IMP: Integrative Multi-species Prediction

Rattus norvegicus

158 known processes

Smad1

SMAD family member 1

(Aliases: Madh1)

Entrez: 25671
Ensembl: ENSRNOG00000018483
RGD: 3030
UniProtKB: Q6P7A6

Process Predictions
Disease Predictions

Smad1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
transcription dna templated	GO:0006351	377	0.720
transcription from rna polymerase ii promoter	GO:0006366	252	0.613
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.501
apoptotic process	GO:0006915	381	0.499
regulation of cellular protein metabolic process	GO:0032268	267	0.479	Rat
nucleic acid templated transcription	GO:0097659	379	0.475
response to wounding	GO:0009611	254	0.472
negative regulation of apoptotic process	GO:0043066	181	0.465
negative regulation of cell death	GO:0060548	229	0.446
regulation of rna metabolic process	GO:0051252	391	0.431
positive regulation of multicellular organismal process	GO:0051240	387	0.429
cell type specific apoptotic process	GO:0097285	134	0.425
regulation of rna biosynthetic process	GO:2001141	381	0.389
regulation of nucleic acid templated transcription	GO:1903506	380	0.376
anatomical structure morphogenesis	GO:0009653	298	0.358
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.357	Rat
positive regulation of rna metabolic process	GO:0051254	203	0.350	Rat
rna biosynthetic process	GO:0032774	380	0.349
regulation of cell development	GO:0060284	263	0.348
regulation of cellular component movement	GO:0051270	150	0.341	Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.331	Rat
intracellular signal transduction	GO:0035556	314	0.325
immune system process	GO:0002376	204	0.315
regulation of phosphorus metabolic process	GO:0051174	349	0.306	Rat
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	1	0.306	Rat
response to hydrogen peroxide	GO:0042542	89	0.299
programmed cell death	GO:0012501	392	0.299
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.292
regulation of programmed cell death	GO:0043067	341	0.290
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.279	Rat
positive regulation of biosynthetic process	GO:0009891	319	0.278	Rat
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.270	Rat
positive regulation of gene expression	GO:0010628	244	0.253	Human Rat
response to estrogen	GO:0043627	232	0.251	Rat
regulation of multicellular organismal development	GO:2000026	376	0.248
regulation of apoptotic process	GO:0042981	335	0.248
response to cytokine	GO:0034097	215	0.244
positive regulation of rna biosynthetic process	GO:1902680	197	0.242	Rat
central nervous system development	GO:0007417	311	0.242
positive regulation of response to stimulus	GO:0048584	285	0.240	Rat
regulation of transcription dna templated	GO:0006355	374	0.239
response to decreased oxygen levels	GO:0036293	237	0.231	Rat
response to mechanical stimulus	GO:0009612	134	0.229
rna metabolic process	GO:0016070	406	0.225
neuron development	GO:0048666	286	0.224
positive regulation of developmental process	GO:0051094	283	0.216
negative regulation of muscle cell apoptotic process	GO:0010656	21	0.211
positive regulation of signal transduction	GO:0009967	175	0.211	Rat
response to oxidative stress	GO:0006979	186	0.210
regulation of cell differentiation	GO:0045595	320	0.209
apoptotic signaling pathway	GO:0097190	27	0.208	Rat
response to inorganic substance	GO:0010035	377	0.204
organelle organization	GO:0006996	266	0.202	Rat
regulation of neuron death	GO:1901214	115	0.202
regulation of phosphorylation	GO:0042325	248	0.199
negative regulation of multicellular organismal process	GO:0051241	203	0.194
neuron projection development	GO:0031175	273	0.193
positive regulation of cellular protein metabolic process	GO:0032270	167	0.192	Rat
behavior	GO:0007610	205	0.191	Rat
development of primary sexual characteristics	GO:0045137	107	0.189
head development	GO:0060322	247	0.188
cellular response to hormone stimulus	GO:0032870	247	0.188
cellular response to endogenous stimulus	GO:0071495	377	0.187	Rat
regulation of phosphate metabolic process	GO:0019220	349	0.186	Rat
regulation of cell proliferation	GO:0042127	359	0.185	Rat
neuron differentiation	GO:0030182	368	0.185
response to reactive oxygen species	GO:0000302	120	0.183
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.182	Rat
muscle cell proliferation	GO:0033002	84	0.181
negative regulation of programmed cell death	GO:0043069	183	0.179
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:2001269	1	0.178	Rat
positive regulation of mesenchymal cell proliferation	GO:0002053	4	0.177
regulation of neurogenesis	GO:0050767	247	0.176
neuron death	GO:0070997	127	0.175
protein phosphorylation	GO:0006468	345	0.175
negative regulation of transcription dna templated	GO:0045892	116	0.173	Rat
gland development	GO:0048732	155	0.171
response to oxygen levels	GO:0070482	265	0.171	Rat
cellular response to lipid	GO:0071396	201	0.167
regulation of cell migration	GO:0030334	128	0.166	Rat
peptidyl amino acid modification	GO:0018193	126	0.163
response to molecule of bacterial origin	GO:0002237	194	0.163
blood vessel morphogenesis	GO:0048514	58	0.159
signal transduction by phosphorylation	GO:0023014	144	0.158
regulation of cellular component organization	GO:0051128	368	0.156
organic acid metabolic process	GO:0006082	292	0.156
cellular response to stress	GO:0033554	269	0.155
cell morphogenesis	GO:0000902	142	0.155
regulation of mesenchymal cell proliferation	GO:0010464	4	0.153
cytokine mediated signaling pathway	GO:0019221	43	0.153
regulation of molecular function	GO:0065009	398	0.152	Rat
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.151
cellular response to cytokine stimulus	GO:0071345	127	0.149
positive regulation of cell communication	GO:0010647	271	0.149	Rat
positive regulation of cell death	GO:0010942	184	0.147	Rat
cell adhesion	GO:0007155	110	0.146	Rat
positive regulation of cell development	GO:0010720	176	0.142
regulation of catalytic activity	GO:0050790	304	0.142	Rat
negative regulation of developmental process	GO:0051093	125	0.142
cellular component movement	GO:0006928	248	0.141	Rat
regulation of protein metabolic process	GO:0051246	289	0.141	Rat
regulation of immune system process	GO:0002682	123	0.140
circulatory system development	GO:0072359	134	0.140
positive regulation of phosphorus metabolic process	GO:0010562	262	0.139	Rat
cellular response to organonitrogen compound	GO:0071417	197	0.138
brain development	GO:0007420	247	0.136
cellular ketone metabolic process	GO:0042180	51	0.134
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.133
amine metabolic process	GO:0009308	38	0.133
regulation of intracellular signal transduction	GO:1902531	218	0.133
mapk cascade	GO:0000165	140	0.132
regulation of neuron apoptotic process	GO:0043523	83	0.132
response to other organism	GO:0051707	220	0.132
regulation of protein modification process	GO:0031399	194	0.132
proteolysis	GO:0006508	175	0.129	Rat
response to hypoxia	GO:0001666	231	0.129	Rat
reproductive process	GO:0022414	372	0.128	Rat
positive regulation of protein metabolic process	GO:0051247	178	0.127	Rat
biological adhesion	GO:0022610	110	0.127	Rat
cellular response to oxygen containing compound	GO:1901701	386	0.127
wound healing	GO:0042060	122	0.126
positive regulation of signaling	GO:0023056	270	0.125	Rat
positive regulation of cellular component movement	GO:0051272	102	0.121	Rat
localization of cell	GO:0051674	202	0.121	Rat
cellular chemical homeostasis	GO:0055082	247	0.118
regulation of neuron projection development	GO:0010975	161	0.118
response to metal ion	GO:0010038	253	0.118
positive regulation of apoptotic process	GO:0043065	154	0.116	Rat
cell migration	GO:0016477	197	0.116	Rat
carboxylic acid metabolic process	GO:0019752	289	0.114
regulation of anatomical structure morphogenesis	GO:0022603	141	0.114
regulation of system process	GO:0044057	208	0.114
oxoacid metabolic process	GO:0043436	290	0.111
response to estradiol	GO:0032355	164	0.110
positive regulation of cellular biosynthetic process	GO:0031328	295	0.109	Rat
regulation of signal transduction	GO:0009966	318	0.108	Rat
tissue development	GO:0009888	252	0.108	Rat
positive regulation of phosphate metabolic process	GO:0045937	262	0.107	Rat
neurological system process	GO:0050877	219	0.107
positive regulation of programmed cell death	GO:0043068	157	0.107	Rat
negative regulation of metabolic process	GO:0009892	331	0.106	Rat
single organism reproductive process	GO:0044702	297	0.106	Rat
response to acid chemical	GO:0001101	222	0.106
regulation of cell motility	GO:2000145	131	0.106	Rat
circulatory system process	GO:0003013	183	0.105
cell projection organization	GO:0030030	302	0.104
protein maturation	GO:0051604	68	0.103	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.101
angiogenesis	GO:0001525	53	0.100
rhythmic process	GO:0048511	156	0.099
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.099	Rat
positive regulation of intracellular signal transduction	GO:1902533	138	0.097
regulation of protein phosphorylation	GO:0001932	183	0.097
mesenchymal cell proliferation	GO:0010463	4	0.097
intracellular transport	GO:0046907	185	0.094
response to growth factor	GO:0070848	189	0.093	Rat
nucleotide metabolic process	GO:0009117	279	0.093
growth	GO:0040007	165	0.093
regulation of cytokine production	GO:0001817	56	0.092	Rat
positive regulation of protein modification process	GO:0031401	142	0.092
response to lipopolysaccharide	GO:0032496	191	0.089
positive regulation of catalytic activity	GO:0043085	184	0.088	Rat
regulation of apoptotic signaling pathway	GO:2001233	13	0.087	Rat
regulation of locomotion	GO:0040012	148	0.087	Rat
dephosphorylation	GO:0016311	98	0.087	Rat
regulation of cellular ketone metabolic process	GO:0010565	27	0.087
positive regulation of immune system process	GO:0002684	90	0.086
regeneration	GO:0031099	163	0.084
positive regulation of transcription dna templated	GO:0045893	197	0.084	Rat
axon development	GO:0061564	96	0.083
extrinsic apoptotic signaling pathway	GO:0097191	10	0.083
learning or memory	GO:0007611	90	0.082
regulation of protein kinase activity	GO:0045859	105	0.082
positive regulation of molecular function	GO:0044093	230	0.081	Rat
heart morphogenesis	GO:0003007	3	0.081
gastrulation	GO:0007369	2	0.079
macromolecular complex subunit organization	GO:0043933	339	0.079	Human Rat
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.079	Rat
myeloid leukocyte differentiation	GO:0002573	20	0.079
secretion	GO:0046903	307	0.078
negative regulation of gene expression	GO:0010629	199	0.077	Rat
protein autophosphorylation	GO:0046777	66	0.077
negative regulation of rna biosynthetic process	GO:1902679	118	0.077	Rat
peptidyl tyrosine phosphorylation	GO:0018108	72	0.076
cellular response to nitrogen compound	GO:1901699	210	0.076
cellular response to peptide hormone stimulus	GO:0071375	120	0.076
response to external biotic stimulus	GO:0043207	221	0.076
inflammatory response	GO:0006954	150	0.075
hematopoietic or lymphoid organ development	GO:0048534	36	0.075
neuron apoptotic process	GO:0051402	88	0.075
positive regulation of smooth muscle cell proliferation	GO:0048661	51	0.075
hepaticobiliary system development	GO:0061008	90	0.074
peptidyl tyrosine modification	GO:0018212	72	0.074
response to ethanol	GO:0045471	162	0.073
cellular protein localization	GO:0034613	122	0.073
positive regulation of neurogenesis	GO:0050769	165	0.073
response to peptide	GO:1901652	292	0.072
response to radiation	GO:0009314	137	0.071
chemical homeostasis	GO:0048878	292	0.071
regulation of cell morphogenesis	GO:0022604	77	0.068
multicellular organism reproduction	GO:0032504	233	0.068
organophosphate metabolic process	GO:0019637	370	0.067
cellular response to tumor necrosis factor	GO:0071356	46	0.067
epithelial cell differentiation	GO:0030855	71	0.067
negative regulation of biosynthetic process	GO:0009890	168	0.066	Rat
positive regulation of cellular amine metabolic process	GO:0033240	3	0.065
reproductive system development	GO:0061458	128	0.065
cellular component morphogenesis	GO:0032989	155	0.065
cellular amino acid metabolic process	GO:0006520	107	0.065
regulation of response to stress	GO:0080134	126	0.065
developmental process involved in reproduction	GO:0003006	159	0.065	Rat
positive regulation of phosphorylation	GO:0042327	177	0.065
positive regulation of cell migration	GO:0030335	96	0.063	Rat
single organism organelle organization	GO:1902589	180	0.063	Rat
sex differentiation	GO:0007548	113	0.063	Rat
cell morphogenesis involved in differentiation	GO:0000904	119	0.062
negative regulation of signal transduction	GO:0009968	83	0.062
protein complex assembly	GO:0006461	263	0.062	Human Rat
purine ribonucleotide metabolic process	GO:0009150	227	0.062
protein complex biogenesis	GO:0070271	263	0.062	Human Rat
vasculature development	GO:0001944	70	0.061
regulation of stem cell proliferation	GO:0072091	14	0.061
divalent metal ion transport	GO:0070838	132	0.061
negative regulation of protein metabolic process	GO:0051248	114	0.061
locomotion	GO:0040011	237	0.060	Rat
cellular response to peptide	GO:1901653	133	0.060
organ morphogenesis	GO:0009887	75	0.060
regulation of cellular amine metabolic process	GO:0033238	8	0.060
response to insulin	GO:0032868	133	0.060
hemopoiesis	GO:0030097	34	0.059
response to ketone	GO:1901654	182	0.059
response to peptide hormone	GO:0043434	278	0.059
negative regulation of macromolecule metabolic process	GO:0010605	260	0.059	Rat
negative regulation of rna metabolic process	GO:0051253	123	0.059	Rat
leukocyte activation	GO:0045321	76	0.059
regulation of metanephros development	GO:0072215	4	0.058
blood circulation	GO:0008015	183	0.058
response to alkaloid	GO:0043279	132	0.058
regulation of smooth muscle cell proliferation	GO:0048660	75	0.058
liver development	GO:0001889	90	0.058
cellular metal ion homeostasis	GO:0006875	172	0.058
cellular homeostasis	GO:0019725	252	0.058
defense response	GO:0006952	194	0.057
regulation of blood circulation	GO:1903522	110	0.057
regulation of growth	GO:0040008	105	0.057
positive regulation of cellular component biogenesis	GO:0044089	55	0.057	Rat
regulation of muscle cell apoptotic process	GO:0010660	26	0.057
cellular amine metabolic process	GO:0044106	38	0.057
cellular response to reactive oxygen species	GO:0034614	55	0.057
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	4	0.056
negative regulation of cell proliferation	GO:0008285	119	0.056	Rat
positive regulation of interleukin 1 beta production	GO:0032731	6	0.056	Rat
homeostatic process	GO:0042592	331	0.056
cellular response to ketone	GO:1901655	51	0.056
cellular component assembly	GO:0022607	360	0.055	Human Rat
cardiovascular system development	GO:0072358	134	0.055
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.055
forebrain development	GO:0030900	98	0.055
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.055	Rat
smooth muscle cell proliferation	GO:0048659	77	0.055
embryonic pattern specification	GO:0009880	1	0.055
multicellular organismal reproductive process	GO:0048609	233	0.055
cell cycle	GO:0007049	101	0.055
regulation of transforming growth factor beta3 production	GO:0032910	2	0.055	Rat
cellular response to steroid hormone stimulus	GO:0071383	93	0.055
epithelium development	GO:0060429	96	0.055
positive regulation of cellular component organization	GO:0051130	200	0.054
regulation of organelle organization	GO:0033043	80	0.054	Rat
positive regulation of cell motility	GO:2000147	97	0.054	Rat
response to interleukin 1	GO:0070555	55	0.053
digestive system development	GO:0055123	41	0.053
establishment of protein localization	GO:0045184	141	0.053
regulation of cellular amino acid metabolic process	GO:0006521	2	0.053
positive regulation of cell differentiation	GO:0045597	217	0.053
spindle organization	GO:0007051	2	0.052
metal ion transport	GO:0030001	289	0.052
immune response	GO:0006955	104	0.052
positive regulation of protein transport	GO:0051222	41	0.052
regulation of nervous system development	GO:0051960	264	0.051
erythrocyte differentiation	GO:0030218	1	0.051
development of primary female sexual characteristics	GO:0046545	56	0.051
negative regulation of signaling	GO:0023057	157	0.051
regulation of cell projection organization	GO:0031344	175	0.051
response to biotic stimulus	GO:0009607	226	0.050
nucleobase containing small molecule metabolic process	GO:0055086	316	0.050
reproduction	GO:0000003	245	0.050
negative regulation of cell differentiation	GO:0045596	99	0.050
cellular component biogenesis	GO:0044085	368	0.049	Human Rat
protein dephosphorylation	GO:0006470	38	0.049
gonad development	GO:0008406	104	0.049
regulation of mapk cascade	GO:0043408	116	0.049
regulation of peptidase activity	GO:0052547	55	0.049	Rat
protein complex subunit organization	GO:0071822	302	0.049	Human Rat
carbohydrate derivative metabolic process	GO:1901135	346	0.049
regulation of ion transport	GO:0043269	245	0.048
cellular response to oxidative stress	GO:0034599	76	0.048
regulation of map kinase activity	GO:0043405	53	0.048
calcium ion transport	GO:0006816	131	0.047
tube development	GO:0035295	89	0.047
response to extracellular stimulus	GO:0009991	380	0.047
positive regulation of cell proliferation	GO:0008284	249	0.046
reproductive structure development	GO:0048608	128	0.046
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.046
blood vessel development	GO:0001568	69	0.046
cytoskeleton organization	GO:0007010	111	0.046	Rat
regulation of immune response	GO:0050776	55	0.046
aging	GO:0007568	241	0.046
formation of primary germ layer	GO:0001704	1	0.045
response to bacterium	GO:0009617	200	0.045
metal ion homeostasis	GO:0055065	186	0.045
reactive oxygen species metabolic process	GO:0072593	37	0.045
positive regulation of protein phosphorylation	GO:0001934	135	0.045
cation homeostasis	GO:0055080	195	0.044
ovulation cycle process	GO:0022602	50	0.044
organic substance catabolic process	GO:1901575	316	0.044
positive regulation of nervous system development	GO:0051962	178	0.044
response to hexose	GO:0009746	144	0.044
bmp signaling pathway	GO:0030509	4	0.044
ion homeostasis	GO:0050801	212	0.044
transforming growth factor beta receptor signaling pathway	GO:0007179	18	0.044	Rat
negative regulation of transport	GO:0051051	136	0.044
regulation of neuron differentiation	GO:0045664	208	0.044
regulation of hydrolase activity	GO:0051336	143	0.043	Rat
positive regulation of hydrolase activity	GO:0051345	86	0.043	Rat
response to toxic substance	GO:0009636	133	0.043
protein localization	GO:0008104	191	0.043
cellular ion homeostasis	GO:0006873	184	0.043
regulation of calcium ion transport	GO:0051924	77	0.042
negative regulation of neuron apoptotic process	GO:0043524	45	0.042
negative regulation of cellular component organization	GO:0051129	83	0.042
cell motility	GO:0048870	202	0.042	Rat
single organism intracellular transport	GO:1902582	166	0.042
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.041	Rat
negative regulation of cellular metabolic process	GO:0031324	281	0.041	Rat
reactive oxygen species biosynthetic process	GO:1903409	8	0.041
negative regulation of cell communication	GO:0010648	158	0.040
transmembrane transport	GO:0055085	412	0.040
response to transition metal nanoparticle	GO:1990267	122	0.040
response to ionizing radiation	GO:0010212	59	0.040
tissue regeneration	GO:0042246	36	0.040
cognition	GO:0050890	92	0.039
response to corticosteroid	GO:0031960	235	0.039
cell activation	GO:0001775	97	0.039
regulation of fat cell differentiation	GO:0045598	3	0.039
response to axon injury	GO:0048678	59	0.039
response to amino acid	GO:0043200	75	0.038
divalent inorganic cation transport	GO:0072511	134	0.038
regulation of response to external stimulus	GO:0032101	106	0.038	Rat
cellular response to corticosteroid stimulus	GO:0071384	69	0.038
positive regulation of immunoglobulin production	GO:0002639	4	0.038
myeloid cell differentiation	GO:0030099	22	0.038
sexual reproduction	GO:0019953	148	0.038
negative regulation of neuron death	GO:1901215	69	0.038
response to carbohydrate	GO:0009743	183	0.037
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.037
positive regulation of mapk cascade	GO:0043410	92	0.037
positive regulation of tumor necrosis factor production	GO:0032760	8	0.037
developmental growth	GO:0048589	100	0.037
calcium ion homeostasis	GO:0055074	162	0.037
regulation of homeostatic process	GO:0032844	101	0.037
actin filament bundle organization	GO:0061572	19	0.036	Rat
axonogenesis	GO:0007409	71	0.036
regulation of lipid metabolic process	GO:0019216	68	0.036
activation of cysteine type endopeptidase activity	GO:0097202	4	0.036	Rat
negative regulation of metanephros development	GO:0072217	2	0.036
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.036
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.036	Rat
immune system development	GO:0002520	41	0.035
protein transport	GO:0015031	132	0.035
catabolic process	GO:0009056	351	0.035
regulation of cell activation	GO:0050865	50	0.035
regulation of metal ion transport	GO:0010959	118	0.035
regulation of cellular localization	GO:0060341	263	0.035
jak stat cascade	GO:0007259	26	0.035
nucleoside triphosphate metabolic process	GO:0009141	144	0.034
regulation of dna metabolic process	GO:0051052	60	0.034
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.034
regulation of defense response	GO:0031347	68	0.033
dna metabolic process	GO:0006259	96	0.033
response to dexamethasone	GO:0071548	49	0.033
cellular response to insulin stimulus	GO:0032869	81	0.033
purine nucleotide biosynthetic process	GO:0006164	83	0.032
mechanoreceptor differentiation	GO:0042490	2	0.032
transforming growth factor beta3 production	GO:0032907	2	0.032	Rat
single organism behavior	GO:0044708	130	0.032
response to camp	GO:0051591	91	0.032
response to purine containing compound	GO:0014074	126	0.032
response to tumor necrosis factor	GO:0034612	56	0.032
cellular response to growth factor stimulus	GO:0071363	162	0.032	Rat
positive regulation of biomineral tissue development	GO:0070169	4	0.032	Rat
cell part morphogenesis	GO:0032990	123	0.032
cellular response to interleukin 1	GO:0071347	37	0.032
digestive tract development	GO:0048565	39	0.032
cellular catabolic process	GO:0044248	295	0.032
positive regulation of focal adhesion assembly	GO:0051894	2	0.032	Rat
multicellular organism growth	GO:0035264	1	0.032
negative regulation of cellular biosynthetic process	GO:0031327	161	0.031	Rat
multi organism reproductive process	GO:0044703	262	0.031
regulation of cell cycle	GO:0051726	73	0.031
macromolecular complex assembly	GO:0065003	273	0.031	Human Rat
muscle structure development	GO:0061061	87	0.031
cellular response to lipopolysaccharide	GO:0071222	55	0.031
negative regulation of kidney development	GO:0090185	2	0.030
organophosphate biosynthetic process	GO:0090407	143	0.030
positive regulation of behavior	GO:0048520	38	0.030	Rat
cell cell signaling	GO:0007267	335	0.030
positive regulation of kinase activity	GO:0033674	77	0.030
cell junction organization	GO:0034330	21	0.030	Rat
actin cytoskeleton organization	GO:0030036	73	0.030	Rat
female sex differentiation	GO:0046660	59	0.030
purine containing compound metabolic process	GO:0072521	253	0.029
actin filament based process	GO:0030029	86	0.029	Rat
muscle cell apoptotic process	GO:0010657	30	0.029
positive regulation of locomotion	GO:0040017	102	0.029	Rat
response to monosaccharide	GO:0034284	159	0.029
purine ribonucleoside metabolic process	GO:0046128	168	0.028
sequestering of calcium ion	GO:0051208	8	0.028
erk1 and erk2 cascade	GO:0070371	48	0.028
cell cycle process	GO:0022402	57	0.028
purine nucleoside metabolic process	GO:0042278	169	0.028
positive regulation of neuron differentiation	GO:0045666	126	0.028
dendrite development	GO:0016358	72	0.028
gamete generation	GO:0007276	124	0.028
cellular response to alcohol	GO:0097306	87	0.028
regulation of transferase activity	GO:0051338	123	0.028
regulation of cytoskeleton organization	GO:0051493	49	0.028	Rat
positive regulation of transport	GO:0051050	245	0.028
cellular macromolecule localization	GO:0070727	122	0.028
cellular calcium ion homeostasis	GO:0006874	160	0.028
intracellular protein transport	GO:0006886	79	0.028
regulation of protein localization	GO:0032880	81	0.027
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.027
cytokine production	GO:0001816	61	0.027	Rat
positive regulation of response to external stimulus	GO:0032103	51	0.027	Rat
ameboidal type cell migration	GO:0001667	26	0.027
motor neuron axon guidance	GO:0008045	1	0.027
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.027
ribose phosphate metabolic process	GO:0019693	235	0.026
oxidation reduction process	GO:0055114	304	0.026
divalent inorganic cation homeostasis	GO:0072507	165	0.026
negative regulation of molecular function	GO:0044092	133	0.026
regulation of developmental growth	GO:0048638	45	0.026
cellular response to acid chemical	GO:0071229	75	0.026
lipid metabolic process	GO:0006629	283	0.026
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	31	0.026	Rat
cell differentiation involved in kidney development	GO:0061005	4	0.026
purine ribonucleotide biosynthetic process	GO:0009152	81	0.026
positive regulation of neuron projection development	GO:0010976	99	0.026
tissue morphogenesis	GO:0048729	22	0.026
sensory perception	GO:0007600	101	0.026
response to glucocorticoid	GO:0051384	223	0.026
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0003340	2	0.025
nucleoside phosphate metabolic process	GO:0006753	283	0.025
response to nutrient levels	GO:0031667	370	0.025
small gtpase mediated signal transduction	GO:0007264	36	0.025
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	4	0.025	Rat
regulation of cell substrate adhesion	GO:0010810	18	0.025	Rat
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.025
limbic system development	GO:0021761	38	0.025
negative regulation of response to stimulus	GO:0048585	155	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.024	Rat
protein heterooligomerization	GO:0051291	89	0.024
striated muscle tissue development	GO:0014706	58	0.024
neuron projection guidance	GO:0097485	24	0.024
regulation of cytokine biosynthetic process	GO:0042035	3	0.024
cation transport	GO:0006812	382	0.024
dendrite morphogenesis	GO:0048813	43	0.024
acute inflammatory response	GO:0002526	58	0.024
regulation of epithelial cell differentiation	GO:0030856	12	0.024
glycosyl compound metabolic process	GO:1901657	182	0.024
renal system development	GO:0072001	67	0.024
cytoplasmic transport	GO:0016482	115	0.024
negative regulation of neurogenesis	GO:0050768	78	0.024
myoblast fusion	GO:0007520	2	0.024
carbohydrate derivative biosynthetic process	GO:1901137	124	0.024
vascular process in circulatory system	GO:0003018	96	0.023
response to organophosphorus	GO:0046683	102	0.023
response to glucose	GO:0009749	136	0.023
positive regulation of cytokine production	GO:0001819	42	0.023	Rat
leukocyte differentiation	GO:0002521	30	0.023
protein import into nucleus	GO:0006606	35	0.023
regulation of smooth muscle cell migration	GO:0014910	36	0.023
regulation of hormone levels	GO:0010817	187	0.023
nuclear import	GO:0051170	35	0.023
regulation of secretion by cell	GO:1903530	208	0.023
regulation of endopeptidase activity	GO:0052548	51	0.023	Rat
female pregnancy	GO:0007565	122	0.023
macromolecule localization	GO:0033036	252	0.023
muscle cell differentiation	GO:0042692	52	0.022
cellular cation homeostasis	GO:0030003	180	0.022
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.022
kidney mesenchyme development	GO:0072074	2	0.022
glial cell differentiation	GO:0010001	65	0.022
regulation of body fluid levels	GO:0050878	90	0.022
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	8	0.022

Smad1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.032

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network