Rattus norvegicus

53 known processes

Irs2

insulin receptor substrate 2

(Aliases: IRS-2,4PS)

Irs2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
carboxylic acid metabolic processGO:00197522890.165
organic acid metabolic processGO:00060822920.146
enzyme linked receptor protein signaling pathwayGO:00071671160.116
apoptotic processGO:00069153810.116
response to peptide hormoneGO:00434342780.110
nucleic acid templated transcriptionGO:00976593790.082
regulation of phosphate metabolic processGO:00192203490.082
response to peptideGO:19016522920.079
transcription dna templatedGO:00063513770.074
regulation of cellular protein metabolic processGO:00322682670.070
blood circulationGO:00080151830.070
negative regulation of macromolecule metabolic processGO:00106052600.068
positive regulation of nitrogen compound metabolic processGO:00511733340.067
regulation of rna biosynthetic processGO:20011413810.067
negative regulation of metabolic processGO:00098923310.067
amine metabolic processGO:0009308380.065
regulation of programmed cell deathGO:00430673410.065
regulation of protein modification processGO:00313991940.063
intracellular signal transductionGO:00355563140.060
regulation of catalytic activityGO:00507903040.060
cellular response to oxygen containing compoundGO:19017013860.060
cellular ketone metabolic processGO:0042180510.060
positive regulation of nucleobase containing compound metabolic processGO:00459353190.060
cellular amine metabolic processGO:0044106380.059
cellular response to stressGO:00335542690.059
regulation of molecular functionGO:00650093980.058
regulation of cellular amine metabolic processGO:003323880.057
regulation of cellular amino acid metabolic processGO:000652120.056
response to campGO:0051591910.055
protein phosphorylationGO:00064683450.055
cell projection organizationGO:00300303020.055
single organism biosynthetic processGO:00447113420.053
regulation of transcription dna templatedGO:00063553740.051
regulation of protein phosphorylationGO:00019321830.051
oxoacid metabolic processGO:00434362900.051
circulatory system processGO:00030131830.050
response to metal ionGO:00100382530.050
regulation of phosphorus metabolic processGO:00511743490.049
positive regulation of multicellular organismal processGO:00512403870.049
cellular amino acid metabolic processGO:00065201070.048
regulation of system processGO:00440572080.047
response to oxidative stressGO:00069791860.046
central nervous system developmentGO:00074173110.045
regulation of cellular ketone metabolic processGO:0010565270.044
programmed cell deathGO:00125013920.044
cellular response to peptide hormone stimulusGO:00713751200.044
regulation of phosphorylationGO:00423252480.044
response to extracellular stimulusGO:00099913800.043
response to estrogenGO:00436272320.043
rna biosynthetic processGO:00327743800.043
response to inorganic substanceGO:00100353770.042
negative regulation of apoptotic processGO:00430661810.041
cellular response to hormone stimulusGO:00328702470.040
cellular response to peptideGO:19016531330.040
carbohydrate derivative metabolic processGO:19011353460.039
negative regulation of cellular metabolic processGO:00313242810.038
response to oxygen levelsGO:00704822650.038
transcription from rna polymerase ii promoterGO:00063662520.038
regulation of cell proliferationGO:00421273590.038
purine containing compound metabolic processGO:00725212530.037
positive regulation of transcription dna templatedGO:00458931970.037
cellular component morphogenesisGO:00329891550.037
mapk cascadeGO:00001651400.037
positive regulation of transportGO:00510502450.037
positive regulation of cellular biosynthetic processGO:00313282950.036
neuron projection developmentGO:00311752730.036
negative regulation of nitrogen compound metabolic processGO:00511721610.036
metal ion transportGO:00300012890.035
cation transportGO:00068123820.035
regulation of rna metabolic processGO:00512523910.035
positive regulation of phosphorus metabolic processGO:00105622620.034
negative regulation of biosynthetic processGO:00098901680.034
negative regulation of cell deathGO:00605482290.034
behaviorGO:00076102050.034
homeostatic processGO:00425923310.034
regulation of intracellular signal transductionGO:19025312180.034
regulation of protein metabolic processGO:00512462890.033
regulation of transcription from rna polymerase ii promoterGO:00063572340.033
gastrulationGO:000736920.032
neuron projection morphogenesisGO:00488121220.032
negative regulation of programmed cell deathGO:00430691830.032
regulation of signal transductionGO:00099663180.032
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.031
peptidyl amino acid modificationGO:00181931260.031
tissue developmentGO:00098882520.031
positive regulation of cellular amine metabolic processGO:003324030.031
neurological system processGO:00508772190.031
neuron deathGO:00709971270.031
lipid metabolic processGO:00066292830.031
catabolic processGO:00090563510.031
cellular chemical homeostasisGO:00550822470.031
neuron developmentGO:00486662860.031
response to hypoxiaGO:00016662310.030
positive regulation of response to stimulusGO:00485842850.030
nucleotide metabolic processGO:00091172790.030
cell morphogenesis involved in differentiationGO:00009041190.030
protein processingGO:0016485680.030
cell morphogenesis involved in neuron differentiationGO:00486671060.030
anatomical structure morphogenesisGO:00096532980.030
cell type specific apoptotic processGO:00972851340.029
response to decreased oxygen levelsGO:00362932370.029
positive regulation of protein metabolic processGO:00512471780.029
response to insulinGO:00328681330.029
organophosphate metabolic processGO:00196373700.029
macromolecular complex subunit organizationGO:00439333390.028
response to organophosphorusGO:00466831020.028
rna metabolic processGO:00160704060.028
negative regulation of gene expressionGO:00106291990.028
axon developmentGO:0061564960.028
cell migrationGO:00164771970.028
positive regulation of cell deathGO:00109421840.028
positive regulation of gene expressionGO:00106282440.028
positive regulation of signalingGO:00230562700.027
ion transmembrane transportGO:00342203650.027
proteolysisGO:00065081750.027
positive regulation of biosynthetic processGO:00098913190.027
positive regulation of cell communicationGO:00106472710.027
regulation of nucleic acid templated transcriptionGO:19035063800.027
cellular component movementGO:00069282480.027
positive regulation of nucleic acid templated transcriptionGO:19035081970.026
protein maturationGO:0051604680.026
calcium ion transportGO:00068161310.026
positive regulation of macromolecule biosynthetic processGO:00105572470.026
cell morphogenesisGO:00009021420.026
chemical homeostasisGO:00488782920.025
negative regulation of molecular functionGO:00440921330.025
organonitrogen compound biosynthetic processGO:19015661670.025
neuron differentiationGO:00301823680.025
secretion by cellGO:00329402480.025
negative regulation of protein metabolic processGO:00512481140.025
heart processGO:0003015570.025
reproductive processGO:00224143720.025
cellular catabolic processGO:00442482950.025
response to glucocorticoidGO:00513842230.025
regulation of cellular localizationGO:00603412630.025
positive regulation of cellular amino acid metabolic processGO:004576410.024
regulation of protein kinase activityGO:00458591050.024
regulation of apoptotic processGO:00429813350.024
single organism reproductive processGO:00447022970.024
response to nutrient levelsGO:00316673700.024
regulation of proteasomal protein catabolic processGO:006113640.024
purine ribonucleotide metabolic processGO:00091502270.024
protein complex assemblyGO:00064612630.023
secretionGO:00469033070.023
response to purine containing compoundGO:00140741260.023
urogenital system developmentGO:0001655780.023
regulation of transferase activityGO:00513381230.023
regulation of cell differentiationGO:00455953200.023
single organism behaviorGO:00447081300.023
regulation of hormone levelsGO:00108171870.023
positive regulation of rna metabolic processGO:00512542030.023
nucleobase containing small molecule metabolic processGO:00550863160.022
locomotionGO:00400112370.022
cellular response to endogenous stimulusGO:00714953770.022
cation transmembrane transportGO:00986552630.022
positive regulation of phosphate metabolic processGO:00459372620.022
response to carbohydrateGO:00097431830.022
cellular response to lipidGO:00713962010.022
dna metabolic processGO:0006259960.022
cell part morphogenesisGO:00329901230.022
cellular lipid metabolic processGO:00442552080.022
gland developmentGO:00487321550.022
regulation of reactive oxygen species metabolic processGO:2000377260.021
reactive oxygen species metabolic processGO:0072593370.021
response to corticosteroidGO:00319602350.021
cation homeostasisGO:00550801950.021
nucleoside phosphate metabolic processGO:00067532830.021
ion homeostasisGO:00508012120.021
cellular response to organonitrogen compoundGO:00714171970.021
localization of cellGO:00516742020.021
protein complex subunit organizationGO:00718223020.021
single organism catabolic processGO:00447122830.021
regulation of cellular component organizationGO:00511283680.021
regulation of nervous system developmentGO:00519602640.020
positive regulation of cellular component organizationGO:00511302000.020
intracellular transportGO:00469071850.020
regulation of canonical wnt signaling pathwayGO:006082840.020
organic substance catabolic processGO:19015753160.020
positive regulation of phosphorylationGO:00423271770.020
renal system developmentGO:0072001670.020
neuron apoptotic processGO:0051402880.019
monovalent inorganic cation transportGO:00156721720.019
lipid biosynthetic processGO:00086101280.019
transmembrane transportGO:00550854120.019
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.019
response to growth factorGO:00708481890.019
ribose phosphate metabolic processGO:00196932350.019
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.019
regulation of cell growthGO:0001558850.019
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.019
cellular response to insulin stimulusGO:0032869810.019
cellular homeostasisGO:00197252520.019
positive regulation of rna biosynthetic processGO:19026801970.019
multi organism reproductive processGO:00447032620.019
negative regulation of developmental processGO:00510931250.019
protein localizationGO:00081041910.018
positive regulation of cellular protein metabolic processGO:00322701670.018
cellular ion homeostasisGO:00068731840.018
single organism organelle organizationGO:19025891800.018
response to ketoneGO:19016541820.018
nucleobase containing compound catabolic processGO:00346551520.018
regulation of secretion by cellGO:19035302080.018
macromolecule localizationGO:00330362520.018
epithelium developmentGO:0060429960.018
positive regulation of programmed cell deathGO:00430681570.018
peptidyl tyrosine modificationGO:0018212720.018
cell adhesionGO:00071551100.018
positive regulation of developmental processGO:00510942830.018
multicellular organism growthGO:003526410.018
head developmentGO:00603222470.018
glycerolipid metabolic processGO:0046486670.018
heterocycle catabolic processGO:00467001670.018
ribonucleotide metabolic processGO:00092592310.018
response to bacteriumGO:00096172000.018
organophosphate biosynthetic processGO:00904071430.018
positive regulation of protein phosphorylationGO:00019341350.017
positive regulation of ion transportGO:0043270940.017
positive regulation of apoptotic processGO:00430651540.017
agingGO:00075682410.017
peptidyl tyrosine phosphorylationGO:0018108720.017
growthGO:00400071650.017
organelle organizationGO:00069962660.017
divalent inorganic cation transportGO:00725111340.017
eye morphogenesisGO:004859240.017
response to dexamethasoneGO:0071548490.017
regulation of cellular component movementGO:00512701500.017
protein complex biogenesisGO:00702712630.017
cell growthGO:00160491040.017
divalent metal ion transportGO:00708381320.017
cellular cation homeostasisGO:00300031800.017
negative regulation of cellular biosynthetic processGO:00313271610.017
regulation of secretionGO:00510462240.017
cellular response to nitrogen compoundGO:19016992100.017
cellular component biogenesisGO:00440853680.017
ras protein signal transductionGO:0007265290.016
negative regulation of phosphorus metabolic processGO:0010563800.016
response to hexoseGO:00097461440.016
positive regulation of protein modification processGO:00314011420.016
regulation of metal ion transportGO:00109591180.016
cytoplasmic transportGO:00164821150.016
regenerationGO:00310991630.016
negative regulation of rna biosynthetic processGO:19026791180.016
macromolecular complex assemblyGO:00650032730.016
response to cytokineGO:00340972150.016
negative regulation of rna metabolic processGO:00512531230.016
sensory organ developmentGO:0007423740.016
inorganic ion transmembrane transportGO:00986602290.016
response to external biotic stimulusGO:00432072210.016
aromatic compound catabolic processGO:00194391680.016
response to biotic stimulusGO:00096072260.016
purine nucleotide metabolic processGO:00061632290.016
ribonucleoside metabolic processGO:00091191740.016
regulation of hydrolase activityGO:00513361430.016
regulation of peptide transportGO:0090087870.016
brain developmentGO:00074202470.016
defense responseGO:00069521940.016
protein autophosphorylationGO:0046777660.016
signal transduction by phosphorylationGO:00230141440.015
positive regulation of catalytic activityGO:00430851840.015
cellular divalent inorganic cation homeostasisGO:00725031620.015
positive regulation of signal transductionGO:00099671750.015
insulin like growth factor receptor signaling pathwayGO:004800930.015
regulation of neurogenesisGO:00507672470.015
regulation of kinase activityGO:00435491170.015
negative regulation of catalytic activityGO:00430861030.015
inorganic cation transmembrane transportGO:00986622020.015
regulation of catabolic processGO:00098941130.015
response to reactive oxygen speciesGO:00003021200.015
regulation of mapk cascadeGO:00434081160.015
amide transportGO:00428861050.015
cellular response to external stimulusGO:00714961180.015
cell projection morphogenesisGO:00488581230.015
regulation of cell migrationGO:00303341280.015
regulation of calcium ion transportGO:0051924770.015
nitrogen compound transportGO:00717052290.015
organonitrogen compound catabolic processGO:19015651790.015
regulation of cellular catabolic processGO:00313291010.015
axonogenesisGO:0007409710.015
regulation of defense responseGO:0031347680.015
response to nutrientGO:00075842480.015
purine nucleoside metabolic processGO:00422781690.015
hormone transportGO:00099141210.014
cytokine mediated signaling pathwayGO:0019221430.014
negative regulation of cellular protein metabolic processGO:00322691060.014
negative regulation of phosphate metabolic processGO:0045936800.014
dephosphorylationGO:0016311980.014
rhythmic processGO:00485111560.014
negative regulation of cell proliferationGO:00082851190.014
response to radiationGO:00093141370.014
reactive oxygen species biosynthetic processGO:190340980.014
chemosensory behaviorGO:000763520.014
cellular calcium ion homeostasisGO:00068741600.014
regulation of nucleotide metabolic processGO:00061401170.014
organic cyclic compound catabolic processGO:19013611750.014
divalent inorganic cation homeostasisGO:00725071650.014
g protein coupled receptor signaling pathwayGO:00071862420.014
sex differentiationGO:00075481130.014
nucleoside phosphate catabolic processGO:19012921400.014
action potentialGO:0001508540.014
multicellular organismal reproductive processGO:00486092330.014
regulation of cell motilityGO:20001451310.014
signal releaseGO:00230611450.014
regulation of dna metabolic processGO:0051052600.014
regulation of reactive oxygen species biosynthetic processGO:190342650.014
embryonic pattern specificationGO:000988010.014
biological adhesionGO:00226101100.014
negative regulation of signalingGO:00230571570.014
positive regulation of molecular functionGO:00440932300.014
regulation of hormone secretionGO:00468831060.013
response to hydrogen peroxideGO:0042542890.013
cellular component assemblyGO:00226073600.013
response to ethanolGO:00454711620.013
tube developmentGO:0035295890.013
response to toxic substanceGO:00096361330.013
cellular metal ion homeostasisGO:00068751720.013
small gtpase mediated signal transductionGO:0007264360.013
collateral sproutingGO:004866820.013
hormone secretionGO:00468791150.013
neuronal action potentialGO:0019228350.013
negative regulation of nucleic acid templated transcriptionGO:19035071170.013
negative regulation of macromolecule biosynthetic processGO:00105581480.013
regulation of cell morphogenesisGO:0022604770.013
response to lipopolysaccharideGO:00324961910.013
circadian rhythmGO:0007623880.013
regulation of cell developmentGO:00602842630.013
positive regulation of intracellular signal transductionGO:19025331380.013
single organism intracellular transportGO:19025821660.013
calcium ion homeostasisGO:00550741620.013
immune system processGO:00023762040.013
organic hydroxy compound metabolic processGO:19016151150.013
establishment of protein localizationGO:00451841410.013
actin filament based movementGO:0030048160.012
negative regulation of cell differentiationGO:0045596990.012
negative regulation of nucleobase containing compound metabolic processGO:00459341530.012
cell cell signalingGO:00072673350.012
regulation of blood circulationGO:19035221100.012
bmp signaling pathwayGO:003050940.012
multicellular organismal signalingGO:0035637440.012
purine ribonucleoside metabolic processGO:00461281680.012
gonad developmentGO:00084061040.012
response to mechanical stimulusGO:00096121340.012
positive regulation of cell proliferationGO:00082842490.012
positive regulation of cell motilityGO:2000147970.012
cell communication involved in cardiac conductionGO:008606520.012
negative regulation of neuron deathGO:1901215690.012
reproductive system developmentGO:00614581280.012
reproductionGO:00000032450.012
negative regulation of muscle cell apoptotic processGO:0010656210.012
cellular response to growth factor stimulusGO:00713631620.012
positive regulation of reactive oxygen species metabolic processGO:2000379160.012
peptide hormone secretionGO:0030072840.012
regulation of proteolysisGO:0030162660.012
cellular nitrogen compound catabolic processGO:00442701630.012
nucleoside metabolic processGO:00091161790.012
small molecule biosynthetic processGO:00442831240.012
regulation of peptide hormone secretionGO:0090276800.012
positive regulation of cell developmentGO:00107201760.012
cellular response to oxidative stressGO:0034599760.012
locomotor rhythmGO:004547510.012
protein oligomerizationGO:00512591910.012
negative regulation of signal transductionGO:0009968830.012
positive regulation of nervous system developmentGO:00519621780.012
regulation of cell projection organizationGO:00313441750.012
developmental process involved in reproductionGO:00030061590.012
regulation of membrane potentialGO:00423911100.011
peptide transportGO:0015833970.011
negative regulation of cell communicationGO:00106481580.011
positive regulation of hydrolase activityGO:0051345860.011
peptide secretionGO:0002790860.011
nucleoside catabolic processGO:00091641260.011
regulation of neuron projection developmentGO:00109751610.011
morphogenesis of an epitheliumGO:0002009200.011
response to woundingGO:00096112540.011
cytosolic calcium ion homeostasisGO:00514801400.011
purine ribonucleoside triphosphate metabolic processGO:00092051400.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
positive regulation of immunoglobulin productionGO:000263940.011
response to acid chemicalGO:00011012220.011
cellular macromolecule localizationGO:00707271220.011
regulation of locomotionGO:00400121480.011
purine nucleoside triphosphate metabolic processGO:00091441410.011
positive regulation of mapk cascadeGO:0043410920.011
regulation of peptide secretionGO:0002791820.011
glycosyl compound catabolic processGO:19016581260.011
negative regulation of multicellular organismal processGO:00512412030.011
gliogenesisGO:0042063930.011
regulation of protein maturationGO:1903317500.011
glycosyl compound metabolic processGO:19016571820.011
regulation of protein localizationGO:0032880810.011
negative regulation of protein phosphorylationGO:0001933440.011
regulation of multicellular organismal developmentGO:20000263760.011
multi multicellular organism processGO:00447061380.011
regulation of bmp signaling pathwayGO:003051020.011
gamete generationGO:00072761240.011
tissue morphogenesisGO:0048729220.011
camera type eye morphogenesisGO:004859320.011
protein targetingGO:0006605610.011
positive regulation of secretion by cellGO:19035321280.011
heart morphogenesisGO:000300730.011
purine ribonucleoside catabolic processGO:00461301240.011
regulation of neuron deathGO:19012141150.011
inflammatory responseGO:00069541500.011
hair cell differentiationGO:003531520.011
protein transportGO:00150311320.010
learning or memoryGO:0007611900.010
ribonucleotide biosynthetic processGO:0009260850.010
insulin secretionGO:0030073690.010
negative regulation of phosphorylationGO:0042326570.010
male germ line stem cell asymmetric divisionGO:004813310.010
regulation of blood pressureGO:0008217830.010
transmission of nerve impulseGO:0019226420.010
regulation of embryonic developmentGO:004599520.010
b cell differentiationGO:003018320.010
nucleoside triphosphate catabolic processGO:00091431230.010
positive regulation of peptide secretionGO:0002793520.010
oxidation reduction processGO:00551143040.010
muscle cell proliferationGO:0033002840.010
actin filament based processGO:0030029860.010
cytokine productionGO:0001816610.010
spermatogenesisGO:0007283990.010
mechanoreceptor differentiationGO:004249020.010
cell motilityGO:00488702020.010
developmental inductionGO:003112820.010
response to other organismGO:00517072200.010
insulin receptor signaling pathwayGO:0008286240.010
cardiac conductionGO:006133720.010
retina morphogenesis in camera type eyeGO:006004210.010
male gamete generationGO:0048232990.010
neural crest cell developmentGO:001403220.010
positive regulation of cytosolic calcium ion concentrationGO:00072041220.010

Irs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.018
disease of metabolismDOID:001466700.015
organ system cancerDOID:005068600.015
cancerDOID:16200.015
sensory system diseaseDOID:005015500.013
nervous system diseaseDOID:86300.013
disease of anatomical entityDOID:700.013