Rattus norvegicus

7 known processes

Ton

tonin

(Aliases: Klk1c2,rGK-2,KLK2)

Ton biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transcription dna templatedGO:00063513770.382
regulation of nucleic acid templated transcriptionGO:19035063800.245
ion transmembrane transportGO:00342203650.184
nucleic acid templated transcriptionGO:00976593790.161
anatomical structure morphogenesisGO:00096532980.151
Mouse
cytosolic calcium ion homeostasisGO:00514801400.143
cellular component movementGO:00069282480.132
rna biosynthetic processGO:00327743800.126
positive regulation of apoptotic processGO:00430651540.113
purine ribonucleotide biosynthetic processGO:0009152810.112
regulation of transcription dna templatedGO:00063553740.110
cellular component biogenesisGO:00440853680.109
rna metabolic processGO:00160704060.102
regulation of cell proliferationGO:00421273590.098
striated muscle tissue developmentGO:0014706580.094
Mouse
metal ion transportGO:00300012890.093
positive regulation of biosynthetic processGO:00098913190.093
regulation of rna metabolic processGO:00512523910.093
ribonucleotide biosynthetic processGO:0009260850.087
negative regulation of nitrogen compound metabolic processGO:00511721610.086
muscle system processGO:00030121150.086
Mouse
response to metal ionGO:00100382530.084
cellular homeostasisGO:00197252520.083
intracellular transportGO:00469071850.083
purine nucleotide biosynthetic processGO:0006164830.081
regulation of transcription from rna polymerase ii promoterGO:00063572340.080
cyclic purine nucleotide metabolic processGO:0052652620.078
positive regulation of cellular biosynthetic processGO:00313282950.078
transmembrane transportGO:00550854120.076
carbohydrate metabolic processGO:00059751300.075
positive regulation of phosphorus metabolic processGO:00105622620.075
Mouse
nucleotide biosynthetic processGO:0009165980.074
positive regulation of secretionGO:00510471400.073
positive regulation of rna metabolic processGO:00512542030.072
nucleoside phosphate biosynthetic processGO:19012931020.071
regulation of catecholamine secretionGO:0050433320.070
regulation of phosphorylationGO:00423252480.069
Mouse
localization of cellGO:00516742020.068
forebrain developmentGO:0030900980.067
negative regulation of biosynthetic processGO:00098901680.066
metal ion homeostasisGO:00550651860.065
positive regulation of nucleobase containing compound metabolic processGO:00459353190.064
regulation of cell developmentGO:00602842630.063
Rat
ion homeostasisGO:00508012120.062
single organism cellular localizationGO:19025801020.062
intracellular signal transductionGO:00355563140.062
Mouse
muscle tissue developmentGO:0060537580.059
Mouse
negative regulation of transportGO:00510511360.059
cellular response to stressGO:00335542690.059
ribose phosphate biosynthetic processGO:0046390870.059
carboxylic acid metabolic processGO:00197522890.059
regulation of metal ion transportGO:00109591180.056
regulation of rna biosynthetic processGO:20011413810.056
positive regulation of multicellular organismal processGO:00512403870.054
Rat
single organism intracellular transportGO:19025821660.054
monoamine transportGO:0015844430.053
organonitrogen compound biosynthetic processGO:19015661670.051
Mouse
negative regulation of uterine smooth muscle contractionGO:007047320.051
regulation of tube sizeGO:0035150890.051
Mouse Rat
organic acid metabolic processGO:00060822920.051
transcription from rna polymerase ii promoterGO:00063662520.051
negative regulation of multicellular organismal processGO:00512412030.050
heart morphogenesisGO:000300730.049
Mouse
carbohydrate derivative metabolic processGO:19011353460.049
small molecule biosynthetic processGO:00442831240.048
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.048
circulatory system processGO:00030131830.048
Mouse Rat
positive regulation of gene expressionGO:00106282440.047
secretionGO:00469033070.046
organic hydroxy compound transportGO:0015850770.046
positive regulation of rna biosynthetic processGO:19026801970.046
organophosphate metabolic processGO:00196373700.045
Mouse
circulatory system developmentGO:00723591340.045
Mouse
cation homeostasisGO:00550801950.044
regulation of molecular functionGO:00650093980.044
Mouse
lipid metabolic processGO:00066292830.043
Mouse
regulation of ion transportGO:00432692450.043
positive regulation of cell deathGO:00109421840.042
response to extracellular stimulusGO:00099913800.042
Rat
positive regulation of developmental processGO:00510942830.042
positive regulation of transcription dna templatedGO:00458931970.041
amine metabolic processGO:0009308380.040
positive regulation of nitrogen compound metabolic processGO:00511733340.040
synaptic transmissionGO:00072682350.040
organophosphate biosynthetic processGO:00904071430.039
regulation of cellular amino acid metabolic processGO:000652120.039
regulation of synaptic transmission gabaergicGO:0032228170.039
cardiac ventricle developmentGO:000323110.038
Mouse
apoptotic processGO:00069153810.038
lipid biosynthetic processGO:00086101280.038
positive regulation of cell proliferationGO:00082842490.038
rhythmic processGO:00485111560.038
oxoacid metabolic processGO:00434362900.038
response to inorganic substanceGO:00100353770.038
divalent inorganic cation homeostasisGO:00725071650.037
positive regulation of saliva secretionGO:004687830.037
positive regulation of cytosolic calcium ion concentrationGO:00072041220.037
regulation of purine nucleotide biosynthetic processGO:1900371460.037
regulation of blood pressureGO:0008217830.036
Mouse
regulation of intracellular signal transductionGO:19025312180.036
cyclic nucleotide biosynthetic processGO:0009190630.036
head developmentGO:00603222470.036
regulation of nucleotide biosynthetic processGO:0030808470.035
carbohydrate catabolic processGO:0016052400.035
positive regulation of secretion by cellGO:19035321280.035
purine containing compound biosynthetic processGO:0072522850.034
regulation of blood vessel sizeGO:0050880890.034
Mouse Rat
sequestering of calcium ionGO:005120880.034
n methyl d aspartate receptor clusteringGO:009711420.034
blood circulationGO:00080151830.034
Mouse Rat
acid secretionGO:0046717480.034
regulation of programmed cell deathGO:00430673410.034
regulation of system processGO:00440572080.033
Rat
muscle structure developmentGO:0061061870.033
Mouse
homeostatic processGO:00425923310.033
negative regulation of cellular metabolic processGO:00313242810.033
carbohydrate derivative biosynthetic processGO:19011371240.033
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.032
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.032
Mouse
nucleoside monophosphate metabolic processGO:0009123930.032
cellular chemical homeostasisGO:00550822470.032
regulation of ion homeostasisGO:2000021630.032
saliva secretionGO:004654130.032
response to cytokineGO:00340972150.031
response to peptideGO:19016522920.031
macromolecular complex assemblyGO:00650032730.031
forebrain neuron differentiationGO:002187970.031
regulation of cellular amine metabolic processGO:003323880.030
macromolecular complex subunit organizationGO:00439333390.030
positive regulation of signalingGO:00230562700.030
negative regulation of cellular biosynthetic processGO:00313271610.030
cellular carbohydrate metabolic processGO:0044262720.030
camp biosynthetic processGO:0006171470.029
urinary bladder smooth muscle contractionGO:001483240.029
cardiovascular system developmentGO:00723581340.029
Mouse
programmed cell deathGO:00125013920.029
regulation of camp biosynthetic processGO:0030817380.029
heart developmentGO:0007507720.028
Mouse
potassium ion transportGO:0006813970.028
negative regulation of nucleobase containing compound metabolic processGO:00459341530.028
cellular divalent inorganic cation homeostasisGO:00725031620.028
negative regulation of ion transportGO:0043271510.028
cellular amine metabolic processGO:0044106380.028
response to nutrientGO:00075842480.028
Rat
single organism biosynthetic processGO:00447113420.028
regulation of neuron projection developmentGO:00109751610.028
Rat
neurotransmitter gated ion channel clusteringGO:007257830.027
monocarboxylic acid transportGO:0015718520.027
calcium ion homeostasisGO:00550741620.027
regulation of cell differentiationGO:00455953200.027
Rat
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.027
cellular calcium ion homeostasisGO:00068741600.027
nucleobase containing small molecule metabolic processGO:00550863160.027
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.027
regulation of neurogenesisGO:00507672470.027
Rat
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719810.027
regulation of apoptotic processGO:00429813350.026
endocrine processGO:0050886320.026
Mouse
regulation of multicellular organismal developmentGO:20000263760.026
Rat
defense responseGO:00069521940.026
Mouse
single organism carbohydrate catabolic processGO:0044724400.026
regulation of muscle system processGO:0090257790.026
response to glucocorticoidGO:00513842230.026
positive regulation of neurogenesisGO:00507691650.026
developmental growthGO:00485891000.026
response to peptide hormoneGO:00434342780.026
central nervous system developmentGO:00074173110.025
cellular cation homeostasisGO:00300031800.025
brain developmentGO:00074202470.025
catecholamine secretionGO:0050432330.025
regulation of transmembrane transporter activityGO:0022898490.025
regulation of nervous system developmentGO:00519602640.025
Rat
negative regulation of metabolic processGO:00098923310.025
circadian rhythmGO:0007623880.025
divalent metal ion transportGO:00708381320.025
second messenger mediated signalingGO:0019932510.025
reproductive processGO:00224143720.024
cellular amino acid metabolic processGO:00065201070.024
small gtpase mediated signal transductionGO:0007264360.024
Mouse
divalent inorganic cation transportGO:00725111340.023
monovalent inorganic cation transportGO:00156721720.023
wound healingGO:00420601220.023
regulation of saliva secretionGO:004687730.023
skeletal system developmentGO:0001501410.023
protein complex subunit organizationGO:00718223020.023
protein phosphorylationGO:00064683450.023
reproductionGO:00000032450.023
cellular ketone metabolic processGO:0042180510.023
cytoplasmic transportGO:00164821150.023
single organism reproductive processGO:00447022970.023
regulation of cyclic nucleotide biosynthetic processGO:0030802450.023
regulation of cellular ketone metabolic processGO:0010565270.023
regulation of systemic arterial blood pressure by norepinephrine epinephrineGO:000199320.023
regulation of camp metabolic processGO:0030814430.022
negative regulation of macromolecule metabolic processGO:00106052600.022
regulation of cellular component organizationGO:00511283680.022
Rat
positive regulation of the force of heart contraction by chemical signalGO:000309920.022
carboxylic acid transportGO:00469421150.022
regulation of sodium ion transmembrane transporter activityGO:200064940.022
heart contractionGO:0060047570.022
Mouse
inorganic ion transmembrane transportGO:00986602290.022
regulation of neuron deathGO:19012141150.022
positive regulation of ion transportGO:0043270940.022
positive regulation of phosphorylationGO:00423271770.022
Mouse
cell projection organizationGO:00300303020.022
Rat
response to cocaineGO:0042220390.021
negative regulation of programmed cell deathGO:00430691830.021
positive regulation of blood pressure by epinephrine norepinephrineGO:000332120.021
ribose phosphate metabolic processGO:00196932350.021
jak stat cascadeGO:0007259260.021
cation transportGO:00068123820.021
negative regulation of cell communicationGO:00106481580.021
cardiac muscle tissue developmentGO:0048738260.021
Mouse
regulation of calcium ion transportGO:0051924770.021
growthGO:00400071650.021
negative regulation of cyclic nucleotide biosynthetic processGO:0030803120.021
purine containing compound metabolic processGO:00725212530.021
locomotionGO:00400112370.021
positive regulation of cell communicationGO:00106472710.021
regulation of blood circulationGO:19035221100.021
Rat
estrous cycle phaseGO:0060206150.020
regulation of phosphorus metabolic processGO:00511743490.020
Mouse
purine ribonucleoside monophosphate metabolic processGO:0009167840.020
response to mineralocorticoidGO:0051385490.020
positive regulation of the force of heart contraction by epinephrine norepinephrineGO:000199720.020
regulation of cell projection organizationGO:00313441750.020
Rat
regulation of membrane potentialGO:00423911100.020
nucleoside phosphate metabolic processGO:00067532830.020
positive regulation of programmed cell deathGO:00430681570.020
camp metabolic processGO:0046058630.020
necroptotic processGO:007026620.020
nucleoside triphosphate metabolic processGO:00091411440.020
response to acid chemicalGO:00011012220.020
maintenance of locationGO:0051235170.020
regulation of transferase activityGO:00513381230.019
Mouse
protein localization to membraneGO:0072657360.019
regulation of ion transmembrane transportGO:00347651210.019
positive regulation of cellular amino acid metabolic processGO:004576410.019
cardiac muscle tissue growthGO:0055017200.019
heart processGO:0003015570.019
Mouse
sequestering of metal ionGO:005123890.019
regulation of response to external stimulusGO:00321011060.019
response to oxygen levelsGO:00704822650.019
regulation of ion transmembrane transporter activityGO:0032412480.019
negative regulation of synaptic transmission glutamatergicGO:005196780.019
establishment of protein localizationGO:00451841410.019
protein complex biogenesisGO:00702712630.018
negative regulation of developmental processGO:00510931250.018
organ morphogenesisGO:0009887750.018
Mouse
purine nucleoside monophosphate metabolic processGO:0009126840.018
positive regulation of intracellular signal transductionGO:19025331380.018
reactive oxygen species metabolic processGO:0072593370.018
regulation of neuron differentiationGO:00456642080.018
Rat
macromolecule localizationGO:00330362520.018
positive regulation of the force of heart contraction by norepinephrineGO:000306110.018
regulation of response to woundingGO:1903034690.018
signal transduction by phosphorylationGO:00230141440.018
hormone transportGO:00099141210.018
sensory perceptionGO:00076001010.018
glutamate secretionGO:0014047190.018
regulation of hormone levelsGO:00108171870.018
anion transportGO:00068201780.018
neuron differentiationGO:00301823680.018
Rat
response to woundingGO:00096112540.017
anterior posterior pattern specificationGO:000995210.017
regulation of systemic arterial blood pressureGO:0003073300.017
Mouse
organic hydroxy compound metabolic processGO:19016151150.017
regulation of neurological system processGO:0031644430.017
muscle organ developmentGO:0007517500.017
Mouse
regulation of the force of heart contraction by chemical signalGO:000305720.017
ribonucleotide metabolic processGO:00092592310.017
positive regulation of lipid metabolic processGO:0045834330.017
Mouse
calcium ion transportGO:00068161310.017
response to reactive oxygen speciesGO:00003021200.017
regulation of inhibitory postsynaptic membrane potentialGO:006008060.017
positive regulation of cell differentiationGO:00455972170.016
positive regulation of neuron differentiationGO:00456661260.016
cell growthGO:00160491040.016
positive regulation of cellular protein metabolic processGO:00322701670.016
cellular response to metal ionGO:0071248550.016
purine ribonucleotide metabolic processGO:00091502270.016
regulation of sodium ion transportGO:0002028210.016
regulation of cellular component movementGO:00512701500.016
positive regulation of nucleic acid templated transcriptionGO:19035081970.016
positive regulation of hormone secretionGO:0046887650.016
regulation of homeostatic processGO:00328441010.016
striated muscle contractionGO:0006941440.016
Mouse
cellular component assemblyGO:00226073600.015
hexose transportGO:0008645290.015
cyclic nucleotide metabolic processGO:0009187800.015
regulation of kinase activityGO:00435491170.015
Mouse
positive regulation of renin secretion into blood streamGO:190013510.015
atp metabolic processGO:0046034720.015
chemical homeostasisGO:00488782920.015
regulation of amine transportGO:0051952540.015
purine nucleotide metabolic processGO:00061632290.015
hepaticobiliary system developmentGO:0061008900.015
embryonic skeletal system developmentGO:004870630.015
regulation of cation channel activityGO:2001257230.015
nucleotide metabolic processGO:00091172790.015
positive regulation of peptide secretionGO:0002793520.015
negative regulation of signalingGO:00230571570.015
positive regulation of cellular amine metabolic processGO:003324030.015
cell cell signalingGO:00072673350.015
regulation of protein phosphorylationGO:00019321830.015
catecholamine transportGO:0051937370.015
response to ethanolGO:00454711620.015
regulation of synaptic transmission glutamatergicGO:0051966260.015
negative regulation of gene expressionGO:00106291990.014
positive regulation of camp biosynthetic processGO:0030819280.014
cellular ion homeostasisGO:00068731840.014
epithelial cell proliferationGO:0050673540.014
response to corticosteroidGO:00319602350.014
olfactory bulb interneuron differentiationGO:002188910.014
purine ribonucleoside monophosphate catabolic processGO:0009169550.014
regulation of reactive oxygen species metabolic processGO:2000377260.014
urinary tract smooth muscle contractionGO:001484840.014
tolerance induction dependent upon immune responseGO:000246120.014
response to amino acidGO:0043200750.014
ribonucleoside monophosphate metabolic processGO:0009161880.014
peptide biosynthetic processGO:004304330.014
Mouse
involuntary skeletal muscle contractionGO:000301120.014
response to alkaloidGO:00432791320.014
Rat
regulation of cyclic nucleotide metabolic processGO:0030799510.014
cell morphogenesisGO:00009021420.014
cytosolic calcium ion transportGO:0060401390.014
dopamine secretionGO:0014046150.014
response to coldGO:0009409290.014
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressureGO:000202510.014
negative regulation of cell projection organizationGO:0031345500.014
multi multicellular organism processGO:00447061380.014
muscle organ morphogenesisGO:004864410.014
Mouse
single organism carbohydrate metabolic processGO:00447231180.014
neurological system processGO:00508772190.013
Mouse
negative regulation of cellular component organizationGO:0051129830.013
regulation of anatomical structure sizeGO:00900661350.013
Mouse Rat
positive regulation of the force of heart contraction by epinephrineGO:000305910.013
forebrain neuron developmentGO:002188430.013
response to glucoseGO:00097491360.013
regulation of growthGO:00400081050.013
acute inflammatory responseGO:0002526580.013
Mouse
negative regulation of transcription dna templatedGO:00458921160.013
regulation of cell growthGO:0001558850.013
organic acid biosynthetic processGO:0016053830.013
intracellular protein transportGO:0006886790.013
response to ammonium ionGO:0060359710.013
positive regulation of protein modification processGO:00314011420.013
proteolysisGO:00065081750.013
positive regulation of homeostatic processGO:0032846490.013
protein complex assemblyGO:00064612630.013
organelle organizationGO:00069962660.013
regulation of muscle tissue developmentGO:1901861250.013
response to calcium ionGO:0051592590.013
response to decreased oxygen levelsGO:00362932370.013
striated muscle cell developmentGO:0055002260.013
negative regulation of neuron differentiationGO:0045665620.013
positive regulation of response to stimulusGO:00485842850.012
protein heterooligomerizationGO:0051291890.012
negative regulation of neurogenesisGO:0050768780.012
amine transportGO:0015837570.012
multicellular organismal reproductive processGO:00486092330.012
regulation of lipid metabolic processGO:0019216680.012
Mouse
multi organism reproductive processGO:00447032620.012
organic anion transportGO:00157111320.012
gland developmentGO:00487321550.012
positive regulation of cell developmentGO:00107201760.012
lipid transportGO:0006869610.012
tube developmentGO:0035295890.012
single organism organelle organizationGO:19025891800.012
tissue developmentGO:00098882520.012
Mouse
positive regulation of camp metabolic processGO:0030816310.012
positive regulation of blood circulationGO:1903524650.012
Rat
negative regulation of homeostatic processGO:0032845470.012
alcohol metabolic processGO:0006066770.012
nitrogen compound transportGO:00717052290.012
palate developmentGO:006002120.012
monosaccharide transportGO:0015749310.012
organic acid transportGO:00158491160.012
g protein coupled receptor signaling pathwayGO:00071862420.012
synaptic growth at neuromuscular junctionGO:005112410.012
mapk cascadeGO:00001651400.012
regulation of jak stat cascadeGO:0046425210.012
protein localizationGO:00081041910.012
response to insulinGO:00328681330.012
cell motilityGO:00488702020.012
positive regulation of mapk cascadeGO:0043410920.012
purine nucleoside monophosphate biosynthetic processGO:0009127200.012
regulation of ossificationGO:0030278320.012
cellular response to inorganic substanceGO:0071241650.012
intracellular receptor signaling pathwayGO:0030522350.011
negative regulation of apoptotic processGO:00430661810.011
regulation of nucleotide metabolic processGO:00061401170.011
cellular response to abiotic stimulusGO:0071214850.011
muscle cell differentiationGO:0042692520.011
secretion by cellGO:00329402480.011
digestive system processGO:0022600240.011
actin filament based movementGO:0030048160.011
positive regulation of protein phosphorylationGO:00019341350.011
vasoconstrictionGO:0042310540.011
Rat
response to progesteroneGO:0032570480.011
negative regulation of cell differentiationGO:0045596990.011
regulation of transmembrane transportGO:00347621220.011
smooth muscle contractionGO:0006939370.011
axis specificationGO:000979840.011
gastrulationGO:000736920.011
embryonic pattern specificationGO:000988010.011
phospholipase c activating serotonin receptor signaling pathwayGO:000720820.011
cardiac muscle tissue morphogenesisGO:005500810.011
Mouse
digestive system developmentGO:0055123410.011
regulation of cellular carbohydrate metabolic processGO:0010675390.011
atp catabolic processGO:0006200540.011
positive regulation of cellular component movementGO:00512721020.011
actin mediated cell contractionGO:0070252120.011
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressureGO:000199910.011
formation of primary germ layerGO:000170410.011
positive regulation of cyclic nucleotide metabolic processGO:0030801370.011
adrenergic receptor signaling pathwayGO:007187590.011
protein homooligomerizationGO:0051260910.011
positive regulation of phosphate metabolic processGO:00459372620.011
Mouse
vesicle mediated transportGO:00161921810.011
eye developmentGO:0001654500.011
cellular response to oxidative stressGO:0034599760.011
muscle tissue morphogenesisGO:006041510.010
Mouse
regulation of inflammatory responseGO:0050727480.010
positive regulation of protein metabolic processGO:00512471780.010
regulation of carbohydrate metabolic processGO:0006109410.010
positive regulation of heart contractionGO:0045823150.010
regulation of release of sequestered calcium ion into cytosolGO:0051279180.010
multicellular organism reproductionGO:00325042330.010
regulation of purine nucleotide metabolic processGO:19005421150.010
purine nucleoside metabolic processGO:00422781690.010
brain renin angiotensin systemGO:000203530.010
Mouse
regulation of adenylate cyclase activityGO:0045761180.010
erk1 and erk2 cascadeGO:0070371480.010

Ton disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.042
disease of anatomical entityDOID:700.042
muscular diseaseDOID:008000000.020
muscle tissue diseaseDOID:6600.020
bone diseaseDOID:008000100.010
connective tissue diseaseDOID:6500.010