IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Ehd2

EH-domain containing 2

(Aliases: MGEPS)

RGD: 1560856
Entrez: 361512
Ensembl: ENSRNOG00000011346
UniProtKB: Q4V8H8

Process Predictions
Disease Predictions

Ehd2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cardiac muscle cell action potential	GO:0086001	5	0.365
negative regulation of endothelial cell proliferation	GO:0001937	5	0.313
protein complex assembly	GO:0006461	263	0.201
negative regulation of neurogenesis	GO:0050768	78	0.174
response to ionizing radiation	GO:0010212	59	0.172
response to wounding	GO:0009611	254	0.167
cellular component assembly	GO:0022607	360	0.150
regulation of cell proliferation	GO:0042127	359	0.149
response to glucocorticoid	GO:0051384	223	0.127
macromolecular complex assembly	GO:0065003	273	0.118
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.106
organonitrogen compound catabolic process	GO:1901565	179	0.105
aging	GO:0007568	241	0.097
regulation of neurogenesis	GO:0050767	247	0.097
protein localization	GO:0008104	191	0.096	Mouse
single organism biosynthetic process	GO:0044711	342	0.093
protein complex subunit organization	GO:0071822	302	0.093
apoptotic process	GO:0006915	381	0.091
cellular response to hormone stimulus	GO:0032870	247	0.088
response to corticosteroid	GO:0031960	235	0.088
cell projection organization	GO:0030030	302	0.087
negative regulation of cardiac muscle tissue development	GO:0055026	3	0.086
ribonucleoside metabolic process	GO:0009119	174	0.086
negative regulation of cell development	GO:0010721	82	0.083
regulation of nervous system development	GO:0051960	264	0.083
nucleotide metabolic process	GO:0009117	279	0.082
cellular component biogenesis	GO:0044085	368	0.080
macromolecule localization	GO:0033036	252	0.076	Mouse
nucleoside catabolic process	GO:0009164	126	0.076
macromolecular complex subunit organization	GO:0043933	339	0.075
regulation of phosphorylation	GO:0042325	248	0.074	Rat
response to nutrient levels	GO:0031667	370	0.073
regulation of membrane potential	GO:0042391	110	0.068
ensheathment of neurons	GO:0007272	40	0.067
cellular protein localization	GO:0034613	122	0.067	Mouse
organelle organization	GO:0006996	266	0.065	Mouse
purine nucleoside metabolic process	GO:0042278	169	0.065
purine ribonucleoside metabolic process	GO:0046128	168	0.064
cellular macromolecule localization	GO:0070727	122	0.064	Mouse
cholesterol efflux	GO:0033344	1	0.064
organic cyclic compound catabolic process	GO:1901361	175	0.062
positive regulation of cellular biosynthetic process	GO:0031328	295	0.062
regulation of cell development	GO:0060284	263	0.062
negative regulation of multicellular organismal process	GO:0051241	203	0.061
organ regeneration	GO:0031100	101	0.061
neuron differentiation	GO:0030182	368	0.061
regulation of microtubule polymerization	GO:0031113	8	0.059
organophosphate metabolic process	GO:0019637	370	0.059
purine containing compound metabolic process	GO:0072521	253	0.058
regulation of phosphate metabolic process	GO:0019220	349	0.057	Rat
negative regulation of cardiac muscle tissue growth	GO:0055022	3	0.056
purine ribonucleoside catabolic process	GO:0046130	124	0.055
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.055
cellular component movement	GO:0006928	248	0.055
protein complex biogenesis	GO:0070271	263	0.054
multi multicellular organism process	GO:0044706	138	0.054
organophosphate catabolic process	GO:0046434	148	0.054
protein oligomerization	GO:0051259	191	0.053
transcription from rna polymerase ii promoter	GO:0006366	252	0.053
blood vessel morphogenesis	GO:0048514	58	0.052
negative regulation of organ growth	GO:0046621	3	0.050
regeneration	GO:0031099	163	0.049
cellular catabolic process	GO:0044248	295	0.049
response to vitamin	GO:0033273	131	0.048
regulation of cellular component organization	GO:0051128	368	0.047	Mouse Rat
nucleoside metabolic process	GO:0009116	179	0.047
ribonucleoside catabolic process	GO:0042454	126	0.047
hepaticobiliary system development	GO:0061008	90	0.047
regulation of neuron differentiation	GO:0045664	208	0.047
circulatory system development	GO:0072359	134	0.046
nucleic acid templated transcription	GO:0097659	379	0.046
transmission of nerve impulse	GO:0019226	42	0.045
ribonucleotide metabolic process	GO:0009259	231	0.043
cellular ketone metabolic process	GO:0042180	51	0.043
regulation of rna metabolic process	GO:0051252	391	0.043
regulation of microtubule polymerization or depolymerization	GO:0031110	12	0.042
vesicle mediated transport	GO:0016192	181	0.042	Human Mouse Rat
purine ribonucleotide metabolic process	GO:0009150	227	0.042
transcription dna templated	GO:0006351	377	0.042
neuronal action potential	GO:0019228	35	0.042
carbohydrate derivative metabolic process	GO:1901135	346	0.041
aromatic compound catabolic process	GO:0019439	168	0.041
response to extracellular stimulus	GO:0009991	380	0.040
organic substance catabolic process	GO:1901575	316	0.040
regulation of apoptotic process	GO:0042981	335	0.039
regulation of cellular ketone metabolic process	GO:0010565	27	0.039
single organism catabolic process	GO:0044712	283	0.039
programmed cell death	GO:0012501	392	0.038
nucleobase containing small molecule metabolic process	GO:0055086	316	0.037
regulation of molecular function	GO:0065009	398	0.037
peptidyl lysine hydroxylation	GO:0017185	1	0.037
ventricular cardiac muscle cell action potential	GO:0086005	2	0.037
endocytosis	GO:0006897	84	0.037	Mouse Rat
negative regulation of muscle hypertrophy	GO:0014741	3	0.036
actin filament based movement	GO:0030048	16	0.036
negative regulation of cell proliferation	GO:0008285	119	0.036
actin mediated cell contraction	GO:0070252	12	0.036
cellular response to external stimulus	GO:0071496	118	0.035
positive regulation of epidermis development	GO:0045684	1	0.035
negative regulation of cell growth involved in cardiac muscle cell development	GO:0061052	1	0.034
response to acid chemical	GO:0001101	222	0.034
response to peptide hormone	GO:0043434	278	0.034
response to oxygen levels	GO:0070482	265	0.034
nucleoside triphosphate metabolic process	GO:0009141	144	0.033
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.033
negative regulation of neuron differentiation	GO:0045665	62	0.033
cellular response to endogenous stimulus	GO:0071495	377	0.033
locomotion	GO:0040011	237	0.033
purine ribonucleotide catabolic process	GO:0009154	136	0.033
regulation of calcineurin nfat signaling cascade	GO:0070884	3	0.032
cardiac muscle cell action potential involved in contraction	GO:0086002	2	0.032
purine containing compound catabolic process	GO:0072523	138	0.032
negative regulation of molecular function	GO:0044092	133	0.032
regulation of programmed cell death	GO:0043067	341	0.032
response to nutrient	GO:0007584	248	0.031
cellular response to metal ion	GO:0071248	55	0.031
regulation of signal transduction	GO:0009966	318	0.031
positive regulation of signaling	GO:0023056	270	0.031
positive regulation of cell proliferation	GO:0008284	249	0.030
protein heterooligomerization	GO:0051291	89	0.030
growth	GO:0040007	165	0.029
negative regulation of response to stimulus	GO:0048585	155	0.029
vasculature development	GO:0001944	70	0.029
ribose phosphate metabolic process	GO:0019693	235	0.029
regulation of phosphorus metabolic process	GO:0051174	349	0.029	Rat
heterocycle catabolic process	GO:0046700	167	0.028
negative regulation of nervous system development	GO:0051961	79	0.028
negative regulation of potassium ion transmembrane transporter activity	GO:1901017	3	0.028
regulation of cardiac muscle tissue development	GO:0055024	12	0.028
organic acid metabolic process	GO:0006082	292	0.028
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.028
negative regulation of developmental process	GO:0051093	125	0.028
cation transmembrane transport	GO:0098655	263	0.028
response to hypoxia	GO:0001666	231	0.027
cellular response to abiotic stimulus	GO:0071214	85	0.027
muscle structure development	GO:0061061	87	0.027	Mouse
nucleobase containing compound catabolic process	GO:0034655	152	0.026
response to radiation	GO:0009314	137	0.026
regulation of protein metabolic process	GO:0051246	289	0.026	Rat
regulation of cell differentiation	GO:0045595	320	0.026	Mouse
negative regulation of epithelial cell proliferation	GO:0050680	16	0.026
intracellular signal transduction	GO:0035556	314	0.026
purine nucleoside catabolic process	GO:0006152	124	0.026
cellular response to corticosteroid stimulus	GO:0071384	69	0.025
negative regulation of cell adhesion molecule production	GO:0060354	1	0.025
cellular nitrogen compound catabolic process	GO:0044270	163	0.025
nucleoside phosphate biosynthetic process	GO:1901293	102	0.025
metal ion transport	GO:0030001	289	0.025
positive regulation of transport	GO:0051050	245	0.025	Mouse
negative regulation of heart growth	GO:0061117	3	0.025
protein homooligomerization	GO:0051260	91	0.025
positive regulation of response to stimulus	GO:0048584	285	0.025
ion transmembrane transport	GO:0034220	365	0.025
cellular response to organic cyclic compound	GO:0071407	202	0.024
regulation of humoral immune response mediated by circulating immunoglobulin	GO:0002923	1	0.024
glycosyl compound metabolic process	GO:1901657	182	0.024
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.024
reproductive process	GO:0022414	372	0.024
endochondral ossification	GO:0001958	2	0.024
response to decreased oxygen levels	GO:0036293	237	0.024
catabolic process	GO:0009056	351	0.024
cellular response to nutrient	GO:0031670	30	0.023
transmembrane transport	GO:0055085	412	0.023
cell cell signaling	GO:0007267	335	0.023
nucleotide catabolic process	GO:0009166	139	0.023
nucleoside phosphate metabolic process	GO:0006753	283	0.023
regulation of endocytosis	GO:0030100	42	0.023	Rat
cation transport	GO:0006812	382	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.022
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.022
gtp metabolic process	GO:0046039	72	0.022
positive regulation of cell communication	GO:0010647	271	0.022
organic acid biosynthetic process	GO:0016053	83	0.022
regulation of transcription dna templated	GO:0006355	374	0.022
regulation of microtubule based process	GO:0032886	14	0.022
negative regulation of cellular metabolic process	GO:0031324	281	0.022
oxoacid metabolic process	GO:0043436	290	0.022
nitrate transport	GO:0015706	1	0.021
purine nucleotide metabolic process	GO:0006163	229	0.021
developmental growth	GO:0048589	100	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.021
neuron development	GO:0048666	286	0.021
regulation of cell projection organization	GO:0031344	175	0.021
mrna transcription from rna polymerase ii promoter	GO:0042789	1	0.021
action potential	GO:0001508	54	0.021
regulation of g0 to g1 transition	GO:0070316	3	0.021
regulation of cell motility	GO:2000145	131	0.021
multi organism reproductive process	GO:0044703	262	0.020
negative regulation of cell differentiation	GO:0045596	99	0.020
small gtpase mediated signal transduction	GO:0007264	36	0.020
response to cytokine	GO:0034097	215	0.020
regulation of cellular amino acid metabolic process	GO:0006521	2	0.020
neuron projection development	GO:0031175	273	0.020
response to inorganic substance	GO:0010035	377	0.020
cardiovascular system development	GO:0072358	134	0.019
inorganic ion transmembrane transport	GO:0098660	229	0.019
cardiac muscle cell contraction	GO:0086003	10	0.019
cellular response to lipid	GO:0071396	201	0.019
response to metal ion	GO:0010038	253	0.019
negative regulation of smooth muscle cell proliferation	GO:0048662	21	0.018
nucleoside phosphate catabolic process	GO:1901292	140	0.018
carboxylic acid metabolic process	GO:0019752	289	0.018
immune system process	GO:0002376	204	0.018
lateral ventricle development	GO:0021670	1	0.018
regulation of tight junction assembly	GO:2000810	2	0.018
atp catabolic process	GO:0006200	54	0.017
gtp catabolic process	GO:0006184	71	0.017
response to ketone	GO:1901654	182	0.017
axon ensheathment	GO:0008366	40	0.017
cellular amine metabolic process	GO:0044106	38	0.017
regulation of cellular amine metabolic process	GO:0033238	8	0.017
regulation of rna biosynthetic process	GO:2001141	381	0.017
cellular response to oxygen containing compound	GO:1901701	386	0.017
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.017
negative regulation of programmed cell death	GO:0043069	183	0.017
positive regulation of cellular component organization	GO:0051130	200	0.017	Mouse
negative regulation of cell communication	GO:0010648	158	0.016
regulation of catalytic activity	GO:0050790	304	0.016
single organism intracellular transport	GO:1902582	166	0.016	Human Mouse
negative regulation of metabolic process	GO:0009892	331	0.016
membrane organization	GO:0061024	94	0.016	Mouse
regulation of cellular component movement	GO:0051270	150	0.015
ras protein signal transduction	GO:0007265	29	0.015
cellular response to peptide hormone stimulus	GO:0071375	120	0.015
multicellular organism reproduction	GO:0032504	233	0.015
rna metabolic process	GO:0016070	406	0.015
cell morphogenesis	GO:0000902	142	0.015
positive regulation of rna metabolic process	GO:0051254	203	0.015
vasculogenesis	GO:0001570	3	0.015
muscle organ development	GO:0007517	50	0.015
nucleoside monophosphate metabolic process	GO:0009123	93	0.015
negative regulation of apoptotic process	GO:0043066	181	0.015
regulation of neuron projection development	GO:0010975	161	0.015
positive regulation of rna biosynthetic process	GO:1902680	197	0.015
negative regulation of cell death	GO:0060548	229	0.015
regulation of multicellular organismal development	GO:2000026	376	0.014
actin filament based process	GO:0030029	86	0.014	Mouse
glial cell differentiation	GO:0010001	65	0.014
localization of cell	GO:0051674	202	0.014
regulation of locomotion	GO:0040012	148	0.014
divalent inorganic cation homeostasis	GO:0072507	165	0.014
regulation of ion transmembrane transport	GO:0034765	121	0.014
purine ribonucleoside monophosphate catabolic process	GO:0009169	55	0.014
multicellular organism growth	GO:0035264	1	0.014
myelination	GO:0042552	39	0.014
cellular response to stress	GO:0033554	269	0.014
positive regulation of protein metabolic process	GO:0051247	178	0.014	Rat
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.013
response to bacterium	GO:0009617	200	0.013
synaptic transmission	GO:0007268	235	0.013
carbohydrate derivative catabolic process	GO:1901136	147	0.013
negative regulation of cell projection organization	GO:0031345	50	0.013
regulation of transmembrane transport	GO:0034762	122	0.013
guanosine containing compound metabolic process	GO:1901068	74	0.013
cellular response to alcohol	GO:0097306	87	0.013
renal filtration	GO:0097205	10	0.013
cell cycle	GO:0007049	101	0.013
rna biosynthetic process	GO:0032774	380	0.013
single organism organelle organization	GO:1902589	180	0.013	Mouse
cellular calcium ion homeostasis	GO:0006874	160	0.013
regulation of mapk cascade	GO:0043408	116	0.013
cellular response to cytokine stimulus	GO:0071345	127	0.012
positive regulation of multicellular organismal process	GO:0051240	387	0.012
glycosyl compound catabolic process	GO:1901658	126	0.012
monocarboxylic acid biosynthetic process	GO:0072330	48	0.012
carbohydrate derivative biosynthetic process	GO:1901137	124	0.012
endomembrane system organization	GO:0010256	48	0.012	Mouse
lipid metabolic process	GO:0006629	283	0.012
regulation of epithelial cell proliferation	GO:0050678	49	0.012
negative regulation of cellular biosynthetic process	GO:0031327	161	0.012
cellular response to interleukin 1	GO:0071347	37	0.012
prostaglandin metabolic process	GO:0006693	12	0.012
positive regulation of gene expression	GO:0010628	244	0.012
regulation of blood pressure	GO:0008217	83	0.012
lipid localization	GO:0010876	62	0.012
tissue regeneration	GO:0042246	36	0.012
tissue development	GO:0009888	252	0.012
regulation of cell growth	GO:0001558	85	0.012
regulation of potassium ion transport	GO:0043266	29	0.012
regulation of stem cell differentiation	GO:2000736	2	0.012
homeostatic process	GO:0042592	331	0.012
negative regulation of innate immune response	GO:0045824	4	0.012
response to vitamin e	GO:0033197	24	0.012
chemical homeostasis	GO:0048878	292	0.012
multicellular organismal signaling	GO:0035637	44	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.012
negative regulation of neuron projection development	GO:0010977	46	0.011
negative regulation of phosphate metabolic process	GO:0045936	80	0.011
central nervous system development	GO:0007417	311	0.011
cellular amino acid metabolic process	GO:0006520	107	0.011
endothelial cell proliferation	GO:0001935	20	0.011
response to growth factor	GO:0070848	189	0.011	Rat
regulation of cellular protein metabolic process	GO:0032268	267	0.011	Rat
nucleotide biosynthetic process	GO:0009165	98	0.011
axis specification	GO:0009798	4	0.011
regulation of synaptic transmission	GO:0050804	141	0.011
regulation of protein modification process	GO:0031399	194	0.011	Rat
response to estradiol	GO:0032355	164	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
regulation of dna metabolic process	GO:0051052	60	0.011
regulation of caveolin mediated endocytosis	GO:2001286	2	0.011
response to other organism	GO:0051707	220	0.011
skeletal muscle cell differentiation	GO:0035914	2	0.011
regulation of cell aging	GO:0090342	1	0.011
isopeptide cross linking	GO:0018262	1	0.011
cellular cation homeostasis	GO:0030003	180	0.011
cytoskeleton dependent cytokinesis	GO:0061640	2	0.011
female pregnancy	GO:0007565	122	0.011
cellular response to mechanical stimulus	GO:0071260	48	0.011
cytoskeleton organization	GO:0007010	111	0.010	Mouse
response to purine containing compound	GO:0014074	126	0.010
coronary vasculature morphogenesis	GO:0060977	3	0.010
response to mechanical stimulus	GO:0009612	134	0.010
actin filament depolymerization	GO:0030042	3	0.010
icosanoid metabolic process	GO:0006690	38	0.010
protein phosphorylation	GO:0006468	345	0.010	Rat
embryo implantation	GO:0007566	15	0.010
erythrocyte homeostasis	GO:0034101	2	0.010
negative regulation of potassium ion transport	GO:0043267	11	0.010
regulation of transferase activity	GO:0051338	123	0.010
cytoplasmic transport	GO:0016482	115	0.010
cellular response to extracellular stimulus	GO:0031668	73	0.010

Ehd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
muscular disease	DOID:0080000	0.078
myopathy	DOID:423	0.078
muscular dystrophy	DOID:9884	0.078
musculoskeletal system disease	DOID:17	0.078
disease of anatomical entity	DOID:7	0.078
muscle tissue disease	DOID:66	0.078
nervous system disease	DOID:863	0.022
skin disease	DOID:37	0.012
lipodystrophy	DOID:811	0.012
integumentary system disease	DOID:16	0.012
central nervous system disease	DOID:331	0.010

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