IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Aplp2

amyloid beta (A4) precursor-like protein 2

(Aliases: WALPLP2,APLP-2,Apph)

RGD: 2128
Entrez: 64312

Process Predictions
Disease Predictions

Aplp2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
single organism catabolic process	GO:0044712	283	0.121
endocytosis	GO:0006897	84	0.119
purine ribonucleotide metabolic process	GO:0009150	227	0.092
secretion	GO:0046903	307	0.091
protein phosphorylation	GO:0006468	345	0.090
organic acid metabolic process	GO:0006082	292	0.079
carboxylic acid metabolic process	GO:0019752	289	0.074
defense response	GO:0006952	194	0.073
establishment of protein localization	GO:0045184	141	0.071
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.068
response to radiation	GO:0009314	137	0.064
catabolic process	GO:0009056	351	0.063
gtp catabolic process	GO:0006184	71	0.059
regulation of intracellular signal transduction	GO:1902531	218	0.053
regulation of signal transduction	GO:0009966	318	0.050
guanosine containing compound metabolic process	GO:1901068	74	0.050
nitrogen compound transport	GO:0071705	229	0.049
hormone transport	GO:0009914	121	0.048
lipid metabolic process	GO:0006629	283	0.047
central nervous system development	GO:0007417	311	0.047
cell type specific apoptotic process	GO:0097285	134	0.046
peptide secretion	GO:0002790	86	0.046
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.045
oxoacid metabolic process	GO:0043436	290	0.043
response to metal ion	GO:0010038	253	0.042
organophosphate metabolic process	GO:0019637	370	0.042
carbohydrate derivative catabolic process	GO:1901136	147	0.041
secretion by cell	GO:0032940	248	0.041
response to oxidative stress	GO:0006979	186	0.041
organelle organization	GO:0006996	266	0.040
hormone secretion	GO:0046879	115	0.040
regulation of cell development	GO:0060284	263	0.040
ribonucleotide metabolic process	GO:0009259	231	0.038
cellular lipid metabolic process	GO:0044255	208	0.038
nucleotide metabolic process	GO:0009117	279	0.038
protein maturation	GO:0051604	68	0.037
cellular response to oxygen containing compound	GO:1901701	386	0.037
ras protein signal transduction	GO:0007265	29	0.037
membrane fusion	GO:0061025	26	0.037
glycosyl compound metabolic process	GO:1901657	182	0.036
signal release	GO:0023061	145	0.036
organophosphate catabolic process	GO:0046434	148	0.035
organonitrogen compound catabolic process	GO:1901565	179	0.034
regulation of cell maturation	GO:1903429	3	0.034
response to lipopolysaccharide	GO:0032496	191	0.034
vesicle mediated transport	GO:0016192	181	0.033
ribonucleoside catabolic process	GO:0042454	126	0.033
transcription dna templated	GO:0006351	377	0.033
cellular catabolic process	GO:0044248	295	0.032
protein homooligomerization	GO:0051260	91	0.032
nucleobase containing small molecule metabolic process	GO:0055086	316	0.032
negative regulation of response to stimulus	GO:0048585	155	0.032
small gtpase mediated signal transduction	GO:0007264	36	0.032
chemical homeostasis	GO:0048878	292	0.031
purine nucleoside metabolic process	GO:0042278	169	0.031
synaptic growth at neuromuscular junction	GO:0051124	1	0.031
head development	GO:0060322	247	0.031
cellular ketone metabolic process	GO:0042180	51	0.031
regulation of cell differentiation	GO:0045595	320	0.031
cellular chemical homeostasis	GO:0055082	247	0.031
ribose phosphate metabolic process	GO:0019693	235	0.031
regulation of protein phosphorylation	GO:0001932	183	0.030
cellular amine metabolic process	GO:0044106	38	0.030
response to molecule of bacterial origin	GO:0002237	194	0.030
gtp metabolic process	GO:0046039	72	0.030
axon choice point recognition	GO:0016198	2	0.030
intracellular transport	GO:0046907	185	0.029
regulation of rna metabolic process	GO:0051252	391	0.029
peptide transport	GO:0015833	97	0.029
heterocycle catabolic process	GO:0046700	167	0.029
synapse assembly	GO:0007416	29	0.028
nucleotide catabolic process	GO:0009166	139	0.028
cellular response to molecule of bacterial origin	GO:0071219	56	0.028
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.028
anterior posterior pattern specification	GO:0009952	1	0.027
response to extracellular stimulus	GO:0009991	380	0.027
regulation of phosphorus metabolic process	GO:0051174	349	0.027
carbohydrate derivative metabolic process	GO:1901135	346	0.027
organic substance catabolic process	GO:1901575	316	0.026
regulation of secretion	GO:0051046	224	0.026
wound healing	GO:0042060	122	0.026
single organism membrane organization	GO:0044802	74	0.026
immune system process	GO:0002376	204	0.026
protein localization to membrane	GO:0072657	36	0.026
amide transport	GO:0042886	105	0.026
amine metabolic process	GO:0009308	38	0.026
peptide hormone secretion	GO:0030072	84	0.026
response to hexose	GO:0009746	144	0.026
negative regulation of multicellular organismal process	GO:0051241	203	0.026
intracellular signal transduction	GO:0035556	314	0.026
response to monosaccharide	GO:0034284	159	0.025
nucleoside triphosphate metabolic process	GO:0009141	144	0.025
response to external biotic stimulus	GO:0043207	221	0.025
membrane organization	GO:0061024	94	0.025
regulation of body fluid levels	GO:0050878	90	0.025
cellular homeostasis	GO:0019725	252	0.024
rna biosynthetic process	GO:0032774	380	0.024
regulation of cellular component organization	GO:0051128	368	0.024
cellular response to stress	GO:0033554	269	0.024
cellular component biogenesis	GO:0044085	368	0.024
regulation of membrane potential	GO:0042391	110	0.024
ribonucleotide catabolic process	GO:0009261	136	0.024
purine nucleotide catabolic process	GO:0006195	136	0.024
response to carbohydrate	GO:0009743	183	0.024
macromolecular complex subunit organization	GO:0043933	339	0.024
regulation of hydrolase activity	GO:0051336	143	0.023
regulation of catalytic activity	GO:0050790	304	0.023
programmed cell death	GO:0012501	392	0.023
cellular response to oxidative stress	GO:0034599	76	0.023
purine containing compound catabolic process	GO:0072523	138	0.023
regulation of hormone levels	GO:0010817	187	0.023
cellular response to endogenous stimulus	GO:0071495	377	0.022
nucleoside phosphate metabolic process	GO:0006753	283	0.022
single organism organelle organization	GO:1902589	180	0.022
regulation of cellular localization	GO:0060341	263	0.022
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.022
cellular response to abiotic stimulus	GO:0071214	85	0.021
purine containing compound metabolic process	GO:0072521	253	0.021
regulation of rna biosynthetic process	GO:2001141	381	0.021
organophosphate biosynthetic process	GO:0090407	143	0.021
purine ribonucleoside catabolic process	GO:0046130	124	0.021
regulation of peptide hormone secretion	GO:0090276	80	0.021
nucleoside metabolic process	GO:0009116	179	0.021
purine ribonucleotide catabolic process	GO:0009154	136	0.021
regulation of establishment of protein localization	GO:0070201	69	0.021
response to growth factor	GO:0070848	189	0.020
apoptotic process	GO:0006915	381	0.020
positive regulation of programmed cell death	GO:0043068	157	0.020
brain development	GO:0007420	247	0.020
positive regulation of molecular function	GO:0044093	230	0.020
purine nucleoside catabolic process	GO:0006152	124	0.020
regulation of hormone secretion	GO:0046883	106	0.020
regulation of protein metabolic process	GO:0051246	289	0.020
homeostatic process	GO:0042592	331	0.020
cellular macromolecule localization	GO:0070727	122	0.020
regulation of cellular amino acid metabolic process	GO:0006521	2	0.020
regulation of purine nucleotide metabolic process	GO:1900542	115	0.020
response to ketone	GO:1901654	182	0.020
negative regulation of innate immune response	GO:0045824	4	0.019
cellular response to corticosteroid stimulus	GO:0071384	69	0.019
response to other organism	GO:0051707	220	0.019
ion homeostasis	GO:0050801	212	0.019
response to glucose	GO:0009749	136	0.019
cellular amino acid metabolic process	GO:0006520	107	0.019
regulation of molecular function	GO:0065009	398	0.018
small molecule biosynthetic process	GO:0044283	124	0.018
negative regulation of cell communication	GO:0010648	158	0.018
nucleobase containing compound catabolic process	GO:0034655	152	0.018
regulation of multicellular organismal development	GO:2000026	376	0.018
negative regulation of developmental process	GO:0051093	125	0.018
positive regulation of cellular component organization	GO:0051130	200	0.018
cell junction maintenance	GO:0034331	1	0.018
response to uv	GO:0009411	8	0.018
neuromuscular process	GO:0050905	2	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.017
regulation of peptide secretion	GO:0002791	82	0.017
positive regulation of hydrolase activity	GO:0051345	86	0.017
regulation of response to external stimulus	GO:0032101	106	0.017
multicellular organism growth	GO:0035264	1	0.017
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.017
proteolysis	GO:0006508	175	0.017
receptor metabolic process	GO:0043112	18	0.017
nucleoside phosphate catabolic process	GO:1901292	140	0.017
positive regulation of biosynthetic process	GO:0009891	319	0.017
regulation of secretion by cell	GO:1903530	208	0.016
response to nutrient levels	GO:0031667	370	0.016
anion transport	GO:0006820	178	0.016
regulation of transcription dna templated	GO:0006355	374	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.016
protein complex assembly	GO:0006461	263	0.016
response to peptide	GO:1901652	292	0.016
regulation of nucleic acid templated transcription	GO:1903506	380	0.016
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.016
cation transport	GO:0006812	382	0.016
meiotic cell cycle process	GO:1903046	3	0.016
positive regulation of secretion	GO:0051047	140	0.015
bmp signaling pathway	GO:0030509	4	0.015
regulation of protein kinase activity	GO:0045859	105	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.015
protein complex biogenesis	GO:0070271	263	0.015
organ formation	GO:0048645	3	0.015
positive regulation of catalytic activity	GO:0043085	184	0.015
regulation of phosphate metabolic process	GO:0019220	349	0.015
protein localization	GO:0008104	191	0.015
regulation of cellular ketone metabolic process	GO:0010565	27	0.015
nucleoside catabolic process	GO:0009164	126	0.015
regulation of cellular amine metabolic process	GO:0033238	8	0.015
regulation of growth	GO:0040008	105	0.015
macromolecule localization	GO:0033036	252	0.015
cellular response to growth factor stimulus	GO:0071363	162	0.014
glycosyl compound catabolic process	GO:1901658	126	0.014
insulin secretion	GO:0030073	69	0.014
cell cell signaling	GO:0007267	335	0.014
reproductive process	GO:0022414	372	0.014
regulation of phosphorylation	GO:0042325	248	0.014
regulation of system process	GO:0044057	208	0.014
cellular response to nitrogen compound	GO:1901699	210	0.014
axon midline choice point recognition	GO:0016199	2	0.014
localization of cell	GO:0051674	202	0.014
regulation of camp metabolic process	GO:0030814	43	0.014
neuron projection development	GO:0031175	273	0.014
protein oligomerization	GO:0051259	191	0.013
rab protein signal transduction	GO:0032482	1	0.013
positive regulation of transport	GO:0051050	245	0.013
response to cytokine	GO:0034097	215	0.013
adult locomotory behavior	GO:0008344	4	0.013
regulation of programmed cell death	GO:0043067	341	0.013
regulation of protein modification process	GO:0031399	194	0.013
alcohol metabolic process	GO:0006066	77	0.013
ribonucleoside metabolic process	GO:0009119	174	0.013
monocarboxylic acid metabolic process	GO:0032787	152	0.013
nucleic acid templated transcription	GO:0097659	379	0.013
metal ion transport	GO:0030001	289	0.013
pyruvate metabolic process	GO:0006090	27	0.013
purine ribonucleoside metabolic process	GO:0046128	168	0.013
negative regulation of catalytic activity	GO:0043086	103	0.013
inflammatory response	GO:0006954	150	0.013
negative regulation of protein metabolic process	GO:0051248	114	0.013
cell projection organization	GO:0030030	302	0.013
divalent inorganic cation transport	GO:0072511	134	0.013
developmental growth	GO:0048589	100	0.013
positive regulation of gene expression	GO:0010628	244	0.013
regulation of apoptotic process	GO:0042981	335	0.012
transcription from rna polymerase ii promoter	GO:0006366	252	0.012
regulation of response to stress	GO:0080134	126	0.012
response to oxygen levels	GO:0070482	265	0.012
nucleoside triphosphate catabolic process	GO:0009143	123	0.012
regulation of nucleotide metabolic process	GO:0006140	117	0.012
negative regulation of protein processing	GO:0010955	47	0.012
protein processing	GO:0016485	68	0.012
negative regulation of metabolic process	GO:0009892	331	0.012
carboxylic acid biosynthetic process	GO:0046394	83	0.012
purine nucleotide metabolic process	GO:0006163	229	0.012
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.012
appendage morphogenesis	GO:0035107	4	0.012
sexual reproduction	GO:0019953	148	0.012
cell morphogenesis involved in differentiation	GO:0000904	119	0.012
transmembrane transport	GO:0055085	412	0.012
anatomical structure morphogenesis	GO:0009653	298	0.012
response to inorganic substance	GO:0010035	377	0.012
cellular response to biotic stimulus	GO:0071216	59	0.012
response to light stimulus	GO:0009416	52	0.012
regulation of defense response	GO:0031347	68	0.012
negative regulation of transport	GO:0051051	136	0.012
regulation of protein transport	GO:0051223	68	0.012
carbohydrate homeostasis	GO:0033500	75	0.011
cellular response to lipid	GO:0071396	201	0.011
generation of precursor metabolites and energy	GO:0006091	62	0.011
cell cycle	GO:0007049	101	0.011
cellular response to acidic ph	GO:0071468	2	0.011
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.011
hepaticobiliary system development	GO:0061008	90	0.011
response to decreased oxygen levels	GO:0036293	237	0.011
glucose homeostasis	GO:0042593	75	0.011
response to ionizing radiation	GO:0010212	59	0.011
ion transmembrane transport	GO:0034220	365	0.011
cellular metal ion homeostasis	GO:0006875	172	0.011
calcium ion transport	GO:0006816	131	0.011
regulation of dna metabolic process	GO:0051052	60	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
rna localization	GO:0006403	4	0.011
regulation of p38mapk cascade	GO:1900744	1	0.011
regulation of neurogenesis	GO:0050767	247	0.011
negative regulation of cell development	GO:0010721	82	0.011
cellular nitrogen compound catabolic process	GO:0044270	163	0.011
response to calcium ion	GO:0051592	59	0.011
negative regulation of cellular component organization	GO:0051129	83	0.011
protein transport	GO:0015031	132	0.011
locomotion	GO:0040011	237	0.011
negative regulation of intracellular signal transduction	GO:1902532	38	0.011
protein geranylgeranylation	GO:0018344	4	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.011
negative regulation of organ growth	GO:0046621	3	0.011
carbohydrate derivative biosynthetic process	GO:1901137	124	0.011
single organism intracellular transport	GO:1902582	166	0.011
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.011
cellular protein localization	GO:0034613	122	0.010
negative regulation of cell proliferation	GO:0008285	119	0.010
negative regulation of endopeptidase activity	GO:0010951	36	0.010
collateral sprouting	GO:0048668	2	0.010
epidermal growth factor receptor signaling pathway	GO:0007173	23	0.010
negative regulation of programmed cell death	GO:0043069	183	0.010
cellular component movement	GO:0006928	248	0.010
negative regulation of molecular function	GO:0044092	133	0.010
p38mapk cascade	GO:0038066	1	0.010
regulation of insulin secretion	GO:0050796	65	0.010
divalent inorganic cation homeostasis	GO:0072507	165	0.010
single organism biosynthetic process	GO:0044711	342	0.010

Aplp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.032
nervous system disease	DOID:863	0.032
central nervous system disease	DOID:331	0.028
disease of metabolism	DOID:0014667	0.027

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network