Rattus norvegicus

47 known processes

Slc12a5

solute carrier family 12 (potassium-chloride transporter), member 5

(Aliases: Kcc2)

Slc12a5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular component organizationGO:00511283680.347
ion transmembrane transportGO:00342203650.311
cell cell signalingGO:00072673350.307
regulation of nervous system developmentGO:00519602640.282
behaviorGO:00076102050.251
transmembrane transportGO:00550854120.221
cation transportGO:00068123820.208
synapse assemblyGO:0007416290.186
regulation of multicellular organismal developmentGO:20000263760.171
cation transmembrane transportGO:00986552630.166
regulation of secretion by cellGO:19035302080.165
cellular component biogenesisGO:00440853680.165
protein complex subunit organizationGO:00718223020.162
intracellular signal transductionGO:00355563140.160
secretionGO:00469033070.147
regulation of neuron differentiationGO:00456642080.139
cellular component assemblyGO:00226073600.133
organic acid transportGO:00158491160.131
positive regulation of cell developmentGO:00107201760.130
neurological system processGO:00508772190.125
secretion by cellGO:00329402480.124
locomotionGO:00400112370.122
central nervous system developmentGO:00074173110.121
head developmentGO:00603222470.120
response to extracellular stimulusGO:00099913800.119
brain developmentGO:00074202470.118
response to nutrient levelsGO:00316673700.108
neuron projection morphogenesisGO:00488121220.108
regulation of cellular localizationGO:00603412630.105
positive regulation of multicellular organismal processGO:00512403870.103
multi organism reproductive processGO:00447032620.103
regulation of cell differentiationGO:00455953200.102
learning or memoryGO:0007611900.097
anatomical structure morphogenesisGO:00096532980.094
response to inorganic substanceGO:00100353770.094
cellular amino acid metabolic processGO:00065201070.093
neuron differentiationGO:00301823680.093
neuron projection developmentGO:00311752730.090
nitrogen compound transportGO:00717052290.089
protein oligomerizationGO:00512591910.088
metal ion transportGO:00300012890.084
regulation of mapk cascadeGO:00434081160.082
anion transportGO:00068201780.081
reproductionGO:00000032450.080
cellular chemical homeostasisGO:00550822470.079
negative regulation of signalingGO:00230571570.078
regulation of membrane potentialGO:00423911100.078
positive regulation of signalingGO:00230562700.077
regulation of neurogenesisGO:00507672470.077
regulation of cell developmentGO:00602842630.073
organelle organizationGO:00069962660.071
inorganic ion transmembrane transportGO:00986602290.069
reproductive processGO:00224143720.068
macromolecular complex subunit organizationGO:00439333390.068
single organism reproductive processGO:00447022970.067
peptide secretionGO:0002790860.066
regulation of ion transportGO:00432692450.065
calcium dependent cell cell adhesion via plasma membrane cell adhesion moleculesGO:001633930.065
sensory perceptionGO:00076001010.064
cellular ion homeostasisGO:00068731840.063
inflammatory responseGO:00069541500.063
single organism behaviorGO:00447081300.063
sensory organ developmentGO:0007423740.063
multicellular organism reproductionGO:00325042330.063
regulation of signal transductionGO:00099663180.063
synaptic transmissionGO:00072682350.062
adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathwayGO:000719650.062
cellular homeostasisGO:00197252520.058
camera type eye developmentGO:0043010480.057
negative regulation of cell communicationGO:00106481580.056
macromolecule localizationGO:00330362520.056
sexual reproductionGO:00199531480.056
programmed cell deathGO:00125013920.055
eye developmentGO:0001654500.055
regulation of protein metabolic processGO:00512462890.055
positive regulation of transportGO:00510502450.055
nucleobase containing small molecule metabolic processGO:00550863160.054
cellular response to endogenous stimulusGO:00714953770.054
regulation of secretionGO:00510462240.052
eye morphogenesisGO:004859240.052
regulation of peptide secretionGO:0002791820.051
homeostatic processGO:00425923310.050
response to radiationGO:00093141370.050
regulation of neuron deathGO:19012141150.049
positive regulation of neuron differentiationGO:00456661260.049
rhythmic processGO:00485111560.049
signal transduction by phosphorylationGO:00230141440.049
calcium ion homeostasisGO:00550741620.048
defense responseGO:00069521940.048
localization of cellGO:00516742020.048
regulation of phosphate metabolic processGO:00192203490.046
carboxylic acid metabolic processGO:00197522890.046
synaptic transmission glutamatergicGO:0035249330.046
regulation of ion transmembrane transportGO:00347651210.046
synaptic growth at neuromuscular junctionGO:005112410.046
neuron developmentGO:00486662860.046
regulation of locomotionGO:00400121480.046
regulation of synaptic transmission glutamatergicGO:0051966260.046
associative learningGO:0008306190.045
cellular response to nitrogen compoundGO:19016992100.045
regulation of synapse structure and activityGO:0050803210.044
regulation of neuron projection developmentGO:00109751610.043
retina development in camera type eyeGO:0060041270.043
cell type specific apoptotic processGO:00972851340.042
organophosphate metabolic processGO:00196373700.041
growthGO:00400071650.040
multicellular organismal reproductive processGO:00486092330.040
positive regulation of phosphorus metabolic processGO:00105622620.040
regulation of phosphorylationGO:00423252480.040
protein complex assemblyGO:00064612630.040
positive regulation of developmental processGO:00510942830.040
response to ethanolGO:00454711620.040
glutamate receptor signaling pathwayGO:0007215430.040
regulation of transmembrane transportGO:00347621220.039
regulation of intracellular signal transductionGO:19025312180.039
ribonucleotide metabolic processGO:00092592310.038
regulation of cellular component movementGO:00512701500.038
regulation of vesicle mediated transportGO:0060627810.038
cognitionGO:0050890920.037
inorganic cation transmembrane transportGO:00986622020.037
regulation of cell proliferationGO:00421273590.036
organic acid metabolic processGO:00060822920.036
chemical homeostasisGO:00488782920.036
negative regulation of cell deathGO:00605482290.035
positive regulation of signal transductionGO:00099671750.035
cellular response to oxygen containing compoundGO:19017013860.035
transcription dna templatedGO:00063513770.034
circadian rhythmGO:0007623880.034
cell projection organizationGO:00300303020.034
response to transition metal nanoparticleGO:19902671220.034
positive regulation of cell deathGO:00109421840.034
positive regulation of nitrogen compound metabolic processGO:00511733340.033
cellular response to external stimulusGO:00714961180.033
regulation of endocytosisGO:0030100420.033
negative regulation of response to stimulusGO:00485851550.032
cell motilityGO:00488702020.032
cell morphogenesis involved in differentiationGO:00009041190.032
cellular response to organic cyclic compoundGO:00714072020.032
apoptotic processGO:00069153810.031
response to monosaccharideGO:00342841590.031
positive regulation of immunoglobulin productionGO:000263940.030
oxoacid metabolic processGO:00434362900.030
organ morphogenesisGO:0009887750.030
positive regulation of synaptic transmissionGO:0050806620.030
potassium ion transportGO:0006813970.030
signal releaseGO:00230611450.030
response to oxygen levelsGO:00704822650.030
macromolecular complex assemblyGO:00650032730.030
positive regulation of cell differentiationGO:00455972170.030
positive regulation of molecular functionGO:00440932300.029
regulation of synaptic transmissionGO:00508041410.029
regulation of phosphorus metabolic processGO:00511743490.029
erk1 and erk2 cascadeGO:0070371480.029
cell part morphogenesisGO:00329901230.029
cation homeostasisGO:00550801950.029
positive regulation of neurogenesisGO:00507691650.029
protein transportGO:00150311320.029
mapk cascadeGO:00001651400.029
second messenger mediated signalingGO:0019932510.028
insulin secretionGO:0030073690.028
response to metal ionGO:00100382530.028
regulation of peptide hormone secretionGO:0090276800.028
positive regulation of cell proliferationGO:00082842490.028
peptide transportGO:0015833970.028
response to glucocorticoidGO:00513842230.027
cellular amine metabolic processGO:0044106380.027
nucleotide metabolic processGO:00091172790.027
carbohydrate homeostasisGO:0033500750.027
response to toxic substanceGO:00096361330.026
regulation of synaptic vesicle recyclingGO:190342110.026
cell projection morphogenesisGO:00488581230.026
negative regulation of transportGO:00510511360.026
regulation of insulin secretionGO:0050796650.026
regulation of neurotransmitter levelsGO:0001505420.026
organic anion transportGO:00157111320.026
regulation of cell migrationGO:00303341280.026
urinary tract smooth muscle contractionGO:001484840.026
protein phosphorylationGO:00064683450.025
protein localizationGO:00081041910.025
nucleoside phosphate metabolic processGO:00067532830.025
negative regulation of hormone secretionGO:0046888460.025
positive regulation of neuron projection developmentGO:0010976990.025
regulation of molecular functionGO:00650093980.025
positive regulation of gene expressionGO:00106282440.025
response to carbohydrateGO:00097431830.025
positive regulation of catalytic activityGO:00430851840.025
regulation of cellular amine metabolic processGO:003323880.025
divalent inorganic cation homeostasisGO:00725071650.025
purine containing compound metabolic processGO:00725212530.025
negative regulation of response to extracellular stimulusGO:003210570.025
regulation of neurotransmitter secretionGO:0046928190.025
serotonin metabolic processGO:004242830.025
response to decreased oxygen levelsGO:00362932370.025
memoryGO:0007613540.024
response to mechanical stimulusGO:00096121340.024
rhythmic synaptic transmissionGO:006002410.024
phosphatidylinositol dephosphorylationGO:004685640.024
positive regulation of cellular amine metabolic processGO:003324030.024
positive regulation of nervous system developmentGO:00519621780.024
regulation of hydrolase activityGO:00513361430.024
gamete generationGO:00072761240.024
positive regulation of cellular component organizationGO:00511302000.024
single organism intracellular transportGO:19025821660.024
regulation of ion transmembrane transporter activityGO:0032412480.024
divalent metal ion transportGO:00708381320.023
cell migrationGO:00164771970.023
learningGO:0007612330.023
acid secretionGO:0046717480.023
axis specificationGO:000979840.023
positive regulation of phosphorylationGO:00423271770.023
response to hexoseGO:00097461440.023
intracellular transportGO:00469071850.023
single organism catabolic processGO:00447122830.023
organophosphate catabolic processGO:00464341480.023
positive regulation of locomotionGO:00400171020.023
regulation of apoptotic processGO:00429813350.023
positive regulation of intracellular signal transductionGO:19025331380.022
regulation of cell motilityGO:20001451310.022
actin filament based processGO:0030029860.022
regulation of cellular amino acid metabolic processGO:000652120.022
regulation of synapse assemblyGO:0051963150.022
cellular potassium ion transportGO:0071804720.022
carboxylic acid transportGO:00469421150.022
cytoskeleton organizationGO:00070101110.022
response to light stimulusGO:0009416520.022
cellular response to abiotic stimulusGO:0071214850.021
cellular response to organonitrogen compoundGO:00714171970.021
regulation of metal ion transportGO:00109591180.021
alpha amino acid metabolic processGO:1901605710.021
response to corticosteroidGO:00319602350.021
cellular component movementGO:00069282480.021
negative regulation of macromolecule metabolic processGO:00106052600.021
negative regulation of cellular metabolic processGO:00313242810.021
regulation of cellular component biogenesisGO:0044087860.021
circulatory system processGO:00030131830.021
positive regulation of cell communicationGO:00106472710.020
purine ribonucleoside triphosphate catabolic processGO:00092071220.020
developmental process involved in reproductionGO:00030061590.020
ribose phosphate metabolic processGO:00196932350.020
organophosphate biosynthetic processGO:00904071430.020
dicarboxylic acid transportGO:0006835340.020
embryonic pattern specificationGO:000988010.020
organic hydroxy compound metabolic processGO:19016151150.020
cellular divalent inorganic cation homeostasisGO:00725031620.020
positive regulation of response to stimulusGO:00485842850.020
glycosyl compound metabolic processGO:19016571820.020
protein heterooligomerizationGO:0051291890.020
multicellular organism growthGO:003526410.020
cellular calcium ion homeostasisGO:00068741600.020
regulation of transporter activityGO:0032409500.019
cellular lipid metabolic processGO:00442552080.019
adult locomotory behaviorGO:000834440.019
enzyme linked receptor protein signaling pathwayGO:00071671160.019
feeding behaviorGO:0007631530.019
response to histamineGO:003477630.019
hormone transportGO:00099141210.019
cytosolic calcium ion homeostasisGO:00514801400.019
regulation of cellular protein metabolic processGO:00322682670.019
ribonucleoside triphosphate metabolic processGO:00091991410.019
purine ribonucleoside metabolic processGO:00461281680.019
aromatic compound catabolic processGO:00194391680.019
calcium mediated signalingGO:0019722230.019
single organism membrane organizationGO:0044802740.019
regulation of peptide transportGO:0090087870.019
negative regulation of ion transportGO:0043271510.019
ionotropic glutamate receptor signaling pathwayGO:0035235340.019
negative regulation of metabolic processGO:00098923310.019
positive regulation of apoptotic processGO:00430651540.019
gliogenesisGO:0042063930.018
response to oxidative stressGO:00069791860.018
neuron apoptotic processGO:0051402880.018
organonitrogen compound catabolic processGO:19015651790.018
regulation of cell projection organizationGO:00313441750.018
potassium ion transmembrane transportGO:0071805710.018
neurotransmitter secretionGO:0007269330.018
carbohydrate derivative metabolic processGO:19011353460.018
regulation of catalytic activityGO:00507903040.018
positive regulation of ion transportGO:0043270940.017
saliva secretionGO:004654130.017
response to glucoseGO:00097491360.017
response to nicotineGO:0035094510.017
cellular ketone metabolic processGO:0042180510.017
blood circulationGO:00080151830.017
cellular amino acid biosynthetic processGO:0008652320.017
regulation of system processGO:00440572080.017
ribonucleoside metabolic processGO:00091191740.017
monoamine transportGO:0015844430.017
phospholipid metabolic processGO:0006644610.017
positive regulation of phosphate metabolic processGO:00459372620.017
regulation of purine nucleotide metabolic processGO:19005421150.017
regulation of hormone secretionGO:00468831060.016
cell cycleGO:00070491010.016
single organism organelle organizationGO:19025891800.016
positive regulation of endocytosisGO:0045807280.016
cytoplasmic transportGO:00164821150.016
cellular response to growth factor stimulusGO:00713631620.016
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.016
nucleoside triphosphate catabolic processGO:00091431230.016
regulation of organelle organizationGO:0033043800.016
metal ion homeostasisGO:00550651860.016
nucleoside metabolic processGO:00091161790.016
regulation of transmembrane transporter activityGO:0022898490.016
anterior posterior pattern specificationGO:000995210.015
monovalent inorganic cation transportGO:00156721720.015
response to cytokineGO:00340972150.015
purine nucleoside metabolic processGO:00422781690.015
amide transportGO:00428861050.015
response to alkaloidGO:00432791320.015
regulation of homeostatic processGO:00328441010.015
regulation of blood circulationGO:19035221100.015
nucleotide biosynthetic processGO:0009165980.015
catabolic processGO:00090563510.015
divalent inorganic cation transportGO:00725111340.015
negative regulation of g protein coupled receptor protein signaling pathwayGO:0045744150.015
tissue developmentGO:00098882520.015
positive regulation of cellular amino acid metabolic processGO:004576410.015
regulation of cellular catabolic processGO:00313291010.015
heart contractionGO:0060047570.015
ras protein signal transductionGO:0007265290.015
regulation of synaptic growth at neuromuscular junctionGO:000858210.015
negative adaptation of signaling pathwayGO:0022401100.015
axon developmentGO:0061564960.015
negative regulation of neuron apoptotic processGO:0043524450.015
lipid metabolic processGO:00066292830.014
peptidyl amino acid modificationGO:00181931260.014
leukocyte cell cell adhesionGO:000715940.014
peptide hormone secretionGO:0030072840.014
purine nucleotide metabolic processGO:00061632290.014
purine ribonucleotide metabolic processGO:00091502270.014
cellular component maintenanceGO:004395440.014
ion homeostasisGO:00508012120.014
cellular response to stressGO:00335542690.014
camera type eye morphogenesisGO:004859320.014
cellular response to glucose stimulusGO:0071333650.014
regulation of response to external stimulusGO:00321011060.014
purine ribonucleotide catabolic processGO:00091541360.014
regulation of nucleic acid templated transcriptionGO:19035063800.014
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activityGO:2000311110.014
glycerolipid metabolic processGO:0046486670.014
regulation of programmed cell deathGO:00430673410.014
calcium ion dependent exocytosis of neurotransmitterGO:004879120.014
glucose homeostasisGO:0042593750.014
heart morphogenesisGO:000300730.014
response to vitaminGO:00332731310.014
regulation of synapse organizationGO:0050807190.014
negative regulation of biosynthetic processGO:00098901680.014
positive regulation of secretion by cellGO:19035321280.014
hormone secretionGO:00468791150.014
positive regulation of cellular biosynthetic processGO:00313282950.014
developmental growthGO:00485891000.013
peristalsisGO:003043220.013
presynaptic membrane organizationGO:009709040.013
small gtpase mediated signal transductionGO:0007264360.013
digestive system processGO:0022600240.013
positive regulation of macromolecule biosynthetic processGO:00105572470.013
cellular response to hexose stimulusGO:0071331650.013
telencephalon developmentGO:0021537620.013
regulation of saliva secretionGO:004687730.013
response to hypoxiaGO:00016662310.013
cardiac muscle cell contractionGO:0086003100.013
response to biotic stimulusGO:00096072260.013
calcium ion transmembrane transportGO:0070588700.013
protein homooligomerizationGO:0051260910.013
activation of mapkkk activityGO:000018510.013
maintenance of protein location in plasma membraneGO:007266010.013
dephosphorylationGO:0016311980.013
cellular metal ion homeostasisGO:00068751720.013
regulation of smooth muscle cell proliferationGO:0048660750.013
negative regulation of programmed cell deathGO:00430691830.013
negative regulation of apoptotic processGO:00430661810.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.012
insulin like growth factor receptor signaling pathwayGO:004800930.012
organonitrogen compound biosynthetic processGO:19015661670.012
agingGO:00075682410.012
neurotransmitter transportGO:0006836420.012
cellular component morphogenesisGO:00329891550.012
regulation of cellular ketone metabolic processGO:0010565270.012
cell morphogenesisGO:00009021420.012
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.012
male gamete generationGO:0048232990.012
vesicle mediated transportGO:00161921810.012
response to ketoneGO:19016541820.012
vascular process in circulatory systemGO:0003018960.012
smooth muscle cell proliferationGO:0048659770.012
positive regulation of mapk cascadeGO:0043410920.012
regulation of growthGO:00400081050.012
purine nucleoside catabolic processGO:00061521240.012
spindle organizationGO:000705120.012
cell activationGO:0001775970.012
protein complex biogenesisGO:00702712630.012
regulation of small gtpase mediated signal transductionGO:0051056480.012
spermatogenesisGO:0007283990.012
inflammatory response to antigenic stimulusGO:0002437180.012
response to external biotic stimulusGO:00432072210.012
leptin mediated signaling pathwayGO:003321030.012
negative regulation of secretionGO:0051048820.012
regulation of rna metabolic processGO:00512523910.012
somatostatin receptor signaling pathwayGO:003816940.012
positive regulation of nucleobase containing compound metabolic processGO:00459353190.012
olfactory behaviorGO:004204820.012
transcription from rna polymerase ii promoterGO:00063662520.011
rna metabolic processGO:00160704060.011
synaptic vesicle endocytosisGO:004848840.011
desensitization of g protein coupled receptor protein signaling pathwayGO:0002029100.011
regulation of anatomical structure sizeGO:00900661350.011
neuron deathGO:00709971270.011
sex differentiationGO:00075481130.011
asymmetric stem cell divisionGO:009872220.011
response to acid chemicalGO:00011012220.011
secretion by tissueGO:0032941370.011
nucleic acid templated transcriptionGO:00976593790.011
forebrain developmentGO:0030900980.011
negative regulation of peptide hormone secretionGO:0090278300.011
calcium ion transportGO:00068161310.011
response to growth factorGO:00708481890.011
mechanoreceptor differentiationGO:004249020.011
response to ammonium ionGO:0060359710.011
long term memoryGO:0007616150.011
negative regulation of multicellular organismal processGO:00512412030.011
adenylate cyclase inhibiting g protein coupled receptor signaling pathwayGO:0007193190.011
cellular macromolecule localizationGO:00707271220.011
embryonic axis specificationGO:000057810.011
g protein coupled receptor signaling pathwayGO:00071862420.011
negative regulation of signal transductionGO:0009968830.011
presynaptic membrane assemblyGO:009710530.011
somatostatin signaling pathwayGO:003817040.011
membrane hyperpolarizationGO:0060081110.011
single organism cellular localizationGO:19025801020.011
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.011
reproductive system developmentGO:00614581280.010
positive regulation of synaptic vesicle transportGO:190280530.010
micturitionGO:006007340.010
regulation of blood vessel sizeGO:0050880890.010
positive regulation of hydrolase activityGO:0051345860.010
response to antibioticGO:0046677390.010
response to electrical stimulusGO:0051602560.010
sensory perception of bitter tasteGO:005091340.010
cell growthGO:00160491040.010
cellular response to alcoholGO:0097306870.010
female pregnancyGO:00075651220.010
early endosome to late endosome transportGO:004502220.010
phototransduction visible lightGO:000760320.010
regulation of organ formationGO:000315620.010
positive regulation of protein phosphorylationGO:00019341350.010
regulation of response to foodGO:0032095110.010
positive regulation of peptide hormone secretionGO:0090277500.010

Slc12a5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.026
disease of anatomical entityDOID:700.026
central nervous system diseaseDOID:33100.021
brain diseaseDOID:93600.021
disease of metabolismDOID:001466700.021
epilepsy syndromeDOID:182600.012