IMP: Integrative Multi-species Prediction

Rattus norvegicus

2 known processes

Fuca1

fucosidase, alpha-L- 1, tissue

(Aliases: Fuca)

RGD: 2636
Ensembl: ENSRNOG00000009325
Entrez: 24375
UniProtKB: P17164

Process Predictions
Disease Predictions

Fuca1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organic substance catabolic process	GO:1901575	316	0.177	Human
negative regulation of apoptotic process	GO:0043066	181	0.141
cellular catabolic process	GO:0044248	295	0.098
protein maturation	GO:0051604	68	0.082
chemical homeostasis	GO:0048878	292	0.078
monosaccharide metabolic process	GO:0005996	61	0.071	Human
positive regulation of signal transduction	GO:0009967	175	0.068
single organism catabolic process	GO:0044712	283	0.062	Human
keratan sulfate metabolic process	GO:0042339	1	0.061
respiratory system development	GO:0060541	45	0.058
developmental growth	GO:0048589	100	0.057
positive regulation of locomotion	GO:0040017	102	0.057
negative regulation of programmed cell death	GO:0043069	183	0.054
collagen catabolic process	GO:0030574	2	0.048
estrogen catabolic process	GO:0006711	1	0.045
cell projection organization	GO:0030030	302	0.044
negative regulation of cell death	GO:0060548	229	0.043
monocarboxylic acid metabolic process	GO:0032787	152	0.042
regulation of hormone levels	GO:0010817	187	0.040
protein processing	GO:0016485	68	0.039
catabolic process	GO:0009056	351	0.038	Human
regulation of protein metabolic process	GO:0051246	289	0.037
carbohydrate derivative metabolic process	GO:1901135	346	0.037	Human
homeostatic process	GO:0042592	331	0.036
sexual reproduction	GO:0019953	148	0.035
cell motility	GO:0048870	202	0.034
positive regulation of catalytic activity	GO:0043085	184	0.033
neurotransmitter biosynthetic process	GO:0042136	2	0.033
erk1 and erk2 cascade	GO:0070371	48	0.031
multicellular organismal catabolic process	GO:0044243	2	0.031
positive regulation of erythrocyte aggregation	GO:0034120	1	0.030
multi organism reproductive process	GO:0044703	262	0.030
positive regulation of signaling	GO:0023056	270	0.030
macromolecule catabolic process	GO:0009057	58	0.029
regulation of cellular component organization	GO:0051128	368	0.029
response to amine	GO:0014075	46	0.029
multicellular organismal reproductive process	GO:0048609	233	0.029
positive regulation of angiogenesis	GO:0045766	28	0.029
vesicle mediated transport	GO:0016192	181	0.028
single organism carbohydrate catabolic process	GO:0044724	40	0.028
growth	GO:0040007	165	0.028
positive regulation of multicellular organismal process	GO:0051240	387	0.028
rubidium ion transport	GO:0035826	1	0.027
tissue development	GO:0009888	252	0.027
neuron projection development	GO:0031175	273	0.023
organic cyclic compound catabolic process	GO:1901361	175	0.023
proteolysis	GO:0006508	175	0.023
response to testosterone	GO:0033574	55	0.023
oxoacid metabolic process	GO:0043436	290	0.023
male gamete generation	GO:0048232	99	0.023
regulation of neurogenesis	GO:0050767	247	0.023
peptide catabolic process	GO:0043171	5	0.023
single organism reproductive process	GO:0044702	297	0.022
hormone secretion	GO:0046879	115	0.022
mapk cascade	GO:0000165	140	0.022
positive regulation of neurogenesis	GO:0050769	165	0.021
cell migration	GO:0016477	197	0.021
aromatic compound catabolic process	GO:0019439	168	0.021
regulation of catalytic activity	GO:0050790	304	0.021
response to wounding	GO:0009611	254	0.020
exocytosis	GO:0006887	60	0.020
response to nutrient levels	GO:0031667	370	0.020
bradykinin catabolic process	GO:0010815	2	0.020
locomotion	GO:0040011	237	0.019
collagen metabolic process	GO:0032963	21	0.019
intramembranous ossification	GO:0001957	1	0.019
epithelium development	GO:0060429	96	0.019
cellular response to thyroid hormone stimulus	GO:0097067	5	0.019
reproductive process	GO:0022414	372	0.019
regeneration	GO:0031099	163	0.019
gamete generation	GO:0007276	124	0.019
positive regulation of cell communication	GO:0010647	271	0.019
negative regulation of peptidase activity	GO:0010466	38	0.019
regulation of apoptotic process	GO:0042981	335	0.019
aging	GO:0007568	241	0.018
response to starvation	GO:0042594	59	0.018
epithelial cell migration	GO:0010631	19	0.018
neuron development	GO:0048666	286	0.018
neuron differentiation	GO:0030182	368	0.018
synaptic transmission	GO:0007268	235	0.018
reactive nitrogen species metabolic process	GO:2001057	1	0.018
autophagic cell death	GO:0048102	4	0.018
regulation of body fluid levels	GO:0050878	90	0.017
metal ion transport	GO:0030001	289	0.017
development of primary sexual characteristics	GO:0045137	107	0.017
lung development	GO:0030324	43	0.017
regulation of hydrolase activity	GO:0051336	143	0.017
regulation of cell migration involved in sprouting angiogenesis	GO:0090049	3	0.017
regulation of proteolysis	GO:0030162	66	0.017
response to peptide	GO:1901652	292	0.017
cellular component movement	GO:0006928	248	0.016
negative regulation of molecular function	GO:0044092	133	0.016
epithelial cell differentiation	GO:0030855	71	0.016
signal transduction by phosphorylation	GO:0023014	144	0.016
positive regulation of cell development	GO:0010720	176	0.016
regulation of neuron differentiation	GO:0045664	208	0.016
heterocycle catabolic process	GO:0046700	167	0.016
regulation of erythrocyte aggregation	GO:0034118	1	0.016
axon regeneration	GO:0031103	28	0.016
positive regulation of response to stimulus	GO:0048584	285	0.016
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	4	0.016
cellular response to stress	GO:0033554	269	0.015
spermatogenesis	GO:0007283	99	0.015
coumarin catabolic process	GO:0046226	3	0.015
hexose metabolic process	GO:0019318	58	0.015	Human
skin morphogenesis	GO:0043589	2	0.015
epithelium migration	GO:0090132	19	0.015
regulation of molecular function	GO:0065009	398	0.015
positive regulation of cell migration	GO:0030335	96	0.015
negative regulation of cellular protein metabolic process	GO:0032269	106	0.015
regulation of epithelial cell migration	GO:0010632	17	0.015
regulation of multicellular organismal development	GO:2000026	376	0.014
positive regulation of transport	GO:0051050	245	0.014
phenylpropanoid catabolic process	GO:0046271	3	0.014
positive regulation of adenylate cyclase activity	GO:0045762	12	0.014
positive regulation of cell projection organization	GO:0031346	111	0.014
kidney development	GO:0001822	67	0.014
carbohydrate metabolic process	GO:0005975	130	0.014	Human
response to acid chemical	GO:0001101	222	0.014
response to extracellular stimulus	GO:0009991	380	0.014
nucleobase containing small molecule metabolic process	GO:0055086	316	0.014
negative regulation of leukocyte apoptotic process	GO:2000107	4	0.014
inorganic ion transmembrane transport	GO:0098660	229	0.013
cellular response to endogenous stimulus	GO:0071495	377	0.013
response to ketone	GO:1901654	182	0.013
lipid metabolic process	GO:0006629	283	0.013
brain development	GO:0007420	247	0.013
tetrapyrrole metabolic process	GO:0033013	11	0.013
ion transmembrane transport	GO:0034220	365	0.013
programmed cell death	GO:0012501	392	0.013
vasculature development	GO:0001944	70	0.013
positive regulation of cell motility	GO:2000147	97	0.013
negative regulation of protein metabolic process	GO:0051248	114	0.013
head development	GO:0060322	247	0.013
transmembrane transport	GO:0055085	412	0.013
organonitrogen compound catabolic process	GO:1901565	179	0.013
regulation of cellular protein metabolic process	GO:0032268	267	0.012
second messenger mediated signaling	GO:0019932	51	0.012
regulation of cell development	GO:0060284	263	0.012
activation of cysteine type endopeptidase activity	GO:0097202	4	0.012
regulation of signal transduction	GO:0009966	318	0.012
circulatory system development	GO:0072359	134	0.012
halogenated hydrocarbon metabolic process	GO:0042197	4	0.012
ion homeostasis	GO:0050801	212	0.012
ameboidal type cell migration	GO:0001667	26	0.012
leukocyte differentiation	GO:0002521	30	0.012
cell cell signaling	GO:0007267	335	0.012
multicellular organismal response to stress	GO:0033555	25	0.012
positive regulation of leukocyte migration	GO:0002687	21	0.011
multicellular organismal homeostasis	GO:0048871	49	0.011
positive regulation of neuron differentiation	GO:0045666	126	0.011
chemical homeostasis within a tissue	GO:0048875	4	0.011
decidualization	GO:0046697	14	0.011
regulation of cell projection organization	GO:0031344	175	0.011
organic acid metabolic process	GO:0006082	292	0.011
negative regulation of microtubule depolymerization	GO:0007026	3	0.011
response to metal ion	GO:0010038	253	0.011
multicellular organism reproduction	GO:0032504	233	0.011
negative regulation of multicellular organismal process	GO:0051241	203	0.011
tissue migration	GO:0090130	19	0.011
regulation of peptidase activity	GO:0052547	55	0.011
response to hexose	GO:0009746	144	0.010
negative regulation of catalytic activity	GO:0043086	103	0.010
positive regulation of homotypic cell cell adhesion	GO:0034112	2	0.010
response to thyroid hormone	GO:0097066	17	0.010
galactose metabolic process	GO:0006012	4	0.010
positive regulation of developmental process	GO:0051094	283	0.010
regulation of peptide hormone secretion	GO:0090276	80	0.010
response to ethanol	GO:0045471	162	0.010
negative regulation of protein maturation	GO:1903318	47	0.010

Fuca1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
lysosomal storage disease	DOID:3211	0.846	Human
disease of metabolism	DOID:0014667	0.846	Human
lipid storage disease	DOID:9455	0.846
inherited metabolic disorder	DOID:655	0.846	Human
brain disease	DOID:936	0.628
disease of anatomical entity	DOID:7	0.628
nervous system disease	DOID:863	0.628
central nervous system disease	DOID:331	0.628
cerebral degeneration	DOID:1443	0.628
epilepsy syndrome	DOID:1826	0.024
electroclinical syndrome	DOID:0050701	0.010

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