Rattus norvegicus

0 known processes

Six1

SIX homeobox 1

Six1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
rna biosynthetic processGO:00327743800.338
Human
regulation of nucleic acid templated transcriptionGO:19035063800.242
Human
regulation of rna metabolic processGO:00512523910.222
Human
transcription from rna polymerase ii promoterGO:00063662520.201
Human
transcription dna templatedGO:00063513770.194
Human
cellular response to endogenous stimulusGO:00714953770.192
rna metabolic processGO:00160704060.191
Human
regulation of transcription from rna polymerase ii promoterGO:00063572340.181
Human
negative regulation of nucleobase containing compound metabolic processGO:00459341530.147
response to peptide hormoneGO:00434342780.125
cellular chemical homeostasisGO:00550822470.123
embryonic skeletal system developmentGO:004870630.118
response to estrogenGO:00436272320.116
negative regulation of nitrogen compound metabolic processGO:00511721610.112
organ morphogenesisGO:0009887750.107
nucleic acid templated transcriptionGO:00976593790.105
Human
response to extracellular stimulusGO:00099913800.100
regulation of rna biosynthetic processGO:20011413810.098
Human
cellular response to hormone stimulusGO:00328702470.094
positive regulation of nucleic acid templated transcriptionGO:19035081970.093
Human
ossificationGO:0001503700.092
positive regulation of transcription dna templatedGO:00458931970.090
Human
positive regulation of nitrogen compound metabolic processGO:00511733340.088
Human
positive regulation of multicellular organismal processGO:00512403870.084
regulation of programmed cell deathGO:00430673410.082
regulation of transcription dna templatedGO:00063553740.080
Human
cellular response to oxygen containing compoundGO:19017013860.079
positive regulation of gene expressionGO:00106282440.079
Human
negative regulation of macromolecule biosynthetic processGO:00105581480.078
positive regulation of macromolecule biosynthetic processGO:00105572470.078
Human
negative regulation of rna metabolic processGO:00512531230.078
regulation of cell proliferationGO:00421273590.077
intracellular signal transductionGO:00355563140.077
anatomical structure morphogenesisGO:00096532980.074
reproductionGO:00000032450.073
positive regulation of biosynthetic processGO:00098913190.073
Human
regulation of multicellular organismal developmentGO:20000263760.072
positive regulation of developmental processGO:00510942830.072
reproductive processGO:00224143720.071
response to peptideGO:19016522920.071
negative regulation of cell deathGO:00605482290.069
response to metal ionGO:00100382530.066
response to nutrientGO:00075842480.066
programmed cell deathGO:00125013920.065
positive regulation of signalingGO:00230562700.065
central nervous system developmentGO:00074173110.064
negative regulation of biosynthetic processGO:00098901680.063
head developmentGO:00603222470.063
cell migrationGO:00164771970.062
cellular response to lipidGO:00713962010.062
chemical homeostasisGO:00488782920.062
response to corticosteroidGO:00319602350.061
renal system developmentGO:0072001670.059
embryonic skeletal system morphogenesisGO:004870430.059
cellular amino acid metabolic processGO:00065201070.058
regulation of cellular protein metabolic processGO:00322682670.058
negative regulation of cellular metabolic processGO:00313242810.058
regulation of cellular localizationGO:00603412630.057
negative regulation of cellular biosynthetic processGO:00313271610.057
multicellular organism reproductionGO:00325042330.056
organic acid metabolic processGO:00060822920.056
negative regulation of gene expressionGO:00106291990.055
regulation of phosphorus metabolic processGO:00511743490.054
carboxylic acid metabolic processGO:00197522890.054
positive regulation of cell proliferationGO:00082842490.054
response to inorganic substanceGO:00100353770.053
positive regulation of response to stimulusGO:00485842850.053
negative regulation of metabolic processGO:00098923310.053
response to acid chemicalGO:00011012220.053
regulation of molecular functionGO:00650093980.053
regulation of phosphorylationGO:00423252480.053
negative regulation of nucleic acid templated transcriptionGO:19035071170.051
cellular ketone metabolic processGO:0042180510.050
locomotionGO:00400112370.050
positive regulation of cell communicationGO:00106472710.049
response to estradiolGO:00323551640.049
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.049
Human
positive regulation of phosphate metabolic processGO:00459372620.048
tissue developmentGO:00098882520.048
multicellular organismal reproductive processGO:00486092330.048
cellular component movementGO:00069282480.048
single organism biosynthetic processGO:00447113420.047
negative regulation of transcription dna templatedGO:00458921160.047
negative regulation of signalingGO:00230571570.047
enzyme linked receptor protein signaling pathwayGO:00071671160.047
positive regulation of signal transductionGO:00099671750.047
skeletal system developmentGO:0001501410.046
positive regulation of rna metabolic processGO:00512542030.045
Human
cellular component biogenesisGO:00440853680.044
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.044
regulation of protein modification processGO:00313991940.044
cation transportGO:00068123820.044
epithelial cell proliferationGO:0050673540.044
rhythmic processGO:00485111560.044
kidney developmentGO:0001822670.044
homeostatic processGO:00425923310.043
positive regulation of protein metabolic processGO:00512471780.043
cellular cation homeostasisGO:00300031800.043
positive regulation of cellular biosynthetic processGO:00313282950.042
Human
multi organism reproductive processGO:00447032620.042
positive regulation of cell differentiationGO:00455972170.042
hormone transportGO:00099141210.042
regulation of ossificationGO:0030278320.042
positive regulation of rna biosynthetic processGO:19026801970.042
Human
urogenital system developmentGO:0001655780.041
cellular response to alcoholGO:0097306870.041
response to oxygen levelsGO:00704822650.041
negative regulation of macromolecule metabolic processGO:00106052600.041
transmembrane transportGO:00550854120.040
regulation of kinase activityGO:00435491170.040
negative regulation of rna biosynthetic processGO:19026791180.040
muscle structure developmentGO:0061061870.040
regulation of cellular ketone metabolic processGO:0010565270.040
apoptotic processGO:00069153810.040
positive regulation of nucleobase containing compound metabolic processGO:00459353190.039
Human
regulation of mesenchymal cell proliferationGO:001046440.038
cellular protein localizationGO:00346131220.038
Human
positive regulation of nervous system developmentGO:00519621780.038
positive regulation of transportGO:00510502450.038
regulation of transferase activityGO:00513381230.037
negative regulation of cell proliferationGO:00082851190.037
regulation of protein kinase activityGO:00458591050.037
negative regulation of cell communicationGO:00106481580.037
regulation of apoptotic processGO:00429813350.037
amine metabolic processGO:0009308380.036
regulation of cell developmentGO:00602842630.036
cellular response to peptide hormone stimulusGO:00713751200.036
cellular homeostasisGO:00197252520.036
response to cytokineGO:00340972150.036
metestrusGO:006021010.036
response to ketoneGO:19016541820.036
non canonical wnt signaling pathwayGO:003556730.036
neural crest cell differentiationGO:001403320.035
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.035
heart morphogenesisGO:000300730.035
positive regulation of molecular functionGO:00440932300.035
regulation of secretionGO:00510462240.034
regulation of neurogenesisGO:00507672470.034
positive regulation of phosphorus metabolic processGO:00105622620.033
nitrogen compound transportGO:00717052290.033
regulation of hormone levelsGO:00108171870.033
protein phosphorylationGO:00064683450.033
oxoacid metabolic processGO:00434362900.032
response to hexoseGO:00097461440.032
regulation of cellular amine metabolic processGO:003323880.032
brain developmentGO:00074202470.032
response to carbohydrateGO:00097431830.032
response to growth factorGO:00708481890.032
response to glucocorticoidGO:00513842230.031
neuron developmentGO:00486662860.031
regulation of protein phosphorylationGO:00019321830.031
inorganic ion transmembrane transportGO:00986602290.031
single organism reproductive processGO:00447022970.031
regulation of cellular amino acid metabolic processGO:000652120.031
neural crest cell developmentGO:001403220.031
regulation of epithelial cell proliferationGO:0050678490.030
cation homeostasisGO:00550801950.030
response to nutrient levelsGO:00316673700.030
cellular response to organic cyclic compoundGO:00714072020.029
regulation of signal transductionGO:00099663180.029
gonad developmentGO:00084061040.029
regulation of secretion by cellGO:19035302080.029
positive regulation of cellular amino acid metabolic processGO:004576410.029
developmental process involved in reproductionGO:00030061590.029
regulation of neuron deathGO:19012141150.029
tube developmentGO:0035295890.028
response to hypoxiaGO:00016662310.028
regulation of cell migrationGO:00303341280.028
positive regulation of cell deathGO:00109421840.028
positive regulation of neurogenesisGO:00507691650.028
intracellular transportGO:00469071850.028
signal releaseGO:00230611450.028
regulation of homeostatic processGO:00328441010.027
regulation of protein metabolic processGO:00512462890.027
negative regulation of molecular functionGO:00440921330.027
cell cell signalingGO:00072673350.027
positive regulation of cellular amine metabolic processGO:003324030.027
anterior posterior pattern specificationGO:000995210.027
negative regulation of signal transductionGO:0009968830.027
hormone secretionGO:00468791150.027
positive regulation of phosphorylationGO:00423271770.026
response to monosaccharideGO:00342841590.026
response to mechanical stimulusGO:00096121340.026
respiratory system developmentGO:0060541450.026
mesonephros developmentGO:0001823140.026
sex differentiationGO:00075481130.026
positive regulation of intracellular signal transductionGO:19025331380.026
response to decreased oxygen levelsGO:00362932370.026
circadian rhythmGO:0007623880.026
positive regulation of cellular protein metabolic processGO:00322701670.026
amide transportGO:00428861050.025
macromolecular complex assemblyGO:00650032730.025
positive regulation of kinase activityGO:0033674770.025
cellular response to steroid hormone stimulusGO:0071383930.025
organophosphate metabolic processGO:00196373700.025
agingGO:00075682410.024
development of primary sexual characteristicsGO:00451371070.024
multi multicellular organism processGO:00447061380.024
regulation of cell motilityGO:20001451310.024
macromolecule localizationGO:00330362520.024
Human
neural crest cell migrationGO:000175510.024
positive regulation of cell developmentGO:00107201760.024
ovulation cycleGO:0042698670.023
cardiovascular system developmentGO:00723581340.023
mapk cascadeGO:00001651400.023
lipid metabolic processGO:00066292830.023
cell motilityGO:00488702020.023
response to radiationGO:00093141370.023
cellular response to organonitrogen compoundGO:00714171970.023
regulation of anatomical structure morphogenesisGO:00226031410.023
positive regulation of protein kinase activityGO:0045860730.023
activation of protein kinase activityGO:0032147470.023
negative regulation of osteoblast differentiationGO:004566820.022
single organism intracellular transportGO:19025821660.022
wnt signaling pathway calcium modulating pathwayGO:000722310.022
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.022
negative regulation of transportGO:00510511360.022
eye morphogenesisGO:004859240.022
regulation of system processGO:00440572080.022
response to ethanolGO:00454711620.022
epithelium developmentGO:0060429960.022
positive regulation of secretionGO:00510471400.022
protein complex subunit organizationGO:00718223020.022
negative regulation of programmed cell deathGO:00430691830.022
embryonic appendage morphogenesisGO:003511340.022
reproductive system developmentGO:00614581280.022
secretionGO:00469033070.021
regulation of ion transportGO:00432692450.021
lung developmentGO:0030324430.021
regenerationGO:00310991630.021
organic acid transportGO:00158491160.021
appendage morphogenesisGO:003510740.021
regulation of peptide transportGO:0090087870.021
female pregnancyGO:00075651220.021
peptide transportGO:0015833970.021
cellular ion homeostasisGO:00068731840.021
negative regulation of response to stimulusGO:00485851550.021
positive regulation of protein modification processGO:00314011420.021
cardiac chamber developmentGO:000320510.021
cytosolic calcium ion homeostasisGO:00514801400.020
organelle organizationGO:00069962660.020
regulation of phosphate metabolic processGO:00192203490.020
regulation of cell differentiationGO:00455953200.020
response to glucoseGO:00097491360.020
response to lipopolysaccharideGO:00324961910.020
muscle cell proliferationGO:0033002840.020
ureteric bud developmentGO:0001657140.020
cellular amine metabolic processGO:0044106380.020
sexual reproductionGO:00199531480.020
regulation of catalytic activityGO:00507903040.020
cellular response to peptideGO:19016531330.020
cellular response to insulin stimulusGO:0032869810.020
secretion by cellGO:00329402480.019
peptidyl tyrosine phosphorylationGO:0018108720.019
positive regulation of protein phosphorylationGO:00019341350.019
cellular lipid metabolic processGO:00442552080.019
regulation of hormone secretionGO:00468831060.019
regulation of nervous system developmentGO:00519602640.019
regulation of mapk cascadeGO:00434081160.019
protein homooligomerizationGO:0051260910.019
regulation of locomotionGO:00400121480.019
peptidyl amino acid modificationGO:00181931260.019
palate developmentGO:006002120.018
regulation of immune system processGO:00026821230.018
regulation of peptide secretionGO:0002791820.018
g protein coupled receptor signaling pathwayGO:00071862420.018
neuron differentiationGO:00301823680.018
telencephalon developmentGO:0021537620.018
neuron deathGO:00709971270.018
protein complex biogenesisGO:00702712630.018
response to biotic stimulusGO:00096072260.018
positive regulation of transferase activityGO:0051347810.018
cellular response to growth factor stimulusGO:00713631620.018
cytoplasmic transportGO:00164821150.017
ion transmembrane transportGO:00342203650.017
protein oligomerizationGO:00512591910.017
positive regulation of epithelial cell proliferationGO:0050679320.017
single organism catabolic processGO:00447122830.017
gamete generationGO:00072761240.017
cellular response to dexamethasone stimulusGO:0071549360.017
ion homeostasisGO:00508012120.017
metal ion transportGO:00300012890.017
positive regulation of hormone secretionGO:0046887650.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.017
embryonic cranial skeleton morphogenesisGO:004870120.017
response to purine containing compoundGO:00140741260.017
reproductive structure developmentGO:00486081280.017
regulation of fat cell differentiationGO:004559830.017
gastrulationGO:000736920.017
blood circulationGO:00080151830.016
response to alkaloidGO:00432791320.016
positive regulation of oxidoreductase activityGO:005135370.016
regulation of osteoblast differentiationGO:0045667140.016
forebrain developmentGO:0030900980.016
nucleotide metabolic processGO:00091172790.016
positive regulation of mapk cascadeGO:0043410920.016
jak stat cascadeGO:0007259260.016
cellular response to cytokine stimulusGO:00713451270.016
negative regulation of apoptotic processGO:00430661810.016
positive regulation of cellular component movementGO:00512721020.016
cellular response to external stimulusGO:00714961180.016
response to activityGO:0014823730.016
positive regulation of cellular component organizationGO:00511302000.016
cellular component assemblyGO:00226073600.016
male gonad developmentGO:0008584590.016
dephosphorylationGO:0016311980.016
sensory organ developmentGO:0007423740.016
positive regulation of mesenchymal cell proliferationGO:000205340.016
response to increased oxygen levelsGO:0036296450.016
regulation of membrane potentialGO:00423911100.016
neurological system processGO:00508772190.016
regulation of establishment of planar polarityGO:009017520.016
mesenchymal cell proliferationGO:001046340.015
growthGO:00400071650.015
regulation of synaptic transmissionGO:00508041410.015
developmental growthGO:00485891000.015
axis specificationGO:000979840.015
macromolecular complex subunit organizationGO:00439333390.015
protein complex assemblyGO:00064612630.015
positive regulation of cell motilityGO:2000147970.015
response to external biotic stimulusGO:00432072210.015
multicellular organism growthGO:003526410.015
protein localizationGO:00081041910.015
Human
organic acid biosynthetic processGO:0016053830.015
protein transportGO:00150311320.015
camera type eye developmentGO:0043010480.015
regulation of lipid metabolic processGO:0019216680.015
cellular response to nitrogen compoundGO:19016992100.015
regulation of cellular component organizationGO:00511283680.014
response to bacteriumGO:00096172000.014
circulatory system developmentGO:00723591340.014
peptide secretionGO:0002790860.014
heart developmentGO:0007507720.014
limb morphogenesisGO:003510840.014
peptidyl tyrosine modificationGO:0018212720.014
cellular response to hexose stimulusGO:0071331650.014
regulation of oxidoreductase activityGO:0051341110.014
negative regulation of canonical wnt signaling pathwayGO:009009040.014
ribonucleotide metabolic processGO:00092592310.014
response to insulinGO:00328681330.014
regulation of hydrolase activityGO:00513361430.014
regulation of cell adhesionGO:0030155520.014
negative regulation of phosphate metabolic processGO:0045936800.014
eye developmentGO:0001654500.014
inflammatory responseGO:00069541500.014
negative regulation of cell differentiationGO:0045596990.014
positive regulation of cell migrationGO:0030335960.014
cellular response to stressGO:00335542690.014
single organism carbohydrate metabolic processGO:00447231180.013
embryonic pattern specificationGO:000988010.013
regulation of canonical wnt signaling pathwayGO:006082840.013
oligopeptide transportGO:000685740.013
oxidation reduction processGO:00551143040.013
positive regulation of immune system processGO:0002684900.013
regulation of cytokine productionGO:0001817560.013
negative regulation of ion transportGO:0043271510.013
regulation of cell cycleGO:0051726730.013
establishment of protein localizationGO:00451841410.013
signal transduction by phosphorylationGO:00230141440.013
cellular response to acid chemicalGO:0071229750.013
mesonephric tubule developmentGO:0072164140.013
dna metabolic processGO:0006259960.013
spermatogenesisGO:0007283990.013
response to calcium ionGO:0051592590.013
regulation of smooth muscle cell proliferationGO:0048660750.013
embryonic limb morphogenesisGO:003032640.013
metal ion homeostasisGO:00550651860.013
cellular component morphogenesisGO:00329891550.013
cell type specific apoptotic processGO:00972851340.013
carbohydrate derivative metabolic processGO:19011353460.013
insulin like growth factor receptor signaling pathwayGO:004800930.013
cation transmembrane transportGO:00986552630.013
response to molecule of bacterial originGO:00022371940.012
intestinal absorptionGO:005089230.012
cellular response to abiotic stimulusGO:0071214850.012
cellular carbohydrate metabolic processGO:0044262720.012
posttranscriptional regulation of gene expressionGO:0010608370.012
neuron projection morphogenesisGO:00488121220.012
muscle cell differentiationGO:0042692520.012
anatomical structure formation involved in morphogenesisGO:0048646830.012
glucose homeostasisGO:0042593750.012
localization of cellGO:00516742020.012
monovalent inorganic cation transportGO:00156721720.012
synaptic growth at neuromuscular junctionGO:005112410.012
synaptic transmissionGO:00072682350.012
single organism organelle organizationGO:19025891800.012
steroid metabolic processGO:0008202730.012
purine nucleotide metabolic processGO:00061632290.012
male sex differentiationGO:0046661640.012
regulation of reactive oxygen species metabolic processGO:2000377260.012
response to vitaminGO:00332731310.012
regulation of organ morphogenesisGO:2000027220.012
positive regulation of homeostatic processGO:0032846490.012
organic anion transportGO:00157111320.012
respiratory tube developmentGO:0030323430.012
peptide hormone secretionGO:0030072840.012
neuron projection developmentGO:00311752730.012
male gamete generationGO:0048232990.012
reactive oxygen species metabolic processGO:0072593370.012
regulation of intracellular signal transductionGO:19025312180.012
glial cell differentiationGO:0010001650.012
negative regulation of multicellular organismal processGO:00512412030.012
gland developmentGO:00487321550.012
regulation of ion transmembrane transportGO:00347651210.012
positive regulation of programmed cell deathGO:00430681570.011
transmission of nerve impulseGO:0019226420.011
regulation of cellular component movementGO:00512701500.011
cell cycle processGO:0022402570.011
response to dexamethasoneGO:0071548490.011
cellular divalent inorganic cation homeostasisGO:00725031620.011
camera type eye morphogenesisGO:004859320.011
organophosphate biosynthetic processGO:00904071430.011
calcium ion homeostasisGO:00550741620.011
muscle system processGO:00030121150.011
nucleobase containing small molecule metabolic processGO:00550863160.011
regulation of insulin secretionGO:0050796650.011
organic hydroxy compound transportGO:0015850770.011
negative regulation of catalytic activityGO:00430861030.011
gliogenesisGO:0042063930.011
regulation of reactive oxygen species biosynthetic processGO:190342650.011
protein localization to organelleGO:0033365570.011
Human
bone developmentGO:0060348250.011
organ regenerationGO:00311001010.011
negative regulation of cellular protein metabolic processGO:00322691060.011
positive regulation of catalytic activityGO:00430851840.011
positive regulation of response to external stimulusGO:0032103510.011
response to toxic substanceGO:00096361330.011
response to oxidative stressGO:00069791860.011
establishment of tissue polarityGO:000716420.011
positive regulation of secretion by cellGO:19035321280.011
carbohydrate homeostasisGO:0033500750.011
neuronal action potentialGO:0019228350.011
b cell differentiationGO:003018320.011
retinal metabolic processGO:004257430.011
salivary gland developmentGO:000743130.011
osteoblast differentiationGO:0001649260.011
organonitrogen compound biosynthetic processGO:19015661670.011
ameboidal type cell migrationGO:0001667260.011
response to testosteroneGO:0033574550.011
hormone metabolic processGO:0042445690.011
cell part morphogenesisGO:00329901230.010
striated muscle tissue developmentGO:0014706580.010
vasculature developmentGO:0001944700.010
reactive nitrogen species metabolic processGO:200105710.010
cellular macromolecule localizationGO:00707271220.010
Human
negative regulation of secretionGO:0051048820.010
negative regulation of developmental processGO:00510931250.010
purine containing compound metabolic processGO:00725212530.010
purine ribonucleotide metabolic processGO:00091502270.010
mesonephric epithelium developmentGO:0072163140.010
regulation of immune responseGO:0050776550.010
nucleocytoplasmic transportGO:0006913480.010
regulation of protein localizationGO:0032880810.010
acrosome assemblyGO:000167530.010
carboxylic acid transportGO:00469421150.010
cellular metal ion homeostasisGO:00068751720.010
anion transportGO:00068201780.010
response to anoxiaGO:003405940.010
reactive oxygen species biosynthetic processGO:190340980.010
positive regulation of lipid catabolic processGO:005099640.010
muscle tissue developmentGO:0060537580.010
chromosome segregationGO:000705920.010
odontogenesisGO:0042476320.010
steroid biosynthetic processGO:0006694480.010
negative regulation of cell cycle phase transitionGO:190198840.010
carboxylic acid biosynthetic processGO:0046394830.010
response to transition metal nanoparticleGO:19902671220.010

Six1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.039
Human
disease of anatomical entityDOID:700.039
Human
musculoskeletal system diseaseDOID:1700.021
sensory system diseaseDOID:005015500.013
Human
urinary system diseaseDOID:1800.012
central nervous system diseaseDOID:33100.011