Rattus norvegicus

119 known processes

Map3k11

mitogen-activated protein kinase kinase kinase 11

(Aliases: Mlk3,RHOE,Mlk-3)

Map3k11 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of apoptotic processGO:00429813350.263
regulation of programmed cell deathGO:00430673410.144
signal transduction by phosphorylationGO:00230141440.136
regulation of catalytic activityGO:00507903040.115
intracellular signal transductionGO:00355563140.110
rna metabolic processGO:00160704060.110
regulation of intracellular signal transductionGO:19025312180.107
positive regulation of cell communicationGO:00106472710.105
cell projection organizationGO:00300303020.105
cellular component biogenesisGO:00440853680.101
protein phosphorylationGO:00064683450.094
regulation of phosphorus metabolic processGO:00511743490.088
positive regulation of nitrogen compound metabolic processGO:00511733340.088
positive regulation of biosynthetic processGO:00098913190.079
positive regulation of signalingGO:00230562700.076
cellular catabolic processGO:00442482950.075
positive regulation of phosphorylationGO:00423271770.075
organophosphate metabolic processGO:00196373700.072
positive regulation of nucleobase containing compound metabolic processGO:00459353190.072
response to peptideGO:19016522920.071
anatomical structure morphogenesisGO:00096532980.071
Fly
apoptotic processGO:00069153810.070
rna biosynthetic processGO:00327743800.070
regulation of signal transductionGO:00099663180.067
cell migrationGO:00164771970.066
positive regulation of cell developmentGO:00107201760.066
positive regulation of rna metabolic processGO:00512542030.065
regulation of cellular localizationGO:00603412630.064
negative regulation of insulin receptor signaling pathwayGO:0046627100.064
transcription from rna polymerase ii promoterGO:00063662520.062
cytoskeleton organizationGO:00070101110.062
cellular lipid metabolic processGO:00442552080.061
negative regulation of nitrogen compound metabolic processGO:00511721610.059
regulation of phosphate metabolic processGO:00192203490.059
negative regulation of phosphorus metabolic processGO:0010563800.058
cellular protein localizationGO:00346131220.058
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.058
programmed cell deathGO:00125013920.057
positive regulation of response to stimulusGO:00485842850.057
cell motilityGO:00488702020.055
regulation of cell differentiationGO:00455953200.055
negative regulation of cellular metabolic processGO:00313242810.055
positive regulation of protein metabolic processGO:00512471780.054
regulation of nucleic acid templated transcriptionGO:19035063800.054
positive regulation of gene expressionGO:00106282440.054
cell morphogenesisGO:00009021420.053
Fly
response to heatGO:0009408600.053
Fly
carboxylic acid metabolic processGO:00197522890.053
negative regulation of cell deathGO:00605482290.052
tissue developmentGO:00098882520.051
Fly
macromolecular complex subunit organizationGO:00439333390.051
regulation of cellular component organizationGO:00511283680.051
Fly
cellular response to organonitrogen compoundGO:00714171970.049
mapk cascadeGO:00001651400.049
catabolic processGO:00090563510.049
cellular response to hormone stimulusGO:00328702470.049
response to nutrient levelsGO:00316673700.048
neuron deathGO:00709971270.048
regulation of transcription from rna polymerase ii promoterGO:00063572340.048
neuron apoptotic processGO:0051402880.048
positive regulation of intracellular signal transductionGO:19025331380.047
cellular response to endogenous stimulusGO:00714953770.047
negative regulation of cellular biosynthetic processGO:00313271610.047
organophosphate catabolic processGO:00464341480.047
regulation of cell proliferationGO:00421273590.046
positive regulation of phosphorus metabolic processGO:00105622620.045
positive regulation of cellular biosynthetic processGO:00313282950.045
regulation of cellular protein metabolic processGO:00322682670.045
positive regulation of macromolecule biosynthetic processGO:00105572470.045
regulation of molecular functionGO:00650093980.045
positive regulation of phosphate metabolic processGO:00459372620.045
response to peptide hormoneGO:00434342780.044
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.044
lipid metabolic processGO:00066292830.044
enzyme linked receptor protein signaling pathwayGO:00071671160.043
regulation of nervous system developmentGO:00519602640.043
protein complex subunit organizationGO:00718223020.042
regulation of rna metabolic processGO:00512523910.042
positive regulation of nucleic acid templated transcriptionGO:19035081970.041
cellular response to oxygen containing compoundGO:19017013860.041
Fly
nucleoside triphosphate metabolic processGO:00091411440.041
positive regulation of cell deathGO:00109421840.041
regulation of neuron apoptotic processGO:0043523830.040
regulation of neuron differentiationGO:00456642080.040
negative regulation of macromolecule biosynthetic processGO:00105581480.040
organic substance catabolic processGO:19015753160.039
cellular amine metabolic processGO:0044106380.039
regulation of immune responseGO:0050776550.039
negative regulation of programmed cell deathGO:00430691830.039
regulation of kinase activityGO:00435491170.038
positive regulation of cellular component organizationGO:00511302000.037
nucleic acid templated transcriptionGO:00976593790.037
negative regulation of cellular response to insulin stimulusGO:1900077110.037
positive regulation of programmed cell deathGO:00430681570.037
macromolecule localizationGO:00330362520.037
transcription dna templatedGO:00063513770.037
regulation of anatomical structure morphogenesisGO:00226031410.037
Fly
negative regulation of metabolic processGO:00098923310.037
cellular response to nitrogen compoundGO:19016992100.037
regulation of neurogenesisGO:00507672470.037
response to other organismGO:00517072200.037
regulation of cellular ketone metabolic processGO:0010565270.036
positive regulation of nervous system developmentGO:00519621780.036
central nervous system developmentGO:00074173110.036
regulation of protein metabolic processGO:00512462890.036
regulation of cell developmentGO:00602842630.035
negative regulation of cell differentiationGO:0045596990.035
positive regulation of transcription dna templatedGO:00458931970.035
positive regulation of cellular protein metabolic processGO:00322701670.035
cellular component movementGO:00069282480.035
positive regulation of multicellular organismal processGO:00512403870.035
neuron projection developmentGO:00311752730.035
response to metal ionGO:00100382530.035
immune system processGO:00023762040.034
regulation of hydrolase activityGO:00513361430.034
organelle organizationGO:00069962660.033
single organism reproductive processGO:00447022970.033
Fly
positive regulation of catalytic activityGO:00430851840.033
regulation of rna biosynthetic processGO:20011413810.033
positive regulation of developmental processGO:00510942830.032
regulation of cellular amine metabolic processGO:003323880.032
purine ribonucleoside catabolic processGO:00461301240.032
organ morphogenesisGO:0009887750.032
Fly
organic cyclic compound catabolic processGO:19013611750.032
neuron developmentGO:00486662860.032
regulation of protein modification processGO:00313991940.031
organic acid metabolic processGO:00060822920.030
regulation of mapk cascadeGO:00434081160.030
positive regulation of cell differentiationGO:00455972170.030
cellular ketone metabolic processGO:0042180510.030
circulatory system developmentGO:00723591340.030
cellular response to peptideGO:19016531330.029
response to acid chemicalGO:00011012220.029
purine containing compound catabolic processGO:00725231380.029
regulation of neuron deathGO:19012141150.029
oxoacid metabolic processGO:00434362900.029
actin filament organizationGO:0007015420.029
amine metabolic processGO:0009308380.028
aromatic compound catabolic processGO:00194391680.028
positive regulation of protein phosphorylationGO:00019341350.028
negative regulation of macromolecule metabolic processGO:00106052600.027
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.027
regulation of cell projection organizationGO:00313441750.027
response to reactive oxygen speciesGO:00003021200.027
secretionGO:00469033070.027
glycosyl compound metabolic processGO:19016571820.027
negative regulation of apoptotic processGO:00430661810.026
regulation of cellular amino acid metabolic processGO:000652120.026
localization of cellGO:00516742020.026
nucleoside metabolic processGO:00091161790.026
gtp catabolic processGO:0006184710.026
multi organism reproductive processGO:00447032620.025
Fly
protein localizationGO:00081041910.025
nucleoside catabolic processGO:00091641260.025
positive regulation of cell proliferationGO:00082842490.025
regulation of phosphorylationGO:00423252480.025
negative regulation of molecular functionGO:00440921330.025
multicellular organism growthGO:003526410.025
single organism membrane organizationGO:0044802740.025
single organism catabolic processGO:00447122830.024
immune responseGO:00069551040.024
response to mechanical stimulusGO:00096121340.024
multicellular organism reproductionGO:00325042330.024
Fly
homeostatic processGO:00425923310.024
positive regulation of neurogenesisGO:00507691650.024
response to campGO:0051591910.024
nucleobase containing compound catabolic processGO:00346551520.023
organonitrogen compound catabolic processGO:19015651790.023
regulation of protein phosphorylationGO:00019321830.023
positive regulation of apoptotic processGO:00430651540.023
cellular amino acid metabolic processGO:00065201070.023
regulation of protein localizationGO:0032880810.023
regulation of transferase activityGO:00513381230.023
regulation of transcription dna templatedGO:00063553740.023
single organism carbohydrate metabolic processGO:00447231180.023
carbohydrate metabolic processGO:00059751300.023
neurological system processGO:00508772190.023
ribonucleotide catabolic processGO:00092611360.023
response to woundingGO:00096112540.023
retinoic acid receptor signaling pathwayGO:004838470.023
small gtpase mediated signal transductionGO:0007264360.022
regulation of multicellular organismal developmentGO:20000263760.022
Fly
positive regulation of rna biosynthetic processGO:19026801970.022
purine nucleoside catabolic processGO:00061521240.022
cellular component morphogenesisGO:00329891550.022
Fly
positive regulation of cellular amino acid metabolic processGO:004576410.022
positive regulation of protein modification processGO:00314011420.022
reproductionGO:00000032450.022
Fly
negative regulation of gene expressionGO:00106291990.022
regulation of response to external stimulusGO:00321011060.022
reproductive processGO:00224143720.022
Fly
response to vitaminGO:00332731310.022
positive regulation of cellular amine metabolic processGO:003324030.022
cellular response to lipidGO:00713962010.022
positive regulation of molecular functionGO:00440932300.022
negative regulation of cell communicationGO:00106481580.021
negative regulation of nervous system developmentGO:0051961790.021
insulin receptor signaling pathwayGO:0008286240.021
cellular component assemblyGO:00226073600.021
nucleobase containing small molecule metabolic processGO:00550863160.021
agingGO:00075682410.021
ribonucleotide metabolic processGO:00092592310.021
establishment of protein localizationGO:00451841410.021
regulation of cell motilityGO:20001451310.020
positive regulation of cellular catabolic processGO:0031331710.020
response to biotic stimulusGO:00096072260.020
lipid biosynthetic processGO:00086101280.020
cellular response to peptide hormone stimulusGO:00713751200.020
cellular response to reactive oxygen speciesGO:0034614550.020
oxidation reduction processGO:00551143040.020
locomotionGO:00400112370.020
neuron differentiationGO:00301823680.020
cellular homeostasisGO:00197252520.020
purine ribonucleotide metabolic processGO:00091502270.020
ribonucleoside triphosphate metabolic processGO:00091991410.020
purine nucleoside triphosphate catabolic processGO:00091461220.020
regulation of cellular response to insulin stimulusGO:1900076160.020
intracellular protein transportGO:0006886790.019
purine nucleotide metabolic processGO:00061632290.019
positive regulation of neuron projection developmentGO:0010976990.019
purine ribonucleoside metabolic processGO:00461281680.019
regulation of membrane potentialGO:00423911100.019
response to ketoneGO:19016541820.019
negative regulation of cellular protein metabolic processGO:00322691060.019
regulation of locomotionGO:00400121480.019
actin cytoskeleton organizationGO:0030036730.019
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.019
secretion by cellGO:00329402480.019
purine ribonucleotide catabolic processGO:00091541360.019
nucleoside phosphate catabolic processGO:19012921400.019
cellular divalent inorganic cation homeostasisGO:00725031620.019
single organism organelle organizationGO:19025891800.019
guanosine containing compound metabolic processGO:1901068740.019
negative regulation of cell developmentGO:0010721820.019
negative regulation of nucleobase containing compound metabolic processGO:00459341530.018
regulation of cellular catabolic processGO:00313291010.018
response to temperature stimulusGO:0009266940.018
Fly
ribonucleoside triphosphate catabolic processGO:00092031220.018
purine nucleotide catabolic processGO:00061951360.018
regulation of neuron projection developmentGO:00109751610.018
ribonucleoside metabolic processGO:00091191740.018
positive regulation of cell projection organizationGO:00313461110.018
single organism cellular localizationGO:19025801020.018
cellular nitrogen compound catabolic processGO:00442701630.018
protein transportGO:00150311320.018
regulation of secretionGO:00510462240.018
ribose phosphate metabolic processGO:00196932350.018
purine nucleoside metabolic processGO:00422781690.018
regulation of hormone levelsGO:00108171870.018
regulation of cellular response to stressGO:0080135490.018
response to oxidative stressGO:00069791860.018
response to inorganic substanceGO:00100353770.018
negative regulation of neuron differentiationGO:0045665620.018
nucleoside phosphate metabolic processGO:00067532830.017
response to nutrientGO:00075842480.017
response to morphineGO:0043278270.017
multi multicellular organism processGO:00447061380.017
heterocycle catabolic processGO:00467001670.017
ras protein signal transductionGO:0007265290.017
actin filament based processGO:0030029860.017
response to insulinGO:00328681330.017
positive regulation of neuron differentiationGO:00456661260.017
positive regulation of protein kinase activityGO:0045860730.017
chemical homeostasisGO:00488782920.017
nitrogen compound transportGO:00717052290.017
negative regulation of neurogenesisGO:0050768780.017
glial cell differentiationGO:0010001650.017
gastrulationGO:000736920.017
positive regulation of transferase activityGO:0051347810.017
macromolecular complex assemblyGO:00650032730.016
carbohydrate derivative catabolic processGO:19011361470.016
negative regulation of cell proliferationGO:00082851190.016
ion homeostasisGO:00508012120.016
negative regulation of protein metabolic processGO:00512481140.016
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.016
positive regulation of mapk cascadeGO:0043410920.016
organophosphate biosynthetic processGO:00904071430.016
muscle structure developmentGO:0061061870.016
negative regulation of signalingGO:00230571570.016
regulation of cellular component movementGO:00512701500.016
negative regulation of response to stimulusGO:00485851550.016
purine nucleoside triphosphate metabolic processGO:00091441410.016
purine containing compound metabolic processGO:00725212530.015
lipid transportGO:0006869610.015
response to oxygen levelsGO:00704822650.015
regulation of protein serine threonine kinase activityGO:0071900640.015
negative regulation of transportGO:00510511360.015
purine ribonucleoside triphosphate metabolic processGO:00092051400.015
regulation of response to stressGO:00801341260.015
regulation of catabolic processGO:00098941130.015
proteolysisGO:00065081750.015
brain developmentGO:00074202470.015
single organism intracellular transportGO:19025821660.015
regulation of growthGO:00400081050.015
lipid storageGO:001991510.015
response to purine containing compoundGO:00140741260.015
cytokine productionGO:0001816610.015
gtp metabolic processGO:0046039720.015
organic anion transportGO:00157111320.015
cellular response to insulin stimulusGO:0032869810.014
regulation of cytoskeleton organizationGO:0051493490.014
response to estrogenGO:00436272320.014
negative regulation of transcription dna templatedGO:00458921160.014
negative regulation of multicellular organismal processGO:00512412030.014
ribonucleoside catabolic processGO:00424541260.014
axis specificationGO:000979840.014
stress activated mapk cascadeGO:0051403350.014
negative regulation of intracellular signal transductionGO:1902532380.014
insulin like growth factor receptor signaling pathwayGO:004800930.014
regulation of lipid metabolic processGO:0019216680.014
defense response to gram positive bacteriumGO:005083020.014
intracellular transportGO:00469071850.014
response to bacteriumGO:00096172000.014
positive regulation of cellular component movementGO:00512721020.014
negative regulation of developmental processGO:00510931250.014
positive regulation of secretionGO:00510471400.014
positive regulation of neuron deathGO:1901216430.014
dna metabolic processGO:0006259960.014
positive regulation of cellular component biogenesisGO:0044089550.014
response to decreased oxygen levelsGO:00362932370.014
positive regulation of signal transductionGO:00099671750.014
positive regulation of secretion by cellGO:19035321280.014
cellular ion homeostasisGO:00068731840.013
sensory perceptionGO:00076001010.013
positive regulation of transportGO:00510502450.013
cellular macromolecule localizationGO:00707271220.013
cellular chemical homeostasisGO:00550822470.013
response to ammonium ionGO:0060359710.013
cellular cation homeostasisGO:00300031800.013
developmental growthGO:00485891000.013
Fly
g protein coupled receptor signaling pathwayGO:00071862420.013
response to growth factorGO:00708481890.013
tube developmentGO:0035295890.013
membrane organizationGO:0061024940.013
rho protein signal transductionGO:0007266110.013
growthGO:00400071650.013
Fly
developmental process involved in reproductionGO:00030061590.013
Fly
embryo developmentGO:0009790490.012
Fly
female pregnancyGO:00075651220.012
positive regulation of immunoglobulin mediated immune responseGO:000289120.012
response to hydrogen peroxideGO:0042542890.012
response to tumor necrosis factorGO:0034612560.012
nucleoside triphosphate catabolic processGO:00091431230.012
b cell mediated immunityGO:001972440.012
carbohydrate derivative metabolic processGO:19011353460.012
glycosyl compound catabolic processGO:19016581260.012
regulation of protein kinase activityGO:00458591050.012
protein complex assemblyGO:00064612630.012
regulation of secretion by cellGO:19035302080.012
regulation of homeostatic processGO:00328441010.012
monovalent inorganic cation transportGO:00156721720.012
negative regulation of cellular component organizationGO:0051129830.012
chromosome segregationGO:000705920.012
negative regulation of phosphate metabolic processGO:0045936800.012
metal ion transportGO:00300012890.012
response to cytokineGO:00340972150.012
metal ion homeostasisGO:00550651860.012
learning or memoryGO:0007611900.012
cell projection assemblyGO:0030031210.012
biological adhesionGO:00226101100.012
regulation of dna metabolic processGO:0051052600.012
cation transmembrane transportGO:00986552630.012
defense response to gram negative bacteriumGO:005082930.012
positive regulation of lipid catabolic processGO:005099640.012
negative regulation of cell projection organizationGO:0031345500.012
negative regulation of rna biosynthetic processGO:19026791180.012
actin filament bundle assemblyGO:0051017190.012
cellular response to stressGO:00335542690.011
mesoderm developmentGO:000749820.011
cholesterol homeostasisGO:004263230.011
purine ribonucleoside triphosphate catabolic processGO:00092071220.011
maintenance of locationGO:0051235170.011
cell adhesionGO:00071551100.011
multicellular organismal reproductive processGO:00486092330.011
Fly
regulation of cellular component biogenesisGO:0044087860.011
regulation of establishment of protein localizationGO:0070201690.011
cardiovascular system developmentGO:00723581340.011
behaviorGO:00076102050.011
gliogenesisGO:0042063930.011
adult locomotory behaviorGO:000834440.011
cilium morphogenesisGO:006027120.011
negative regulation of biosynthetic processGO:00098901680.011
positive regulation of kinase activityGO:0033674770.011
protein complex biogenesisGO:00702712630.011
positive regulation of catabolic processGO:0009896780.011
regulation of platelet derived growth factor receptor signaling pathwayGO:001064020.011
response to organophosphorusGO:00466831020.011
divalent inorganic cation homeostasisGO:00725071650.011
amide transportGO:00428861050.011
sterol homeostasisGO:005509230.011
positive regulation of triglyceride metabolic processGO:009020840.010
regenerationGO:00310991630.010
cell part morphogenesisGO:00329901230.010
cation homeostasisGO:00550801950.010
immunoglobulin mediated immune responseGO:001606440.010
b cell differentiationGO:003018320.010
acylglycerol metabolic processGO:0006639210.010
regulation of anatomical structure sizeGO:00900661350.010
cell cell signalingGO:00072673350.010
regulation of immune system processGO:00026821230.010
cellular macromolecular complex assemblyGO:0034622580.010
negative regulation of rna metabolic processGO:00512531230.010
guanosine containing compound catabolic processGO:1901069710.010
spindle organizationGO:000705120.010
organic hydroxy compound metabolic processGO:19016151150.010
sensory perception of bitter tasteGO:005091340.010
protein localization to membraneGO:0072657360.010
response to lipopolysaccharideGO:00324961910.010
response to alkaloidGO:00432791320.010
monosaccharide metabolic processGO:0005996610.010
positive regulation of isotype switchingGO:004583010.010
negative regulation of neuron projection developmentGO:0010977460.010
protein processingGO:0016485680.010

Map3k11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.044
nervous system diseaseDOID:86300.044
central nervous system diseaseDOID:33100.018
sensory system diseaseDOID:005015500.013