IMP: Integrative Multi-species Prediction

Rattus norvegicus

35 known processes

Eif5a

eukaryotic translation initiation factor 5A

(Aliases: MGC124873)

Ensembl: ENSRNOG00000016478
Entrez: 287444
RGD: 1308029
UniProtKB: Q3T1J1

Process Predictions
Disease Predictions

Eif5a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
response to cytokine	GO:0034097	215	0.487
tissue development	GO:0009888	252	0.295
regulation of cellular component organization	GO:0051128	368	0.270
cellular component assembly	GO:0022607	360	0.263
macromolecular complex subunit organization	GO:0043933	339	0.228
cellular response to cytokine stimulus	GO:0071345	127	0.224
cellular component biogenesis	GO:0044085	368	0.194
regulation of phosphate metabolic process	GO:0019220	349	0.169
response to purine containing compound	GO:0014074	126	0.161
positive regulation of phosphate metabolic process	GO:0045937	262	0.152
programmed cell death	GO:0012501	392	0.140
regulation of cellular protein metabolic process	GO:0032268	267	0.114
organophosphate biosynthetic process	GO:0090407	143	0.113
macromolecular complex assembly	GO:0065003	273	0.108
receptor internalization	GO:0031623	14	0.103
organic substance catabolic process	GO:1901575	316	0.098
cell cycle	GO:0007049	101	0.094
intracellular transport	GO:0046907	185	0.094
regulation of cell development	GO:0060284	263	0.092
protein complex subunit organization	GO:0071822	302	0.090
positive regulation of phosphorus metabolic process	GO:0010562	262	0.089
cell cycle process	GO:0022402	57	0.087
cardiovascular system development	GO:0072358	134	0.081
anatomical structure morphogenesis	GO:0009653	298	0.080
cellular macromolecular complex assembly	GO:0034622	58	0.079
cell projection organization	GO:0030030	302	0.077
regulation of cellular catabolic process	GO:0031329	101	0.075
regulation of organelle organization	GO:0033043	80	0.072
positive regulation of response to stimulus	GO:0048584	285	0.070
organonitrogen compound biosynthetic process	GO:1901566	167	0.069
positive regulation of cellular component organization	GO:0051130	200	0.068
positive regulation of cellular biosynthetic process	GO:0031328	295	0.065
positive regulation of biosynthetic process	GO:0009891	319	0.065
regulation of phosphorus metabolic process	GO:0051174	349	0.065
purine containing compound metabolic process	GO:0072521	253	0.064
negative regulation of metabolic process	GO:0009892	331	0.060
positive regulation of cellular component biogenesis	GO:0044089	55	0.060
regulation of meiotic cell cycle	GO:0051445	3	0.060
protein phosphorylation	GO:0006468	345	0.059
locomotion	GO:0040011	237	0.057
protein complex assembly	GO:0006461	263	0.057
nucleoside phosphate metabolic process	GO:0006753	283	0.057
regulation of transcription dna templated	GO:0006355	374	0.057
polyamine biosynthetic process	GO:0006596	4	0.057
rna biosynthetic process	GO:0032774	380	0.057
dephosphorylation	GO:0016311	98	0.056
generation of precursor metabolites and energy	GO:0006091	62	0.055
macromolecule localization	GO:0033036	252	0.053
tube development	GO:0035295	89	0.052
protein complex biogenesis	GO:0070271	263	0.051
apoptotic process	GO:0006915	381	0.050
regulation of protein phosphorylation	GO:0001932	183	0.049
muscle tissue morphogenesis	GO:0060415	1	0.049
posttranscriptional regulation of gene expression	GO:0010608	37	0.049
regulation of protein modification process	GO:0031399	194	0.048
rna metabolic process	GO:0016070	406	0.046
purine ribonucleotide metabolic process	GO:0009150	227	0.046
circulatory system development	GO:0072359	134	0.045
positive regulation of protein metabolic process	GO:0051247	178	0.045
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.045
positive regulation of catalytic activity	GO:0043085	184	0.044
positive regulation of protein modification process	GO:0031401	142	0.043
nucleic acid templated transcription	GO:0097659	379	0.043
heart development	GO:0007507	72	0.043
regulation of programmed cell death	GO:0043067	341	0.043
ribonucleotide metabolic process	GO:0009259	231	0.043
regulation of neuron differentiation	GO:0045664	208	0.042
hematopoietic progenitor cell differentiation	GO:0002244	2	0.041
positive regulation of phosphorylation	GO:0042327	177	0.040
cellular protein complex assembly	GO:0043623	44	0.040
amine metabolic process	GO:0009308	38	0.040
regulation of apoptotic process	GO:0042981	335	0.039
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.038
regulation of neurogenesis	GO:0050767	247	0.038
negative regulation of apoptotic process	GO:0043066	181	0.038
nucleocytoplasmic transport	GO:0006913	48	0.038
neuron differentiation	GO:0030182	368	0.037
purine nucleotide catabolic process	GO:0006195	136	0.037
negative regulation of cell death	GO:0060548	229	0.037
regulation of protein polymerization	GO:0032271	19	0.036
single organism organelle organization	GO:1902589	180	0.036
homeostatic process	GO:0042592	331	0.036
neuron projection development	GO:0031175	273	0.036
cellular response to growth factor stimulus	GO:0071363	162	0.035
positive regulation of cell death	GO:0010942	184	0.035
positive regulation of organelle organization	GO:0010638	48	0.035
nucleoside phosphate biosynthetic process	GO:1901293	102	0.034
cellular amine metabolic process	GO:0044106	38	0.034
regulation of multicellular organismal development	GO:2000026	376	0.032
regulation of nucleotide metabolic process	GO:0006140	117	0.032
organophosphate metabolic process	GO:0019637	370	0.032
lipid localization	GO:0010876	62	0.031
multi organism reproductive process	GO:0044703	262	0.031
modification dependent macromolecule catabolic process	GO:0043632	14	0.031
positive regulation of gene expression	GO:0010628	244	0.031
endocytosis	GO:0006897	84	0.031
regulation of nervous system development	GO:0051960	264	0.031
positive regulation of apoptotic process	GO:0043065	154	0.031
eye development	GO:0001654	50	0.030
positive regulation of nucleotide metabolic process	GO:0045981	91	0.029
regulation of purine nucleotide metabolic process	GO:1900542	115	0.028
cellular homeostasis	GO:0019725	252	0.028
aging	GO:0007568	241	0.028
cellular protein catabolic process	GO:0044257	19	0.028
regulation of signal transduction	GO:0009966	318	0.028
receptor mediated endocytosis	GO:0006898	42	0.027
positive regulation of cellular protein metabolic process	GO:0032270	167	0.027
protein import into nucleus	GO:0006606	35	0.027
ribosomal small subunit biogenesis	GO:0042274	6	0.027
cytoplasmic transport	GO:0016482	115	0.026
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.026
negative regulation of cell development	GO:0010721	82	0.026
negative regulation of signaling	GO:0023057	157	0.026
regulation of phosphorylation	GO:0042325	248	0.025
carbohydrate derivative metabolic process	GO:1901135	346	0.025
single organism reproductive process	GO:0044702	297	0.025
tissue morphogenesis	GO:0048729	22	0.024
reproduction	GO:0000003	245	0.024
positive regulation of signal transduction	GO:0009967	175	0.024
purine nucleotide metabolic process	GO:0006163	229	0.024
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.024
nucleotide metabolic process	GO:0009117	279	0.024
positive regulation of cell communication	GO:0010647	271	0.024
hematopoietic or lymphoid organ development	GO:0048534	36	0.024
circadian regulation of gene expression	GO:0032922	3	0.024
maintenance of location	GO:0051235	17	0.024
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.023
organic acid transport	GO:0015849	116	0.023
positive regulation of programmed cell death	GO:0043068	157	0.023
glycosyl compound metabolic process	GO:1901657	182	0.023
transcription dna templated	GO:0006351	377	0.023
cellular catabolic process	GO:0044248	295	0.023
lipid storage	GO:0019915	1	0.023
multicellular organism reproduction	GO:0032504	233	0.023
cardiac muscle tissue development	GO:0048738	26	0.023
muscle cell differentiation	GO:0042692	52	0.023
positive regulation of protein phosphorylation	GO:0001934	135	0.022
ribose phosphate metabolic process	GO:0019693	235	0.022
carboxylic acid metabolic process	GO:0019752	289	0.022
positive regulation of endocytosis	GO:0045807	28	0.022
positive regulation of hydrolase activity	GO:0051345	86	0.022
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.021
neuron development	GO:0048666	286	0.021
positive regulation of purine nucleotide biosynthetic process	GO:1900373	36	0.021
proteasomal protein catabolic process	GO:0010498	8	0.021
positive regulation of rna biosynthetic process	GO:1902680	197	0.021
cellular component movement	GO:0006928	248	0.021
organic cyclic compound catabolic process	GO:1901361	175	0.021
multicellular organismal reproductive process	GO:0048609	233	0.020
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.020
guanosine containing compound metabolic process	GO:1901068	74	0.020
regulation of cellular component biogenesis	GO:0044087	86	0.020
positive regulation of developmental process	GO:0051094	283	0.020
chemical homeostasis	GO:0048878	292	0.020
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	1	0.019
energy derivation by oxidation of organic compounds	GO:0015980	46	0.019
negative regulation of macromolecule metabolic process	GO:0010605	260	0.019
heart morphogenesis	GO:0003007	3	0.019
cell migration	GO:0016477	197	0.019
cell morphogenesis	GO:0000902	142	0.019
brain development	GO:0007420	247	0.019
nucleoside metabolic process	GO:0009116	179	0.019
central nervous system development	GO:0007417	311	0.019
positive regulation of molecular function	GO:0044093	230	0.019
regulation of cell growth	GO:0001558	85	0.019
negative regulation of cellular metabolic process	GO:0031324	281	0.019
negative regulation of cell communication	GO:0010648	158	0.018
organelle organization	GO:0006996	266	0.018
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.018
regulation of arp2 3 complex mediated actin nucleation	GO:0034315	2	0.018
regulation of catabolic process	GO:0009894	113	0.018
positive regulation of transport	GO:0051050	245	0.018
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.018
eye morphogenesis	GO:0048592	4	0.018
regulation of neuron projection development	GO:0010975	161	0.018
regulation of transferase activity	GO:0051338	123	0.018
cell part morphogenesis	GO:0032990	123	0.018
oxoacid metabolic process	GO:0043436	290	0.018
response to growth factor	GO:0070848	189	0.018
response to peptide hormone	GO:0043434	278	0.018
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	4	0.017
regulation of catalytic activity	GO:0050790	304	0.017
purine ribonucleoside metabolic process	GO:0046128	168	0.017
growth	GO:0040007	165	0.017
cellular chemical homeostasis	GO:0055082	247	0.017
translation	GO:0006412	35	0.017
nucleoside phosphate catabolic process	GO:1901292	140	0.017
pyrimidine nucleoside triphosphate biosynthetic process	GO:0009148	3	0.017
localization of cell	GO:0051674	202	0.017
nucleobase containing small molecule metabolic process	GO:0055086	316	0.017
positive regulation of multicellular organismal process	GO:0051240	387	0.017
nuclear import	GO:0051170	35	0.016
gland development	GO:0048732	155	0.016
positive regulation of cellular catabolic process	GO:0031331	71	0.016
muscle organ morphogenesis	GO:0048644	1	0.016
regulation of nucleotide catabolic process	GO:0030811	65	0.016
cation homeostasis	GO:0055080	195	0.016
regulation of cell projection organization	GO:0031344	175	0.016
catabolic process	GO:0009056	351	0.015
carbohydrate derivative biosynthetic process	GO:1901137	124	0.015
regulation of protein metabolic process	GO:0051246	289	0.015
regulation of immune system process	GO:0002682	123	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	7	0.015
biological adhesion	GO:0022610	110	0.015
sensory organ development	GO:0007423	74	0.015
organonitrogen compound catabolic process	GO:1901565	179	0.015
cellular biogenic amine biosynthetic process	GO:0042401	4	0.015
peptidyl amino acid modification	GO:0018193	126	0.015
nuclear transport	GO:0051169	49	0.015
triglyceride homeostasis	GO:0070328	2	0.015
pyrimidine nucleoside triphosphate metabolic process	GO:0009147	4	0.015
cell growth	GO:0016049	104	0.015
negative regulation of myeloid cell differentiation	GO:0045638	3	0.014
regulation of molecular function	GO:0065009	398	0.014
protein oligomerization	GO:0051259	191	0.014
regulation of nucleic acid templated transcription	GO:1903506	380	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.014
cellular metal ion homeostasis	GO:0006875	172	0.014
regulation of nucleoside metabolic process	GO:0009118	66	0.014
negative regulation of cell differentiation	GO:0045596	99	0.013
positive regulation of gtp catabolic process	GO:0033126	48	0.013
positive regulation of transcription dna templated	GO:0045893	197	0.013
regulation of hydrolase activity	GO:0051336	143	0.013
regulation of cell differentiation	GO:0045595	320	0.013
regulation of cell migration	GO:0030334	128	0.013
cation transport	GO:0006812	382	0.013
regulation of locomotion	GO:0040012	148	0.013
coenzyme metabolic process	GO:0006732	86	0.013
cellular macromolecule catabolic process	GO:0044265	29	0.013
er to golgi vesicle mediated transport	GO:0006888	10	0.013
cell motility	GO:0048870	202	0.013
regulation of rna metabolic process	GO:0051252	391	0.013
intracellular signal transduction	GO:0035556	314	0.013
positive regulation of catabolic process	GO:0009896	78	0.013
regulation of canonical wnt signaling pathway	GO:0060828	4	0.012
positive regulation of actin filament polymerization	GO:0030838	5	0.012
ribonucleotide biosynthetic process	GO:0009260	85	0.012
regulation of cellular amino acid metabolic process	GO:0006521	2	0.012
acylglycerol homeostasis	GO:0055090	2	0.012
amino acid transport	GO:0006865	70	0.012
purine nucleoside metabolic process	GO:0042278	169	0.012
purine nucleoside biosynthetic process	GO:0042451	21	0.012
male gamete generation	GO:0048232	99	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.012
g protein coupled receptor signaling pathway	GO:0007186	242	0.012
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.012
cardiocyte differentiation	GO:0035051	22	0.012
cellular amino acid metabolic process	GO:0006520	107	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.012
developmental growth	GO:0048589	100	0.012
cellular response to stress	GO:0033554	269	0.012
cellular nitrogen compound catabolic process	GO:0044270	163	0.011
regulation of cellular component size	GO:0032535	51	0.011
regulation of rna biosynthetic process	GO:2001141	381	0.011
regulation of cell motility	GO:2000145	131	0.011
organ morphogenesis	GO:0009887	75	0.011
regulation of actin nucleation	GO:0051125	2	0.011
regulation of cellular localization	GO:0060341	263	0.011
spermatogenesis	GO:0007283	99	0.011
negative regulation of gene expression	GO:0010629	199	0.011
regulation of ubiquitin protein transferase activity	GO:0051438	1	0.011
regulation of vesicle mediated transport	GO:0060627	81	0.011
aromatic compound catabolic process	GO:0019439	168	0.011
regulation of actin filament based process	GO:0032970	42	0.011
purine nucleoside monophosphate biosynthetic process	GO:0009127	20	0.011
regulation of cell morphogenesis	GO:0022604	77	0.011
regulation of synaptic plasticity	GO:0048167	70	0.011
cellular ion homeostasis	GO:0006873	184	0.011
purine containing compound catabolic process	GO:0072523	138	0.011
positive regulation of transferase activity	GO:0051347	81	0.011
regulation of protein kinase activity	GO:0045859	105	0.011
organelle fission	GO:0048285	25	0.011
regulation of myeloid leukocyte differentiation	GO:0002761	12	0.010
positive regulation of cell proliferation	GO:0008284	249	0.010
striated muscle cell differentiation	GO:0051146	39	0.010
synaptic transmission	GO:0007268	235	0.010
angiogenesis	GO:0001525	53	0.010
macroautophagy	GO:0016236	4	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.010
regulation of intracellular signal transduction	GO:1902531	218	0.010
neuron death	GO:0070997	127	0.010
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.010
positive regulation of rna metabolic process	GO:0051254	203	0.010
cellular response to extracellular stimulus	GO:0031668	73	0.010
cation transmembrane transport	GO:0098655	263	0.010
cardiac cell development	GO:0055006	16	0.010
hemopoiesis	GO:0030097	34	0.010
carboxylic acid transport	GO:0046942	115	0.010
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	3	0.010
single organism catabolic process	GO:0044712	283	0.010

Eif5a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.053
nervous system disease	DOID:863	0.053
disease of cellular proliferation	DOID:14566	0.020
organ system cancer	DOID:0050686	0.020
cancer	DOID:162	0.020

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