Rattus norvegicus

66 known processes

Mthfr

methylenetetrahydrofolate reductase (NAD(P)H)

Mthfr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of transcription dna templatedGO:00063553740.490
rna metabolic processGO:00160704060.323
regulation of nucleic acid templated transcriptionGO:19035063800.312
response to inorganic substanceGO:00100353770.203
head developmentGO:00603222470.189
protein complex assemblyGO:00064612630.183
positive regulation of biosynthetic processGO:00098913190.181
positive regulation of nucleic acid templated transcriptionGO:19035081970.171
protein heterooligomerizationGO:0051291890.161
regulation of programmed cell deathGO:00430673410.160
positive regulation of nitrogen compound metabolic processGO:00511733340.159
positive regulation of macromolecule biosynthetic processGO:00105572470.158
nucleic acid templated transcriptionGO:00976593790.143
carboxylic acid metabolic processGO:00197522890.143
transcription dna templatedGO:00063513770.142
rna biosynthetic processGO:00327743800.140
positive regulation of transcription dna templatedGO:00458931970.139
positive regulation of rna metabolic processGO:00512542030.135
apoptotic processGO:00069153810.133
central nervous system developmentGO:00074173110.133
regulation of cellular amino acid metabolic processGO:000652120.125
positive regulation of gene expressionGO:00106282440.123
regulation of transcription from rna polymerase ii promoterGO:00063572340.116
cellular amino acid metabolic processGO:00065201070.110
developmental process involved in reproductionGO:00030061590.110
regulation of rna biosynthetic processGO:20011413810.103
macromolecular complex assemblyGO:00650032730.103
protein complex biogenesisGO:00702712630.100
carbohydrate derivative metabolic processGO:19011353460.095
positive regulation of nucleobase containing compound metabolic processGO:00459353190.094
immune system processGO:00023762040.092
regulation of rna metabolic processGO:00512523910.090
cellular component biogenesisGO:00440853680.089
single organism biosynthetic processGO:00447113420.089
regulation of apoptotic processGO:00429813350.088
brain developmentGO:00074202470.086
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.086
negative regulation of macromolecule metabolic processGO:00106052600.086
positive regulation of rna biosynthetic processGO:19026801970.085
positive regulation of neurogenesisGO:00507691650.084
regulation of protein metabolic processGO:00512462890.084
cellular component assemblyGO:00226073600.083
neuron projection developmentGO:00311752730.082
transcription from rna polymerase ii promoterGO:00063662520.079
positive regulation of cellular biosynthetic processGO:00313282950.077
response to woundingGO:00096112540.074
organophosphate metabolic processGO:00196373700.073
macromolecular complex subunit organizationGO:00439333390.073
positive regulation of programmed cell deathGO:00430681570.073
organic acid metabolic processGO:00060822920.071
digestive system developmentGO:0055123410.070
oxoacid metabolic processGO:00434362900.070
protein oligomerizationGO:00512591910.067
positive regulation of cell proliferationGO:00082842490.067
anterior posterior pattern specificationGO:000995210.063
reproductive processGO:00224143720.058
nucleobase containing small molecule metabolic processGO:00550863160.058
mesoderm developmentGO:000749820.058
amine metabolic processGO:0009308380.058
cell projection morphogenesisGO:00488581230.057
neuron differentiationGO:00301823680.056
development of primary sexual characteristicsGO:00451371070.056
response to metal ionGO:00100382530.054
axon developmentGO:0061564960.054
single organism cellular localizationGO:19025801020.054
negative regulation of nitrogen compound metabolic processGO:00511721610.054
neuron developmentGO:00486662860.053
negative regulation of metabolic processGO:00098923310.053
peptidyl amino acid modificationGO:00181931260.053
organophosphate biosynthetic processGO:00904071430.052
immune responseGO:00069551040.052
organonitrogen compound biosynthetic processGO:19015661670.051
cellular response to stressGO:00335542690.051
rhythmic processGO:00485111560.050
regulation of neuron projection developmentGO:00109751610.050
single organism reproductive processGO:00447022970.049
programmed cell deathGO:00125013920.048
regulation of cellular ketone metabolic processGO:0010565270.048
regulation of cell differentiationGO:00455953200.048
positive regulation of cell deathGO:00109421840.047
secretionGO:00469033070.047
cerebral cortex tangential migrationGO:002180010.047
negative regulation of cellular biosynthetic processGO:00313271610.046
reproductionGO:00000032450.045
multicellular organism reproductionGO:00325042330.045
negative regulation of biosynthetic processGO:00098901680.045
homeostatic processGO:00425923310.045
nucleotide metabolic processGO:00091172790.045
cell projection organizationGO:00300303020.043
myelinationGO:0042552390.043
vesicle mediated transportGO:00161921810.043
response to other organismGO:00517072200.043
positive regulation of cellular amino acid metabolic processGO:004576410.042
negative regulation of growthGO:0045926370.042
negative regulation of nucleobase containing compound metabolic processGO:00459341530.042
carbohydrate derivative biosynthetic processGO:19011371240.042
cell adhesionGO:00071551100.041
female gonad developmentGO:0008585530.041
positive regulation of developmental processGO:00510942830.041
cellular response to oxygen containing compoundGO:19017013860.041
immune system developmentGO:0002520410.041
cellular amine metabolic processGO:0044106380.040
negative regulation of transcription dna templatedGO:00458921160.040
enzyme linked receptor protein signaling pathwayGO:00071671160.040
neuron projection morphogenesisGO:00488121220.040
organelle organizationGO:00069962660.039
negative regulation of cellular metabolic processGO:00313242810.039
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.039
multicellular organismal reproductive processGO:00486092330.039
cytokine mediated signaling pathwayGO:0019221430.038
chemical homeostasisGO:00488782920.038
coenzyme metabolic processGO:0006732860.038
cell morphogenesis involved in neuron differentiationGO:00486671060.037
negative regulation of nucleic acid templated transcriptionGO:19035071170.037
regulation of nervous system developmentGO:00519602640.037
dendrite developmentGO:0016358720.036
negative regulation of multicellular organismal processGO:00512412030.036
female pregnancyGO:00075651220.036
response to cytokineGO:00340972150.036
protein phosphorylationGO:00064683450.036
regulation of neuron differentiationGO:00456642080.035
metal ion homeostasisGO:00550651860.035
protein complex subunit organizationGO:00718223020.034
cellular ketone metabolic processGO:0042180510.034
positive regulation of cell developmentGO:00107201760.034
cellular macromolecule localizationGO:00707271220.034
negative regulation of macromolecule biosynthetic processGO:00105581480.034
peptidyl tyrosine phosphorylationGO:0018108720.033
agingGO:00075682410.032
positive regulation of neuron differentiationGO:00456661260.032
cation transportGO:00068123820.031
response to biotic stimulusGO:00096072260.031
negative regulation of programmed cell deathGO:00430691830.031
organ morphogenesisGO:0009887750.031
salivary gland developmentGO:000743130.031
regulation of phosphorus metabolic processGO:00511743490.031
cellular response to nitrogen compoundGO:19016992100.031
negative regulation of gene expressionGO:00106291990.030
negative regulation of rna metabolic processGO:00512531230.030
protein targetingGO:0006605610.030
cell part morphogenesisGO:00329901230.029
forebrain developmentGO:0030900980.029
limbic system developmentGO:0021761380.029
reproductive structure developmentGO:00486081280.029
regulation of cellular response to stressGO:0080135490.029
regulation of cellular localizationGO:00603412630.028
regulation of molecular functionGO:00650093980.028
g protein coupled receptor signaling pathwayGO:00071862420.028
sex differentiationGO:00075481130.028
regulation of neuron deathGO:19012141150.028
purine nucleotide metabolic processGO:00061632290.028
regulation of cellular protein metabolic processGO:00322682670.027
cellular response to organic cyclic compoundGO:00714072020.027
regulation of cell developmentGO:00602842630.027
biological adhesionGO:00226101100.027
neural crest cell migrationGO:000175510.027
regulation of phosphorylationGO:00423252480.027
endocytosisGO:0006897840.026
positive regulation of cell differentiationGO:00455972170.026
ribonucleotide metabolic processGO:00092592310.026
regulation of protein modification processGO:00313991940.026
protein autophosphorylationGO:0046777660.026
cellular protein localizationGO:00346131220.026
circulatory system developmentGO:00723591340.025
negative regulation of developmental processGO:00510931250.025
negative regulation of cell communicationGO:00106481580.025
negative regulation of neuron differentiationGO:0045665620.025
positive regulation of cellular amine metabolic processGO:003324030.025
hemopoiesisGO:0030097340.025
neuronal action potentialGO:0019228350.025
purine nucleoside metabolic processGO:00422781690.025
single organism carbohydrate metabolic processGO:00447231180.025
positive regulation of nervous system developmentGO:00519621780.025
regulation of fat cell differentiationGO:004559830.024
cellular response to cytokine stimulusGO:00713451270.024
intracellular signal transductionGO:00355563140.024
positive regulation of apoptotic processGO:00430651540.024
fatty acid biosynthetic processGO:0006633330.024
hematopoietic or lymphoid organ developmentGO:0048534360.024
cell cycleGO:00070491010.024
axon ensheathmentGO:0008366400.024
purine nucleotide biosynthetic processGO:0006164830.023
negative regulation of apoptotic processGO:00430661810.023
regulation of secretionGO:00510462240.023
protein localization to organelleGO:0033365570.023
multi organism reproductive processGO:00447032620.023
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.023
cellular metal ion homeostasisGO:00068751720.023
regulation of response to stressGO:00801341260.023
regulation of neurogenesisGO:00507672470.023
positive regulation of multicellular organismal processGO:00512403870.022
regulation of immune system processGO:00026821230.022
regulation of cellular amine metabolic processGO:003323880.022
development of primary female sexual characteristicsGO:0046545560.022
ribonucleotide biosynthetic processGO:0009260850.022
small molecule biosynthetic processGO:00442831240.022
neuron deathGO:00709971270.022
negative regulation of cell differentiationGO:0045596990.022
multicellular organism growthGO:003526410.021
cellular ion homeostasisGO:00068731840.021
regulation of signal transductionGO:00099663180.021
regulation of protein phosphorylationGO:00019321830.021
negative regulation of muscle cell apoptotic processGO:0010656210.021
peptidyl tyrosine modificationGO:0018212720.021
positive regulation of phosphate metabolic processGO:00459372620.021
transmission of nerve impulseGO:0019226420.021
phototransduction visible lightGO:000760320.020
behavioral response to nicotineGO:003509520.020
parasympathetic nervous system developmentGO:004848610.020
leukocyte activationGO:0045321760.020
hematopoietic progenitor cell differentiationGO:000224420.020
tissue developmentGO:00098882520.020
defense responseGO:00069521940.020
embryonic pattern specificationGO:000988010.020
positive regulation of immune system processGO:0002684900.020
negative regulation of rna biosynthetic processGO:19026791180.020
positive regulation of cellular protein metabolic processGO:00322701670.020
response to estradiolGO:00323551640.020
positive regulation of protein metabolic processGO:00512471780.019
dendrite morphogenesisGO:0048813430.019
positive regulation of cyclic nucleotide metabolic processGO:0030801370.019
female sex differentiationGO:0046660590.019
response to molecule of bacterial originGO:00022371940.019
response to ketoneGO:19016541820.019
nuclear transportGO:0051169490.019
regulation of catalytic activityGO:00507903040.019
response to hydrogen peroxideGO:0042542890.019
regulation of phosphate metabolic processGO:00192203490.019
response to oxidative stressGO:00069791860.019
transmembrane transportGO:00550854120.019
cell morphogenesisGO:00009021420.018
response to decreased oxygen levelsGO:00362932370.018
glial cell differentiationGO:0010001650.018
positive regulation of protein phosphorylationGO:00019341350.018
gland developmentGO:00487321550.018
cofactor metabolic processGO:0051186950.018
regulation of multicellular organismal developmentGO:20000263760.018
gastrulationGO:000736920.018
reactive oxygen species metabolic processGO:0072593370.018
neural crest cell developmentGO:001403220.017
regulation of sequence specific dna binding transcription factor activityGO:0051090350.017
sensory organ developmentGO:0007423740.017
gonad developmentGO:00084061040.017
negative regulation of cell proliferationGO:00082851190.017
cyclic purine nucleotide metabolic processGO:0052652620.017
mesoderm morphogenesisGO:004833210.017
anatomical structure morphogenesisGO:00096532980.017
action potentialGO:0001508540.017
negative regulation of organ growthGO:004662130.017
reproductive system developmentGO:00614581280.017
purine containing compound metabolic processGO:00725212530.017
gliogenesisGO:0042063930.017
cytoplasmic transportGO:00164821150.017
ovulation cycleGO:0042698670.017
detection of visible lightGO:000958430.017
negative regulation of tyrosine phosphorylation of stat5 proteinGO:004252410.017
mechanoreceptor differentiationGO:004249020.017
multicellular organismal signalingGO:0035637440.017
establishment of protein localizationGO:00451841410.017
carbohydrate metabolic processGO:00059751300.017
negative regulation of collagen biosynthetic processGO:003296640.017
ribose phosphate metabolic processGO:00196932350.017
response to bacteriumGO:00096172000.017
positive regulation of secretionGO:00510471400.017
nitrogen compound transportGO:00717052290.016
cellular component morphogenesisGO:00329891550.016
purine ribonucleotide metabolic processGO:00091502270.016
regulation of dendrite developmentGO:0050773590.016
macromolecule localizationGO:00330362520.016
response to external biotic stimulusGO:00432072210.016
lipid metabolic processGO:00066292830.016
peptide transportGO:0015833970.016
response to ethanolGO:00454711620.016
organelle localizationGO:0051640550.016
positive regulation of phosphorus metabolic processGO:00105622620.016
single organism intracellular transportGO:19025821660.016
ras protein signal transductionGO:0007265290.016
regulation of cell proliferationGO:00421273590.016
digestive tract developmentGO:0048565390.016
negative regulation of cell deathGO:00605482290.016
leukocyte differentiationGO:0002521300.015
positive regulation of purine nucleotide biosynthetic processGO:1900373360.015
ion transmembrane transportGO:00342203650.015
behaviorGO:00076102050.015
cellular response to organonitrogen compoundGO:00714171970.015
positive regulation of neuron projection developmentGO:0010976990.015
pancreatic stellate cell proliferationGO:007234320.015
positive regulation of phosphorylationGO:00423271770.015
bmp signaling pathwayGO:003050940.015
jak stat cascadeGO:0007259260.015
axonogenesisGO:0007409710.015
positive regulation of signal transductionGO:00099671750.015
regulation of stress activated protein kinase signaling cascadeGO:0070302230.015
response to estrogenGO:00436272320.015
regulation of purine nucleotide metabolic processGO:19005421150.015
response to peptide hormoneGO:00434342780.015
potassium ion transportGO:0006813970.015
oxidation reduction processGO:00551143040.015
response to growth factorGO:00708481890.015
cellular cation homeostasisGO:00300031800.015
lipid biosynthetic processGO:00086101280.014
maintenance of locationGO:0051235170.014
morphogenesis of embryonic epitheliumGO:001633130.014
small gtpase mediated signal transductionGO:0007264360.014
mesoderm formationGO:000170710.014
regulation of intracellular signal transductionGO:19025312180.014
cellular homeostasisGO:00197252520.014
cellular response to vitamin eGO:007130630.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.014
regulation of system processGO:00440572080.014
cell activationGO:0001775970.014
synaptic transmissionGO:00072682350.014
lymphoid progenitor cell differentiationGO:000232020.014
positive regulation of response to stimulusGO:00485842850.014
cellular chemical homeostasisGO:00550822470.014
neural crest cell differentiationGO:001403320.014
positive regulation of signalingGO:00230562700.014
cell morphogenesis involved in differentiationGO:00009041190.014
reactive nitrogen species metabolic processGO:200105710.014
regulation of reactive oxygen species metabolic processGO:2000377260.014
response to glucoseGO:00097491360.014
purine ribonucleotide biosynthetic processGO:0009152810.013
positive regulation of camp biosynthetic processGO:0030819280.013
cyclic nucleotide biosynthetic processGO:0009190630.013
response to hexoseGO:00097461440.013
sympathetic nervous system developmentGO:004848510.013
neurological system processGO:00508772190.013
amide transportGO:00428861050.013
protein localization to nucleusGO:0034504390.013
nucleotide biosynthetic processGO:0009165980.013
tube formationGO:003514830.013
potassium ion transmembrane transportGO:0071805710.013
monocarboxylic acid metabolic processGO:00327871520.013
multi multicellular organism processGO:00447061380.013
regulation of stress activated mapk cascadeGO:0032872230.013
negative regulation of molecular functionGO:00440921330.013
negative regulation of neurogenesisGO:0050768780.013
response to retinoic acidGO:0032526630.013
cell fate determinationGO:000170920.013
dna metabolic processGO:0006259960.013
hexose metabolic processGO:0019318580.013
anion transportGO:00068201780.013
establishment of protein localization to organelleGO:0072594440.012
tube developmentGO:0035295890.012
regulation of growthGO:00400081050.012
positive regulation of secretion by cellGO:19035321280.012
membrane organizationGO:0061024940.012
regulation of embryonic developmentGO:004599520.012
monovalent inorganic cation transportGO:00156721720.012
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.012
response to carbohydrateGO:00097431830.012
mrna transcriptionGO:000929920.012
regulation of blood pressureGO:0008217830.012
immune effector processGO:0002252530.012
nucleocytoplasmic transportGO:0006913480.012
cell growthGO:00160491040.012
autonomic nervous system developmentGO:004848330.012
chordate embryonic developmentGO:0043009180.012
endocrine system developmentGO:0035270300.012
intracellular receptor signaling pathwayGO:0030522350.012
single organism catabolic processGO:00447122830.012
embryo developmentGO:0009790490.012
ovulation cycle processGO:0022602500.012
embryonic skeletal system developmentGO:004870630.012
cellular calcium ion homeostasisGO:00068741600.012
ribonucleoside triphosphate catabolic processGO:00092031220.012
ensheathment of neuronsGO:0007272400.012
camp metabolic processGO:0046058630.012
vitamin d receptor signaling pathwayGO:007056110.012
generation of precursor metabolites and energyGO:0006091620.012
formation of primary germ layerGO:000170410.012
positive regulation of receptor activityGO:200027340.012
chemosensory behaviorGO:000763520.012
anatomical structure formation involved in morphogenesisGO:0048646830.012
response to transition metal nanoparticleGO:19902671220.011
regulation of intracellular transportGO:0032386650.011
negative regulation of cellular component organizationGO:0051129830.011
ribose phosphate biosynthetic processGO:0046390870.011
vasculogenesisGO:000157030.011
response to hypoxiaGO:00016662310.011
ribonucleoside catabolic processGO:00424541260.011
regulation of skeletal muscle tissue regenerationGO:004341620.011
response to lipopolysaccharideGO:00324961910.011
regulation of secretion by cellGO:19035302080.011
positive regulation of cell communicationGO:00106472710.011
forebrain neuron developmentGO:002188430.011
development of primary male sexual characteristicsGO:0046546590.011
response to toxic substanceGO:00096361330.011
positive regulation of mapk cascadeGO:0043410920.011
positive regulation of camp metabolic processGO:0030816310.011
response to campGO:0051591910.011
regulation of protein localizationGO:0032880810.011
hair cell differentiationGO:003531520.011
cellular potassium ion transportGO:0071804720.011
chromosome segregationGO:000705920.011
protein import into nucleusGO:0006606350.011
b cell differentiationGO:003018320.011
negative regulation of transportGO:00510511360.011
energy derivation by oxidation of organic compoundsGO:0015980460.011
temperature homeostasisGO:0001659170.011
cyclic nucleotide metabolic processGO:0009187800.011
single organism organelle organizationGO:19025891800.011
epithelium developmentGO:0060429960.011
lipid storageGO:001991510.011
regulation of catabolic processGO:00098941130.010
preganglionic parasympathetic nervous system developmentGO:002178310.010
myeloid cell differentiationGO:0030099220.010
negative regulation of cellular amine metabolic processGO:003323930.010
nucleoside phosphate metabolic processGO:00067532830.010
negative regulation of phosphorus metabolic processGO:0010563800.010
thyroid gland developmentGO:003087810.010
negative regulation of protein metabolic processGO:00512481140.010
digestive tract morphogenesisGO:004854680.010
positive regulation of catalytic activityGO:00430851840.010
positive regulation of protein modification processGO:00314011420.010
response to reactive oxygen speciesGO:00003021200.010
glycosyl compound catabolic processGO:19016581260.010
protein homooligomerizationGO:0051260910.010
embryonic neurocranium morphogenesisGO:004870220.010
negative regulation of cardiac muscle tissue developmentGO:005502630.010

Mthfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.052
disease of anatomical entityDOID:700.052
disease of metabolismDOID:001466700.036
disease of cellular proliferationDOID:1456600.033
sensory system diseaseDOID:005015500.029
cancerDOID:16200.019
organ system cancerDOID:005068600.019
eye and adnexa diseaseDOID:149200.018
eye diseaseDOID:561400.018
inherited metabolic disorderDOID:65500.016
type 2 diabetes mellitusDOID:935200.013
acquired metabolic diseaseDOID:006015800.013
diabetes mellitusDOID:935100.013
carbohydrate metabolism diseaseDOID:005001300.013
glucose metabolism diseaseDOID:419400.013
central nervous system diseaseDOID:33100.012
retinal degenerationDOID:846600.010
retinal diseaseDOID:567900.010