Rattus norvegicus

0 known processes

Prss22

protease, serine, 22

Prss22 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to biotic stimulusGO:00096072260.565
response to bacteriumGO:00096172000.407
response to other organismGO:00517072200.387
regulation of cell proliferationGO:00421273590.352
regulation of multicellular organismal developmentGO:20000263760.308
positive regulation of cell proliferationGO:00082842490.280
response to glucocorticoidGO:00513842230.272
response to lipopolysaccharideGO:00324961910.243
response to external biotic stimulusGO:00432072210.230
cellular response to endogenous stimulusGO:00714953770.209
regulation of cell differentiationGO:00455953200.200
positive regulation of signalingGO:00230562700.184
mesoderm developmentGO:000749820.173
response to mechanical stimulusGO:00096121340.161
amino acid transportGO:0006865700.154
response to peptide hormoneGO:00434342780.153
Rat
response to nutrient levelsGO:00316673700.148
neuron differentiationGO:00301823680.146
apoptotic processGO:00069153810.146
cellular component biogenesisGO:00440853680.141
negative regulation of developmental processGO:00510931250.140
reproductive processGO:00224143720.137
cellular response to hormone stimulusGO:00328702470.136
positive regulation of phosphorus metabolic processGO:00105622620.134
response to molecule of bacterial originGO:00022371940.131
cellular response to oxygen containing compoundGO:19017013860.131
regulation of neurogenesisGO:00507672470.124
regulation of nervous system developmentGO:00519602640.121
negative regulation of multicellular organismal processGO:00512412030.121
cellular homeostasisGO:00197252520.119
programmed cell deathGO:00125013920.114
negative regulation of macromolecule biosynthetic processGO:00105581480.110
response to radiationGO:00093141370.108
positive regulation of multicellular organismal processGO:00512403870.108
response to purine containing compoundGO:00140741260.105
organic acid metabolic processGO:00060822920.101
response to corticosteroidGO:00319602350.099
Rat
cellular response to stressGO:00335542690.098
carboxylic acid metabolic processGO:00197522890.098
agingGO:00075682410.097
response to inorganic substanceGO:00100353770.097
response to tumor necrosis factorGO:0034612560.096
gland developmentGO:00487321550.094
negative regulation of cell differentiationGO:0045596990.091
response to growth factorGO:00708481890.089
regulation of cell developmentGO:00602842630.089
positive regulation of phosphate metabolic processGO:00459372620.089
response to extracellular stimulusGO:00099913800.089
cellular chemical homeostasisGO:00550822470.088
positive regulation of cell developmentGO:00107201760.087
response to cytokineGO:00340972150.086
positive regulation of biosynthetic processGO:00098913190.086
multi multicellular organism processGO:00447061380.084
positive regulation of cellular biosynthetic processGO:00313282950.084
positive regulation of nitrogen compound metabolic processGO:00511733340.084
negative regulation of nucleobase containing compound metabolic processGO:00459341530.083
organic anion transportGO:00157111320.082
response to metal ionGO:00100382530.081
gliogenesisGO:0042063930.080
epithelium developmentGO:0060429960.079
oxoacid metabolic processGO:00434362900.078
anion transportGO:00068201780.078
organelle organizationGO:00069962660.077
negative regulation of metabolic processGO:00098923310.076
cellular response to growth factor stimulusGO:00713631620.073
regulation of cellular component organizationGO:00511283680.072
response to reactive oxygen speciesGO:00003021200.071
response to woundingGO:00096112540.068
positive regulation of response to stimulusGO:00485842850.068
protein maturationGO:0051604680.066
cell growthGO:00160491040.066
response to decreased oxygen levelsGO:00362932370.065
positive regulation of immune system processGO:0002684900.065
enzyme linked receptor protein signaling pathwayGO:00071671160.064
response to zinc ionGO:0010043390.064
positive regulation of signal transductionGO:00099671750.063
regulation of phosphate metabolic processGO:00192203490.063
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.062
positive regulation of developmental processGO:00510942830.061
cellular amine metabolic processGO:0044106380.060
catabolic processGO:00090563510.060
amine metabolic processGO:0009308380.058
positive regulation of nucleobase containing compound metabolic processGO:00459353190.058
regulation of ion transportGO:00432692450.058
response to insulinGO:00328681330.058
macromolecule localizationGO:00330362520.058
organic acid transportGO:00158491160.057
response to estrogenGO:00436272320.057
intracellular signal transductionGO:00355563140.057
response to ketoneGO:19016541820.056
negative regulation of cell deathGO:00605482290.056
protein phosphorylationGO:00064683450.056
tissue developmentGO:00098882520.055
regulation of protein kinase activityGO:00458591050.055
negative regulation of gene expressionGO:00106291990.055
multi organism reproductive processGO:00447032620.054
cell morphogenesisGO:00009021420.054
regulation of cellular ketone metabolic processGO:0010565270.054
circulatory system processGO:00030131830.053
secretionGO:00469033070.053
response to oxygen levelsGO:00704822650.053
hormone metabolic processGO:0042445690.053
glial cell differentiationGO:0010001650.052
response to oxidative stressGO:00069791860.052
regulation of phosphorylationGO:00423252480.052
negative regulation of biosynthetic processGO:00098901680.052
protein complex subunit organizationGO:00718223020.051
growthGO:00400071650.051
positive regulation of cellular amine metabolic processGO:003324030.050
positive regulation of cell differentiationGO:00455972170.050
immune responseGO:00069551040.049
cellular response to organonitrogen compoundGO:00714171970.049
reproductive structure developmentGO:00486081280.048
response to estradiolGO:00323551640.048
anterior posterior pattern specificationGO:000995210.048
multicellular organism reproductionGO:00325042330.047
positive regulation of cellular amino acid metabolic processGO:004576410.047
nucleic acid templated transcriptionGO:00976593790.047
response to hypoxiaGO:00016662310.047
nitrogen compound transportGO:00717052290.047
transcription dna templatedGO:00063513770.047
regulation of body fluid levelsGO:0050878900.046
organic hydroxy compound metabolic processGO:19016151150.046
cation transportGO:00068123820.046
Rat
positive regulation of cell communicationGO:00106472710.046
regulation of protein metabolic processGO:00512462890.045
regulation of cell projection organizationGO:00313441750.045
cell projection organizationGO:00300303020.045
positive regulation of cellular protein metabolic processGO:00322701670.045
response to gonadotropinGO:0034698340.045
regulation of secretion by cellGO:19035302080.044
nucleoside phosphate catabolic processGO:19012921400.044
cell cell signalingGO:00072673350.044
macromolecular complex subunit organizationGO:00439333390.044
aromatic compound catabolic processGO:00194391680.044
carboxylic acid transportGO:00469421150.044
developmental process involved in reproductionGO:00030061590.044
reproductionGO:00000032450.044
wound healingGO:00420601220.043
positive regulation of intracellular signal transductionGO:19025331380.043
chemical homeostasisGO:00488782920.043
amine transportGO:0015837570.043
regulation of system processGO:00440572080.043
embryonic pattern specificationGO:000988010.043
response to toxic substanceGO:00096361330.042
positive regulation of nervous system developmentGO:00519621780.042
renal filtrationGO:0097205100.042
rhythmic processGO:00485111560.042
regulation of organic acid transportGO:0032890350.041
muscle system processGO:00030121150.041
cellular component morphogenesisGO:00329891550.041
regulation of smooth muscle contractionGO:0006940290.041
neuron developmentGO:00486662860.041
response to peptideGO:19016522920.041
Rat
single organism reproductive processGO:00447022970.040
regulation of growthGO:00400081050.040
behaviorGO:00076102050.040
homeostatic processGO:00425923310.040
cellular hormone metabolic processGO:0034754490.040
cellular response to nitrogen compoundGO:19016992100.040
regulation of rna metabolic processGO:00512523910.039
regulation of cellular amino acid metabolic processGO:000652120.039
negative regulation of rna metabolic processGO:00512531230.039
purine nucleoside metabolic processGO:00422781690.038
organonitrogen compound biosynthetic processGO:19015661670.038
regulation of apoptotic processGO:00429813350.038
regulation of cell cycleGO:0051726730.038
regulation of signal transductionGO:00099663180.038
positive regulation of neurogenesisGO:00507691650.038
regulation of cell activationGO:0050865500.037
positive regulation of molecular functionGO:00440932300.037
negative regulation of response to stimulusGO:00485851550.037
cell type specific apoptotic processGO:00972851340.037
positive regulation of behaviorGO:0048520380.037
regulation of neuron differentiationGO:00456642080.036
transcription from rna polymerase ii promoterGO:00063662520.036
regulation of phosphorus metabolic processGO:00511743490.036
cell activationGO:0001775970.036
cellular response to lipidGO:00713962010.035
neuron projection developmentGO:00311752730.035
coagulationGO:0050817280.035
neuromuscular processGO:005090520.035
bmp signaling pathwayGO:003050940.035
response to transition metal nanoparticleGO:19902671220.035
defense responseGO:00069521940.035
regulation of synaptic transmissionGO:00508041410.035
mapk cascadeGO:00001651400.035
glomerular filtrationGO:0003094100.035
regulation of protein phosphorylationGO:00019321830.034
intracellular transportGO:00469071850.034
neurological system processGO:00508772190.034
epithelial cell differentiationGO:0030855710.034
secretion by cellGO:00329402480.033
regulation of tube sizeGO:0035150890.033
cellular component movementGO:00069282480.033
regulation of secretionGO:00510462240.033
nucleobase containing small molecule metabolic processGO:00550863160.033
organophosphate catabolic processGO:00464341480.033
regulation of rna biosynthetic processGO:20011413810.033
response to hydrogen peroxideGO:0042542890.033
cellular response to peptideGO:19016531330.032
cellular response to cytokine stimulusGO:00713451270.032
reproductive system developmentGO:00614581280.032
cation homeostasisGO:00550801950.032
multicellular organismal reproductive processGO:00486092330.032
negative regulation of nitrogen compound metabolic processGO:00511721610.032
actin filament based processGO:0030029860.031
negative regulation of rna biosynthetic processGO:19026791180.031
single organism catabolic processGO:00447122830.031
regulation of nucleic acid templated transcriptionGO:19035063800.031
cellular amino acid metabolic processGO:00065201070.031
positive regulation of cell migrationGO:0030335960.031
negative regulation of secretionGO:0051048820.031
carbohydrate derivative catabolic processGO:19011361470.030
regulation of muscle system processGO:0090257790.030
muscle contractionGO:0006936880.030
negative regulation of apoptotic processGO:00430661810.030
response to temperature stimulusGO:0009266940.030
cellular response to external stimulusGO:00714961180.030
neuron deathGO:00709971270.030
response to amino acidGO:0043200750.030
indole containing compound metabolic processGO:0042430110.030
cellular nitrogen compound catabolic processGO:00442701630.030
female pregnancyGO:00075651220.029
single organismal cell cell adhesionGO:0016337420.029
lymphoid progenitor cell differentiationGO:000232020.029
cellular ketone metabolic processGO:0042180510.029
regulation of cellular amine metabolic processGO:003323880.029
circulatory system developmentGO:00723591340.029
positive regulation of protein phosphorylationGO:00019341350.029
regulation of anatomical structure morphogenesisGO:00226031410.028
regulation of cellular localizationGO:00603412630.028
response to monosaccharideGO:00342841590.028
regulation of programmed cell deathGO:00430673410.028
regulation of catalytic activityGO:00507903040.028
steroid biosynthetic processGO:0006694480.028
cellular component assemblyGO:00226073600.028
brain developmentGO:00074202470.028
positive regulation of protein modification processGO:00314011420.028
carbohydrate derivative metabolic processGO:19011353460.028
muscle tissue morphogenesisGO:006041510.028
cellular response to oxidative stressGO:0034599760.027
positive regulation of cell deathGO:00109421840.027
biological adhesionGO:00226101100.027
regulation of hormone levelsGO:00108171870.027
ribose phosphate metabolic processGO:00196932350.027
cardiac chamber developmentGO:000320510.027
regulation of cytokine productionGO:0001817560.027
single organism organelle organizationGO:19025891800.027
heterocycle catabolic processGO:00467001670.027
cell communication by chemical couplingGO:001064320.026
regulation of reactive oxygen species metabolic processGO:2000377260.026
cognitionGO:0050890920.026
cellular modified amino acid metabolic processGO:0006575610.026
leukocyte differentiationGO:0002521300.026
negative regulation of cell communicationGO:00106481580.026
steroid metabolic processGO:0008202730.026
chronic inflammatory responseGO:0002544160.026
negative regulation of transcription dna templatedGO:00458921160.026
regulation of protein modification processGO:00313991940.026
lipid biosynthetic processGO:00086101280.026
positive regulation of transportGO:00510502450.026
organonitrogen compound catabolic processGO:19015651790.025
cellular response to tumor necrosis factorGO:0071356460.025
neuron apoptotic processGO:0051402880.025
regulation of kinase activityGO:00435491170.025
positive regulation of kinase activityGO:0033674770.025
cardiovascular system developmentGO:00723581340.025
nucleoside phosphate metabolic processGO:00067532830.025
nucleotide metabolic processGO:00091172790.025
sulfur compound metabolic processGO:0006790700.025
protein complex biogenesisGO:00702712630.025
regulation of glomerular filtrationGO:000309390.025
synaptic growth at neuromuscular junctionGO:005112410.025
gamete generationGO:00072761240.025
regulation of blood circulationGO:19035221100.024
peptidyl amino acid modificationGO:00181931260.024
regulation of blood vessel sizeGO:0050880890.024
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.024
negative regulation of macromolecule metabolic processGO:00106052600.024
small gtpase mediated signal transductionGO:0007264360.024
regulation of transcription dna templatedGO:00063553740.024
positive regulation of gene expressionGO:00106282440.024
organic substance catabolic processGO:19015753160.024
negative regulation of cellular metabolic processGO:00313242810.024
regulation of cellular protein metabolic processGO:00322682670.024
positive regulation of protein kinase activityGO:0045860730.023
response to ionizing radiationGO:0010212590.023
hepaticobiliary system developmentGO:0061008900.023
negative regulation of programmed cell deathGO:00430691830.023
rna metabolic processGO:00160704060.023
positive regulation of catalytic activityGO:00430851840.023
renal system processGO:0003014400.023
response to campGO:0051591910.023
neuron neuron synaptic transmissionGO:0007270600.022
nucleoside triphosphate metabolic processGO:00091411440.022
central nervous system developmentGO:00074173110.022
regulation of anion transportGO:0044070430.022
regulation of response to stressGO:00801341260.022
cellular response to transforming growth factor beta stimulusGO:0071560410.022
regulation of cell adhesionGO:0030155520.022
comma shaped body morphogenesisGO:007204920.022
regulation of response to woundingGO:1903034690.022
heart contractionGO:0060047570.021
rna biosynthetic processGO:00327743800.021
g protein coupled receptor signaling pathwayGO:00071862420.021
protein processingGO:0016485680.021
positive regulation of nucleic acid templated transcriptionGO:19035081970.021
regulation of neuron deathGO:19012141150.021
spindle organizationGO:000705120.021
vascular process in circulatory systemGO:0003018960.021
ribonucleotide catabolic processGO:00092611360.021
chemosensory behaviorGO:000763520.021
positive regulation of macromolecule biosynthetic processGO:00105572470.021
negative regulation of cellular biosynthetic processGO:00313271610.021
regulation of neuron projection developmentGO:00109751610.021
mononuclear cell proliferationGO:0032943290.021
cellular lipid metabolic processGO:00442552080.021
smooth muscle contractionGO:0006939370.020
t cell activationGO:0042110290.020
immune system processGO:00023762040.020
calcium ion transportGO:00068161310.020
ras protein signal transductionGO:0007265290.020
c21 steroid hormone biosynthetic processGO:0006700100.020
positive regulation of rna biosynthetic processGO:19026801970.020
hormone biosynthetic processGO:0042446250.020
anatomical structure formation involved in morphogenesisGO:0048646830.020
single organism biosynthetic processGO:00447113420.020
regulation of immune system processGO:00026821230.020
endothelium developmentGO:0003158120.020
positive regulation of rna metabolic processGO:00512542030.020
regulation of transferase activityGO:00513381230.020
organic acid biosynthetic processGO:0016053830.020
nucleoside metabolic processGO:00091161790.020
organ regenerationGO:00311001010.019
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.019
hematopoietic progenitor cell differentiationGO:000224420.019
smooth muscle cell proliferationGO:0048659770.019
regulation of transcription from rna polymerase ii promoterGO:00063572340.019
positive regulation of cellular component organizationGO:00511302000.019
head developmentGO:00603222470.019
positive regulation of ion transportGO:0043270940.019
negative regulation of immune system processGO:0002683390.019
cellular cation homeostasisGO:00300031800.019
skin developmentGO:0043588170.019
negative regulation of nervous system developmentGO:0051961790.019
anatomical structure morphogenesisGO:00096532980.019
ribonucleoside metabolic processGO:00091191740.019
purine ribonucleoside triphosphate catabolic processGO:00092071220.019
positive regulation of protein metabolic processGO:00512471780.019
purine containing compound metabolic processGO:00725212530.019
positive regulation of secretion by cellGO:19035321280.019
muscle structure developmentGO:0061061870.019
organic cyclic compound catabolic processGO:19013611750.019
negative regulation of protein metabolic processGO:00512481140.019
response to ethanolGO:00454711620.019
positive regulation of dna metabolic processGO:0051054390.018
lipid metabolic processGO:00066292830.018
regulation of membrane potentialGO:00423911100.018
regulation of synaptic growth at neuromuscular junctionGO:000858210.018
regulation of vasoconstrictionGO:0019229440.018
blood circulationGO:00080151830.018
regulation of purine nucleotide metabolic processGO:19005421150.018
cell part morphogenesisGO:00329901230.018
response to vitaminGO:00332731310.018
positive regulation of organelle organizationGO:0010638480.018
cell cell junction assemblyGO:000704370.018
response to alkaloidGO:00432791320.018
positive regulation of response to woundingGO:1903036340.018
locomotionGO:00400112370.018
epithelial cell proliferationGO:0050673540.017
reactive oxygen species metabolic processGO:0072593370.017
actin cytoskeleton organizationGO:0030036730.017
glycosyl compound catabolic processGO:19016581260.017
signal transduction by phosphorylationGO:00230141440.017
purine nucleoside catabolic processGO:00061521240.017
divalent inorganic cation homeostasisGO:00725071650.017
prostaglandin secretionGO:003231060.017
regulation of leukocyte proliferationGO:0070663260.017
cellular response to peptide hormone stimulusGO:00713751200.017
purine nucleoside triphosphate catabolic processGO:00091461220.017
cardiac ventricle developmentGO:000323110.017
cell cycleGO:00070491010.017
response to nutrientGO:00075842480.017
purine ribonucleotide metabolic processGO:00091502270.017
response to gamma radiationGO:0010332240.017
cellular response to insulin stimulusGO:0032869810.016
regulation of blood pressureGO:0008217830.016
purine containing compound catabolic processGO:00725231380.016
icosanoid metabolic processGO:0006690380.016
ovulation cycle processGO:0022602500.016
positive regulation of response to external stimulusGO:0032103510.016
positive regulation of cytosolic calcium ion concentrationGO:00072041220.016
glycosyl compound metabolic processGO:19016571820.016
regulation of intracellular signal transductionGO:19025312180.016
ribonucleoside catabolic processGO:00424541260.016
response to organophosphorusGO:00466831020.016
positive regulation of transferase activityGO:0051347810.016
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.016
ribonucleotide metabolic processGO:00092592310.016
response to calcium ionGO:0051592590.016
regulation of vasodilationGO:0042312360.016
single organism cell adhesionGO:0098602460.016
regulation of response to external stimulusGO:00321011060.016
positive regulation of phosphorylationGO:00423271770.016
regulation of synaptic plasticityGO:0048167700.016
regulation of mapk cascadeGO:00434081160.016
negative regulation of cell proliferationGO:00082851190.016
potassium ion transportGO:0006813970.015
inflammatory response to antigenic stimulusGO:0002437180.015
tube developmentGO:0035295890.015
purine nucleoside triphosphate metabolic processGO:00091441410.015
gonad developmentGO:00084061040.015
positive regulation of cell motilityGO:2000147970.015
negative regulation of secretion by cellGO:1903531720.015
regulation of leukocyte differentiationGO:1902105200.015
neuronal stem cell maintenanceGO:009715020.015
cellular response to molecule of bacterial originGO:0071219560.015
positive regulation of myeloid cell differentiationGO:004563970.015
cellular response to gonadotropin stimulusGO:0071371170.015
cell adhesionGO:00071551100.015
cellular response to organic cyclic compoundGO:00714072020.015
regulation of cellular response to stressGO:0080135490.015
cellular amide metabolic processGO:0043603440.015
nucleotide catabolic processGO:00091661390.015
negative regulation of mitotic cell cycle phase transitionGO:190199130.015
nucleoside catabolic processGO:00091641260.015
protein oligomerizationGO:00512591910.015
vasoconstrictionGO:0042310540.015
epidermal growth factor receptor signaling pathwayGO:0007173230.015
olfactory behaviorGO:004204820.015
regulation of systemic arterial blood pressureGO:0003073300.015
ion homeostasisGO:00508012120.015
erbb signaling pathwayGO:0038127230.015
cellular response to corticosteroid stimulusGO:0071384690.015
cardiac muscle tissue morphogenesisGO:005500810.014
negative regulation of nucleic acid templated transcriptionGO:19035071170.014
cellular catabolic processGO:00442482950.014
organ morphogenesisGO:0009887750.014
regulation of cell morphogenesisGO:0022604770.014
response to acid chemicalGO:00011012220.014
sex differentiationGO:00075481130.014
jak stat cascadeGO:0007259260.014
carboxylic acid biosynthetic processGO:0046394830.014
acid secretionGO:0046717480.014
axis specificationGO:000979840.014
myeloid cell differentiationGO:0030099220.014
positive regulation of transcription dna templatedGO:00458931970.014
regulation of behaviorGO:0050795610.014
olfactory learningGO:000835510.014
neuronal action potentialGO:0019228350.014
membrane hyperpolarizationGO:0060081110.014
establishment of protein localizationGO:00451841410.014
regulation of cellular component biogenesisGO:0044087860.014
apoptotic signaling pathwayGO:0097190270.014
purine ribonucleoside metabolic processGO:00461281680.014
response to transforming growth factor betaGO:0071559460.014
negative regulation of neuron deathGO:1901215690.014
regenerationGO:00310991630.014
regulation of cell growthGO:0001558850.013
peptidyl tyrosine modificationGO:0018212720.013
hematopoietic or lymphoid organ developmentGO:0048534360.013
urogenital system developmentGO:0001655780.013
nucleoside triphosphate catabolic processGO:00091431230.013
positive regulation of cellular component movementGO:00512721020.013
cellular ion homeostasisGO:00068731840.013
vasodilationGO:0042311440.013
myeloid leukocyte migrationGO:0097529200.013
intracellular protein transportGO:0006886790.013
male sex differentiationGO:0046661640.013
cell cell signaling involved in cell fate commitmentGO:004516820.013
response to corticosteroneGO:0051412400.013
forebrain developmentGO:0030900980.013
neuron projection morphogenesisGO:00488121220.013
organ formationGO:004864530.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
positive regulation of hydrolase activityGO:0051345860.013
cell fate commitment involved in pattern specificationGO:006058120.012
ribonucleoside triphosphate catabolic processGO:00092031220.012
development of primary sexual characteristicsGO:00451371070.012
reactive nitrogen species metabolic processGO:200105710.012
hindbrain morphogenesisGO:002157520.012
purine nucleotide catabolic processGO:00061951360.012
nucleobase containing compound catabolic processGO:00346551520.012
nuclear transportGO:0051169490.012
regulation of cellular catabolic processGO:00313291010.012
protein complex assemblyGO:00064612630.012
cytoplasmic transportGO:00164821150.012
positive regulation of mapk cascadeGO:0043410920.012
cellular response to acid chemicalGO:0071229750.012
muscle tissue developmentGO:0060537580.012

Prss22 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.026
disease of anatomical entityDOID:700.026
sensory system diseaseDOID:005015500.023
disease of metabolismDOID:001466700.020
inherited metabolic disorderDOID:65500.020
gastrointestinal system diseaseDOID:7700.013
musculoskeletal system diseaseDOID:1700.012