoptotic processGO:0043523830.018
response to cytokineGO:00340972150.018
cell projection morphogenesisGO:00488581230.018
regulation of dendrite developmentGO:0050773590.018
regulation of cell migrationGO:00303341280.018
regenerationGO:00310991630.018
gonad developmentGO:00084061040.018
Rat
organelle organizationGO:00069962660.017
negative regulation of developmental processGO:00510931250.017
response to estradiolGO:00323551640.017
negative regulation of macromolecule metabolic processGO:00106052600.017
secretion by cellGO:00329402480.017
regulation of neuron deathGO:19012141150.017
heterocycle catabolic processGO:00467001670.017
metal ion homeostasisGO:00550651860.017
establishment of protein localizationGO:00451841410.017
regulation of proteasomal protein catabolic processGO:006113640.017
positive regulation of mapk cascadeGO:0043410920.017
regulation of hormone levelsGO:00108171870.017
positive regulation of cell deathGO:00109421840.017
cellular response to organonitrogen compoundGO:00714171970.017
response to oxygen levelsGO:00704822650.017
cardiovascular system developmentGO:00723581340.017
response to purine containing compoundGO:00140741260.017
macromolecule localizationGO:00330362520.017
purine ribonucleoside metabolic processGO:00461281680.017
regulation of apoptotic processGO:00429813350.017
cellular calcium ion homeostasisGO:00068741600.017
organophosphate biosynthetic processGO:00904071430.017
negative regulation of cellular metabolic processGO:00313242810.017
nucleobase containing compound catabolic processGO:00346551520.017
cell adhesionGO:00071551100.017
nucleoside metabolic processGO:00091161790.017
response to ketoneGO:19016541820.017
purine nucleoside triphosphate catabolic processGO:00091461220.017
single organism carbohydrate metabolic processGO:00447231180.016
positive regulation of cytosolic calcium ion concentrationGO:00072041220.016
purine nucleotide catabolic processGO:00061951360.016
response to reactive oxygen speciesGO:00003021200.016
response to nutrientGO:00075842480.016
response to metal ionGO:00100382530.016
transmembrane transportGO:00550854120.016
gastrulationGO:000736920.016
cellular macromolecule localizationGO:00707271220.016
sequestering of calcium ionGO:005120880.016
cellular protein localizationGO:00346131220.016
ribonucleoside metabolic processGO:00091191740.016
protein complex biogenesisGO:00702712630.016
cellular ketone metabolic processGO:0042180510.016
single organism intracellular transportGO:19025821660.016
positive regulation of intracellular signal transductionGO:19025331380.016
sexual reproductionGO:00199531480.016
protein complex assemblyGO:00064612630.016
inorganic cation transmembrane transportGO:00986622020.016
cellular response to steroid hormone stimulusGO:0071383930.016
divalent inorganic cation homeostasisGO:00725071650.016
purine nucleoside catabolic processGO:00061521240.016
nucleoside phosphate biosynthetic processGO:19012931020.016
dendrite developmentGO:0016358720.016
negative regulation of canonical wnt signaling pathwayGO:009009040.015
wound healingGO:00420601220.015
regulation of nucleotide metabolic processGO:00061401170.015
cellular divalent inorganic cation homeostasisGO:00725031620.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.015
embryonic pattern specificationGO:000988010.015
regulation of response to external stimulusGO:00321011060.015
forebrain developmentGO:0030900980.015
membrane organizationGO:0061024940.015
response to hypoxiaGO:00016662310.015
regulation of nucleotide catabolic processGO:0030811650.015
positive regulation of ion transportGO:0043270940.015
regulation of metal ion transportGO:00109591180.015
synaptic transmissionGO:00072682350.015
dephosphorylationGO:0016311980.015
positive regulation of cell motilityGO:2000147970.015
reproductive structure developmentGO:00486081280.015
Rat
negative regulation of biosynthetic processGO:00098901680.015
negative regulation of cell developmentGO:0010721820.015
response to decreased oxygen levelsGO:00362932370.015
positive regulation of phosphorylationGO:00423271770.015
regulation of anatomical structure sizeGO:00900661350.015
inflammatory responseGO:00069541500.015
ribonucleoside catabolic processGO:00424541260.015
regulation of ion transportGO:00432692450.015
divalent metal ion transportGO:00708381320.015
muscle cell proliferationGO:0033002840.015
development of primary sexual characteristicsGO:00451371070.015
Rat
mapk cascadeGO:00001651400.014
regulation of cell morphogenesis involved in differentiationGO:0010769720.014
cellular response to acid chemicalGO:0071229750.014
cell morphogenesisGO:00009021420.014
cellular response to reactive oxygen speciesGO:0034614550.014
neurological system processGO:00508772190.014
female sex differentiationGO:0046660590.014
Rat
eye morphogenesisGO:004859240.014
response to alkaloidGO:00432791320.014
purine nucleotide biosynthetic processGO:0006164830.014
protein oligomerizationGO:00512591910.014
macromolecular complex subunit organizationGO:00439333390.014
cellular response to ketoneGO:1901655510.014
regulation of growthGO:00400081050.014
cell cycleGO:00070491010.014
sequestering of metal ionGO:005123890.014
organic hydroxy compound transportGO:0015850770.014
negative regulation of cell differentiationGO:0045596990.014
blood circulationGO:00080151830.014
response to monosaccharideGO:00342841590.014
ribonucleotide biosynthetic processGO:0009260850.014
regulation of protein metabolic processGO:00512462890.014
divalent inorganic cation transportGO:00725111340.014
inorganic ion transmembrane transportGO:00986602290.014
positive regulation of protein modification processGO:00314011420.014
negative regulation of nervous system developmentGO:0051961790.014
gtp metabolic processGO:0046039720.014
response to hydrogen peroxideGO:0042542890.013
cellular response to oxidative stressGO:0034599760.013
negative regulation of signal transductionGO:0009968830.013
positive regulation of transcription dna templatedGO:00458931970.013
Rat
regulation of cell growthGO:0001558850.013
negative regulation of nitrogen compound metabolic processGO:00511721610.013
female gonad developmentGO:0008585530.013
Rat
response to oxidative stressGO:00069791860.013
response to glucoseGO:00097491360.013
regulation of protein localizationGO:0032880810.013
negative regulation of apoptotic processGO:00430661810.013
negative regulation of molecular functionGO:00440921330.013
positive regulation of protein metabolic processGO:00512471780.013
response to corticosteroidGO:00319602350.013
response to carbohydrateGO:00097431830.013
multicellular organism growthGO:003526410.013
cellular response to external stimulusGO:00714961180.013
response to bacteriumGO:00096172000.013
negative regulation of macromolecule biosynthetic processGO:00105581480.013
regulation of mapk cascadeGO:00434081160.013
organ morphogenesisGO:0009887750.013
nucleotide biosynthetic processGO:0009165980.013
regulation of locomotionGO:00400121480.013
amino acid transportGO:0006865700.013
chromosome segregationGO:000705920.013
cytosolic calcium ion homeostasisGO:00514801400.013
cellular response to alcoholGO:0097306870.013
axonogenesisGO:0007409710.012
cell growthGO:00160491040.012
negative regulation of neuron differentiationGO:0045665620.012
single organism membrane organizationGO:0044802740.012
lipid biosynthetic processGO:00086101280.012
immune system processGO:00023762040.012
sex differentiationGO:00075481130.012
Rat
proteolysisGO:00065081750.012
negative regulation of gene expressionGO:00106291990.012
motor neuron axon guidanceGO:000804510.012
negative regulation of protein metabolic processGO:00512481140.012
nucleoside catabolic processGO:00091641260.012
regulation of stem cell differentiationGO:200073620.012
guanosine containing compound catabolic processGO:1901069710.012
ribonucleoside triphosphate metabolic processGO:00091991410.012
regulation of blood circulationGO:19035221100.012
regulation of homeostatic processGO:00328441010.012
calcium ion transportGO:00068161310.012
muscle system processGO:00030121150.012
cellular response to peptide hormone stimulusGO:00713751200.012
glycosyl compound catabolic processGO:19016581260.012
purine ribonucleoside catabolic processGO:00461301240.012
regulation of muscle system processGO:0090257790.012
response to hexoseGO:00097461440.012
negative regulation of catalytic activityGO:00430861030.012
negative regulation of cellular biosynthetic processGO:00313271610.012
cyclic nucleotide metabolic processGO:0009187800.012
epithelium developmentGO:0060429960.012
negative regulation of neurogenesisGO:0050768780.012
negative regulation of cell projection organizationGO:0031345500.012
dendrite morphogenesisGO:0048813430.012
cell type specific apoptotic processGO:00972851340.012
purine ribonucleotide biosynthetic processGO:0009152810.012
muscle structure developmentGO:0061061870.011
neuronal action potentialGO:0019228350.011
gamete generationGO:00072761240.011
appendage morphogenesisGO:003510740.011
cell cell signalingGO:00072673350.011
organonitrogen compound biosynthetic processGO:19015661670.011
positive regulation of cellular protein metabolic processGO:00322701670.011
response to campGO:0051591910.011
glucose metabolic processGO:0006006520.011
regulation of purine nucleotide metabolic processGO:19005421150.011
regulation of anatomical structure morphogenesisGO:00226031410.011
monosaccharide metabolic processGO:0005996610.011
carbohydrate derivative biosynthetic processGO:19011371240.011
negative regulation of neuron deathGO:1901215690.011
retina morphogenesis in camera type eyeGO:006004210.011
cellular response to peptideGO:19016531330.011
circadian rhythmGO:0007623880.011
cellular response to glucocorticoid stimulusGO:0071385680.011
cofactor metabolic processGO:0051186950.011
response to insulinGO:00328681330.011
glial cell differentiationGO:0010001650.011
gtp catabolic processGO:0006184710.011
cyclic purine nucleotide metabolic processGO:0052652620.011
heart developmentGO:0007507720.011
spermatogenesisGO:0007283990.011
response to external biotic stimulusGO:00432072210.011
action potentialGO:0001508540.011
response to ethanolGO:00454711620.011
salivary gland developmentGO:000743130.011
oxidation reduction processGO:00551143040.011
regulation of nucleoside metabolic processGO:0009118660.011
male gamete generationGO:0048232990.011
mesoderm developmentGO:000749820.011
taxisGO:0042330670.011
regulation of protein modification processGO:00313991940.011
rho protein signal transductionGO:0007266110.011
positive regulation of nucleoside metabolic processGO:0045979550.011
response to lipopolysaccharideGO:00324961910.011
monovalent inorganic cation transportGO:00156721720.010
response to other organismGO:00517072200.010
purine containing compound biosynthetic processGO:0072522850.010
establishment of tissue polarityGO:000716420.010
negative regulation of cellular protein metabolic processGO:00322691060.010
development of primary female sexual characteristicsGO:0046545560.010
Rat
learning or memoryGO:0007611900.010
regulation of cell cycleGO:0051726730.010
cellular response to corticosteroid stimulusGO:0071384690.010
regulation of protein phosphorylationGO:00019321830.010
regulation of body fluid levelsGO:0050878900.010
regulation of cellular catabolic processGO:00313291010.010
response to glucocorticoidGO:00513842230.010
cellular carbohydrate metabolic processGO:0044262720.010
positive regulation of growthGO:0045927550.010
cell cycle checkpointGO:000007520.010

Tox disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.041
nervous system diseaseDOID:86300.041
central nervous system diseaseDOID:33100.015
musculoskeletal system diseaseDOID:1700.014