Rattus norvegicus

0 known processes

Psmb8

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

(Aliases: Lmp7,Ring10,MGC124945)

Psmb8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of tolerance inductionGO:000264510.384
response to cytokineGO:00340972150.355
proteolysisGO:00065081750.327
Yeast
positive regulation of leukocyte mediated cytotoxicityGO:000191270.252
regulation of tolerance induction dependent upon immune responseGO:000265210.248
cellular amino acid metabolic processGO:00065201070.204
immune system processGO:00023762040.193
Mouse
proteasome mediated ubiquitin dependent protein catabolic processGO:004316170.187
Yeast
regulation of arp2 3 complex mediated actin nucleationGO:003431520.184
positive regulation of t cell mediated cytotoxicityGO:000191640.177
antigen processing and presentationGO:001988220.173
Mouse
antigen processing and presentation of endogenous peptide antigen via mhc class iGO:001988510.169
cellular catabolic processGO:00442482950.167
Yeast
modification dependent protein catabolic processGO:0019941140.166
Yeast
response to other organismGO:00517072200.160
macromolecular complex subunit organizationGO:00439333390.156
Yeast Fly
cellular response to stressGO:00335542690.139
Fly
cellular component biogenesisGO:00440853680.131
Yeast
negative regulation of actin nucleationGO:005112610.129
intracellular signal transductionGO:00355563140.127
immune effector processGO:0002252530.126
t cell mediated cytotoxicityGO:000191350.120
protein complex biogenesisGO:00702712630.116
Yeast
macromolecular complex assemblyGO:00650032730.115
Yeast
negative regulation of natural killer cell mediated immunityGO:000271640.114
cellular response to peptide hormone stimulusGO:00713751200.106
negative regulation of cell killingGO:003134250.106
rhythmic processGO:00485111560.105
proteolysis involved in cellular protein catabolic processGO:0051603190.100
Yeast
gland developmentGO:00487321550.098
immune responseGO:00069551040.097
t cell tolerance inductionGO:000251730.091
cellular response to cytokine stimulusGO:00713451270.087
cellular protein catabolic processGO:0044257190.087
Yeast
regulation of tolerance induction to nonself antigenGO:000265510.086
innate immune responseGO:0045087350.086
positive regulation of cellular component organizationGO:00511302000.086
proteasomal protein catabolic processGO:001049880.086
Yeast
catabolic processGO:00090563510.084
Yeast
macromolecule catabolic processGO:0009057580.083
Yeast
amide biosynthetic processGO:0043604100.081
tolerance induction to nonself antigenGO:000246220.076
reproductive processGO:00224143720.071
actin cytoskeleton organizationGO:0030036730.070
multicellular organismal reproductive processGO:00486092330.070
response to external biotic stimulusGO:00432072210.070
response to purine containing compoundGO:00140741260.070
carbohydrate derivative metabolic processGO:19011353460.070
reproductionGO:00000032450.067
cellular response to iron ion starvationGO:001010610.066
multicellular organism reproductionGO:00325042330.066
glycosyl compound metabolic processGO:19016571820.065
regulation of protein metabolic processGO:00512462890.064
regulation of phosphate metabolic processGO:00192203490.062
cellular response to organonitrogen compoundGO:00714171970.061
cell killingGO:0001906130.060
regulation of programmed cell deathGO:00430673410.060
negative regulation of rna metabolic processGO:00512531230.059
regulation of cellular component organizationGO:00511283680.059
positive regulation of response to stimulusGO:00485842850.059
lymphocyte activationGO:0046649430.058
cellular response to peptideGO:19016531330.058
cellular response to nitrogen compoundGO:19016992100.058
protein complex assemblyGO:00064612630.057
Yeast
regulation of rna biosynthetic processGO:20011413810.056
negative regulation of macromolecule metabolic processGO:00106052600.056
negative regulation of arp2 3 complex mediated actin nucleationGO:003431610.055
cellular response to endogenous stimulusGO:00714953770.055
response to acid chemicalGO:00011012220.055
cellular component assemblyGO:00226073600.054
Yeast
cellular ketone metabolic processGO:0042180510.053
sensory organ developmentGO:0007423740.052
negative regulation of metabolic processGO:00098923310.052
organ regenerationGO:00311001010.052
regulation of cellular amine metabolic processGO:003323880.051
protein complex subunit organizationGO:00718223020.051
Yeast Fly
response to woundingGO:00096112540.050
female pregnancyGO:00075651220.049
positive regulation of catalytic activityGO:00430851840.049
response to hexoseGO:00097461440.049
response to estradiolGO:00323551640.049
positive regulation of biosynthetic processGO:00098913190.048
liver developmentGO:0001889900.048
response to peptide hormoneGO:00434342780.047
multi organism reproductive processGO:00447032620.047
cell activationGO:0001775970.046
jak stat cascadeGO:0007259260.045
regulation of multicellular organismal developmentGO:20000263760.044
negative regulation of cellular metabolic processGO:00313242810.043
nitrogen compound transportGO:00717052290.043
cell morphogenesisGO:00009021420.043
cellular response to organic cyclic compoundGO:00714072020.042
regulation of transcription from rna polymerase ii promoterGO:00063572340.042
single organism reproductive processGO:00447022970.042
mononuclear cell proliferationGO:0032943290.042
regulation of cellular ketone metabolic processGO:0010565270.042
regulation of cell differentiationGO:00455953200.041
antigen processing and presentation of peptide antigen via mhc class iGO:000247410.041
developmental process involved in reproductionGO:00030061590.041
leukocyte mediated cytotoxicityGO:0001909100.041
nucleoside catabolic processGO:00091641260.041
regulation of nucleic acid templated transcriptionGO:19035063800.040
positive regulation of nucleic acid templated transcriptionGO:19035081970.040
regulation of protein kinase activityGO:00458591050.040
modification dependent macromolecule catabolic processGO:0043632140.039
Yeast
nucleoside metabolic processGO:00091161790.039
regulation of immune responseGO:0050776550.039
peptidyl tyrosine phosphorylationGO:0018108720.039
cellular component morphogenesisGO:00329891550.038
response to interferon betaGO:003545610.038
regulation of phosphorylationGO:00423252480.038
neurological system processGO:00508772190.037
rna biosynthetic processGO:00327743800.037
single organism organelle organizationGO:19025891800.036
Fly
protein catabolic processGO:0030163300.036
Yeast
regulation of catalytic activityGO:00507903040.036
regulation of cell killingGO:0031341120.036
cellular amine metabolic processGO:0044106380.035
regulation of immune system processGO:00026821230.035
cellular response to hormone stimulusGO:00328702470.035
regulation of body fluid levelsGO:0050878900.035
mitochondrion organizationGO:0007005350.035
oxoacid metabolic processGO:00434362900.035
chemical homeostasisGO:00488782920.035
regulation of cellular protein metabolic processGO:00322682670.034
response to biotic stimulusGO:00096072260.034
response to inorganic substanceGO:00100353770.034
regulation of cellular amino acid metabolic processGO:000652120.033
nucleoside phosphate metabolic processGO:00067532830.033
gonad developmentGO:00084061040.033
positive regulation of immune system processGO:0002684900.033
single organism biosynthetic processGO:00447113420.033
development of primary sexual characteristicsGO:00451371070.033
protein localizationGO:00081041910.033
leukocyte activationGO:0045321760.033
response to decreased oxygen levelsGO:00362932370.032
homeostatic processGO:00425923310.032
regulation of cell proliferationGO:00421273590.032
secretionGO:00469033070.031
biological adhesionGO:00226101100.031
aromatic compound catabolic processGO:00194391680.031
intracellular transportGO:00469071850.030
negative regulation of cell communicationGO:00106481580.030
response to carbohydrateGO:00097431830.030
negative regulation of nitrogen compound metabolic processGO:00511721610.030
response to nicotineGO:0035094510.030
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.030
regulation of protein modification processGO:00313991940.030
nucleobase containing small molecule metabolic processGO:00550863160.030
cell cell signalingGO:00072673350.029
protein transportGO:00150311320.029
regulation of satellite cell proliferationGO:001484210.029
peptide biosynthetic processGO:004304330.029
single organism intracellular transportGO:19025821660.029
carboxylic acid metabolic processGO:00197522890.029
positive regulation of multicellular organismal processGO:00512403870.029
protein maturationGO:0051604680.028
response to metal ionGO:00100382530.028
tolerance induction dependent upon immune responseGO:000246120.028
adaptive immune responseGO:0002250140.028
amine metabolic processGO:0009308380.028
ubiquitin dependent protein catabolic processGO:0006511140.028
Yeast
purine ribonucleoside metabolic processGO:00461281680.027
positive regulation of developmental processGO:00510942830.027
actin filament based processGO:0030029860.027
macromolecule localizationGO:00330362520.027
rna metabolic processGO:00160704060.027
response to nutrient levelsGO:00316673700.026
regulation of organelle organizationGO:0033043800.026
agingGO:00075682410.026
multi multicellular organism processGO:00447061380.026
brain developmentGO:00074202470.026
response to heatGO:0009408600.026
regulation of intracellular signal transductionGO:19025312180.026
cellular protein localizationGO:00346131220.026
regulation of cellular localizationGO:00603412630.025
purine ribonucleotide metabolic processGO:00091502270.025
head developmentGO:00603222470.025
single organism behaviorGO:00447081300.025
cell projection organizationGO:00300303020.025
response to monosaccharideGO:00342841590.025
positive regulation of molecular functionGO:00440932300.024
intracellular protein transportGO:0006886790.024
negative regulation of signalingGO:00230571570.024
regulation of neuron deathGO:19012141150.024
regulation of adaptive immune responseGO:000281980.024
regulation of phosphorus metabolic processGO:00511743490.024
apoptotic processGO:00069153810.024
cellular response to oxygen containing compoundGO:19017013860.024
ribonucleotide metabolic processGO:00092592310.024
regulation of molecular functionGO:00650093980.024
negative regulation of response to stimulusGO:00485851550.023
programmed cell deathGO:00125013920.023
cellular protein complex assemblyGO:0043623440.023
Yeast
hepaticobiliary system developmentGO:0061008900.023
negative regulation of peptidase activityGO:0010466380.023
positive regulation of cellular biosynthetic processGO:00313282950.023
atp metabolic processGO:0046034720.022
neuron differentiationGO:00301823680.022
olfactory learningGO:000835510.022
nephron tubule epithelial cell differentiationGO:007216010.022
regulation of response to stressGO:00801341260.022
peptide transportGO:0015833970.022
protein oligomerizationGO:00512591910.022
cellular response to tumor necrosis factorGO:0071356460.022
negative regulation of kidney developmentGO:009018520.021
negative regulation of signal transductionGO:0009968830.021
ribonucleoside triphosphate metabolic processGO:00091991410.021
ribonucleoside metabolic processGO:00091191740.021
female gonad developmentGO:0008585530.021
organophosphate metabolic processGO:00196373700.021
positive regulation of nitrogen compound metabolic processGO:00511733340.021
regulation of signal transductionGO:00099663180.021
negative regulation of mitotic cell cycle phase transitionGO:190199130.021
blood circulationGO:00080151830.021
cation homeostasisGO:00550801950.020
response to organophosphorusGO:00466831020.020
cellular macromolecular complex assemblyGO:0034622580.020
Yeast
organic acid metabolic processGO:00060822920.020
negative regulation of cellular component organizationGO:0051129830.020
cell cycleGO:00070491010.020
Fly
regulation of interleukin 1 beta secretionGO:005070630.020
amide transportGO:00428861050.020
nucleotide catabolic processGO:00091661390.020
neuron developmentGO:00486662860.020
ovulation cycleGO:0042698670.020
glycosyl compound catabolic processGO:19016581260.019
negative regulation of innate immune responseGO:004582440.019
ribose phosphate metabolic processGO:00196932350.019
negative regulation of phosphate metabolic processGO:0045936800.019
purine nucleoside metabolic processGO:00422781690.019
purine nucleoside monophosphate metabolic processGO:0009126840.019
response to glucoseGO:00097491360.019
regulation of cell morphogenesis involved in differentiationGO:0010769720.018
positive regulation of cell proliferationGO:00082842490.018
tube developmentGO:0035295890.018
negative regulation of gene expressionGO:00106291990.018
purine nucleoside triphosphate metabolic processGO:00091441410.018
positive regulation of leukocyte mediated immunityGO:0002705130.018
t cell proliferationGO:0042098190.018
cell morphogenesis involved in differentiationGO:00009041190.018
positive regulation of protein kinase activityGO:0045860730.018
muscle structure developmentGO:0061061870.018
regulation of cell morphogenesisGO:0022604770.018
protein polymerizationGO:0051258220.018
cell part morphogenesisGO:00329901230.018
positive regulation of protein phosphorylationGO:00019341350.018
negative regulation of protein metabolic processGO:00512481140.017
organonitrogen compound catabolic processGO:19015651790.017
carbohydrate derivative biosynthetic processGO:19011371240.017
purine nucleoside catabolic processGO:00061521240.017
regulation of apoptotic processGO:00429813350.017
regulation of protein phosphorylationGO:00019321830.017
positive regulation of gene expressionGO:00106282440.017
negative regulation of programmed cell deathGO:00430691830.017
regulation of natural killer cell mediated cytotoxicityGO:004226960.017
negative regulation of biosynthetic processGO:00098901680.017
positive regulation of cellular protein metabolic processGO:00322701670.017
transcription dna templatedGO:00063513770.017
cell adhesionGO:00071551100.017
arp2 3 complex mediated actin nucleationGO:003431420.017
ovulation cycle processGO:0022602500.016
response to hydrogen peroxideGO:0042542890.016
organelle organizationGO:00069962660.016
Fly
positive regulation of rna metabolic processGO:00512542030.016
regulation of cell adhesionGO:0030155520.016
negative regulation of cell developmentGO:0010721820.016
nucleobase containing compound catabolic processGO:00346551520.016
positive regulation of organelle organizationGO:0010638480.016
nucleic acid templated transcriptionGO:00976593790.016
negative regulation of leukocyte mediated immunityGO:000270460.016
response to reactive oxygen speciesGO:00003021200.016
cellular amide metabolic processGO:0043603440.016
negative regulation of defense responseGO:0031348190.016
positive regulation of growth factor dependent skeletal muscle satellite cell proliferationGO:190272810.016
neuron projection developmentGO:00311752730.016
positive regulation of cell killingGO:003134390.015
tissue developmentGO:00098882520.015
negative regulation of immune system processGO:0002683390.015
regulation of transcription dna templatedGO:00063553740.015
response to bacteriumGO:00096172000.015
positive regulation of tolerance induction to nonself antigenGO:000265710.015
negative regulation of catalytic activityGO:00430861030.015
cellular response to retinoic acidGO:0071300270.015
negative regulation of cellular protein metabolic processGO:00322691060.015
positive regulation of kinase activityGO:0033674770.015
cell motilityGO:00488702020.015
leukocyte proliferationGO:0070661290.015
regulation of secretion by cellGO:19035302080.015
negative regulation of molecular functionGO:00440921330.014
response to transition metal nanoparticleGO:19902671220.014
regulation of intracellular transportGO:0032386650.014
positive regulation of macromolecule biosynthetic processGO:00105572470.014
regulation of establishment of protein localizationGO:0070201690.014
locomotionGO:00400112370.014
negative regulation of cell differentiationGO:0045596990.014
salivary gland morphogenesisGO:000743510.014
metal ion homeostasisGO:00550651860.014
response to tumor necrosis factorGO:0034612560.014
salivary gland developmentGO:000743130.014
nucleoside monophosphate metabolic processGO:0009123930.014
regulation of interleukin 1 secretionGO:005070430.014
response to estrogenGO:00436272320.014
negative regulation of protein modification processGO:0031400520.014
antigen processing and presentation of exogenous antigenGO:001988410.014
glucose homeostasisGO:0042593750.014
negative regulation of cellular amine metabolic processGO:003323930.014
regulation of leukocyte mediated immunityGO:0002703190.014
lymphocyte homeostasisGO:000226020.014
regulation of actin cytoskeleton organizationGO:0032956300.014
cellular component movementGO:00069282480.014
cellular nitrogen compound catabolic processGO:00442701630.014
cytoplasmic transportGO:00164821150.013
circulatory system processGO:00030131830.013
regulation of smooth muscle cell proliferationGO:0048660750.013
regulation of anatomical structure sizeGO:00900661350.013
negative regulation of phosphorus metabolic processGO:0010563800.013
muscle tissue developmentGO:0060537580.013
cellular response to dna damage stimulusGO:0006974190.013
Fly
negative regulation of cell cycle phase transitionGO:190198840.013
protein phosphorylationGO:00064683450.013
negative regulation of protein phosphorylationGO:0001933440.013
ribonucleotide catabolic processGO:00092611360.013
regulation of defense responseGO:0031347680.013
regulation of transferase activityGO:00513381230.013
negative regulation of nucleobase containing compound metabolic processGO:00459341530.013
purine nucleoside monophosphate catabolic processGO:0009128550.013
inorganic ion transmembrane transportGO:00986602290.013
cell cycle checkpointGO:000007520.013
purine nucleotide metabolic processGO:00061632290.013
skeletal muscle satellite cell proliferationGO:001484110.013
response to insulinGO:00328681330.013
cellular macromolecule catabolic processGO:0044265290.013
Yeast
positive regulation of protein metabolic processGO:00512471780.012
rho protein signal transductionGO:0007266110.012
cellular ion homeostasisGO:00068731840.012
response to ketoneGO:19016541820.012
negative regulation of transportGO:00510511360.012
response to ethanolGO:00454711620.012
negative regulation of cell deathGO:00605482290.012
negative regulation of jak stat cascadeGO:004642630.012
purine ribonucleoside triphosphate metabolic processGO:00092051400.012
nucleoside phosphate catabolic processGO:19012921400.012
peptidyl amino acid modificationGO:00181931260.012
positive regulation of response to woundingGO:1903036340.012
platelet aggregationGO:007052740.012
negative regulation of apoptotic processGO:00430661810.012
positive regulation of programmed cell deathGO:00430681570.012
negative regulation of secretionGO:0051048820.012
tyrosine phosphorylation of stat1 proteinGO:004250830.012
cellular chemical homeostasisGO:00550822470.012
negative regulation of homeostatic processGO:0032845470.012
interleukin 1 beta secretionGO:005070230.012
response to cadmium ionGO:0046686350.012
gtp catabolic processGO:0006184710.012
regulation of cell developmentGO:00602842630.012
regulation of actin filament based processGO:0032970420.012
regulation of tolerance inductionGO:000264320.012
interleukin 1 secretionGO:005070130.012
nucleotide metabolic processGO:00091172790.012
positive regulation of phosphate metabolic processGO:00459372620.012
positive regulation of interleukin 1 beta secretionGO:005071830.012
single organism catabolic processGO:00447122830.012
positive regulation of neuron apoptotic processGO:0043525330.011
regulation of protein localizationGO:0032880810.011
response to amino acidGO:0043200750.011
neuron deathGO:00709971270.011
reproductive structure developmentGO:00486081280.011
negative regulation of cellular amino acid metabolic processGO:004576300.011
nucleoside triphosphate metabolic processGO:00091411440.011
regulation of protein complex assemblyGO:0043254330.011
g protein coupled receptor signaling pathwayGO:00071862420.011
regulation of leukocyte mediated cytotoxicityGO:0001910100.011
reproductive system developmentGO:00614581280.011
positive regulation of cellular component biogenesisGO:0044089550.011
purine containing compound metabolic processGO:00725212530.011
regulation of reactive oxygen species biosynthetic processGO:190342650.011
positive regulation of secretion by cellGO:19035321280.011
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.011
positive regulation of signalingGO:00230562700.011
defense responseGO:00069521940.011
cellular response to acid chemicalGO:0071229750.011
carbohydrate derivative catabolic processGO:19011361470.011
response to campGO:0051591910.011
negative regulation of rna biosynthetic processGO:19026791180.011
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.010
positive regulation of cell communicationGO:00106472710.010
negative regulation of cellular carbohydrate metabolic processGO:001067770.010
nucleoside triphosphate catabolic processGO:00091431230.010
cellular response to insulin stimulusGO:0032869810.010
negative regulation of nervous system developmentGO:0051961790.010
actin filament polymerizationGO:0030041110.010
renal sodium excretionGO:0035812200.010
regulation of hydrolase activityGO:00513361430.010
response to interferon alphaGO:003545510.010
anatomical structure morphogenesisGO:00096532980.010
negative regulation of phosphorylationGO:0042326570.010
male sex differentiationGO:0046661640.010
membrane organizationGO:0061024940.010
positive regulation of circadian sleep wake cycle sleepGO:004593890.010

Psmb8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:291400.016
primary immunodeficiency diseaseDOID:61200.016
combined t cell and b cell immunodeficiencyDOID:62800.016
disease of anatomical entityDOID:700.016
severe combined immunodeficiencyDOID:62700.016