Rattus norvegicus

0 known processes

Map3k12

mitogen activated protein kinase kinase kinase 12

(Aliases: DLK,PK,Zpk,MUK)

Map3k12 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
intracellular signal transductionGO:00355563140.136
Worm
rna metabolic processGO:00160704060.109
regulation of transcription dna templatedGO:00063553740.107
nucleic acid templated transcriptionGO:00976593790.105
regulation of nucleic acid templated transcriptionGO:19035063800.098
neuron differentiationGO:00301823680.092
Fly
regulation of rna metabolic processGO:00512523910.086
regulation of signal transductionGO:00099663180.085
Worm
rna biosynthetic processGO:00327743800.083
transcription dna templatedGO:00063513770.080
organophosphate metabolic processGO:00196373700.073
regulation of cell developmentGO:00602842630.069
positive regulation of nucleobase containing compound metabolic processGO:00459353190.068
cell cell signalingGO:00072673350.066
Worm Fly
regulation of rna biosynthetic processGO:20011413810.058
regulation of transcription from rna polymerase ii promoterGO:00063572340.056
positive regulation of nitrogen compound metabolic processGO:00511733340.054
positive regulation of response to stimulusGO:00485842850.053
Worm
positive regulation of phosphate metabolic processGO:00459372620.053
Worm
cellular response to endogenous stimulusGO:00714953770.052
cellular component biogenesisGO:00440853680.051
response to inorganic substanceGO:00100353770.050
positive regulation of signalingGO:00230562700.049
Worm
regulation of apoptotic processGO:00429813350.047
regulation of phosphorus metabolic processGO:00511743490.047
Worm
transcription from rna polymerase ii promoterGO:00063662520.047
positive regulation of cellular biosynthetic processGO:00313282950.047
cellular catabolic processGO:00442482950.046
negative regulation of cellular metabolic processGO:00313242810.045
positive regulation of macromolecule biosynthetic processGO:00105572470.044
carbohydrate derivative metabolic processGO:19011353460.043
positive regulation of biosynthetic processGO:00098913190.043
apoptotic processGO:00069153810.043
neuron projection developmentGO:00311752730.042
Fly
regulation of phosphate metabolic processGO:00192203490.042
Worm
positive regulation of cell differentiationGO:00455972170.042
ras protein signal transductionGO:0007265290.042
regulation of catalytic activityGO:00507903040.041
Worm
chemical homeostasisGO:00488782920.040
regulation of programmed cell deathGO:00430673410.039
nucleotide metabolic processGO:00091172790.039
programmed cell deathGO:00125013920.039
protein phosphorylationGO:00064683450.038
Human Mouse Worm
positive regulation of developmental processGO:00510942830.037
protein transportGO:00150311320.037
heart morphogenesisGO:000300730.037
nitrogen compound transportGO:00717052290.037
positive regulation of multicellular organismal processGO:00512403870.037
regulation of neuron differentiationGO:00456642080.037
positive regulation of phosphorylationGO:00423271770.037
Worm
small gtpase mediated signal transductionGO:0007264360.036
negative regulation of nitrogen compound metabolic processGO:00511721610.036
carboxylic acid metabolic processGO:00197522890.036
regulation of nervous system developmentGO:00519602640.036
negative regulation of macromolecule metabolic processGO:00106052600.036
nucleobase containing small molecule metabolic processGO:00550863160.036
negative regulation of metabolic processGO:00098923310.036
homeostatic processGO:00425923310.035
reproductive processGO:00224143720.035
Fly
negative regulation of nucleic acid templated transcriptionGO:19035071170.035
anatomical structure morphogenesisGO:00096532980.034
Fly
positive regulation of catalytic activityGO:00430851840.034
Worm
cell morphogenesis involved in differentiationGO:00009041190.034
Fly
nucleoside phosphate metabolic processGO:00067532830.034
regulation of intracellular signal transductionGO:19025312180.033
Worm
central nervous system developmentGO:00074173110.032
response to monosaccharideGO:00342841590.032
secretionGO:00469033070.032
response to metal ionGO:00100382530.032
regulation of cellular localizationGO:00603412630.032
cellular response to hormone stimulusGO:00328702470.031
regulation of cellular component organizationGO:00511283680.031
Worm Fly
establishment of protein localizationGO:00451841410.031
purine ribonucleotide metabolic processGO:00091502270.031
cellular amine metabolic processGO:0044106380.031
regulation of molecular functionGO:00650093980.031
Worm
positive regulation of cell deathGO:00109421840.031
negative regulation of programmed cell deathGO:00430691830.031
regulation of cellular amino acid metabolic processGO:000652120.031
negative regulation of biosynthetic processGO:00098901680.031
regulation of cell differentiationGO:00455953200.030
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.030
multicellular organismal reproductive processGO:00486092330.030
Fly
positive regulation of cell communicationGO:00106472710.030
Worm
regulation of cellular ketone metabolic processGO:0010565270.029
anion transportGO:00068201780.029
cellular component assemblyGO:00226073600.029
positive regulation of gene expressionGO:00106282440.029
cellular amino acid metabolic processGO:00065201070.029
positive regulation of rna metabolic processGO:00512542030.029
organic acid metabolic processGO:00060822920.029
vesicle mediated transportGO:00161921810.029
negative regulation of rna biosynthetic processGO:19026791180.028
regulation of protein modification processGO:00313991940.028
Worm
regulation of cell morphogenesisGO:0022604770.028
regulation of cellular amine metabolic processGO:003323880.028
cellular homeostasisGO:00197252520.028
catabolic processGO:00090563510.028
single organism intracellular transportGO:19025821660.028
ion transmembrane transportGO:00342203650.028
intracellular transportGO:00469071850.027
single organism biosynthetic processGO:00447113420.027
growthGO:00400071650.027
Fly
ion homeostasisGO:00508012120.027
organelle organizationGO:00069962660.027
Mouse Fly
regulation of multicellular organismal developmentGO:20000263760.027
cation transportGO:00068123820.027
cellular chemical homeostasisGO:00550822470.027
response to carbohydrateGO:00097431830.027
embryonic pattern specificationGO:000988010.027
neuron developmentGO:00486662860.027
Fly
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.027
regulation of neuron deathGO:19012141150.026
purine ribonucleoside metabolic processGO:00461281680.026
response to acid chemicalGO:00011012220.026
regulation of proteasomal protein catabolic processGO:006113640.026
positive regulation of nucleic acid templated transcriptionGO:19035081970.026
single organism organelle organizationGO:19025891800.026
Mouse
oxoacid metabolic processGO:00434362900.026
nucleoside phosphate catabolic processGO:19012921400.026
regulation of phosphorylationGO:00423252480.026
Worm
synaptic transmissionGO:00072682350.026
Worm Fly
regulation of hydrolase activityGO:00513361430.026
macromolecular complex subunit organizationGO:00439333390.026
Mouse
response to estrogenGO:00436272320.026
negative regulation of gene expressionGO:00106291990.026
negative regulation of transcription dna templatedGO:00458921160.026
cellular response to oxygen containing compoundGO:19017013860.026
localization of cellGO:00516742020.025
signal transduction by phosphorylationGO:00230141440.025
Worm
regulation of neurogenesisGO:00507672470.025
head developmentGO:00603222470.025
aromatic compound catabolic processGO:00194391680.025
purine containing compound metabolic processGO:00725212530.025
response to woundingGO:00096112540.025
Fly
cellular component movementGO:00069282480.025
single organism reproductive processGO:00447022970.025
Fly
organic substance catabolic processGO:19015753160.025
nucleoside metabolic processGO:00091161790.025
organic anion transportGO:00157111320.025
positive regulation of cell developmentGO:00107201760.025
cellular response to stressGO:00335542690.024
Fly
negative regulation of rna metabolic processGO:00512531230.024
cation homeostasisGO:00550801950.024
ribonucleotide catabolic processGO:00092611360.024
anterior posterior pattern specificationGO:000995210.024
regulation of anatomical structure morphogenesisGO:00226031410.024
regulation of cell morphogenesis involved in differentiationGO:0010769720.024
response to oxidative stressGO:00069791860.024
ribose phosphate metabolic processGO:00196932350.024
nucleoside triphosphate metabolic processGO:00091411440.024
multi organism reproductive processGO:00447032620.023
Fly
regulation of neuron projection developmentGO:00109751610.023
positive regulation of molecular functionGO:00440932300.023
Worm
regulation of hormone levelsGO:00108171870.023
ribonucleoside metabolic processGO:00091191740.023
positive regulation of programmed cell deathGO:00430681570.023
hormone transportGO:00099141210.023
response to decreased oxygen levelsGO:00362932370.023
proteolysisGO:00065081750.023
response to glucoseGO:00097491360.023
purine ribonucleoside triphosphate metabolic processGO:00092051400.023
cellular ketone metabolic processGO:0042180510.023
regulation of catabolic processGO:00098941130.023
regulation of cell projection organizationGO:00313441750.023
organophosphate catabolic processGO:00464341480.023
cellular response to growth factor stimulusGO:00713631620.023
purine nucleoside metabolic processGO:00422781690.023
regulation of cellular catabolic processGO:00313291010.023
response to extracellular stimulusGO:00099913800.023
metal ion transportGO:00300012890.023
regulation of cellular protein metabolic processGO:00322682670.023
Worm
cell projection organizationGO:00300303020.023
Fly
cellular response to lipidGO:00713962010.022
positive regulation of cellular component organizationGO:00511302000.022
blood vessel developmentGO:0001568690.022
organic acid transportGO:00158491160.022
immune system processGO:00023762040.022
amine metabolic processGO:0009308380.022
secretion by cellGO:00329402480.022
ribonucleoside triphosphate catabolic processGO:00092031220.022
single organism catabolic processGO:00447122830.022
positive regulation of transcription dna templatedGO:00458931970.021
response to nutrient levelsGO:00316673700.021
cell morphogenesisGO:00009021420.021
Fly
protein oligomerizationGO:00512591910.021
signal releaseGO:00230611450.021
response to oxygen levelsGO:00704822650.021
purine nucleotide metabolic processGO:00061632290.021
response to growth factorGO:00708481890.021
negative regulation of cell communicationGO:00106481580.021
tissue developmentGO:00098882520.021
negative regulation of response to stimulusGO:00485851550.021
response to hexoseGO:00097461440.021
regenerationGO:00310991630.021
Fly
peptidyl amino acid modificationGO:00181931260.021
Mouse
positive regulation of rna biosynthetic processGO:19026801970.020
purine nucleoside triphosphate catabolic processGO:00091461220.020
enzyme linked receptor protein signaling pathwayGO:00071671160.020
cardiovascular system developmentGO:00723581340.020
negative regulation of cellular component organizationGO:0051129830.020
response to peptideGO:19016522920.020
cellular cation homeostasisGO:00300031800.020
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.020
circulatory system developmentGO:00723591340.020
nucleoside triphosphate catabolic processGO:00091431230.019
agingGO:00075682410.019
axis specificationGO:000979840.019
positive regulation of phosphorus metabolic processGO:00105622620.019
Worm
eye morphogenesisGO:004859240.019
cellular divalent inorganic cation homeostasisGO:00725031620.019
positive regulation of transportGO:00510502450.019
regulation of protein phosphorylationGO:00019321830.019
Worm
cellular macromolecule localizationGO:00707271220.019
protein complex subunit organizationGO:00718223020.019
negative regulation of multicellular organismal processGO:00512412030.019
cellular response to organonitrogen compoundGO:00714171970.019
cell migrationGO:00164771970.019
cellular response to nitrogen compoundGO:19016992100.019
regulation of purine nucleotide metabolic processGO:19005421150.019
gastrulationGO:000736920.019
transmembrane transportGO:00550854120.019
negative regulation of cellular biosynthetic processGO:00313271610.019
regulation of hormone secretionGO:00468831060.018
positive regulation of signal transductionGO:00099671750.018
Worm
negative regulation of cell differentiationGO:0045596990.018
lipid metabolic processGO:00066292830.018
cellular protein localizationGO:00346131220.018
organic cyclic compound catabolic processGO:19013611750.018
protein complex biogenesisGO:00702712630.018
reproductionGO:00000032450.018
Fly
cytoskeleton organizationGO:00070101110.018
response to radiationGO:00093141370.018
protein complex assemblyGO:00064612630.018
sexual reproductionGO:00199531480.018
Fly
heart developmentGO:0007507720.018
cellular nitrogen compound catabolic processGO:00442701630.018
response to cytokineGO:00340972150.018
cellular response to peptideGO:19016531330.018
negative regulation of nucleobase containing compound metabolic processGO:00459341530.017
cellular ion homeostasisGO:00068731840.017
tube developmentGO:0035295890.017
regulation of system processGO:00440572080.017
purine ribonucleoside catabolic processGO:00461301240.017
neuron deathGO:00709971270.017
positive regulation of protein phosphorylationGO:00019341350.017
Worm
negative regulation of macromolecule biosynthetic processGO:00105581480.017
chromosome segregationGO:000705920.017
negative regulation of signalingGO:00230571570.017
hormone secretionGO:00468791150.017
intracellular protein transportGO:0006886790.017
positive regulation of cellular amino acid metabolic processGO:004576410.017
multicellular organism reproductionGO:00325042330.017
Fly
ribonucleoside triphosphate metabolic processGO:00091991410.016
heterocycle catabolic processGO:00467001670.016
morphogenesis of embryonic epitheliumGO:001633130.016
carboxylic acid transportGO:00469421150.016
negative regulation of apoptotic processGO:00430661810.016
regulation of secretion by cellGO:19035302080.016
regulation of membrane potentialGO:00423911100.016
cytoplasmic transportGO:00164821150.016
ribonucleoside catabolic processGO:00424541260.016
cellular lipid metabolic processGO:00442552080.016
glycosyl compound catabolic processGO:19016581260.016
negative regulation of transportGO:00510511360.016
cellular response to organic cyclic compoundGO:00714072020.016
positive regulation of apoptotic processGO:00430651540.016
g protein coupled receptor signaling pathwayGO:00071862420.016
ribonucleotide metabolic processGO:00092592310.016
regulation of cell proliferationGO:00421273590.016
carbohydrate derivative catabolic processGO:19011361470.016
developmental growthGO:00485891000.016
Fly
response to ketoneGO:19016541820.016
negative regulation of cell deathGO:00605482290.016
brain developmentGO:00074202470.015
positive regulation of purine nucleotide metabolic processGO:1900544910.015
cell morphogenesis involved in neuron differentiationGO:00486671060.015
Fly
single organism cellular localizationGO:19025801020.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.015
positive regulation of cellular amine metabolic processGO:003324030.015
response to nutrientGO:00075842480.015
organonitrogen compound catabolic processGO:19015651790.015
inorganic cation transmembrane transportGO:00986622020.015
positive regulation of neuron differentiationGO:00456661260.015
divalent metal ion transportGO:00708381320.015
angiogenesisGO:0001525530.015
synapse organizationGO:0050808460.015
Worm Fly
cell cycleGO:00070491010.015
positive regulation of cellular catabolic processGO:0031331710.015
negative regulation of nervous system developmentGO:0051961790.015
response to hypoxiaGO:00016662310.015
cellular response to abiotic stimulusGO:0071214850.015
nucleobase containing compound catabolic processGO:00346551520.014
inorganic ion transmembrane transportGO:00986602290.014
regulation of synaptic transmissionGO:00508041410.014
positive regulation of mapk cascadeGO:0043410920.014
Worm
positive regulation of nervous system developmentGO:00519621780.014
regulation of secretionGO:00510462240.014
positive regulation of catabolic processGO:0009896780.014
mesoderm developmentGO:000749820.014
neurological system processGO:00508772190.014
gamete generationGO:00072761240.014
Fly
kidney developmentGO:0001822670.014
metal ion homeostasisGO:00550651860.014
cell growthGO:00160491040.014
Fly
regulation of protein kinase activityGO:00458591050.014
Worm
glycosyl compound metabolic processGO:19016571820.014
nucleotide catabolic processGO:00091661390.014
purine nucleoside triphosphate metabolic processGO:00091441410.014
positive regulation of intracellular signal transductionGO:19025331380.014
Worm
purine nucleotide catabolic processGO:00061951360.014
rhythmic processGO:00485111560.014
cell fate determinationGO:000170920.014
response to reactive oxygen speciesGO:00003021200.014
macromolecular complex assemblyGO:00650032730.014
multicellular organismal signalingGO:0035637440.014
response to peptide hormoneGO:00434342780.014
regulation of chromosome segregationGO:005198310.014
spindle organizationGO:000705120.014
purine nucleoside catabolic processGO:00061521240.014
regulation of synaptic growth at neuromuscular junctionGO:000858210.014
embryonic axis specificationGO:000057810.014
positive regulation of protein modification processGO:00314011420.014
Worm
divalent inorganic cation homeostasisGO:00725071650.014
positive regulation of secretion by cellGO:19035321280.014
muscle structure developmentGO:0061061870.014
macromolecule localizationGO:00330362520.013
response to estradiolGO:00323551640.013
regulation of fat cell differentiationGO:004559830.013
negative regulation of protein metabolic processGO:00512481140.013
blood circulationGO:00080151830.013
cell motilityGO:00488702020.013
response to purine containing compoundGO:00140741260.013
vasculature developmentGO:0001944700.013
positive regulation of neurogenesisGO:00507691650.013
cellular metal ion homeostasisGO:00068751720.013
cytoskeleton dependent cytokinesisGO:006164020.013
amide transportGO:00428861050.013
dna metabolic processGO:0006259960.013
regulation of protein metabolic processGO:00512462890.013
Worm
cell type specific apoptotic processGO:00972851340.013
purine ribonucleoside triphosphate catabolic processGO:00092071220.013
locomotionGO:00400112370.013
cation transmembrane transportGO:00986552630.013
cellular response to peptide hormone stimulusGO:00713751200.013
regulation of synaptic plasticityGO:0048167700.013
appendage morphogenesisGO:003510740.013
immune responseGO:00069551040.013
positive regulation of protein metabolic processGO:00512471780.013
Worm
positive regulation of nucleotide metabolic processGO:0045981910.013
negative regulation of cell proliferationGO:00082851190.013
nucleoside catabolic processGO:00091641260.013
regulation of ion transportGO:00432692450.013
regulation of growthGO:00400081050.013
muscle cell proliferationGO:0033002840.013
positive regulation of hydrolase activityGO:0051345860.013
embryonic skeletal system developmentGO:004870630.013
calcium ion homeostasisGO:00550741620.013
regulation of peptide hormone secretionGO:0090276800.013
synaptic growth at neuromuscular junctionGO:005112410.012
lipid biosynthetic processGO:00086101280.012
amino acid transportGO:0006865700.012
cytosolic calcium ion homeostasisGO:00514801400.012
cellular component morphogenesisGO:00329891550.012
Fly
forebrain developmentGO:0030900980.012
mapk cascadeGO:00001651400.012
Worm
biological adhesionGO:00226101100.012
positive regulation of cell projection organizationGO:00313461110.012
maintenance of locationGO:0051235170.012
regulation of smooth muscle cell proliferationGO:0048660750.012
response to molecule of bacterial originGO:00022371940.012
regulation of nucleotide metabolic processGO:00061401170.012
negative regulation of cellular protein metabolic processGO:00322691060.012
negative regulation of molecular functionGO:00440921330.012
purine containing compound catabolic processGO:00725231380.012
regulation of mapk cascadeGO:00434081160.012
Worm
positive regulation of cellular protein metabolic processGO:00322701670.012
Worm
axonogenesisGO:0007409710.012
Fly
organic hydroxy compound metabolic processGO:19016151150.012
single organism carbohydrate metabolic processGO:00447231180.012
developmental process involved in reproductionGO:00030061590.012
response to interleukin 1GO:0070555550.012
regulation of homeostatic processGO:00328441010.012
protein autophosphorylationGO:0046777660.012
Mouse
spermatogenesisGO:0007283990.012
Fly
positive regulation of cell proliferationGO:00082842490.012
protein localizationGO:00081041910.011
regulation of canonical wnt signaling pathwayGO:006082840.011
circulatory system processGO:00030131830.011
peptide hormone secretionGO:0030072840.011
rho protein signal transductionGO:0007266110.011
epithelium developmentGO:0060429960.011
tube formationGO:003514830.011
lipid storageGO:001991510.011
regulation of protein transportGO:0051223680.011
regulation of cell migrationGO:00303341280.011
cellular calcium ion homeostasisGO:00068741600.011
urogenital system developmentGO:0001655780.011
gland developmentGO:00487321550.011
circadian regulation of gene expressionGO:003292230.011
multicellular organism growthGO:003526410.011
regulation of nucleotide catabolic processGO:0030811650.011
regulation of response to stressGO:00801341260.011
cognitionGO:0050890920.011
positive regulation of protein kinase activityGO:0045860730.011
Worm
peptide secretionGO:0002790860.011
positive regulation of secretionGO:00510471400.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
response to ethanolGO:00454711620.011
epithelial cell proliferationGO:0050673540.011
response to external biotic stimulusGO:00432072210.011
male gamete generationGO:0048232990.011
Fly
reactive oxygen species biosynthetic processGO:190340980.011
muscle system processGO:00030121150.011
gtp metabolic processGO:0046039720.011
gtp catabolic processGO:0006184710.011
cell adhesionGO:00071551100.011
positive regulation of cytosolic calcium ion concentrationGO:00072041220.011
centrosome cycleGO:000709810.011
regulation of anatomical structure sizeGO:00900661350.010
rna localizationGO:000640340.010
respiratory system developmentGO:0060541450.010
response to fatty acidGO:0070542650.010
renal system developmentGO:0072001670.010
behaviorGO:00076102050.010
cardiac chamber developmentGO:000320510.010
insulin secretionGO:0030073690.010
regulation of peptide transportGO:0090087870.010
organ morphogenesisGO:0009887750.010
alpha amino acid metabolic processGO:1901605710.010
regulation of neuron apoptotic processGO:0043523830.010
neuron projection morphogenesisGO:00488121220.010
Fly
regulation of ras protein signal transductionGO:0046578450.010
calcium ion transportGO:00068161310.010
divalent inorganic cation transportGO:00725111340.010
response to alkaloidGO:00432791320.010

Map3k12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.016
disease of anatomical entityDOID:700.016
disease of cellular proliferationDOID:1456600.012
musculoskeletal system diseaseDOID:1700.011
disease of metabolismDOID:001466700.011