Rattus norvegicus

48 known processes

Spink3

serine peptidase inhibitor, Kazal type 3

(Aliases: Psti-1,Tilp,Spink1)

Spink3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to nutrientGO:00075842480.300
regulation of phosphorus metabolic processGO:00511743490.240
Mouse
organic acid transportGO:00158491160.236
neurological system processGO:00508772190.234
transmembrane transportGO:00550854120.228
Mouse
cell motilityGO:00488702020.222
positive regulation of multicellular organismal processGO:00512403870.192
response to extracellular stimulusGO:00099913800.178
anion transportGO:00068201780.175
regulation of multicellular organismal developmentGO:20000263760.164
protein phosphorylationGO:00064683450.159
Mouse
negative regulation of molecular functionGO:00440921330.158
cellular amino acid metabolic processGO:00065201070.148
intracellular signal transductionGO:00355563140.144
Mouse
regulation of nervous system developmentGO:00519602640.140
regulation of molecular functionGO:00650093980.138
response to corticosteroidGO:00319602350.133
response to glucocorticoidGO:00513842230.130
behaviorGO:00076102050.124
cellular homeostasisGO:00197252520.119
regenerationGO:00310991630.118
regulation of cellular protein metabolic processGO:00322682670.118
regulation of phosphorylationGO:00423252480.117
Mouse
response to purine containing compoundGO:00140741260.105
positive regulation of response to stimulusGO:00485842850.104
regulation of signal transductionGO:00099663180.104
Mouse
lipid biosynthetic processGO:00086101280.099
response to woundingGO:00096112540.099
regulation of hydrolase activityGO:00513361430.096
response to toxic substanceGO:00096361330.096
cell migrationGO:00164771970.095
locomotionGO:00400112370.094
response to nutrient levelsGO:00316673700.093
regulation of catalytic activityGO:00507903040.092
amino acid transportGO:0006865700.092
response to campGO:0051591910.092
homeostatic processGO:00425923310.092
regulation of rna biosynthetic processGO:20011413810.091
regulation of neuron projection developmentGO:00109751610.091
regulation of intracellular signal transductionGO:19025312180.090
Mouse
metal ion transportGO:00300012890.087
Mouse
regulation of phosphate metabolic processGO:00192203490.083
Mouse
regulation of cell projection organizationGO:00313441750.082
regulation of protein metabolic processGO:00512462890.081
cellular chemical homeostasisGO:00550822470.080
regulation of neurogenesisGO:00507672470.079
carboxylic acid metabolic processGO:00197522890.078
response to other organismGO:00517072200.078
signal transduction by phosphorylationGO:00230141440.077
regulation of neuron differentiationGO:00456642080.076
immune responseGO:00069551040.076
carboxylic acid transportGO:00469421150.074
myeloid leukocyte differentiationGO:0002573200.073
response to biotic stimulusGO:00096072260.071
transcription from rna polymerase ii promoterGO:00063662520.071
mapk cascadeGO:00001651400.070
single organism behaviorGO:00447081300.067
regulation of cell developmentGO:00602842630.067
circulatory system developmentGO:00723591340.067
aromatic compound catabolic processGO:00194391680.066
regulation of cellular component organizationGO:00511283680.065
heterocycle catabolic processGO:00467001670.065
protein maturationGO:0051604680.065
cellular component movementGO:00069282480.064
regulation of ion transportGO:00432692450.064
Mouse
oxoacid metabolic processGO:00434362900.063
localization of cellGO:00516742020.062
amine metabolic processGO:0009308380.062
organic anion transportGO:00157111320.062
peptidyl tyrosine phosphorylationGO:0018108720.061
Mouse
negative regulation of gene expressionGO:00106291990.060
inflammatory responseGO:00069541500.060
cellular ketone metabolic processGO:0042180510.060
response to external biotic stimulusGO:00432072210.058
response to cytokineGO:00340972150.056
neuron developmentGO:00486662860.055
positive regulation of catalytic activityGO:00430851840.054
cell projection organizationGO:00300303020.054
monocarboxylic acid transportGO:0015718520.052
regulation of programmed cell deathGO:00430673410.052
regulation of cell differentiationGO:00455953200.052
regulation of response to external stimulusGO:00321011060.052
response to lead ionGO:0010288330.050
neuron projection developmentGO:00311752730.050
hepaticobiliary system developmentGO:0061008900.049
organic substance catabolic processGO:19015753160.048
immune system processGO:00023762040.048
organic acid metabolic processGO:00060822920.048
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.047
single organism reproductive processGO:00447022970.047
Mouse
ion transmembrane transportGO:00342203650.046
Mouse
protein processingGO:0016485680.045
cellular catabolic processGO:00442482950.044
cardiac chamber developmentGO:000320510.044
positive regulation of biosynthetic processGO:00098913190.043
response to lipopolysaccharideGO:00324961910.042
organic cyclic compound catabolic processGO:19013611750.042
calcium ion importGO:0070509220.042
Mouse
lipid metabolic processGO:00066292830.042
renin angiotensin regulation of aldosterone productionGO:000201830.042
negative regulation of cell proliferationGO:00082851190.041
neuron differentiationGO:00301823680.040
positive regulation of nitrogen compound metabolic processGO:00511733340.040
acute inflammatory responseGO:0002526580.040
angiogenesisGO:0001525530.039
response to decreased oxygen levelsGO:00362932370.039
synaptic transmissionGO:00072682350.038
cellular protein localizationGO:00346131220.038
secretion by cellGO:00329402480.038
Mouse
positive regulation of cellular component organizationGO:00511302000.038
regulation of cell proliferationGO:00421273590.038
cell cell signalingGO:00072673350.038
negative regulation of protein metabolic processGO:00512481140.038
regulation of transcription from rna polymerase ii promoterGO:00063572340.038
carbohydrate derivative metabolic processGO:19011353460.037
positive regulation of phosphate metabolic processGO:00459372620.037
regulation of cellular ketone metabolic processGO:0010565270.036
brain renin angiotensin systemGO:000203530.036
response to temperature stimulusGO:0009266940.036
cellular response to fluid shear stressGO:007149840.036
regulation of body fluid levelsGO:0050878900.035
regulation of mapk cascadeGO:00434081160.034
negative regulation of macromolecule metabolic processGO:00106052600.034
nitrogen compound transportGO:00717052290.034
organ inductionGO:000175910.033
positive regulation of phosphorylationGO:00423271770.033
negative regulation of signalingGO:00230571570.033
Mouse
positive regulation of transcription dna templatedGO:00458931970.032
positive regulation of cell communicationGO:00106472710.031
regulation of apoptotic processGO:00429813350.031
acute phase responseGO:0006953200.031
response to nicotineGO:0035094510.031
negative regulation of catalytic activityGO:00430861030.031
circulatory system processGO:00030131830.031
positive regulation of molecular functionGO:00440932300.030
calcium ion transportGO:00068161310.030
Mouse
positive regulation of cell differentiationGO:00455972170.029
liver developmentGO:0001889900.029
regulation of secretionGO:00510462240.029
Mouse
single organism catabolic processGO:00447122830.029
positive regulation of gene expressionGO:00106282440.028
response to triglycerideGO:003401430.028
positive regulation of nervous system developmentGO:00519621780.028
organic hydroxy compound transportGO:0015850770.028
chemical homeostasisGO:00488782920.028
response to axon injuryGO:0048678590.027
erk1 and erk2 cascadeGO:0070371480.027
catabolic processGO:00090563510.027
regulation of transcription dna templatedGO:00063553740.027
angiotensin mediated drinking behaviorGO:000305120.027
neural crest cell differentiationGO:001403320.027
negative regulation of metabolic processGO:00098923310.026
response to growth factorGO:00708481890.026
negative regulation of protein maturationGO:1903318470.025
response to vitamin b6GO:003451610.025
blood vessel developmentGO:0001568690.025
response to peptideGO:19016522920.025
cellular amine metabolic processGO:0044106380.025
response to reactive oxygen speciesGO:00003021200.025
regulation of protein maturationGO:1903317500.025
dicarboxylic acid transportGO:0006835340.025
regulation of response to stressGO:00801341260.025
renal system developmentGO:0072001670.025
response to chromateGO:004668730.025
cardiac ventricle developmentGO:000323110.025
regulation of protein phosphorylationGO:00019321830.024
Mouse
intracellular transportGO:00469071850.024
apoptotic processGO:00069153810.024
response to estradiolGO:00323551640.024
positive regulation of rna biosynthetic processGO:19026801970.024
nucleic acid templated transcriptionGO:00976593790.024
extracellular matrix constituent secretionGO:007027840.024
cellular nitrogen compound catabolic processGO:00442701630.024
ion homeostasisGO:00508012120.023
positive regulation of developmental processGO:00510942830.023
positive regulation of intracellular signal transductionGO:19025331380.023
small molecule biosynthetic processGO:00442831240.023
negative regulation of transportGO:00510511360.023
Mouse
divalent metal ion transportGO:00708381320.023
Mouse
response to peptide hormoneGO:00434342780.023
negative regulation of endopeptidase activityGO:0010951360.023
cardiovascular system developmentGO:00723581340.023
organophosphate metabolic processGO:00196373700.023
defense responseGO:00069521940.023
negative regulation of protein processingGO:0010955470.022
regulation of cellular amino acid metabolic processGO:000652120.022
cognitionGO:0050890920.022
establishment of protein localizationGO:00451841410.022
positive regulation of mapk cascadeGO:0043410920.022
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.022
negative regulation of cellular protein metabolic processGO:00322691060.022
nucleobase containing small molecule metabolic processGO:00550863160.021
regulation of nucleotide metabolic processGO:00061401170.021
regulation of synaptic transmissionGO:00508041410.021
regulation of ion transmembrane transportGO:00347651210.021
Mouse
alpha amino acid metabolic processGO:1901605710.021
blood vessel morphogenesisGO:0048514580.021
anatomical structure morphogenesisGO:00096532980.021
positive regulation of nucleobase containing compound metabolic processGO:00459353190.021
cellular response to corticosteroid stimulusGO:0071384690.020
proteolysisGO:00065081750.020
response to bacteriumGO:00096172000.020
sulfur compound metabolic processGO:0006790700.020
wound healingGO:00420601220.020
negative regulation of proteolysisGO:0045861410.020
multicellular organism reproductionGO:00325042330.020
positive regulation of neurogenesisGO:00507691650.020
anion transmembrane transportGO:0098656770.020
negative regulation of peptidase activityGO:0010466380.020
vascular process in circulatory systemGO:0003018960.020
positive regulation of synaptic transmissionGO:0050806620.019
positive regulation of programmed cell deathGO:00430681570.019
regulation of reactive oxygen species biosynthetic processGO:190342650.019
regulation of lipid metabolic processGO:0019216680.019
protein localizationGO:00081041910.019
regulation of cellular amine metabolic processGO:003323880.019
response to oxidative stressGO:00069791860.019
indole containing compound metabolic processGO:0042430110.019
positive regulation of rna metabolic processGO:00512542030.019
negative regulation of programmed cell deathGO:00430691830.019
response to glucoseGO:00097491360.019
nucleobase containing compound catabolic processGO:00346551520.019
negative regulation of ion transmembrane transportGO:0034766160.019
Mouse
programmed cell deathGO:00125013920.018
insecticide metabolic processGO:001714340.018
positive regulation of phosphorus metabolic processGO:00105622620.018
negative regulation of cell developmentGO:0010721820.018
response to inorganic substanceGO:00100353770.018
regulation of protein modification processGO:00313991940.018
Mouse
positive regulation of protein metabolic processGO:00512471780.018
cellular response to stressGO:00335542690.018
cellular component biogenesisGO:00440853680.018
cation transportGO:00068123820.018
Mouse
positive regulation of hydrolase activityGO:0051345860.018
regulation of protein kinase activityGO:00458591050.018
macromolecular complex assemblyGO:00650032730.018
cellular response to steroid hormone stimulusGO:0071383930.018
vesicle mediated transportGO:00161921810.017
Mouse
regulation of membrane potentialGO:00423911100.017
positive regulation of reactive oxygen species biosynthetic processGO:190342820.017
regulation of secretion by cellGO:19035302080.017
Mouse
regulation of epithelial cell proliferationGO:0050678490.017
cellular response to glucocorticoid stimulusGO:0071385680.017
negative regulation of nervous system developmentGO:0051961790.017
divalent inorganic cation transportGO:00725111340.017
Mouse
cellular response to organonitrogen compoundGO:00714171970.017
transcription dna templatedGO:00063513770.017
g protein coupled receptor signaling pathwayGO:00071862420.016
organophosphate catabolic processGO:00464341480.016
rna metabolic processGO:00160704060.016
positive regulation of macromolecule biosynthetic processGO:00105572470.016
blood circulationGO:00080151830.016
agingGO:00075682410.016
reactive nitrogen species metabolic processGO:200105710.016
multi multicellular organism processGO:00447061380.016
positive regulation of cell projection organizationGO:00313461110.016
nucleoside phosphate metabolic processGO:00067532830.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.016
regulation of blood pressureGO:0008217830.016
rna biosynthetic processGO:00327743800.016
response to metal ionGO:00100382530.016
glycosyl compound metabolic processGO:19016571820.016
regulation of anatomical structure morphogenesisGO:00226031410.016
regulation of anatomical structure sizeGO:00900661350.016
regulation of vasoconstrictionGO:0019229440.016
store operated calcium entryGO:000211520.016
Mouse
positive regulation of nucleic acid templated transcriptionGO:19035081970.015
secretionGO:00469033070.015
Mouse
gliogenesisGO:0042063930.015
cellular modified amino acid metabolic processGO:0006575610.015
negative regulation of cellular metabolic processGO:00313242810.015
small gtpase mediated signal transductionGO:0007264360.015
ras protein signal transductionGO:0007265290.015
single organism biosynthetic processGO:00447113420.015
response to cgmpGO:007030530.015
reactive oxygen species biosynthetic processGO:190340980.015
regulation of cellular component movementGO:00512701500.015
purine nucleoside metabolic processGO:00422781690.015
negative regulation of calcium ion importGO:009028120.015
Mouse
small molecule catabolic processGO:0044282590.015
purine containing compound metabolic processGO:00725212530.015
protein complex assemblyGO:00064612630.014
response to antibioticGO:0046677390.014
development of primary sexual characteristicsGO:00451371070.014
intestinal absorptionGO:005089230.014
reproductive processGO:00224143720.014
Mouse
regulation of locomotionGO:00400121480.014
negative regulation of response to external stimulusGO:0032102370.014
reactive oxygen species metabolic processGO:0072593370.014
response to transition metal nanoparticleGO:19902671220.014
detection of visible lightGO:000958430.014
positive regulation of immune system processGO:0002684900.014
sexual reproductionGO:00199531480.014
Mouse
peptidyl tyrosine modificationGO:0018212720.014
Mouse
regulation of protein processingGO:0070613500.014
protein localization to membraneGO:0072657360.014
nucleotide metabolic processGO:00091172790.014
regulation of kinase activityGO:00435491170.014
regulation of cellular localizationGO:00603412630.014
Mouse
cellular response to nitrogen compoundGO:19016992100.014
tissue remodelingGO:0048771400.014
positive regulation of cellular protein metabolic processGO:00322701670.014
nucleoside phosphate catabolic processGO:19012921400.014
regulation of lipid biosynthetic processGO:0046890380.014
aromatic amino acid family catabolic processGO:000907470.014
cellular response to cytokine stimulusGO:00713451270.014
tryptophan metabolic processGO:000656850.014
negative regulation of hydrolase activityGO:0051346520.014
smooth muscle cell proliferationGO:0048659770.014
regulation of proteolysisGO:0030162660.013
central nervous system developmentGO:00074173110.013
defense response to gram negative bacteriumGO:005082930.013
male sex differentiationGO:0046661640.013
kidney developmentGO:0001822670.013
reproductive system developmentGO:00614581280.013
cellular biogenic amine catabolic processGO:004240290.013
tissue developmentGO:00098882520.013
regulation of rna metabolic processGO:00512523910.013
positive regulation of signal transductionGO:00099671750.013
positive regulation of transferase activityGO:0051347810.013
muscle tissue morphogenesisGO:006041510.013
negative regulation of phosphorus metabolic processGO:0010563800.013
Mouse
multicellular organismal reproductive processGO:00486092330.013
protein transportGO:00150311320.013
steroid metabolic processGO:0008202730.013
ribose phosphate metabolic processGO:00196932350.013
response to vitaminGO:00332731310.013
gland developmentGO:00487321550.013
carbohydrate metabolic processGO:00059751300.013
cation transmembrane transportGO:00986552630.013
regulation of tube sizeGO:0035150890.013
vasculature developmentGO:0001944700.013
negative regulation of response to stimulusGO:00485851550.013
Mouse
coenzyme metabolic processGO:0006732860.013
muscle tissue developmentGO:0060537580.013
protein targetingGO:0006605610.013
gonad developmentGO:00084061040.013
cell type specific apoptotic processGO:00972851340.013
detection of stimulusGO:0051606240.013
nucleoside catabolic processGO:00091641260.013
positive regulation of secretionGO:00510471400.013
response to xenobiotic stimulusGO:0009410230.013
positive regulation of nucleotide metabolic processGO:0045981910.013
protein oligomerizationGO:00512591910.012
male mating behaviorGO:006017930.012
response to organophosphorusGO:00466831020.012
positive regulation of catabolic processGO:0009896780.012
negative regulation of developmental processGO:00510931250.012
cell adhesionGO:00071551100.012
response to ddtGO:004668010.012
cellular amino acid catabolic processGO:0009063210.012
response to mechanical stimulusGO:00096121340.012
macromolecule localizationGO:00330362520.012
regulation of cell morphogenesisGO:0022604770.012
negative regulation of neuron projection developmentGO:0010977460.012
organ regenerationGO:00311001010.012
organic acid catabolic processGO:0016054490.012
protein autophosphorylationGO:0046777660.012
female gonad developmentGO:0008585530.012
regulation of transmembrane transportGO:00347621220.012
Mouse
purine containing compound catabolic processGO:00725231380.012
negative regulation of neuron differentiationGO:0045665620.012
positive regulation of cell deathGO:00109421840.012
reproductionGO:00000032450.012
Mouse
response to acid chemicalGO:00011012220.012
regulation of transferase activityGO:00513381230.011
response to activityGO:0014823730.011
regulation of blood circulationGO:19035221100.011
axon developmentGO:0061564960.011
anatomical structure homeostasisGO:0060249290.011
positive regulation of cellular catabolic processGO:0031331710.011
regulation of immunoglobulin mediated immune responseGO:000288920.011
response to monosaccharideGO:00342841590.011
response to carbohydrateGO:00097431830.011
response to heatGO:0009408600.011
reproductive structure developmentGO:00486081280.011
anatomical structure formation involved in morphogenesisGO:0048646830.011
purine nucleoside triphosphate metabolic processGO:00091441410.011
response to alkaloidGO:00432791320.011
purine ribonucleoside catabolic processGO:00461301240.011
positive regulation of erk1 and erk2 cascadeGO:0070374290.011
regulation of cellular response to stressGO:0080135490.011
positive regulation of extracellular matrix constituent secretionGO:000333120.011
response to estrogenGO:00436272320.011
regulation of immune system processGO:00026821230.011
positive regulation of nucleotide catabolic processGO:0030813530.011
purine ribonucleoside metabolic processGO:00461281680.011
regulation of peptidase activityGO:0052547550.011
single organism cellular localizationGO:19025801020.011
regulation of tissue remodelingGO:0034103140.011
neural crest cell migrationGO:000175510.011
glial cell differentiationGO:0010001650.011
ribonucleoside metabolic processGO:00091191740.011
response to vitamin eGO:0033197240.011
memoryGO:0007613540.011
regulation of system processGO:00440572080.011
positive regulation of neuron differentiationGO:00456661260.011
response to molecule of bacterial originGO:00022371940.011
acetylcholine secretion neurotransmissionGO:001405540.011
muscle organ morphogenesisGO:004864410.011
positive regulation of humoral immune responseGO:000292220.011
response to hypoxiaGO:00016662310.010
development of primary male sexual characteristicsGO:0046546590.010
regulation of acrosome reactionGO:006004610.010
Mouse
regulation of endopeptidase activityGO:0052548510.010
purine nucleotide catabolic processGO:00061951360.010
positive regulation of cell proliferationGO:00082842490.010
protein complex biogenesisGO:00702712630.010
receptor mediated endocytosisGO:0006898420.010
myelinationGO:0042552390.010
response to oxygen levelsGO:00704822650.010
response to fibroblast growth factorGO:0071774290.010
regulation of cellular catabolic processGO:00313291010.010
regulation of calcium ion transportGO:0051924770.010
Mouse
single organism membrane organizationGO:0044802740.010
negative regulation of phosphorylationGO:0042326570.010
Mouse
negative regulation of secretionGO:0051048820.010
response to vitamin aGO:0033189360.010

Spink3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.035
nervous system diseaseDOID:86300.035
bone diseaseDOID:008000100.029
connective tissue diseaseDOID:6500.029
musculoskeletal system diseaseDOID:1700.029
cardiovascular system diseaseDOID:128700.016
urinary system diseaseDOID:1800.012
central nervous system diseaseDOID:33100.011