Rattus norvegicus

84 known processes

Hspa8

heat shock protein 8

(Aliases: MGC114311,Hsc70)

Hspa8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein refoldingGO:004202631.000
Human Yeast
de novo protein foldingGO:000645820.989
positive regulation of protein import into nucleus translocationGO:003316070.982
de novo posttranslational protein foldingGO:005108420.979
regulation of cardiac muscle contractionGO:0055117170.966
chaperone mediated protein folding requiring cofactorGO:005108520.954
positive regulation of intracellular protein transportGO:0090316200.921
regulation of striated muscle contractionGO:0006942210.919
chaperone mediated protein foldingGO:006107760.876
skeletal muscle contractionGO:0003009170.873
response to tumor cellGO:000234740.821
response to heatGO:0009408600.817
Yeast
positive regulation of cardiac muscle contractionGO:006045240.791
positive regulation of protein bindingGO:003209290.770
cation transportGO:00068123820.705
positive regulation of nucleocytoplasmic transportGO:0046824170.700
protein foldingGO:0006457120.605
cardiac muscle contractionGO:0060048270.564
positive regulation of muscle contractionGO:0045933220.515
myosin filament organizationGO:003103320.511
protein import into nucleus translocationGO:000006090.448
Yeast
regulation of phosphorus metabolic processGO:00511743490.435
negative regulation of neuron apoptotic processGO:0043524450.417
neuron apoptotic processGO:0051402880.396
heart contractionGO:0060047570.358
purine ribonucleoside monophosphate metabolic processGO:0009167840.341
response to temperature stimulusGO:0009266940.339
Yeast
negative regulation of apoptotic processGO:00430661810.332
Rat
regulation of chromosome organizationGO:003304490.327
positive regulation of phosphorus metabolic processGO:00105622620.322
positive regulation of lamellipodium assemblyGO:001059240.315
regulation of programmed cell deathGO:00430673410.296
Rat
establishment of protein localization to organelleGO:0072594440.291
Yeast
negative regulation of cell deathGO:00605482290.264
Rat
striated muscle contractionGO:0006941440.264
myosin filament assemblyGO:003103410.257
establishment of protein localizationGO:00451841410.255
Yeast
muscle system processGO:00030121150.247
response to salt stressGO:0009651210.236
toxin transportGO:190199830.235
circulatory system processGO:00030131830.234
Rat
dna replicationGO:0006260370.230
positive regulation of phosphate metabolic processGO:00459372620.219
positive regulation of lamellipodium organizationGO:190274540.210
positive regulation of molecular functionGO:00440932300.206
musculoskeletal movementGO:0050881170.202
response to unfolded proteinGO:000698660.199
Rat
programmed cell deathGO:00125013920.192
Rat
response to metal ionGO:00100382530.187
regulation of system processGO:00440572080.184
Rat
muscle contractionGO:0006936880.178
multicellular organismal movementGO:0050879170.178
muscle cell apoptotic processGO:0010657300.174
somatic recombination of immunoglobulin genes involved in immune responseGO:000220410.174
blood circulationGO:00080151830.174
Rat
mitochondrial transportGO:0006839190.171
Yeast
positive regulation of transportGO:00510502450.170
single organism organelle organizationGO:19025891800.162
Yeast
protein localizationGO:00081041910.158
Yeast
regulation of protein targetingGO:1903533280.157
positive regulation of homeostatic processGO:0032846490.154
positive regulation of heart contractionGO:0045823150.151
regulation of phosphate metabolic processGO:00192203490.150
regulation of protein import into nucleusGO:0042306240.150
cellular response to oxygen containing compoundGO:19017013860.147
regulation of muscle contractionGO:0006937530.142
vesicle mediated transportGO:00161921810.140
Yeast Mouse Fly
transmembrane transportGO:00550854120.138
Yeast
blood vessel developmentGO:0001568690.136
positive regulation of catalytic activityGO:00430851840.134
regulation of neuron apoptotic processGO:0043523830.134
neuron deathGO:00709971270.130
regulation of heart contractionGO:0008016480.130
regulation of apoptotic processGO:00429813350.129
Rat
mitochondrion organizationGO:0007005350.129
Yeast
positive regulation of cellular biosynthetic processGO:00313282950.129
purine containing compound metabolic processGO:00725212530.126
dna metabolic processGO:0006259960.122
protein localization to mitochondrionGO:007058570.122
Yeast
single organism nuclear importGO:1902593350.120
Yeast
cell type specific apoptotic processGO:00972851340.117
Rat
regulation of muscle system processGO:0090257790.116
response to estrogenGO:00436272320.116
positive regulation of macromolecule biosynthetic processGO:00105572470.116
regulation of molecular functionGO:00650093980.114
Rat
regulation of phosphorylationGO:00423252480.112
cellular response to organic cyclic compoundGO:00714072020.110
heart processGO:0003015570.109
apoptotic processGO:00069153810.108
Rat
positive regulation of protein import into nucleusGO:0042307140.107
positive regulation of multicellular organismal processGO:00512403870.107
Rat
regulation of protein phosphorylationGO:00019321830.106
positive regulation of protein localization to nucleusGO:1900182150.105
positive regulation of interferon gamma productionGO:003272920.105
ribonucleotide metabolic processGO:00092592310.104
immune response to tumor cellGO:000241830.103
single organism biosynthetic processGO:00447113420.101
protein complex biogenesisGO:00702712630.100
protein targetingGO:0006605610.100
Yeast
protein complex assemblyGO:00064612630.098
regulation of homeostatic processGO:00328441010.093
protein phosphorylationGO:00064683450.091
regulation of protein metabolic processGO:00512462890.087
Rat
localization of cellGO:00516742020.087
homeostatic processGO:00425923310.085
regulation of blood circulationGO:19035221100.084
Rat
positive regulation of nucleobase containing compound metabolic processGO:00459353190.084
Mouse
regulation of protein modification processGO:00313991940.081
regulation of cellular protein metabolic processGO:00322682670.080
Rat
organophosphate catabolic processGO:00464341480.079
b cell activation involved in immune responseGO:000231210.078
regulation of catalytic activityGO:00507903040.078
Rat
neuron migrationGO:0001764210.075
detection of stimulusGO:0051606240.075
positive regulation of biosynthetic processGO:00098913190.074
cellular component morphogenesisGO:00329891550.074
Fly
response to atpGO:0033198130.074
negative regulation of programmed cell deathGO:00430691830.072
Rat
cytoplasmic transportGO:00164821150.071
Yeast
ribose phosphate metabolic processGO:00196932350.070
chromosome organizationGO:0051276360.070
regulation of cell proliferationGO:00421273590.069
regulation of protein transportGO:0051223680.069
single organism intracellular transportGO:19025821660.067
Yeast
regulation of cellular component biogenesisGO:0044087860.067
regulation of response to tumor cellGO:000283430.067
protein transportGO:00150311320.067
Yeast
organophosphate metabolic processGO:00196373700.067
ribonucleotide catabolic processGO:00092611360.066
positive regulation of protein kinase activityGO:0045860730.066
somatic diversification of immune receptorsGO:000220020.066
cellular protein complex assemblyGO:0043623440.064
positive regulation of protein phosphorylationGO:00019341350.063
positive regulation of protein transportGO:0051222410.063
regulation of neuron deathGO:19012141150.063
inorganic cation transmembrane transportGO:00986622020.061
positive regulation of blood circulationGO:1903524650.061
defense responseGO:00069521940.061
Rat
cellular component assemblyGO:00226073600.060
macromolecular complex subunit organizationGO:00439333390.059
Yeast Mouse
regulation of lamellipodium assemblyGO:001059150.057
organelle organizationGO:00069962660.056
Yeast
circulatory system developmentGO:00723591340.055
immunoglobulin mediated immune responseGO:001606440.055
macromolecule localizationGO:00330362520.055
Yeast
vasculature developmentGO:0001944700.053
positive regulation of cell projection organizationGO:00313461110.053
ion transmembrane transportGO:00342203650.052
negative regulation of phosphorus metabolic processGO:0010563800.051
somatic diversification of immunoglobulins involved in immune responseGO:000220810.050
positive regulation of nitrogen compound metabolic processGO:00511733340.050
Mouse
protein import into nucleusGO:0006606350.049
Yeast
regulation of protein serine threonine kinase activityGO:0071900640.049
angiogenesisGO:0001525530.049
intracellular protein transportGO:0006886790.049
Yeast
response to cytokineGO:00340972150.048
positive regulation of cell sizeGO:004579380.048
positive regulation of protein serine threonine kinase activityGO:0071902520.047
cardiovascular system developmentGO:00723581340.046
regulation of dna metabolic processGO:0051052600.046
regulation of protein localizationGO:0032880810.045
regulation of cellular localizationGO:00603412630.045
intracellular transportGO:00469071850.045
Yeast
monovalent inorganic cation transportGO:00156721720.044
cellular component biogenesisGO:00440853680.044
cellular response to oxidative stressGO:0034599760.044
positive regulation of cellular component biogenesisGO:0044089550.043
anatomical structure homeostasisGO:0060249290.043
metal ion transportGO:00300012890.042
negative regulation of neuron deathGO:1901215690.042
aromatic compound catabolic processGO:00194391680.042
protein importGO:0017038370.041
Yeast
cellular response to organonitrogen compoundGO:00714171970.041
secretion by cellGO:00329402480.041
Fly
positive regulation of striated muscle contractionGO:004598950.040
cell projection organizationGO:00300303020.040
Fly
nucleoside triphosphate catabolic processGO:00091431230.039
response to extracellular stimulusGO:00099913800.039
lamellipodium organizationGO:009758150.039
inorganic ion transmembrane transportGO:00986602290.038
regulation of calcium ion transmembrane transporter activityGO:1901019170.038
response to decreased oxygen levelsGO:00362932370.038
regulation of establishment of protein localizationGO:0070201690.038
positive regulation of protein metabolic processGO:00512471780.038
somatic diversification of immune receptors via germline recombination within a single locusGO:000256220.038
positive regulation of cellular protein metabolic processGO:00322701670.038
positive regulation of protein modification processGO:00314011420.037
secretionGO:00469033070.037
Fly
isotype switching to igg isotypesGO:004829110.037
regulation of interleukin 6 productionGO:0032675120.037
regulation of cell sizeGO:0008361370.036
somatic cell dna recombinationGO:001644420.036
nuclear importGO:0051170350.036
Yeast
regulation of nucleocytoplasmic transportGO:0046822280.035
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.035
cation transmembrane transportGO:00986552630.035
neurotransmitter uptakeGO:000150430.035
axonogenesisGO:0007409710.035
Fly
protein heterooligomerizationGO:0051291890.034
regulation of lamellipodium organizationGO:190274350.034
regulation of metal ion transportGO:00109591180.034
regulation of organelle organizationGO:0033043800.034
cellular component movementGO:00069282480.034
Fly
nucleoside phosphate catabolic processGO:19012921400.034
leukocyte activation involved in immune responseGO:0002366160.033
nucleoside metabolic processGO:00091161790.033
regulation of response to stressGO:00801341260.033
response to oxygen levelsGO:00704822650.033
regulation of interferon gamma productionGO:003264930.032
ion homeostasisGO:00508012120.032
cellular macromolecule localizationGO:00707271220.032
Yeast
cell activationGO:0001775970.032
nucleocytoplasmic transportGO:0006913480.031
Yeast
ribonucleoside triphosphate metabolic processGO:00091991410.031
cellular response to unfolded proteinGO:003462020.030
cellular homeostasisGO:00197252520.030
positive regulation of phosphorylationGO:00423271770.030
purine ribonucleotide metabolic processGO:00091502270.030
regulation of interleukin 12 productionGO:003265530.030
regulation of intracellular transportGO:0032386650.029
regulation of reactive oxygen species metabolic processGO:2000377260.029
anatomical structure formation involved in morphogenesisGO:0048646830.029
multicellular organismal reproductive processGO:00486092330.029
ribonucleoside monophosphate catabolic processGO:0009158550.029
macromolecular complex assemblyGO:00650032730.029
reproductive processGO:00224143720.029
response to osmotic stressGO:0006970420.029
regulation of kinase activityGO:00435491170.029
regulation of transferase activityGO:00513381230.029
regulation of protein kinase activityGO:00458591050.028
negative regulation of metabolic processGO:00098923310.028
Human Rat Fly
regulation of transcription dna templatedGO:00063553740.028
Human
purine nucleoside monophosphate catabolic processGO:0009128550.028
cell motilityGO:00488702020.028
regulation of response to woundingGO:1903034690.027
positive regulation of cytoplasmic transportGO:1903651320.027
spindle organizationGO:000705120.027
response to hypoxiaGO:00016662310.027
somatic recombination of immunoglobulin gene segmentsGO:001644710.026
protein localization to nucleusGO:0034504390.026
Yeast
cation homeostasisGO:00550801950.026
cellular response to cytokine stimulusGO:00713451270.026
nucleotide catabolic processGO:00091661390.025
leukocyte proliferationGO:0070661290.025
cytokinetic processGO:003250610.025
chromosome segregationGO:000705920.025
response to purine containing compoundGO:00140741260.025
cell redox homeostasisGO:004545410.025
nucleoside monophosphate metabolic processGO:0009123930.025
locomotionGO:00400112370.025
Fly
reproductionGO:00000032450.025
protein localization to organelleGO:0033365570.024
Yeast
regulation of cellular component organizationGO:00511283680.024
Human
nucleoside phosphate metabolic processGO:00067532830.024
regulation of cell projection organizationGO:00313441750.024
camp biosynthetic processGO:0006171470.024
response to woundingGO:00096112540.024
rna metabolic processGO:00160704060.023
Human Mouse
regulation of reactive oxygen species biosynthetic processGO:190342650.023
divalent inorganic cation homeostasisGO:00725071650.023
positive regulation of transferase activityGO:0051347810.023
blood vessel morphogenesisGO:0048514580.022
tetrapyrrole metabolic processGO:0033013110.022
single organism cellular localizationGO:19025801020.022
Yeast
toll like receptor signaling pathwayGO:000222490.022
protein secretionGO:0009306340.022
positive regulation of reactive oxygen species metabolic processGO:2000379160.022
calcium ion homeostasisGO:00550741620.022
positive regulation of organelle organizationGO:0010638480.021
negative regulation of cellular protein metabolic processGO:00322691060.021
Rat
regulation of adaptive immune responseGO:000281980.021
Rat
response to cadmium ionGO:0046686350.021
intracellular signal transductionGO:00355563140.021
negative regulation of nucleobase containing compound metabolic processGO:00459341530.021
Human
histamine secretion by mast cellGO:000255330.020
regulation of jnk cascadeGO:0046328190.020
purine ribonucleoside triphosphate metabolic processGO:00092051400.020
reactive nitrogen species metabolic processGO:200105710.020
response to organophosphorusGO:00466831020.020
regulation of ion transportGO:00432692450.020
cellular response to peptideGO:19016531330.020
regulation of rna biosynthetic processGO:20011413810.020
Human
cellular response to stressGO:00335542690.019
Yeast Fly
purine nucleoside monophosphate metabolic processGO:0009126840.019
chemical homeostasisGO:00488782920.019
purine nucleotide catabolic processGO:00061951360.019
response to transition metal nanoparticleGO:19902671220.019
cellular response to hormone stimulusGO:00328702470.019
cellular protein localizationGO:00346131220.019
Yeast
regulation of membrane potentialGO:00423911100.018
regulation of intracellular protein transportGO:0033157340.018
anatomical structure morphogenesisGO:00096532980.018
Fly
response to inorganic substanceGO:00100353770.018
myeloid leukocyte activationGO:0002274360.018
organelle localizationGO:0051640550.018
protein targeting to nucleusGO:0044744350.018
Yeast
positive regulation of interleukin 6 productionGO:003275580.018
regulation of body fluid levelsGO:0050878900.018
atp metabolic processGO:0046034720.018
interleukin 10 productionGO:003261330.018
proteolysisGO:00065081750.018
Yeast Rat
cellular response to nitrogen compoundGO:19016992100.018
protein transmembrane transportGO:007180620.018
Yeast
synaptic growth at neuromuscular junctionGO:005112410.017
positive regulation of reactive oxygen species biosynthetic processGO:190342820.017
glycogen metabolic processGO:0005977230.017
sexual reproductionGO:00199531480.017
immune system processGO:00023762040.017
Rat
protein complex subunit organizationGO:00718223020.017
Yeast Mouse
cellular macromolecular complex assemblyGO:0034622580.017
cell projection morphogenesisGO:00488581230.017
Fly
regulation of nucleotide biosynthetic processGO:0030808470.017
response to bacteriumGO:00096172000.017
nucleoside triphosphate metabolic processGO:00091411440.016
regulation of cellular component sizeGO:0032535510.016
positive regulation of cellular component organizationGO:00511302000.016
response to topologically incorrect proteinGO:003596680.016
Rat Fly
positive regulation of chromosome organizationGO:200125260.016
response to peptide hormoneGO:00434342780.016
cyclic nucleotide biosynthetic processGO:0009190630.016
er associated ubiquitin dependent protein catabolic processGO:003043310.016
dna damage response detection of dna damageGO:004276920.015
transcription dna templatedGO:00063513770.015
Human
single organism reproductive processGO:00447022970.015
organophosphate biosynthetic processGO:00904071430.015
regulation of cellular amino acid metabolic processGO:000652120.015
regulation of cell activationGO:0050865500.015
cellular cation homeostasisGO:00300031800.015
multi organism reproductive processGO:00447032620.015
response to nutrient levelsGO:00316673700.015
protein targeting to mitochondrionGO:000662670.015
Yeast
carbohydrate derivative biosynthetic processGO:19011371240.015
pattern recognition receptor signaling pathwayGO:000222190.015
lymphocyte activation involved in immune responseGO:000228530.015
regulation of hydrolase activityGO:00513361430.015
Rat
response to calcium ionGO:0051592590.015
cell migrationGO:00164771970.015
porphyrin containing compound metabolic processGO:000677880.015
heart morphogenesisGO:000300730.015
nucleoside catabolic processGO:00091641260.014
nucleic acid templated transcriptionGO:00976593790.014
Human
chromatin modificationGO:0016568330.014
cellular chemical homeostasisGO:00550822470.014
cellular response to topologically incorrect proteinGO:003596730.014
Fly
muscle structure developmentGO:0061061870.014
organonitrogen compound catabolic processGO:19015651790.014
negative regulation of cell communicationGO:00106481580.014
positive regulation of dna metabolic processGO:0051054390.014
regulation of protein import into nucleus translocationGO:003315880.014
cellular amine metabolic processGO:0044106380.014
reproductive structure developmentGO:00486081280.014
glycosyl compound catabolic processGO:19016581260.014
purine nucleoside triphosphate catabolic processGO:00091461220.014
axon developmentGO:0061564960.014
Fly
peptidyl amino acid modificationGO:00181931260.014
regulation of secretionGO:00510462240.014
growthGO:00400071650.013
nucleoside monophosphate catabolic processGO:0009125560.013
centrosome organizationGO:005129710.013
positive regulation of cell deathGO:00109421840.013
regulation of multicellular organismal developmentGO:20000263760.013
Rat
cyclic purine nucleotide metabolic processGO:0052652620.013
purine ribonucleoside metabolic processGO:00461281680.013
multicellular organism growthGO:003526410.013
developmental process involved in reproductionGO:00030061590.013
purine nucleoside metabolic processGO:00422781690.013
regulation of leukocyte mediated immunityGO:0002703190.013
Rat
positive regulation of hydrolase activityGO:0051345860.013
activation of cysteine type endopeptidase activity involved in apoptotic processGO:000691940.013
positive regulation of intracellular transportGO:0032388390.013
carbohydrate derivative metabolic processGO:19011353460.013
ribonucleotide biosynthetic processGO:0009260850.013
nucleobase containing small molecule metabolic processGO:00550863160.013
cellular ion homeostasisGO:00068731840.013
covalent chromatin modificationGO:0016569300.013
male gamete generationGO:0048232990.012
ras protein signal transductionGO:0007265290.012
response to ammonium ionGO:0060359710.012
response to hydrogen peroxideGO:0042542890.012
regulation of nucleotide metabolic processGO:00061401170.012
regulation of purine nucleotide metabolic processGO:19005421150.012
cardiac muscle cell contractionGO:0086003100.012
regulation of macrophage activationGO:004303010.012
sequestering of metal ionGO:005123890.012
cellular calcium ion homeostasisGO:00068741600.012
negative regulation of cellular metabolic processGO:00313242810.012
Human Rat
regulation of ion transmembrane transportGO:00347651210.012
organic substance catabolic processGO:19015753160.012
response to biotic stimulusGO:00096072260.012
response to hyperoxiaGO:0055093450.012
cell morphogenesis involved in neuron differentiationGO:00486671060.012
Fly
cell projection assemblyGO:0030031210.012
regulation of dna replicationGO:0006275290.012
actin filament based processGO:0030029860.012
regulation of cysteine type endopeptidase activityGO:2000116320.012
Rat
regulation of camp metabolic processGO:0030814430.012
negative regulation of transportGO:00510511360.012
purine nucleotide metabolic processGO:00061632290.012
organic acid metabolic processGO:00060822920.011
negative regulation of catalytic activityGO:00430861030.011
Rat
transcription from rna polymerase ii promoterGO:00063662520.011
porphyrin containing compound biosynthetic processGO:000677960.011
ribonucleoside metabolic processGO:00091191740.011
histone acetylationGO:001657380.011
positive regulation of cellular amino acid metabolic processGO:004576410.011
immune response regulating signaling pathwayGO:0002764190.011
divalent metal ion transportGO:00708381320.011
response to growth factorGO:00708481890.011
striated muscle cell differentiationGO:0051146390.011
gamete generationGO:00072761240.011
carbohydrate derivative catabolic processGO:19011361470.011
positive regulation of purine nucleotide metabolic processGO:1900544910.011
positive regulation of transcription dna templatedGO:00458931970.011
nucleotide metabolic processGO:00091172790.011
regulation of neurotransmitter levelsGO:0001505420.011
Fly
anion transportGO:00068201780.011
regulation of cell projection assemblyGO:0060491140.011
adult locomotory behaviorGO:000834440.011
cellular nitrogen compound catabolic processGO:00442701630.011
positive regulation of response to external stimulusGO:0032103510.011
regulation of nitric oxide synthase activityGO:005099980.011
platelet aggregationGO:007052740.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
response to molecule of bacterial originGO:00022371940.011
protein processingGO:0016485680.011
Rat
innate immune response activating signal transductionGO:000275890.011
muscle cell developmentGO:0055001260.010
action potentialGO:0001508540.010
positive regulation of programmed cell deathGO:00430681570.010
isotype switchingGO:004519010.010
purine ribonucleoside catabolic processGO:00461301240.010
regulation of synaptic growth at neuromuscular junctionGO:000858210.010
response to external biotic stimulusGO:00432072210.010
regulation of defense responseGO:0031347680.010
metal ion homeostasisGO:00550651860.010
cellular divalent inorganic cation homeostasisGO:00725031620.010
regulation of rna metabolic processGO:00512523910.010
Human Mouse
response to oxidative stressGO:00069791860.010

Hspa8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:33100.063
nervous system diseaseDOID:86300.063
disease of anatomical entityDOID:700.063
paraplegiaDOID:60700.016
hereditary spastic paraplegiaDOID:247600.016