Rattus norvegicus

253 known processes

Hsd3b1

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

(Aliases: MGC105549)

Hsd3b1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to organic cyclic compoundGO:00714072020.538
response to acid chemicalGO:00011012220.488
response to biotic stimulusGO:00096072260.431
response to corticosteroidGO:00319602350.431
response to peptideGO:19016522920.406
estrogen biosynthetic processGO:000670360.393
c21 steroid hormone biosynthetic processGO:0006700100.377
androgen biosynthetic processGO:0006702100.365
response to other organismGO:00517072200.363
cellular response to lipidGO:00713962010.353
carboxylic acid metabolic processGO:00197522890.350
lipid biosynthetic processGO:00086101280.333
organic anion transportGO:00157111320.320
organic acid transportGO:00158491160.301
carboxylic acid transportGO:00469421150.295
response to mineralocorticoidGO:0051385490.277
amino acid transportGO:0006865700.259
response to insulinGO:00328681330.256
cellular amino acid metabolic processGO:00065201070.255
response to cytokineGO:00340972150.254
regulation of ion transportGO:00432692450.241
Rat
oxoacid metabolic processGO:00434362900.237
response to inorganic substanceGO:00100353770.229
organic acid biosynthetic processGO:0016053830.221
response to extracellular stimulusGO:00099913800.220
lipid metabolic processGO:00066292830.217
cellular lipid metabolic processGO:00442552080.215
blood circulationGO:00080151830.212
small molecule biosynthetic processGO:00442831240.211
negative regulation of glutamate secretionGO:001405090.204
immune system processGO:00023762040.193
acid secretionGO:0046717480.190
response to peptide hormoneGO:00434342780.189
cellular response to endogenous stimulusGO:00714953770.186
anion transportGO:00068201780.182
testosterone biosynthetic processGO:006137050.181
neurological system processGO:00508772190.181
response to nutrientGO:00075842480.167
macromolecular complex subunit organizationGO:00439333390.165
hormone metabolic processGO:0042445690.159
response to herbicideGO:0009635160.157
brain developmentGO:00074202470.154
secretionGO:00469033070.153
response to toxic substanceGO:00096361330.153
circulatory system processGO:00030131830.152
single organism biosynthetic processGO:00447113420.146
muscle contractionGO:0006936880.146
benzene containing compound metabolic processGO:0042537220.140
synaptic transmissionGO:00072682350.139
negative regulation of metabolic processGO:00098923310.133
leydig cell differentiationGO:003332780.131
heart processGO:0003015570.129
response to ketoneGO:19016541820.126
insecticide metabolic processGO:001714340.125
response to glucocorticoidGO:00513842230.122
regulation of immune system processGO:00026821230.121
monocarboxylic acid transportGO:0015718520.120
androgen metabolic processGO:0008209140.119
carboxylic acid biosynthetic processGO:0046394830.117
response to estradiolGO:00323551640.110
homeostatic processGO:00425923310.110
organic acid metabolic processGO:00060822920.108
response to oxygen levelsGO:00704822650.104
vascular process in circulatory systemGO:0003018960.104
organic hydroxy compound metabolic processGO:19016151150.104
steroid metabolic processGO:0008202730.104
head developmentGO:00603222470.102
response to nutrient levelsGO:00316673700.102
regulation of cellular protein metabolic processGO:00322682670.100
behaviorGO:00076102050.100
cellular response to cytokine stimulusGO:00713451270.099
regulation of organic acid transportGO:0032890350.095
response to estrogenGO:00436272320.092
dicarboxylic acid transportGO:0006835340.090
cellular component movementGO:00069282480.090
regulation of neurological system processGO:0031644430.086
glutamate secretionGO:0014047190.085
cellular chemical homeostasisGO:00550822470.083
regulation of programmed cell deathGO:00430673410.083
male gonad developmentGO:0008584590.082
positive regulation of calcium ion transportGO:0051928360.078
second messenger mediated signalingGO:0019932510.078
positive regulation of immune system processGO:0002684900.076
positive regulation of cellular component movementGO:00512721020.075
kidney developmentGO:0001822670.075
fatty acid derivative metabolic processGO:1901568380.074
programmed cell deathGO:00125013920.074
g protein coupled receptor signaling pathwayGO:00071862420.072
response to bacteriumGO:00096172000.071
action potentialGO:0001508540.070
cellular response to oxygen containing compoundGO:19017013860.069
central nervous system developmentGO:00074173110.069
response to lipopolysaccharideGO:00324961910.069
response to dexamethasoneGO:0071548490.069
positive regulation of transportGO:00510502450.069
cellular ketone metabolic processGO:0042180510.068
rhythmic processGO:00485111560.068
protein complex assemblyGO:00064612630.068
multi multicellular organism processGO:00447061380.068
regulation of metal ion transportGO:00109591180.068
Rat
cellular response to peptideGO:19016531330.067
immune responseGO:00069551040.067
response to reactive oxygen speciesGO:00003021200.066
positive regulation of amine transportGO:0051954260.066
positive regulation of response to external stimulusGO:0032103510.066
response to decreased oxygen levelsGO:00362932370.066
reproductive structure developmentGO:00486081280.064
regulation of catalytic activityGO:00507903040.063
cell activationGO:0001775970.062
response to carbohydrateGO:00097431830.062
response to purine containing compoundGO:00140741260.060
single organism behaviorGO:00447081300.060
development of primary sexual characteristicsGO:00451371070.059
cellular response to organonitrogen compoundGO:00714171970.059
regulation of system processGO:00440572080.058
cellular modified amino acid metabolic processGO:0006575610.056
negative regulation of cellular metabolic processGO:00313242810.056
regulation of phosphate metabolic processGO:00192203490.055
regulation of homeostatic processGO:00328441010.055
fractalkine metabolic processGO:005075630.055
single organism reproductive processGO:00447022970.054
positive regulation of ion transportGO:0043270940.054
positive regulation of leukocyte migrationGO:0002687210.054
multicellular organism reproductionGO:00325042330.053
developmental process involved in reproductionGO:00030061590.053
response to hypoxiaGO:00016662310.052
regulation of leukocyte activationGO:0002694450.052
regulation of amino acid transportGO:0051955250.052
urogenital system developmentGO:0001655780.052
protein complex subunit organizationGO:00718223020.051
ovulation cycleGO:0042698670.050
positive regulation of cell migrationGO:0030335960.050
sensory perceptionGO:00076001010.049
muscle system processGO:00030121150.049
regulation of blood pressureGO:0008217830.049
leukocyte activationGO:0045321760.049
positive regulation of biosynthetic processGO:00098913190.049
positive regulation of cytosolic calcium ion concentrationGO:00072041220.049
icosanoid metabolic processGO:0006690380.048
renal system developmentGO:0072001670.048
regulation of phosphorylationGO:00423252480.047
defense responseGO:00069521940.047
negative regulation of cellular biosynthetic processGO:00313271610.047
cellular divalent inorganic cation homeostasisGO:00725031620.047
cellular response to alcoholGO:0097306870.047
localization of cellGO:00516742020.046
alpha amino acid metabolic processGO:1901605710.046
response to molecule of bacterial originGO:00022371940.046
amine metabolic processGO:0009308380.046
cell cell signalingGO:00072673350.046
protein phosphorylationGO:00064683450.045
macromolecule localizationGO:00330362520.045
female pregnancyGO:00075651220.044
multicellular organismal reproductive processGO:00486092330.044
regulation of signal transductionGO:00099663180.044
regulation of blood circulationGO:19035221100.044
telencephalon developmentGO:0021537620.043
positive regulation of multicellular organismal processGO:00512403870.043
tube developmentGO:0035295890.043
response to monosaccharideGO:00342841590.043
positive regulation of locomotionGO:00400171020.042
cellular response to peptide hormone stimulusGO:00713751200.042
response to amino acidGO:0043200750.042
divalent inorganic cation transportGO:00725111340.042
response to organophosphorusGO:00466831020.042
positive regulation of transferase activityGO:0051347810.042
gonad developmentGO:00084061040.042
response to fungicideGO:0060992200.041
reproductive processGO:00224143720.041
phenol containing compound metabolic processGO:0018958300.041
phthalate metabolic processGO:001896380.040
cytosolic calcium ion homeostasisGO:00514801400.040
regulation of cell migrationGO:00303341280.040
progesterone biosynthetic processGO:000670130.039
nitrogen compound transportGO:00717052290.039
chemical homeostasisGO:00488782920.038
organic hydroxy compound biosynthetic processGO:1901617510.038
cellular response to hormone stimulusGO:00328702470.038
response to metal ionGO:00100382530.037
cellular response to abiotic stimulusGO:0071214850.037
cellular response to tumor necrosis factorGO:0071356460.037
regulation of phosphorus metabolic processGO:00511743490.037
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.037
cation transportGO:00068123820.037
Rat
regulation of cellular amine metabolic processGO:003323880.037
regulation of hormone levelsGO:00108171870.037
choline transportGO:001587140.036
regulation of apoptotic processGO:00429813350.036
cellular response to steroid hormone stimulusGO:0071383930.036
response to transition metal nanoparticleGO:19902671220.036
regulation of calcium ion transportGO:0051924770.035
steroid biosynthetic processGO:0006694480.035
leukocyte proliferationGO:0070661290.035
organonitrogen compound biosynthetic processGO:19015661670.035
cellular response to ketoneGO:1901655510.035
response to cadmium ionGO:0046686350.034
positive regulation of apoptotic processGO:00430651540.034
apoptotic processGO:00069153810.034
cellular response to corticosteroid stimulusGO:0071384690.034
negative regulation of cell communicationGO:00106481580.034
negative regulation of nitrogen compound metabolic processGO:00511721610.033
regulation of chronic inflammatory responseGO:000267630.033
male sex differentiationGO:0046661640.033
regulation of muscle system processGO:0090257790.032
regulation of membrane potentialGO:00423911100.032
regulation of tube sizeGO:0035150890.032
divalent inorganic cation homeostasisGO:00725071650.032
divalent metal ion transportGO:00708381320.032
multi organism reproductive processGO:00447032620.032
regulation of secretionGO:00510462240.032
cellular metal ion homeostasisGO:00068751720.031
intracellular signal transductionGO:00355563140.031
response to external biotic stimulusGO:00432072210.030
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200270.030
regulation of protein metabolic processGO:00512462890.030
unsaturated fatty acid metabolic processGO:0033559390.030
sexual reproductionGO:00199531480.030
acute inflammatory responseGO:0002526580.030
cellular component biogenesisGO:00440853680.030
response to campGO:0051591910.029
naphthalene containing compound metabolic processGO:009042020.029
cellular response to lipopolysaccharideGO:0071222550.029
hormone transportGO:00099141210.029
renal system processGO:0003014400.028
calcium ion transport into cytosolGO:0060402380.028
regulation of protein modification processGO:00313991940.028
cellular response to gonadotropin stimulusGO:0071371170.028
cellular amino acid biosynthetic processGO:0008652320.028
monocarboxylic acid metabolic processGO:00327871520.028
response to interleukin 1GO:0070555550.028
metal ion homeostasisGO:00550651860.028
protein complex biogenesisGO:00702712630.028
heart contractionGO:0060047570.027
positive regulation of molecular functionGO:00440932300.027
cellular response to interleukin 1GO:0071347370.027
response to gonadotropinGO:0034698340.027
sequestering of metal ionGO:005123890.027
regulation of nucleic acid templated transcriptionGO:19035063800.027
regulation of cell proliferationGO:00421273590.027
carbohydrate derivative metabolic processGO:19011353460.027
single organism catabolic processGO:00447122830.027
calcium ion homeostasisGO:00550741620.027
response to ethanolGO:00454711620.027
cell migrationGO:00164771970.027
hormone biosynthetic processGO:0042446250.026
response to ammonium ionGO:0060359710.026
response to antibioticGO:0046677390.026
response to mechanical stimulusGO:00096121340.026
regulation of secretion by cellGO:19035302080.026
positive regulation of catalytic activityGO:00430851840.026
alcohol metabolic processGO:0006066770.026
dibenzo p dioxin metabolic processGO:0018894100.026
positive regulation of phosphorylationGO:00423271770.026
response to hexoseGO:00097461440.026
ion homeostasisGO:00508012120.026
mononuclear cell proliferationGO:0032943290.026
circadian rhythmGO:0007623880.026
regulation of ion homeostasisGO:2000021630.025
lymphocyte proliferationGO:0046651290.025
cellular calcium ion homeostasisGO:00068741600.025
positive regulation of response to woundingGO:1903036340.025
negative regulation of cell deathGO:00605482290.025
transmembrane transportGO:00550854120.025
monovalent inorganic cation transportGO:00156721720.025
lipid localizationGO:0010876620.025
cell projection organizationGO:00300303020.025
regulation of lymphocyte proliferationGO:0050670260.025
regulation of hormone secretionGO:00468831060.024
calcitriol biosynthetic process from calciolGO:003637820.024
reproductionGO:00000032450.024
protein homooligomerizationGO:0051260910.024
positive regulation of gamma aminobutyric acid secretionGO:001405440.024
cellular response to glucocorticoid stimulusGO:0071385680.024
leukocyte migrationGO:0050900380.024
muscle cell proliferationGO:0033002840.024
cellular amine metabolic processGO:0044106380.023
macromolecular complex assemblyGO:00650032730.023
cellular cation homeostasisGO:00300031800.023
regulation of multicellular organismal developmentGO:20000263760.023
cellular response to stressGO:00335542690.023
negative regulation of macromolecule metabolic processGO:00106052600.023
transcription dna templatedGO:00063513770.023
regulation of inflammatory responseGO:0050727480.022
cellular ion homeostasisGO:00068731840.022
cytoplasmic transportGO:00164821150.022
negative regulation of programmed cell deathGO:00430691830.022
positive regulation of cellular biosynthetic processGO:00313282950.022
cation homeostasisGO:00550801950.022
negative regulation of signalingGO:00230571570.022
regulation of anion transportGO:0044070430.022
regulation of cell activationGO:0050865500.022
fatty acid metabolic processGO:0006631990.022
positive regulation of nitrogen compound metabolic processGO:00511733340.022
reproductive system developmentGO:00614581280.022
regulation of intracellular signal transductionGO:19025312180.022
development of primary male sexual characteristicsGO:0046546590.022
positive regulation of muscle contractionGO:0045933220.021
regulation of cellular component movementGO:00512701500.021
negative regulation of rna metabolic processGO:00512531230.021
sex differentiationGO:00075481130.021
positive regulation of programmed cell deathGO:00430681570.021
response to calcium ionGO:0051592590.021
positive regulation of protein phosphorylationGO:00019341350.021
circadian sleep wake cycleGO:0042745230.021
positive regulation of macromolecule biosynthetic processGO:00105572470.021
c21 steroid hormone metabolic processGO:0008207140.021
organonitrogen compound catabolic processGO:19015651790.021
cellular response to nitrogen compoundGO:19016992100.021
intracellular transportGO:00469071850.021
isoprenoid metabolic processGO:0006720450.021
positive regulation of response to stimulusGO:00485842850.021
glycerolipid metabolic processGO:0046486670.020
response to xenobiotic stimulusGO:0009410230.020
estrogen metabolic processGO:0008210110.020
proteolysisGO:00065081750.020
regulation of leukocyte migrationGO:0002685240.020
actin filament based processGO:0030029860.020
ovulation cycle processGO:0022602500.020
cellular response to extracellular stimulusGO:0031668730.020
circulatory system developmentGO:00723591340.020
regulation of release of sequestered calcium ion into cytosolGO:0051279180.020
positive regulation of cellular component organizationGO:00511302000.020
regulation of protein phosphorylationGO:00019321830.019
maintenance of locationGO:0051235170.019
muscle cell migrationGO:0014812360.019
striated muscle contractionGO:0006941440.019
regulation of kinase activityGO:00435491170.019
positive regulation of protein modification processGO:00314011420.019
agingGO:00075682410.019
regulation of systemic arterial blood pressureGO:0003073300.019
regulation of nervous system developmentGO:00519602640.018
respiratory system developmentGO:0060541450.018
lipid transportGO:0006869610.018
regulation of cellular amino acid metabolic processGO:000652120.018
purine containing compound biosynthetic processGO:0072522850.018
positive regulation of phosphate metabolic processGO:00459372620.018
positive regulation of secretionGO:00510471400.018
negative regulation of natural killer cell mediated immunityGO:000271640.018
response to osmotic stressGO:0006970420.018
memoryGO:0007613540.018
cell motilityGO:00488702020.018
calcium ion transportGO:00068161310.017
negative regulation of cell proliferationGO:00082851190.017
glucocorticoid biosynthetic processGO:000670450.017
regulation of molecular functionGO:00650093980.017
protein oligomerizationGO:00512591910.017
peptidyl tyrosine modificationGO:0018212720.017
cellular response to external stimulusGO:00714961180.017
innate immune responseGO:0045087350.017
positive regulation of defense responseGO:0031349370.017
response to woundingGO:00096112540.017
negative regulation of nucleobase containing compound metabolic processGO:00459341530.017
regulation of defense responseGO:0031347680.017
sulfur compound metabolic processGO:0006790700.017
cardiac muscle contractionGO:0060048270.017
epithelium developmentGO:0060429960.017
organophosphate metabolic processGO:00196373700.016
regulation of calcium ion transport into cytosolGO:0010522250.016
neuron neuron synaptic transmissionGO:0007270600.016
cellular component assemblyGO:00226073600.016
chemotaxisGO:0006935660.016
ion transmembrane transportGO:00342203650.016
regulation of cellular localizationGO:00603412630.016
regulation of heart contractionGO:0008016480.016
epithelial cell differentiationGO:0030855710.016
response to radiationGO:00093141370.016
regulation of locomotionGO:00400121480.016
leukocyte cell cell adhesionGO:000715940.016
purine containing compound metabolic processGO:00725212530.016
neuromuscular synaptic transmissionGO:000727420.016
negative regulation of biosynthetic processGO:00098901680.016
regulation of reactive oxygen species metabolic processGO:2000377260.016
positive regulation of signalingGO:00230562700.015
negative regulation of rna biosynthetic processGO:19026791180.015
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001088040.015
regulation of sensory perceptionGO:0051931290.015
cytosolic calcium ion transportGO:0060401390.015
chronic inflammatory response to non antigenic stimulusGO:000254510.015
modified amino acid transportGO:0072337120.015
positive regulation of inflammatory responseGO:0050729240.015
response to hydrogen peroxideGO:0042542890.015
smooth muscle cell proliferationGO:0048659770.015
female sex differentiationGO:0046660590.015
alpha amino acid catabolic processGO:1901606200.015
cellular response to inorganic substanceGO:0071241650.015
regulation of smooth muscle cell migrationGO:0014910360.015
regulation of cellular ketone metabolic processGO:0010565270.015
sequestering of calcium ionGO:005120880.015
maternal process involved in female pregnancyGO:0060135380.015
rna biosynthetic processGO:00327743800.015
t cell activationGO:0042110290.015
regulation of response to external stimulusGO:00321011060.015
negative regulation of transportGO:00510511360.015
Rat
alkaloid metabolic processGO:000982030.015
cellular response to dexamethasone stimulusGO:0071549360.014
vasoconstrictionGO:0042310540.014
smooth muscle cell migrationGO:0014909360.014
positive regulation of lymphocyte proliferationGO:0050671200.014
neuron developmentGO:00486662860.014
cellular response to follicle stimulating hormone stimulusGO:0071372130.014
regulation of neurogenesisGO:00507672470.014
alcohol biosynthetic processGO:0046165380.014
aromatic compound catabolic processGO:00194391680.014
calcium ion importGO:0070509220.014
cellular amide metabolic processGO:0043603440.014
phasic smooth muscle contractionGO:001482130.014
negative regulation of molecular functionGO:00440921330.014
single organism intracellular transportGO:19025821660.014
nucleobase containing small molecule metabolic processGO:00550863160.014
dopamine metabolic processGO:0042417120.014
monocarboxylic acid biosynthetic processGO:0072330480.014
positive regulation of cell motilityGO:2000147970.014
positive regulation of action potentialGO:004576080.014
catecholamine transportGO:0051937370.014
neuron differentiationGO:00301823680.014
regulation of glutamate secretionGO:0014048170.014
response to tumor necrosis factorGO:0034612560.014
regulation of leukocyte proliferationGO:0070663260.014
positive regulation of phosphorus metabolic processGO:00105622620.014
positive regulation of developmental processGO:00510942830.014
smooth muscle contractionGO:0006939370.014
metal ion transportGO:00300012890.013
Rat
positive regulation of organic acid transportGO:0032892220.013
peptide transportGO:0015833970.013
regulation of vasoconstrictionGO:0019229440.013
peptidyl amino acid modificationGO:00181931260.013
regulation of transferase activityGO:00513381230.013
response to electrical stimulusGO:0051602560.013
negative regulation of immune system processGO:0002683390.013
positive regulation of protein metabolic processGO:00512471780.013
chemokine metabolic processGO:005075530.013
antibiotic transportGO:004289120.013
regulation of cell cycleGO:0051726730.013
reactive oxygen species metabolic processGO:0072593370.013
regulation of peptide secretionGO:0002791820.013
taxisGO:0042330670.013
inorganic ion transmembrane transportGO:00986602290.013
negative regulation of amino acid transportGO:0051956130.013
cellular protein localizationGO:00346131220.013
negative regulation of cellular protein metabolic processGO:00322691060.013
epithelial cell proliferationGO:0050673540.013
synaptic transmission glycinergicGO:006001220.013
neuron projection developmentGO:00311752730.012
secretion by cellGO:00329402480.012
positive regulation of cell proliferationGO:00082842490.012
tissue developmentGO:00098882520.012
receptor mediated endocytosisGO:0006898420.012
positive regulation of cellular amine metabolic processGO:003324030.012
phosphatidylinositol dephosphorylationGO:004685640.012
ribose phosphate metabolic processGO:00196932350.012
inflammatory responseGO:00069541500.012
response to cgmpGO:007030530.012
positive regulation of somatostatin secretionGO:009027440.012
cell morphogenesisGO:00009021420.012
adrenal gland developmentGO:0030325110.012
transmission of nerve impulseGO:0019226420.012
long chain fatty acid metabolic processGO:0001676320.012
multicellular organismal signalingGO:0035637440.012
locomotionGO:00400112370.012
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001480840.012
response to corticosteroneGO:0051412400.012
inorganic cation transmembrane transportGO:00986622020.012
cellular catabolic processGO:00442482950.012
positive regulation of nucleobase containing compound metabolic processGO:00459353190.012
cellular macromolecule localizationGO:00707271220.011
response to lead ionGO:0010288330.011
cellular response to acid chemicalGO:0071229750.011
positive regulation of smooth muscle contractionGO:0045987180.011
cellular response to insulin stimulusGO:0032869810.011
organic hydroxy compound transportGO:0015850770.011
cellular homeostasisGO:00197252520.011
response to oxidative stressGO:00069791860.011
positive regulation of cell projection organizationGO:00313461110.011
negative regulation of macromolecule biosynthetic processGO:00105581480.011
regulation of action potentialGO:0098900140.011
positive regulation of leukocyte proliferationGO:0070665200.011
response to interferon gammaGO:0034341200.011
chlorinated hydrocarbon metabolic processGO:004219640.011
salivary gland developmentGO:000743130.011
positive regulation of leukocyte activationGO:0002696300.011
cellular response to metal ionGO:0071248550.011
negative regulation of organic acid transportGO:0032891140.011
regulation of phosphatidylinositol dephosphorylationGO:006030410.011
amide transportGO:00428861050.011
small molecule catabolic processGO:0044282590.011
rna metabolic processGO:00160704060.011
cellular response to histamineGO:007142030.011
positive regulation of cellular amino acid metabolic processGO:004576410.011
negative regulation of gene expressionGO:00106291990.011
regulation of cellular component biogenesisGO:0044087860.011
defense response to gram negative bacteriumGO:005082930.011

Hsd3b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.080
epilepsy syndromeDOID:182600.080
disease of anatomical entityDOID:700.080
central nervous system diseaseDOID:33100.080
brain diseaseDOID:93600.080
musculoskeletal system diseaseDOID:1700.024
connective tissue diseaseDOID:6500.011