Rattus norvegicus

26 known processes

Slc12a3

solute carrier family 12 (sodium/chloride transporters), member 3

(Aliases: NCC,TSC)

Slc12a3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to extracellular stimulusGO:00099913800.644
ion transmembrane transportGO:00342203650.553
cation transmembrane transportGO:00986552630.532
response to nutrient levelsGO:00316673700.474
response to oxygen levelsGO:00704822650.361
response to inorganic substanceGO:00100353770.323
regulation of secretionGO:00510462240.275
regulation of molecular functionGO:00650093980.232
inorganic cation transmembrane transportGO:00986622020.214
neurological system processGO:00508772190.193
blood circulationGO:00080151830.192
establishment of protein localizationGO:00451841410.177
Rat
regulation of secretion by cellGO:19035302080.174
cell cell signalingGO:00072673350.174
intracellular signal transductionGO:00355563140.173
negative regulation of multicellular organismal processGO:00512412030.172
transmembrane transportGO:00550854120.162
regulation of phosphorylationGO:00423252480.158
circulatory system processGO:00030131830.158
organic acid metabolic processGO:00060822920.156
carbohydrate derivative metabolic processGO:19011353460.145
positive regulation of phosphorus metabolic processGO:00105622620.137
positive regulation of multicellular organismal processGO:00512403870.135
regulation of cell proliferationGO:00421273590.132
cell type specific apoptotic processGO:00972851340.131
regulation of multicellular organismal developmentGO:20000263760.127
organonitrogen compound biosynthetic processGO:19015661670.122
cellular response to endogenous stimulusGO:00714953770.117
purine nucleotide metabolic processGO:00061632290.116
oxoacid metabolic processGO:00434362900.113
lipid metabolic processGO:00066292830.108
Rat
metal ion transportGO:00300012890.106
organic substance catabolic processGO:19015753160.105
nucleoside phosphate metabolic processGO:00067532830.105
response to nutrientGO:00075842480.105
carboxylic acid metabolic processGO:00197522890.104
inorganic ion transmembrane transportGO:00986602290.102
cellular response to organonitrogen compoundGO:00714171970.102
positive regulation of nucleobase containing compound metabolic processGO:00459353190.101
nucleotide metabolic processGO:00091172790.099
purine ribonucleoside triphosphate metabolic processGO:00092051400.093
regulation of cell differentiationGO:00455953200.091
response to nicotineGO:0035094510.091
positive regulation of cell proliferationGO:00082842490.090
synaptic transmissionGO:00072682350.089
regulation of phosphate metabolic processGO:00192203490.089
positive regulation of phosphate metabolic processGO:00459372620.087
response to hypoxiaGO:00016662310.086
positive regulation of protein metabolic processGO:00512471780.085
regulation of phosphorus metabolic processGO:00511743490.085
regulation of catalytic activityGO:00507903040.085
nitrogen compound transportGO:00717052290.085
response to decreased oxygen levelsGO:00362932370.084
purine ribonucleotide metabolic processGO:00091502270.082
rhythmic processGO:00485111560.081
response to cytokineGO:00340972150.080
nucleobase containing small molecule metabolic processGO:00550863160.079
cellular component biogenesisGO:00440853680.079
tissue developmentGO:00098882520.079
secretion by cellGO:00329402480.079
regulation of programmed cell deathGO:00430673410.077
response to organophosphorusGO:00466831020.077
ribonucleotide metabolic processGO:00092592310.075
positive regulation of catalytic activityGO:00430851840.075
positive regulation of nucleotide metabolic processGO:0045981910.074
catabolic processGO:00090563510.073
cellular response to oxygen containing compoundGO:19017013860.073
amine metabolic processGO:0009308380.072
regulation of system processGO:00440572080.072
cellular amine metabolic processGO:0044106380.070
glycosyl compound metabolic processGO:19016571820.069
regulation of cellular localizationGO:00603412630.069
purine containing compound metabolic processGO:00725212530.069
organophosphate metabolic processGO:00196373700.069
purine nucleoside catabolic processGO:00061521240.069
programmed cell deathGO:00125013920.068
homeostatic processGO:00425923310.067
Rat
regulation of apoptotic processGO:00429813350.067
macromolecular complex subunit organizationGO:00439333390.067
positive regulation of transportGO:00510502450.066
protein phosphorylationGO:00064683450.066
regulation of purine nucleotide metabolic processGO:19005421150.064
response to transition metal nanoparticleGO:19902671220.063
response to peptide hormoneGO:00434342780.063
single organism catabolic processGO:00447122830.062
positive regulation of developmental processGO:00510942830.062
cellular amino acid metabolic processGO:00065201070.060
secretionGO:00469033070.060
regulation of membrane potentialGO:00423911100.058
apoptotic processGO:00069153810.058
chemical homeostasisGO:00488782920.058
response to acid chemicalGO:00011012220.056
response to metal ionGO:00100382530.056
response to purine containing compoundGO:00140741260.056
monovalent inorganic cation transportGO:00156721720.056
ribose phosphate metabolic processGO:00196932350.054
positive regulation of protein phosphorylationGO:00019341350.054
regulation of anatomical structure sizeGO:00900661350.054
nucleobase containing compound catabolic processGO:00346551520.053
purine ribonucleoside catabolic processGO:00461301240.053
protein complex biogenesisGO:00702712630.053
positive regulation of biosynthetic processGO:00098913190.053
response to ketoneGO:19016541820.052
positive regulation of ion transportGO:0043270940.052
purine nucleoside triphosphate catabolic processGO:00091461220.051
negative regulation of signalingGO:00230571570.051
negative regulation of cell deathGO:00605482290.051
cellular component assemblyGO:00226073600.051
positive regulation of nitrogen compound metabolic processGO:00511733340.050
circadian rhythmGO:0007623880.050
positive regulation of cell communicationGO:00106472710.050
macromolecular complex assemblyGO:00650032730.049
single organism biosynthetic processGO:00447113420.049
negative regulation of response to stimulusGO:00485851550.049
regulation of tube sizeGO:0035150890.049
ribonucleoside metabolic processGO:00091191740.048
cellular ketone metabolic processGO:0042180510.048
cellular protein localizationGO:00346131220.047
Rat
response to radiationGO:00093141370.046
reproductionGO:00000032450.046
regulation of cellular amine metabolic processGO:003323880.046
regulation of homeostatic processGO:00328441010.046
nucleoside catabolic processGO:00091641260.046
multicellular organism reproductionGO:00325042330.045
peptide secretionGO:0002790860.045
cellular component movementGO:00069282480.045
protein complex assemblyGO:00064612630.045
ribonucleoside triphosphate metabolic processGO:00091991410.044
peptidyl amino acid modificationGO:00181931260.043
nucleoside phosphate catabolic processGO:19012921400.043
neuron deathGO:00709971270.043
protein transportGO:00150311320.043
small gtpase mediated signal transductionGO:0007264360.043
sensory perception of painGO:0019233730.042
locomotionGO:00400112370.042
aromatic compound catabolic processGO:00194391680.042
cellular macromolecule localizationGO:00707271220.041
Rat
positive regulation of signal transductionGO:00099671750.041
regulation of blood pressureGO:0008217830.041
ossificationGO:0001503700.041
urogenital system developmentGO:0001655780.040
cellular response to abiotic stimulusGO:0071214850.040
regulation of hormone levelsGO:00108171870.040
intracellular transportGO:00469071850.040
carbohydrate homeostasisGO:0033500750.040
g protein coupled receptor signaling pathwayGO:00071862420.040
Rat
positive regulation of cellular amino acid metabolic processGO:004576410.040
anatomical structure morphogenesisGO:00096532980.040
cation transportGO:00068123820.040
purine ribonucleotide biosynthetic processGO:0009152810.039
organelle organizationGO:00069962660.039
negative regulation of programmed cell deathGO:00430691830.039
cellular response to hormone stimulusGO:00328702470.038
regulation of nucleotide metabolic processGO:00061401170.038
multicellular organismal homeostasisGO:0048871490.038
cellular response to nitrogen compoundGO:19016992100.038
regulation of blood circulationGO:19035221100.037
positive regulation of molecular functionGO:00440932300.037
positive regulation of purine nucleotide metabolic processGO:1900544910.037
regulation of protein metabolic processGO:00512462890.037
positive regulation of cell differentiationGO:00455972170.037
response to alkaloidGO:00432791320.037
negative regulation of apoptotic processGO:00430661810.037
regulation of cell migrationGO:00303341280.037
action potentialGO:0001508540.037
single organism reproductive processGO:00447022970.037
organonitrogen compound catabolic processGO:19015651790.036
ion homeostasisGO:00508012120.036
response to ethanolGO:00454711620.036
male mating behaviorGO:006017930.036
positive regulation of cellular biosynthetic processGO:00313282950.036
neuron apoptotic processGO:0051402880.036
organophosphate catabolic processGO:00464341480.035
purine ribonucleoside metabolic processGO:00461281680.035
purine nucleoside metabolic processGO:00422781690.035
regulation of cellular protein metabolic processGO:00322682670.035
macromolecule localizationGO:00330362520.035
Rat
sensory perceptionGO:00076001010.034
regulation of ion transportGO:00432692450.034
cellular homeostasisGO:00197252520.034
Rat
positive regulation of cellular protein metabolic processGO:00322701670.034
response to woundingGO:00096112540.034
regulation of cellular amino acid metabolic processGO:000652120.034
positive regulation of cyclic nucleotide metabolic processGO:0030801370.034
response to hexoseGO:00097461440.034
positive regulation of phosphorylationGO:00423271770.033
circulatory system developmentGO:00723591340.033
regulation of protein modification processGO:00313991940.033
nucleotide catabolic processGO:00091661390.033
immune system processGO:00023762040.033
carbohydrate derivative catabolic processGO:19011361470.032
regulation of peptide secretionGO:0002791820.032
heart morphogenesisGO:000300730.032
nucleoside triphosphate metabolic processGO:00091411440.032
regulation of cytoskeleton organizationGO:0051493490.032
response to starvationGO:0042594590.032
single organism intracellular transportGO:19025821660.032
regulation of cellular ketone metabolic processGO:0010565270.032
regulation of signal transductionGO:00099663180.031
regulation of hydrolase activityGO:00513361430.031
regulation of organelle organizationGO:0033043800.030
positive regulation of secretionGO:00510471400.030
negative regulation of response to foodGO:003209670.030
regulation of ion homeostasisGO:2000021630.030
regulation of protein localizationGO:0032880810.030
regulation of purine nucleotide catabolic processGO:0033121650.030
nucleic acid templated transcriptionGO:00976593790.030
reproductive processGO:00224143720.030
regulation of cellular catabolic processGO:00313291010.030
negative regulation of cell developmentGO:0010721820.030
positive regulation of protein modification processGO:00314011420.030
regulation of neuron apoptotic processGO:0043523830.029
endocytosisGO:0006897840.029
multi multicellular organism processGO:00447061380.029
actin filament based processGO:0030029860.029
protein localizationGO:00081041910.029
Rat
epithelium developmentGO:0060429960.029
positive regulation of hydrolase activityGO:0051345860.028
cell motilityGO:00488702020.028
signal releaseGO:00230611450.028
carbohydrate metabolic processGO:00059751300.028
multicellular organismal reproductive processGO:00486092330.028
response to other organismGO:00517072200.028
positive regulation of cellular component organizationGO:00511302000.027
organic cyclic compound catabolic processGO:19013611750.027
developmental growthGO:00485891000.027
positive regulation of cellular amine metabolic processGO:003324030.027
positive regulation of cellular catabolic processGO:0031331710.027
regenerationGO:00310991630.027
response to estrogenGO:00436272320.027
peptide transportGO:0015833970.026
positive regulation of camp biosynthetic processGO:0030819280.026
cellular nitrogen compound catabolic processGO:00442701630.026
localization of cellGO:00516742020.026
ras protein signal transductionGO:0007265290.026
cell projection organizationGO:00300303020.026
regulation of growthGO:00400081050.026
glucose homeostasisGO:0042593750.026
sodium ion transmembrane transportGO:0035725670.026
response to glucoseGO:00097491360.026
positive regulation of nervous system developmentGO:00519621780.026
sequestering of metal ionGO:005123890.026
growthGO:00400071650.025
cardiovascular system developmentGO:00723581340.025
response to reactive oxygen speciesGO:00003021200.025
response to campGO:0051591910.025
inflammatory responseGO:00069541500.025
regulation of neuron deathGO:19012141150.025
response to monosaccharideGO:00342841590.025
organophosphate biosynthetic processGO:00904071430.025
cytoplasmic transportGO:00164821150.025
regulation of kinase activityGO:00435491170.025
amide transportGO:00428861050.025
response to carbohydrateGO:00097431830.025
regulation of nucleotide catabolic processGO:0030811650.024
carbohydrate derivative biosynthetic processGO:19011371240.024
ribonucleoside triphosphate catabolic processGO:00092031220.024
cellular response to stressGO:00335542690.024
cyclic nucleotide biosynthetic processGO:0009190630.024
regulation of intracellular signal transductionGO:19025312180.024
maintenance of locationGO:0051235170.024
purine nucleoside triphosphate metabolic processGO:00091441410.024
calcium ion homeostasisGO:00550741620.024
positive regulation of catabolic processGO:0009896780.024
heart contractionGO:0060047570.024
positive regulation of protein kinase activityGO:0045860730.024
regulation of transmembrane transportGO:00347621220.024
regulation of protein phosphorylationGO:00019321830.023
ribonucleotide biosynthetic processGO:0009260850.023
rna biosynthetic processGO:00327743800.023
peptide hormone secretionGO:0030072840.023
vesicle mediated transportGO:00161921810.023
regulation of rna biosynthetic processGO:20011413810.023
peptidyl tyrosine phosphorylationGO:0018108720.023
regulation of catabolic processGO:00098941130.023
cellular catabolic processGO:00442482950.023
protein homooligomerizationGO:0051260910.022
purine containing compound catabolic processGO:00725231380.022
cellular lipid metabolic processGO:00442552080.022
Rat
response to mechanical stimulusGO:00096121340.022
hormone metabolic processGO:0042445690.022
agingGO:00075682410.022
Rat
regulation of nucleoside metabolic processGO:0009118660.022
response to light stimulusGO:0009416520.022
ribonucleoside catabolic processGO:00424541260.022
signal transduction by phosphorylationGO:00230141440.021
multicellular organismal response to stressGO:0033555250.021
regulation of neurogenesisGO:00507672470.021
regulation of cellular component movementGO:00512701500.021
hormone secretionGO:00468791150.021
positive regulation of cyclic nucleotide biosynthetic processGO:0030804340.021
response to molecule of bacterial originGO:00022371940.021
regulation of cell developmentGO:00602842630.021
protein complex subunit organizationGO:00718223020.021
positive regulation of signalingGO:00230562700.021
response to oxidative stressGO:00069791860.021
response to estradiolGO:00323551640.021
regulation of small gtpase mediated signal transductionGO:0051056480.021
purine nucleotide catabolic processGO:00061951360.021
nucleoside triphosphate catabolic processGO:00091431230.021
cellular response to external stimulusGO:00714961180.021
cell migrationGO:00164771970.020
positive regulation of peptide hormone secretionGO:0090277500.020
cardiac muscle tissue morphogenesisGO:005500810.020
purine ribonucleoside triphosphate catabolic processGO:00092071220.020
response to corticosteroidGO:00319602350.020
response to lipopolysaccharideGO:00324961910.020
heterocycle catabolic processGO:00467001670.020
regulation of leukocyte activationGO:0002694450.020
sensory perception of light stimulusGO:005095330.020
protein oligomerizationGO:00512591910.020
purine nucleotide biosynthetic processGO:0006164830.020
gonad developmentGO:00084061040.020
multi organism reproductive processGO:00447032620.020
cellular response to tumor necrosis factorGO:0071356460.020
vascular process in circulatory systemGO:0003018960.020
guanosine containing compound catabolic processGO:1901069710.019
anion transmembrane transportGO:0098656770.019
regulation of fat cell differentiationGO:004559830.019
divalent inorganic cation transportGO:00725111340.019
potassium ion transportGO:0006813970.019
Rat Fly
positive regulation of macromolecule biosynthetic processGO:00105572470.019
regulation of transcription dna templatedGO:00063553740.019
alpha amino acid metabolic processGO:1901605710.019
apoptotic signaling pathwayGO:0097190270.019
potassium ion transmembrane transportGO:0071805710.019
protein processingGO:0016485680.019
cellular response to hexose stimulusGO:0071331650.019
regulation of peptide transportGO:0090087870.019
exploration behaviorGO:003564010.019
neuron neuron synaptic transmissionGO:0007270600.019
regulation of feeding behaviorGO:0060259140.018
embryonic pattern specificationGO:000988010.018
male gonad developmentGO:0008584590.018
mapk cascadeGO:00001651400.018
regulation of cell activationGO:0050865500.018
purine ribonucleotide catabolic processGO:00091541360.018
neuronal action potentialGO:0019228350.018
regulation of neurological system processGO:0031644430.018
response to glucocorticoidGO:00513842230.018
positive regulation of cell deathGO:00109421840.018
sequestering of calcium ionGO:005120880.018
behaviorGO:00076102050.017
ribonucleotide catabolic processGO:00092611360.017
adult behaviorGO:0030534160.017
learningGO:0007612330.017
regulation of cell motilityGO:20001451310.017
negative regulation of signal transductionGO:0009968830.017
glycosyl compound catabolic processGO:19016581260.017
positive regulation of kinase activityGO:0033674770.017
development of primary sexual characteristicsGO:00451371070.017
regulation of vesicle mediated transportGO:0060627810.017
cellular response to organic cyclic compoundGO:00714072020.017
cellular ion homeostasisGO:00068731840.017
regulation of transmembrane transporter activityGO:0022898490.017
positive regulation of programmed cell deathGO:00430681570.017
adult locomotory behaviorGO:000834440.017
palate developmentGO:006002120.017
reproductive behaviorGO:0019098100.016
brain developmentGO:00074202470.016
positive regulation of cyclase activityGO:0031281150.016
visual perceptionGO:000760130.016
sex differentiationGO:00075481130.016
negative regulation of neurogenesisGO:0050768780.016
excretionGO:0007588240.016
regulation of establishment of protein localizationGO:0070201690.016
response to peptideGO:19016522920.016
nucleoside phosphate biosynthetic processGO:19012931020.016
peptidyl tyrosine modificationGO:0018212720.016
regulation of transcription from rna polymerase ii promoterGO:00063572340.016
gtp metabolic processGO:0046039720.016
regulation of immune system processGO:00026821230.016
cellular response to glucose stimulusGO:0071333650.016
heart developmentGO:0007507720.016
regulation of blood vessel sizeGO:0050880890.016
defense responseGO:00069521940.016
cation homeostasisGO:00550801950.016
jak stat cascadeGO:0007259260.016
reproductive structure developmentGO:00486081280.016
regulation of actin filament based processGO:0032970420.016
positive regulation of cell migrationGO:0030335960.016
negative regulation of neuron deathGO:1901215690.016
cellular chemical homeostasisGO:00550822470.016
single organism behaviorGO:00447081300.015
positive regulation of response to stimulusGO:00485842850.015
positive regulation of leukocyte activationGO:0002696300.015
mechanoreceptor differentiationGO:004249020.015
rna metabolic processGO:00160704060.015
response to cgmpGO:007030530.015
positive regulation of purine nucleotide biosynthetic processGO:1900373360.015
cell activationGO:0001775970.015
renal system developmentGO:0072001670.015
response to temperature stimulusGO:0009266940.015
cyclic nucleotide metabolic processGO:0009187800.015
regulation of neuron projection developmentGO:00109751610.015
regulation of rna metabolic processGO:00512523910.015
neuron developmentGO:00486662860.015
cellular response to peptideGO:19016531330.015
neuromuscular synaptic transmissionGO:000727420.014
membrane hyperpolarizationGO:0060081110.014
biological adhesionGO:00226101100.014
neuron projection developmentGO:00311752730.014
positive regulation of synaptic transmissionGO:0050806620.014
transcription dna templatedGO:00063513770.014
regulation of developmental growthGO:0048638450.014
guanosine containing compound metabolic processGO:1901068740.014
negative regulation of sequestering of calcium ionGO:0051283250.014
positive regulation of immune responseGO:0050778420.014
cellular potassium ion transportGO:0071804720.014
regulation of ras protein signal transductionGO:0046578450.014
positive regulation of cell activationGO:0050867340.014
oxidation reduction processGO:00551143040.014
cartilage development involved in endochondral bone morphogenesisGO:006035130.014
regulation of peptide hormone secretionGO:0090276800.014
wound healing spreading of epidermal cellsGO:003531320.014
nucleoside metabolic processGO:00091161790.014
positive regulation of organelle organizationGO:0010638480.013
organ morphogenesisGO:0009887750.013
nucleotide biosynthetic processGO:0009165980.013
response to tumor necrosis factorGO:0034612560.013
wound healingGO:00420601220.013
response to external biotic stimulusGO:00432072210.013
positive regulation of cell motilityGO:2000147970.013
cellular cation homeostasisGO:00300031800.013
epiboly involved in wound healingGO:009050520.013
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.013
regulation of cyclic nucleotide metabolic processGO:0030799510.013
negative regulation of cell communicationGO:00106481580.013
enzyme linked receptor protein signaling pathwayGO:00071671160.013
protein secretionGO:0009306340.013
anatomical structure homeostasisGO:0060249290.013
olfactory learningGO:000835510.013
cellular response to drugGO:0035690300.013
regulation of cellular component organizationGO:00511283680.013
regulation of nervous system developmentGO:00519602640.013
positive regulation of transferase activityGO:0051347810.013
cognitionGO:0050890920.013
response to blue lightGO:000963710.013
response to vitaminGO:00332731310.013
divalent metal ion transportGO:00708381320.013
regulation of skeletal muscle tissue regenerationGO:004341620.013
cellular response to cytokine stimulusGO:00713451270.013
cellular response to lipidGO:00713962010.013
behavioral response to painGO:004826650.013
positive regulation of apoptotic processGO:00430651540.013
monosaccharide transportGO:0015749310.013
development of primary male sexual characteristicsGO:0046546590.013
positive regulation of cytoskeleton organizationGO:0051495260.013
membrane organizationGO:0061024940.013
Rat
response to painGO:0048265110.012
negative regulation of cell proliferationGO:00082851190.012
cellular response to metal ionGO:0071248550.012
positive regulation of nucleotide biosynthetic processGO:0030810360.012
macromolecule catabolic processGO:0009057580.012
kidney developmentGO:0001822670.012
hepaticobiliary system developmentGO:0061008900.012
axis specificationGO:000979840.012
leukocyte activationGO:0045321760.012
positive regulation of homeostatic processGO:0032846490.012
membrane repolarizationGO:008600910.012
erythrocyte differentiationGO:003021810.012
anion transportGO:00068201780.012
positive regulation of gene expressionGO:00106282440.012
negative regulation of immune system processGO:0002683390.012
hexose transportGO:0008645290.012
cardiac chamber developmentGO:000320510.012
transcription from rna polymerase ii promoterGO:00063662520.012
rho protein signal transductionGO:0007266110.012
cellular response to inorganic substanceGO:0071241650.012
positive regulation of nucleoside metabolic processGO:0045979550.012
regulation of immune responseGO:0050776550.012
regulation of gtpase activityGO:0043087570.012
single organism organelle organizationGO:19025891800.012
multicellular organism growthGO:003526410.012
proteolysisGO:00065081750.012
positive regulation of neuron differentiationGO:00456661260.012
striated muscle contractionGO:0006941440.012
cellular response to monosaccharide stimulusGO:0071326670.012
regulation of cell growthGO:0001558850.012
head developmentGO:00603222470.012
cellular glucose homeostasisGO:0001678660.012
regulation of cyclic nucleotide biosynthetic processGO:0030802450.012

Slc12a3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
kidney diseaseDOID:55700.390
Human
disease of anatomical entityDOID:700.390
Human
urinary system diseaseDOID:1800.390
Human
renal tubular transport diseaseDOID:44700.316
Human
musculoskeletal system diseaseDOID:1700.031
nervous system diseaseDOID:86300.024
disease of metabolismDOID:001466700.022
connective tissue diseaseDOID:6500.021
inherited metabolic disorderDOID:65500.015
bone diseaseDOID:008000100.014
long qt syndromeDOID:284300.014
nutrition diseaseDOID:37400.012
acquired metabolic diseaseDOID:006015800.012