Rattus norvegicus

15 known processes

Bace1

beta-site APP cleaving enzyme 1

(Aliases: Bace)

Bace1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron developmentGO:00486662860.253
protein complex subunit organizationGO:00718223020.211
regulation of cellular component organizationGO:00511283680.190
regulation of molecular functionGO:00650093980.181
cellular component assemblyGO:00226073600.173
vesicle mediated transportGO:00161921810.170
nucleoside phosphate catabolic processGO:19012921400.168
growthGO:00400071650.156
cellular component biogenesisGO:00440853680.147
cell morphogenesisGO:00009021420.141
regulation of signal transductionGO:00099663180.129
cell projection organizationGO:00300303020.125
macromolecular complex subunit organizationGO:00439333390.115
organophosphate catabolic processGO:00464341480.112
regulation of growthGO:00400081050.111
positive regulation of nervous system developmentGO:00519621780.111
biological adhesionGO:00226101100.108
synaptic transmissionGO:00072682350.101
regulation of nervous system developmentGO:00519602640.096
neuron differentiationGO:00301823680.095
brain developmentGO:00074202470.094
catabolic processGO:00090563510.093
cell growthGO:00160491040.092
endocytosisGO:0006897840.089
carbohydrate derivative metabolic processGO:19011353460.089
protein complex assemblyGO:00064612630.087
aromatic compound catabolic processGO:00194391680.087
regulation of metal ion transportGO:00109591180.086
rhythmic processGO:00485111560.086
regulation of neuron differentiationGO:00456642080.086
positive regulation of molecular functionGO:00440932300.086
macromolecular complex assemblyGO:00650032730.081
response to temperature stimulusGO:0009266940.081
regulation of multicellular organismal developmentGO:20000263760.080
neuron projection developmentGO:00311752730.078
purine nucleotide catabolic processGO:00061951360.077
regulation of protein phosphorylationGO:00019321830.074
nucleobase containing small molecule metabolic processGO:00550863160.072
cell adhesionGO:00071551100.071
regulation of neurogenesisGO:00507672470.069
synapse organizationGO:0050808460.069
positive regulation of cell developmentGO:00107201760.068
positive regulation of neurogenesisGO:00507691650.068
intracellular signal transductionGO:00355563140.068
protein complex biogenesisGO:00702712630.066
response to radiationGO:00093141370.065
regulation of cell developmentGO:00602842630.065
transmembrane transportGO:00550854120.064
cell morphogenesis involved in differentiationGO:00009041190.063
neurological system processGO:00508772190.063
organophosphate metabolic processGO:00196373700.062
regulation of cell differentiationGO:00455953200.062
axonogenesisGO:0007409710.062
single organism catabolic processGO:00447122830.060
establishment of organelle localizationGO:0051656370.059
regulation of ion transportGO:00432692450.058
negative regulation of signalingGO:00230571570.057
nucleotide catabolic processGO:00091661390.056
positive regulation of catalytic activityGO:00430851840.056
positive regulation of cell differentiationGO:00455972170.056
purine containing compound catabolic processGO:00725231380.055
single organism biosynthetic processGO:00447113420.054
positive regulation of phosphate metabolic processGO:00459372620.053
regulation of catalytic activityGO:00507903040.051
cation homeostasisGO:00550801950.050
nucleoside phosphate metabolic processGO:00067532830.049
regulation of cell growthGO:0001558850.048
inorganic ion transmembrane transportGO:00986602290.048
cell cell signalingGO:00072673350.047
organic substance catabolic processGO:19015753160.047
anatomical structure morphogenesisGO:00096532980.046
protein localizationGO:00081041910.046
positive regulation of neuron migrationGO:200122420.046
regulation of neuron projection developmentGO:00109751610.045
regulation of phosphorus metabolic processGO:00511743490.045
positive regulation of developmental processGO:00510942830.045
synaptic growth at neuromuscular junctionGO:005112410.045
positive regulation of nucleotide metabolic processGO:0045981910.045
negative regulation of cell communicationGO:00106481580.045
purine ribonucleotide metabolic processGO:00091502270.044
response to oxygen levelsGO:00704822650.044
ribose phosphate metabolic processGO:00196932350.044
carbohydrate derivative catabolic processGO:19011361470.044
cellular catabolic processGO:00442482950.043
ion transmembrane transportGO:00342203650.043
regulation of phosphate metabolic processGO:00192203490.043
regulation of cell proliferationGO:00421273590.043
regulation of intracellular signal transductionGO:19025312180.042
negative regulation of gene expressionGO:00106291990.042
purine nucleotide metabolic processGO:00061632290.042
nucleoside triphosphate metabolic processGO:00091411440.041
response to organophosphorusGO:00466831020.041
cellular component movementGO:00069282480.041
regulation of protein metabolic processGO:00512462890.041
central nervous system developmentGO:00074173110.041
negative regulation of apoptotic processGO:00430661810.041
regulation of vesicle mediated transportGO:0060627810.040
organelle organizationGO:00069962660.040
cell part morphogenesisGO:00329901230.040
reproductive processGO:00224143720.040
regulation of locomotionGO:00400121480.039
purine ribonucleotide catabolic processGO:00091541360.039
positive regulation of response to stimulusGO:00485842850.038
metal ion transportGO:00300012890.038
nucleoside metabolic processGO:00091161790.038
retina morphogenesis in camera type eyeGO:006004210.038
positive regulation of signal transductionGO:00099671750.037
purine ribonucleoside catabolic processGO:00461301240.037
motor neuron axon guidanceGO:000804510.037
purine ribonucleoside triphosphate catabolic processGO:00092071220.037
lipid biosynthetic processGO:00086101280.037
developmental growthGO:00485891000.036
response to purine containing compoundGO:00140741260.036
multi organism reproductive processGO:00447032620.036
rna metabolic processGO:00160704060.035
secretionGO:00469033070.035
head developmentGO:00603222470.035
positive regulation of phosphorylationGO:00423271770.035
guanosine containing compound metabolic processGO:1901068740.035
regulation of protein modification processGO:00313991940.034
developmental process involved in reproductionGO:00030061590.034
response to bacteriumGO:00096172000.034
protein oligomerizationGO:00512591910.034
regulation of cell morphogenesis involved in differentiationGO:0010769720.034
cellular response to organonitrogen compoundGO:00714171970.033
regulation of secretion by cellGO:19035302080.033
nucleotide metabolic processGO:00091172790.033
organ morphogenesisGO:0009887750.033
regulation of cell adhesionGO:0030155520.032
nucleobase containing compound catabolic processGO:00346551520.032
purine nucleoside triphosphate catabolic processGO:00091461220.032
positive regulation of protein phosphorylationGO:00019341350.032
cation transportGO:00068123820.032
nucleic acid templated transcriptionGO:00976593790.032
nucleoside catabolic processGO:00091641260.032
regulation of programmed cell deathGO:00430673410.032
protein heterooligomerizationGO:0051291890.032
positive regulation of cellular component organizationGO:00511302000.031
negative regulation of metabolic processGO:00098923310.031
multicellular organism growthGO:003526410.031
positive regulation of multicellular organismal processGO:00512403870.031
purine nucleoside metabolic processGO:00422781690.031
cardiovascular system developmentGO:00723581340.031
protein phosphorylationGO:00064683450.031
l glutamate importGO:005193820.031
regulation of nucleotide metabolic processGO:00061401170.031
metal ion homeostasisGO:00550651860.031
calcium ion transportGO:00068161310.030
organic cyclic compound catabolic processGO:19013611750.030
regulation of cell projection organizationGO:00313441750.030
synapse assemblyGO:0007416290.030
ribonucleoside triphosphate catabolic processGO:00092031220.030
cation transmembrane transportGO:00986552630.030
organonitrogen compound biosynthetic processGO:19015661670.029
regulation of anatomical structure morphogenesisGO:00226031410.029
positive regulation of cell communicationGO:00106472710.029
epithelium developmentGO:0060429960.028
ribonucleotide catabolic processGO:00092611360.028
positive regulation of protein modification processGO:00314011420.028
macromolecule localizationGO:00330362520.028
purine ribonucleotide biosynthetic processGO:0009152810.028
cellular response to endogenous stimulusGO:00714953770.028
positive regulation of neuron differentiationGO:00456661260.028
regulation of apoptotic processGO:00429813350.028
cell morphogenesis involved in neuron differentiationGO:00486671060.027
guanosine containing compound catabolic processGO:1901069710.027
regulation of ion transmembrane transporter activityGO:0032412480.027
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.027
signal transduction by phosphorylationGO:00230141440.027
g protein coupled receptor signaling pathwayGO:00071862420.027
heterocycle catabolic processGO:00467001670.027
positive regulation of neuron projection developmentGO:0010976990.027
tube developmentGO:0035295890.027
circadian rhythmGO:0007623880.027
positive regulation of transportGO:00510502450.027
regulation of axonogenesisGO:0050770370.026
positive regulation of phosphorus metabolic processGO:00105622620.026
negative regulation of cellular metabolic processGO:00313242810.026
cellular ketone metabolic processGO:0042180510.026
ribonucleotide metabolic processGO:00092592310.026
positive regulation of growthGO:0045927550.026
cellular response to nitrogen compoundGO:19016992100.025
gland developmentGO:00487321550.025
organonitrogen compound catabolic processGO:19015651790.025
purine nucleoside triphosphate metabolic processGO:00091441410.025
regulation of phosphorylationGO:00423252480.025
vasculature developmentGO:0001944700.025
ribonucleoside metabolic processGO:00091191740.025
positive regulation of cellular protein metabolic processGO:00322701670.025
negative regulation of response to stimulusGO:00485851550.025
regulation of transcription dna templatedGO:00063553740.024
cellular protein localizationGO:00346131220.024
wound healingGO:00420601220.024
regulation of membrane potentialGO:00423911100.024
positive regulation of apoptotic processGO:00430651540.024
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.024
anterior posterior pattern specificationGO:000995210.024
regulation of transcription from rna polymerase ii promoterGO:00063572340.024
gonad developmentGO:00084061040.024
regulation of kinase activityGO:00435491170.024
single organism organelle organizationGO:19025891800.024
purine ribonucleoside triphosphate metabolic processGO:00092051400.024
locomotor rhythmGO:004547510.024
positive regulation of biosynthetic processGO:00098913190.023
negative regulation of macromolecule biosynthetic processGO:00105581480.023
response to growth factorGO:00708481890.023
gastrulationGO:000736920.023
negative regulation of rna biosynthetic processGO:19026791180.023
regulation of lipid metabolic processGO:0019216680.023
positive regulation of cell deathGO:00109421840.023
negative regulation of cellular biosynthetic processGO:00313271610.023
circulatory system developmentGO:00723591340.023
fatty acid metabolic processGO:0006631990.023
inorganic cation transmembrane transportGO:00986622020.023
cellular component morphogenesisGO:00329891550.023
regulation of rna biosynthetic processGO:20011413810.023
amide transportGO:00428861050.023
response to campGO:0051591910.023
gtp metabolic processGO:0046039720.022
nucleoside triphosphate catabolic processGO:00091431230.022
regulation of nucleic acid templated transcriptionGO:19035063800.022
ribonucleoside catabolic processGO:00424541260.022
ion homeostasisGO:00508012120.022
organic hydroxy compound metabolic processGO:19016151150.022
monovalent inorganic cation transportGO:00156721720.022
agingGO:00075682410.022
cellular nitrogen compound catabolic processGO:00442701630.022
anatomical structure formation involved in morphogenesisGO:0048646830.022
negative regulation of cell proliferationGO:00082851190.022
positive regulation of mapk cascadeGO:0043410920.021
cell cycleGO:00070491010.021
negative regulation of transcription dna templatedGO:00458921160.021
locomotionGO:00400112370.021
regulation of hormone secretionGO:00468831060.021
synaptic vesicle endocytosisGO:004848840.021
exocytosisGO:0006887600.021
intracellular protein transportGO:0006886790.021
regulation of cellular component movementGO:00512701500.021
regulation of endocytosisGO:0030100420.021
divalent inorganic cation transportGO:00725111340.021
negative regulation of phosphate metabolic processGO:0045936800.021
positive regulation of signalingGO:00230562700.021
negative regulation of cell deathGO:00605482290.021
negative regulation of signal transductionGO:0009968830.020
cellular response to external stimulusGO:00714961180.020
response to blue lightGO:000963710.020
purine containing compound metabolic processGO:00725212530.020
response to woundingGO:00096112540.020
glycosyl compound catabolic processGO:19016581260.020
single organism reproductive processGO:00447022970.020
negative regulation of macromolecule metabolic processGO:00106052600.020
cell motilityGO:00488702020.020
cellular cation homeostasisGO:00300031800.020
regulation of transmembrane transportGO:00347621220.020
sex differentiationGO:00075481130.019
positive regulation of gene expressionGO:00106282440.019
synaptic vesicle transportGO:0048489230.019
developmental inductionGO:003112820.019
neurotransmitter gated ion channel clusteringGO:007257830.019
gliogenesisGO:0042063930.019
pallium developmentGO:0021543420.019
negative regulation of nucleobase containing compound metabolic processGO:00459341530.019
urinary bladder smooth muscle contractionGO:001483240.019
positive regulation of cell proliferationGO:00082842490.019
cellular response to abiotic stimulusGO:0071214850.019
response to heatGO:0009408600.019
rna biosynthetic processGO:00327743800.019
glycosyl compound metabolic processGO:19016571820.019
lipid metabolic processGO:00066292830.019
positive regulation of cellular component biogenesisGO:0044089550.019
negative regulation of nitrogen compound metabolic processGO:00511721610.019
small gtpase mediated signal transductionGO:0007264360.018
negative regulation of programmed cell deathGO:00430691830.018
apoptotic processGO:00069153810.018
positive regulation of transferase activityGO:0051347810.018
divalent metal ion transportGO:00708381320.018
regulation of purine nucleotide metabolic processGO:19005421150.018
regulation of gtpase activityGO:0043087570.018
phospholipid metabolic processGO:0006644610.018
cellular ion homeostasisGO:00068731840.018
axon developmentGO:0061564960.018
cell projection morphogenesisGO:00488581230.018
response to toxic substanceGO:00096361330.018
protein transportGO:00150311320.018
purine ribonucleoside metabolic processGO:00461281680.018
regulation of cell morphogenesisGO:0022604770.018
regulation of cellular protein metabolic processGO:00322682670.018
reproductive structure developmentGO:00486081280.018
negative regulation of stress activated mapk cascadeGO:003287340.017
cellular calcium ion homeostasisGO:00068741600.017
positive regulation of cytosolic calcium ion concentrationGO:00072041220.017
neuron deathGO:00709971270.017
regulation of response to external stimulusGO:00321011060.017
sodium ion transportGO:0006814820.017
localization of cellGO:00516742020.017
epithelial cell differentiationGO:0030855710.017
positive regulation of gtpase activityGO:0043547470.017
multicellular organism reproductionGO:00325042330.017
cellular macromolecule localizationGO:00707271220.017
lipid modificationGO:0030258520.017
negative regulation of cellular protein metabolic processGO:00322691060.017
neuron projection morphogenesisGO:00488121220.017
response to glucoseGO:00097491360.017
secretion by cellGO:00329402480.016
regulation of anatomical structure sizeGO:00900661350.016
dna metabolic processGO:0006259960.016
tissue morphogenesisGO:0048729220.016
purine nucleoside catabolic processGO:00061521240.016
response to external biotic stimulusGO:00432072210.016
behaviorGO:00076102050.016
positive regulation of gtp catabolic processGO:0033126480.016
embryo developmentGO:0009790490.016
protein targetingGO:0006605610.016
response to carbohydrateGO:00097431830.016
ras protein signal transductionGO:0007265290.016
organelle localizationGO:0051640550.016
proteolysisGO:00065081750.016
circulatory system processGO:00030131830.016
organophosphate biosynthetic processGO:00904071430.016
membrane organizationGO:0061024940.016
peptide secretionGO:0002790860.016
regulation of protein kinase activityGO:00458591050.016
cerebral cortex tangential migrationGO:002180010.016
reproductive system developmentGO:00614581280.016
positive regulation of cell projection organizationGO:00313461110.016
negative regulation of biosynthetic processGO:00098901680.016
regulation of vasculature developmentGO:1901342440.015
positive regulation of nucleobase containing compound metabolic processGO:00459353190.015
negative regulation of cellular component organizationGO:0051129830.015
central nervous system neuron developmentGO:002195450.015
response to biotic stimulusGO:00096072260.015
regulation of blood vessel sizeGO:0050880890.015
negative regulation of stress activated protein kinase signaling cascadeGO:007030340.015
single organism intracellular transportGO:19025821660.015
negative regulation of rna metabolic processGO:00512531230.015
calcium ion homeostasisGO:00550741620.015
blood vessel developmentGO:0001568690.015
regulation of transporter activityGO:0032409500.015
regulation of cell migrationGO:00303341280.015
ribonucleoside triphosphate metabolic processGO:00091991410.015
response to monosaccharideGO:00342841590.015
regulation of rna metabolic processGO:00512523910.014
regulation of calcium ion transportGO:0051924770.014
positive regulation of purine nucleotide metabolic processGO:1900544910.014
female pregnancyGO:00075651220.014
female gonad developmentGO:0008585530.014
response to hydrogen peroxideGO:0042542890.014
response to anoxiaGO:003405940.014
regulation of body fluid levelsGO:0050878900.014
blood circulationGO:00080151830.014
response to mechanical stimulusGO:00096121340.014
regulation of small gtpase mediated signal transductionGO:0051056480.014
cytoskeleton organizationGO:00070101110.014
muscle contractionGO:0006936880.014
regulation of cellular localizationGO:00603412630.014
regulation of heart contractionGO:0008016480.014
salivary gland developmentGO:000743130.014
cell migrationGO:00164771970.014
carbohydrate derivative biosynthetic processGO:19011371240.014
development of primary sexual characteristicsGO:00451371070.014
programmed cell deathGO:00125013920.014
phototransduction visible lightGO:000760320.014
positive regulation of programmed cell deathGO:00430681570.014
respiratory system developmentGO:0060541450.014
positive regulation of intracellular signal transductionGO:19025331380.014
membrane hyperpolarizationGO:0060081110.013
ovulation cycle processGO:0022602500.013
positive regulation of the force of heart contraction by epinephrine norepinephrineGO:000199720.013
protein localization to organelleGO:0033365570.013
negative regulation of developmental processGO:00510931250.013
carbohydrate metabolic processGO:00059751300.013
negative regulation of nucleic acid templated transcriptionGO:19035071170.013
regulation of developmental growthGO:0048638450.013
negative regulation of cell differentiationGO:0045596990.013
steroid metabolic processGO:0008202730.013
glycogen metabolic processGO:0005977230.013
positive regulation of synaptic vesicle exocytosisGO:200030230.013
cellular lipid metabolic processGO:00442552080.013
response to estrogenGO:00436272320.013
cellular response to oxygen containing compoundGO:19017013860.013
regulation of transferase activityGO:00513381230.013
response to peptide hormoneGO:00434342780.013
response to hypoxiaGO:00016662310.013
cytosolic calcium ion homeostasisGO:00514801400.013
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200270.013
homeostatic processGO:00425923310.013
regulation of nucleoside metabolic processGO:0009118660.013
eye morphogenesisGO:004859240.013
cellular polysaccharide metabolic processGO:0044264230.013
spermatogenesisGO:0007283990.013
positive regulation of cellular catabolic processGO:0031331710.012
axon midline choice point recognitionGO:001619920.012
positive regulation of protein metabolic processGO:00512471780.012
cyclic nucleotide biosynthetic processGO:0009190630.012
blood vessel morphogenesisGO:0048514580.012
cell cell signaling involved in cell fate commitmentGO:004516820.012
positive regulation of renin secretion into blood streamGO:190013510.012
regulation of cell motilityGO:20001451310.012
potassium ion transportGO:0006813970.012
divalent inorganic cation homeostasisGO:00725071650.012
developmental growth involved in morphogenesisGO:0060560330.012
single organism cell adhesionGO:0098602460.012
response to light stimulusGO:0009416520.012
neuron projection extensionGO:1990138260.012
cerebral cortex cell migrationGO:002179540.012
positive regulation of hydrolase activityGO:0051345860.012
regulation of organ formationGO:000315620.012
multicellular organismal reproductive processGO:00486092330.012
regulation of mapk cascadeGO:00434081160.012
olfactory bulb interneuron differentiationGO:002188910.012
regulation of response to stressGO:00801341260.012
rho protein signal transductionGO:0007266110.012
single organism behaviorGO:00447081300.012
positive regulation of nucleoside metabolic processGO:0045979550.012
regulation of cyclic nucleotide biosynthetic processGO:0030802450.012
regulation of canonical wnt signaling pathwayGO:006082840.012
transmission of nerve impulseGO:0019226420.012
cellular protein complex assemblyGO:0043623440.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.011
positive regulation of cell growthGO:0030307440.011
embryonic pattern specificationGO:000988010.011
cellular amine metabolic processGO:0044106380.011
cellular macromolecular complex assemblyGO:0034622580.011
regulation of organelle organizationGO:0033043800.011
positive regulation of adherens junction organizationGO:190339320.011
positive regulation of purine nucleotide catabolic processGO:0033123530.011
intracellular transportGO:00469071850.011
morphogenesis of an epitheliumGO:0002009200.011
sensory perception of painGO:0019233730.011
regulation of catabolic processGO:00098941130.011
cellular chemical homeostasisGO:00550822470.011
gtp catabolic processGO:0006184710.011
positive regulation of macromolecule biosynthetic processGO:00105572470.011
reproductionGO:00000032450.011
response to alkaloidGO:00432791320.011
regulation of muscle contractionGO:0006937530.011
regulation of notch signaling pathwayGO:000859330.011
axon extensionGO:0048675260.011
female sex differentiationGO:0046660590.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.011
forebrain neuron developmentGO:002188430.011
steroid biosynthetic processGO:0006694480.011
organ senescenceGO:001026020.011
lipid transportGO:0006869610.011
response to estradiolGO:00323551640.011
cellular glucan metabolic processGO:0006073230.010
regulation of neuron deathGO:19012141150.010
regulation of nucleotide catabolic processGO:0030811650.010
oxoacid metabolic processGO:00434362900.010
male gamete generationGO:0048232990.010
eye developmentGO:0001654500.010
cytoplasmic transportGO:00164821150.010
chemical homeostasisGO:00488782920.010
regulation of hormone levelsGO:00108171870.010
sensory perception of light stimulusGO:005095330.010
cellular homeostasisGO:00197252520.010
negative regulation of jnk cascadeGO:004632940.010

Bace1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:005015500.032
nervous system diseaseDOID:86300.032
disease of anatomical entityDOID:700.032
disease of metabolismDOID:001466700.022
eye and adnexa diseaseDOID:149200.016
eye diseaseDOID:561400.016
inherited metabolic disorderDOID:65500.011
carbohydrate metabolic disorderDOID:297800.010