IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Sh2d1a

SH2 domain protein 1A

(Aliases: RGD1562408)

RGD: 1562408
Entrez: 501502
Ensembl: ENSRNOG00000006263
UniProtKB: B2RZ59

Process Predictions
Disease Predictions

Sh2d1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
transcription dna templated	GO:0006351	377	0.171
regulation of rna biosynthetic process	GO:2001141	381	0.170
regulation of rna metabolic process	GO:0051252	391	0.159
immune system process	GO:0002376	204	0.159	Mouse
rna biosynthetic process	GO:0032774	380	0.146
rna metabolic process	GO:0016070	406	0.144
regulation of nucleic acid templated transcription	GO:1903506	380	0.136
regulation of transcription dna templated	GO:0006355	374	0.131
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.108
negative regulation of rna metabolic process	GO:0051253	123	0.085
transcription from rna polymerase ii promoter	GO:0006366	252	0.085
negative regulation of cellular metabolic process	GO:0031324	281	0.082
positive regulation of multicellular organismal process	GO:0051240	387	0.079
chemical homeostasis	GO:0048878	292	0.077
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.075
negative regulation of biosynthetic process	GO:0009890	168	0.072
positive regulation of transport	GO:0051050	245	0.071
positive regulation of regulatory t cell differentiation	GO:0045591	2	0.070
response to extracellular stimulus	GO:0009991	380	0.069
response to nutrient levels	GO:0031667	370	0.067
regulation of cellular localization	GO:0060341	263	0.067
response to nutrient	GO:0007584	248	0.065
negative regulation of metabolic process	GO:0009892	331	0.064
immune response	GO:0006955	104	0.063	Mouse
positive regulation of biosynthetic process	GO:0009891	319	0.063
positive regulation of gene expression	GO:0010628	244	0.062
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.061
response to biotic stimulus	GO:0009607	226	0.060
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.058
divalent inorganic cation homeostasis	GO:0072507	165	0.056
response to wounding	GO:0009611	254	0.055
regulation of molecular function	GO:0065009	398	0.055
metal ion homeostasis	GO:0055065	186	0.054
nucleic acid templated transcription	GO:0097659	379	0.054
positive regulation of rna biosynthetic process	GO:1902680	197	0.053
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.052
cellular ion homeostasis	GO:0006873	184	0.052
response to growth factor	GO:0070848	189	0.052
cellular calcium ion homeostasis	GO:0006874	160	0.051
homeostatic process	GO:0042592	331	0.051
regulation of regulatory t cell differentiation	GO:0045589	2	0.051
positive regulation of cellular biosynthetic process	GO:0031328	295	0.051
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.049
negative regulation of cellular biosynthetic process	GO:0031327	161	0.048
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.047
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.046
secretion	GO:0046903	307	0.046
positive regulation of natural killer cell mediated cytotoxicity	GO:0045954	2	0.046	Mouse
cellular chemical homeostasis	GO:0055082	247	0.044
regulation of neurogenesis	GO:0050767	247	0.044
cellular homeostasis	GO:0019725	252	0.044
response to cytokine	GO:0034097	215	0.043
regulation of alpha beta t cell activation	GO:0046634	2	0.043
positive regulation of response to stimulus	GO:0048584	285	0.042	Mouse
cellular response to growth factor stimulus	GO:0071363	162	0.042
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.042
protein complex subunit organization	GO:0071822	302	0.042
response to peptide hormone	GO:0043434	278	0.041
cytosolic calcium ion homeostasis	GO:0051480	140	0.041
negative regulation of macromolecule metabolic process	GO:0010605	260	0.040
leukocyte differentiation	GO:0002521	30	0.040
response to external biotic stimulus	GO:0043207	221	0.039
regulation of secretion	GO:0051046	224	0.039
macromolecular complex subunit organization	GO:0043933	339	0.039
behavior	GO:0007610	205	0.038
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.037
ion homeostasis	GO:0050801	212	0.037
cell activation	GO:0001775	97	0.037
negative regulation of cell death	GO:0060548	229	0.037
negative regulation of gene expression	GO:0010629	199	0.036
cellular cation homeostasis	GO:0030003	180	0.035
cellular component movement	GO:0006928	248	0.035
regulation of immune response to tumor cell	GO:0002837	3	0.035
negative regulation of rna biosynthetic process	GO:1902679	118	0.035
immune effector process	GO:0002252	53	0.035	Mouse
regulation of lymphocyte chemotaxis	GO:1901623	1	0.034
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.034
regulation of protein modification process	GO:0031399	194	0.034
positive regulation of transcription dna templated	GO:0045893	197	0.033
response to molecule of bacterial origin	GO:0002237	194	0.033
leukocyte activation	GO:0045321	76	0.033
localization of cell	GO:0051674	202	0.033
aging	GO:0007568	241	0.033
nitrogen compound transport	GO:0071705	229	0.033
positive regulation of cell proliferation	GO:0008284	249	0.032
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.032
organophosphate metabolic process	GO:0019637	370	0.032
inflammatory response	GO:0006954	150	0.032
secretion by cell	GO:0032940	248	0.032
cellular component biogenesis	GO:0044085	368	0.031
regulation of signal transduction	GO:0009966	318	0.030
positive regulation of developmental process	GO:0051094	283	0.030
negative regulation of transcription dna templated	GO:0045892	116	0.030
positive regulation of rna metabolic process	GO:0051254	203	0.030
positive regulation of cell development	GO:0010720	176	0.030
response to oxidative stress	GO:0006979	186	0.029
macromolecular complex assembly	GO:0065003	273	0.029
cell projection organization	GO:0030030	302	0.029
response to hydrogen peroxide	GO:0042542	89	0.029
regulation of cell differentiation	GO:0045595	320	0.029
cell motility	GO:0048870	202	0.029
regulation of phosphorus metabolic process	GO:0051174	349	0.028
protein complex biogenesis	GO:0070271	263	0.028
positive regulation of cell migration	GO:0030335	96	0.028
programmed cell death	GO:0012501	392	0.028
cellular response to stress	GO:0033554	269	0.028
positive regulation of neurogenesis	GO:0050769	165	0.028
cellular component assembly	GO:0022607	360	0.028
regulation of secretion by cell	GO:1903530	208	0.027
regulation of neuron death	GO:1901214	115	0.027
single organism biosynthetic process	GO:0044711	342	0.027
nucleobase containing small molecule metabolic process	GO:0055086	316	0.027
protein phosphorylation	GO:0006468	345	0.026
positive regulation of protein modification process	GO:0031401	142	0.026
purine containing compound metabolic process	GO:0072521	253	0.026
regulation of locomotion	GO:0040012	148	0.026
calcium ion homeostasis	GO:0055074	162	0.026
regulation of t cell chemotaxis	GO:0010819	1	0.025
positive regulation of phosphate metabolic process	GO:0045937	262	0.025
negative regulation of immune response to tumor cell	GO:0002838	2	0.025
response to inorganic substance	GO:0010035	377	0.025
regulation of programmed cell death	GO:0043067	341	0.025
cellular metal ion homeostasis	GO:0006875	172	0.025
anatomical structure morphogenesis	GO:0009653	298	0.025
cellular response to external stimulus	GO:0071496	118	0.025
protein complex assembly	GO:0006461	263	0.025
t cell receptor signaling pathway	GO:0050852	1	0.025
positive regulation of cellular component movement	GO:0051272	102	0.025
positive regulation of cell differentiation	GO:0045597	217	0.025
reproductive process	GO:0022414	372	0.025
response to acid chemical	GO:0001101	222	0.024
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.024
amine metabolic process	GO:0009308	38	0.024
single organism intracellular transport	GO:1902582	166	0.024
neuron differentiation	GO:0030182	368	0.024
neuron projection development	GO:0031175	273	0.024
metal ion transport	GO:0030001	289	0.024
muscle system process	GO:0003012	115	0.024
regulation of cellular amine metabolic process	GO:0033238	8	0.024
divalent inorganic cation transport	GO:0072511	134	0.024
intracellular transport	GO:0046907	185	0.024
cellular response to lipid	GO:0071396	201	0.024
alpha beta t cell differentiation	GO:0046632	2	0.024
defense response	GO:0006952	194	0.024	Mouse
carbohydrate derivative metabolic process	GO:1901135	346	0.023
response to tumor cell	GO:0002347	4	0.023
positive regulation of phosphorus metabolic process	GO:0010562	262	0.023
positive regulation of alpha beta t cell activation	GO:0046635	2	0.023
regulation of interferon gamma production	GO:0032649	3	0.023
intracellular signal transduction	GO:0035556	314	0.022
regulation of cell migration	GO:0030334	128	0.022
regulation of cell development	GO:0060284	263	0.022
cell migration	GO:0016477	197	0.022
cellular response to oxygen containing compound	GO:1901701	386	0.021
regulation of apoptotic process	GO:0042981	335	0.021
cellular amino acid metabolic process	GO:0006520	107	0.021
positive regulation of b cell mediated immunity	GO:0002714	2	0.021
positive regulation of necroptotic process	GO:0060545	2	0.021
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.021
locomotion	GO:0040011	237	0.021
cytoskeleton organization	GO:0007010	111	0.021
cellular response to endogenous stimulus	GO:0071495	377	0.021
positive regulation of immune response	GO:0050778	42	0.021	Mouse
glycosyl compound metabolic process	GO:1901657	182	0.020
negative regulation of response to stimulus	GO:0048585	155	0.020
response to metal ion	GO:0010038	253	0.020
central nervous system development	GO:0007417	311	0.020
transmembrane transport	GO:0055085	412	0.020
single organism organelle organization	GO:1902589	180	0.020
regulation of cytokine production	GO:0001817	56	0.020
positive regulation of secretion by cell	GO:1903532	128	0.020
positive regulation of protein metabolic process	GO:0051247	178	0.020
immune system development	GO:0002520	41	0.020
cellular amine metabolic process	GO:0044106	38	0.020
biological adhesion	GO:0022610	110	0.019
regulation of cell motility	GO:2000145	131	0.019
purine nucleoside metabolic process	GO:0042278	169	0.019
cardiovascular system development	GO:0072358	134	0.019
regulation of cellular component movement	GO:0051270	150	0.019
positive regulation of t cell migration	GO:2000406	1	0.019
response to reactive oxygen species	GO:0000302	120	0.019
peptidyl amino acid modification	GO:0018193	126	0.019
actin cytoskeleton organization	GO:0030036	73	0.019
cellular response to oxidative stress	GO:0034599	76	0.018
organelle organization	GO:0006996	266	0.018
regulation of necroptotic process	GO:0060544	2	0.018
reactive oxygen species biosynthetic process	GO:1903409	8	0.018
regulation of catalytic activity	GO:0050790	304	0.018
cation homeostasis	GO:0055080	195	0.018
single organism reproductive process	GO:0044702	297	0.018
alpha beta t cell activation	GO:0046631	3	0.018
response to other organism	GO:0051707	220	0.018
response to peptide	GO:1901652	292	0.018
hematopoietic or lymphoid organ development	GO:0048534	36	0.018
regulation of ion transport	GO:0043269	245	0.018
wound healing	GO:0042060	122	0.018
positive regulation of molecular function	GO:0044093	230	0.018
regulation of multicellular organismal development	GO:2000026	376	0.018
cellular response to hormone stimulus	GO:0032870	247	0.018
negative regulation of transport	GO:0051051	136	0.018
response to estrogen	GO:0043627	232	0.018
regulation of cellular ketone metabolic process	GO:0010565	27	0.018
hormone transport	GO:0009914	121	0.018
immunoglobulin mediated immune response	GO:0016064	4	0.018
regulation of cellular component organization	GO:0051128	368	0.018
regulation of hormone levels	GO:0010817	187	0.018
response to bacterium	GO:0009617	200	0.018
circulatory system process	GO:0003013	183	0.017
purine ribonucleotide metabolic process	GO:0009150	227	0.017
response to ethanol	GO:0045471	162	0.017
nucleoside phosphate metabolic process	GO:0006753	283	0.017
negative regulation of response to tumor cell	GO:0002835	2	0.017
circulatory system development	GO:0072359	134	0.017
cellular response to vitamin k	GO:0071307	1	0.017
immune response to tumor cell	GO:0002418	3	0.017
positive regulation of cellular protein metabolic process	GO:0032270	167	0.017
positive regulation of natural killer cell mediated immunity	GO:0002717	2	0.017	Mouse
positive regulation of protein phosphorylation	GO:0001934	135	0.017
multi organism reproductive process	GO:0044703	262	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.016
cellular response to extracellular stimulus	GO:0031668	73	0.016
regulation of cell proliferation	GO:0042127	359	0.016
negative regulation of natural killer cell mediated immune response to tumor cell	GO:0002856	1	0.016
regulation of protein metabolic process	GO:0051246	289	0.016
apoptotic process	GO:0006915	381	0.016
antigen receptor mediated signaling pathway	GO:0050851	1	0.016
regulation of intracellular transport	GO:0032386	65	0.016
regulation of cellular protein metabolic process	GO:0032268	267	0.016
regulation of cellular amino acid metabolic process	GO:0006521	2	0.016
positive regulation of nervous system development	GO:0051962	178	0.016
regulation of defense response	GO:0031347	68	0.016	Mouse
negative regulation of immune system process	GO:0002683	39	0.016
regulation of cd4 positive alpha beta t cell activation	GO:2000514	1	0.016
cytoplasmic transport	GO:0016482	115	0.016
cellular response to nitrogen compound	GO:1901699	210	0.016
cd4 positive alpha beta t cell activation	GO:0035710	1	0.016
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.016
positive regulation of defense response	GO:0031349	37	0.016	Mouse
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.015
pseudopodium assembly	GO:0031269	3	0.015
cation transport	GO:0006812	382	0.015
signal release	GO:0023061	145	0.015
b cell differentiation	GO:0030183	2	0.015
g protein coupled receptor signaling pathway	GO:0007186	242	0.015
positive regulation of immunoglobulin mediated immune response	GO:0002891	2	0.015
cytokine mediated signaling pathway	GO:0019221	43	0.015
cell adhesion	GO:0007155	110	0.015
nucleoside metabolic process	GO:0009116	179	0.015
regulation of intracellular signal transduction	GO:1902531	218	0.015
ribonucleotide metabolic process	GO:0009259	231	0.015
regulation of calcium ion transport	GO:0051924	77	0.015
multicellular organismal reproductive process	GO:0048609	233	0.015
regulation of immune system process	GO:0002682	123	0.015	Mouse
regulation of natural killer cell mediated immune response to tumor cell	GO:0002855	1	0.015
lymphocyte chemotaxis	GO:0048247	3	0.015
ribonucleoside metabolic process	GO:0009119	174	0.015
reactive nitrogen species metabolic process	GO:2001057	1	0.015
regulation of lymphocyte migration	GO:2000401	1	0.015
response to amino acid	GO:0043200	75	0.015
regulation of response to stress	GO:0080134	126	0.015	Mouse
hemopoiesis	GO:0030097	34	0.015
positive regulation of neuron differentiation	GO:0045666	126	0.015
response to oxygen levels	GO:0070482	265	0.015
response to corticosteroid	GO:0031960	235	0.015
ribose phosphate metabolic process	GO:0019693	235	0.015
ras protein signal transduction	GO:0007265	29	0.015
hormone secretion	GO:0046879	115	0.015
regulation of membrane potential	GO:0042391	110	0.015
negative regulation of homeostatic process	GO:0032845	47	0.015
lipid metabolic process	GO:0006629	283	0.015
neuron death	GO:0070997	127	0.015
regulation of metal ion transport	GO:0010959	118	0.014
nucleotide metabolic process	GO:0009117	279	0.014
positive regulation of protein kinase activity	GO:0045860	73	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.014
regulation of nervous system development	GO:0051960	264	0.014
natural killer cell mediated immune response to tumor cell	GO:0002423	1	0.014
negative regulation of cell communication	GO:0010648	158	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.014
divalent metal ion transport	GO:0070838	132	0.014
response to lipopolysaccharide	GO:0032496	191	0.014
negative regulation of programmed cell death	GO:0043069	183	0.014
cell cell signaling	GO:0007267	335	0.014	Human
pseudopodium organization	GO:0031268	3	0.014
regulation of hormone secretion	GO:0046883	106	0.014
cellular response to alcohol	GO:0097306	87	0.014
carbohydrate derivative catabolic process	GO:1901136	147	0.014
lymphocyte activation	GO:0046649	43	0.014
cellular response to organic cyclic compound	GO:0071407	202	0.014
regeneration	GO:0031099	163	0.014
response to decreased oxygen levels	GO:0036293	237	0.014
positive regulation of cell death	GO:0010942	184	0.014
sequestering of calcium ion	GO:0051208	8	0.014
regulation of response to external stimulus	GO:0032101	106	0.014
nucleobase containing compound catabolic process	GO:0034655	152	0.014
cellular response to ketone	GO:1901655	51	0.014
purine containing compound catabolic process	GO:0072523	138	0.013
regulation of homeostatic process	GO:0032844	101	0.013
negative regulation of signaling	GO:0023057	157	0.013
growth	GO:0040007	165	0.013
regulation of system process	GO:0044057	208	0.013
sequestering of metal ion	GO:0051238	9	0.013
negative regulation of neuron death	GO:1901215	69	0.013
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
organic acid metabolic process	GO:0006082	292	0.013
reactive oxygen species metabolic process	GO:0072593	37	0.013
small gtpase mediated signal transduction	GO:0007264	36	0.013
cation transmembrane transport	GO:0098655	263	0.013
cellular response to lipopolysaccharide	GO:0071222	55	0.013
response to tumor necrosis factor	GO:0034612	56	0.013
necroptotic process	GO:0070266	2	0.013
cellular response to cytokine stimulus	GO:0071345	127	0.013
t cell activation	GO:0042110	29	0.012
aromatic compound catabolic process	GO:0019439	168	0.012
negative regulation of innate immune response	GO:0045824	4	0.012
sexual reproduction	GO:0019953	148	0.012
regulation of fc receptor mediated stimulatory signaling pathway	GO:0060368	3	0.012
catabolic process	GO:0009056	351	0.012
purine ribonucleoside metabolic process	GO:0046128	168	0.012
positive regulation of endothelial cell migration	GO:0010595	4	0.012
proteolysis	GO:0006508	175	0.012
cellular ketone metabolic process	GO:0042180	51	0.012
regulation of catabolic process	GO:0009894	113	0.012
positive regulation of lymphocyte activation	GO:0051251	25	0.012
negative regulation of cell differentiation	GO:0045596	99	0.012
acute inflammatory response	GO:0002526	58	0.012
viral transcription	GO:0019083	2	0.012
regulation of mesenchymal cell proliferation	GO:0010464	4	0.012
oxoacid metabolic process	GO:0043436	290	0.012
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.012
regulation of neuron projection development	GO:0010975	161	0.012
organic cyclic compound catabolic process	GO:1901361	175	0.012
regulation of response to wounding	GO:1903034	69	0.012
tissue development	GO:0009888	252	0.012
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	GO:0002859	1	0.012
positive regulation of cellular amine metabolic process	GO:0033240	3	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.012
response to carbohydrate	GO:0009743	183	0.012
salivary gland morphogenesis	GO:0007435	1	0.011
lymphocyte migration	GO:0072676	3	0.011
regulation of immunoglobulin mediated immune response	GO:0002889	2	0.011
cellular response to reactive oxygen species	GO:0034614	55	0.011
regulation of protein phosphorylation	GO:0001932	183	0.011
positive regulation of lipid kinase activity	GO:0090218	2	0.011
t cell migration	GO:0072678	2	0.011
heterocycle catabolic process	GO:0046700	167	0.011
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.011
regulation of phosphate metabolic process	GO:0019220	349	0.011
single organism catabolic process	GO:0044712	283	0.011
cytokine production	GO:0001816	61	0.011
cell morphogenesis involved in differentiation	GO:0000904	119	0.011
interferon gamma production	GO:0032609	3	0.011
neuron development	GO:0048666	286	0.011
positive regulation of cellular component organization	GO:0051130	200	0.011
regulation of interleukin 1 alpha biosynthetic process	GO:0050721	1	0.011
reproduction	GO:0000003	245	0.011
regulation of peptide secretion	GO:0002791	82	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
regulation of neuron differentiation	GO:0045664	208	0.011
glycosyl compound catabolic process	GO:1901658	126	0.011
response to vitamin	GO:0033273	131	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.011
negative regulation of developmental process	GO:0051093	125	0.011
carboxylic acid metabolic process	GO:0019752	289	0.011
negative regulation of molecular function	GO:0044092	133	0.011
regulation of lipid metabolic process	GO:0019216	68	0.011
protein oligomerization	GO:0051259	191	0.011
purine nucleotide metabolic process	GO:0006163	229	0.011
positive regulation of locomotion	GO:0040017	102	0.011
programmed necrotic cell death	GO:0097300	2	0.011
cellular response to acid chemical	GO:0071229	75	0.011
cellular macromolecular complex assembly	GO:0034622	58	0.011
negative regulation of catalytic activity	GO:0043086	103	0.011
positive regulation of signal transduction	GO:0009967	175	0.011
cellular component morphogenesis	GO:0032989	155	0.011
response to mechanical stimulus	GO:0009612	134	0.010
positive regulation of mesenchymal cell proliferation	GO:0002053	4	0.010
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.010
macromolecule localization	GO:0033036	252	0.010
actin filament based process	GO:0030029	86	0.010
calcium ion transport into cytosol	GO:0060402	38	0.010
nucleoside triphosphate metabolic process	GO:0009141	144	0.010
nucleotide catabolic process	GO:0009166	139	0.010
purine ribonucleotide catabolic process	GO:0009154	136	0.010
response to hexose	GO:0009746	144	0.010
response to estradiol	GO:0032355	164	0.010
inorganic ion transmembrane transport	GO:0098660	229	0.010
positive regulation of cell motility	GO:2000147	97	0.010
myeloid leukocyte activation	GO:0002274	36	0.010
cellular response to organonitrogen compound	GO:0071417	197	0.010
response to hypoxia	GO:0001666	231	0.010

Sh2d1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.011
	musculoskeletal system disease	DOID:17	0	0.011

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