IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Itm2c

integral membrane protein 2C

(Aliases: MGC94903)

Ensembl: ENSRNOG00000017359
Entrez: 301575
RGD: 1309503
UniProtKB: Q5PQL7

Process Predictions
Disease Predictions

Itm2c biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to cytokine	GO:0034097	215	0.152
central nervous system development	GO:0007417	311	0.122
cellular amino acid metabolic process	GO:0006520	107	0.112
apoptotic process	GO:0006915	381	0.111	Mouse
regulation of cell proliferation	GO:0042127	359	0.109
oxoacid metabolic process	GO:0043436	290	0.098
organic acid metabolic process	GO:0006082	292	0.091
reproduction	GO:0000003	245	0.078
response to inorganic substance	GO:0010035	377	0.074
carboxylic acid metabolic process	GO:0019752	289	0.071
brain development	GO:0007420	247	0.069
cellular component movement	GO:0006928	248	0.067
regulation of apoptotic process	GO:0042981	335	0.067	Mouse
regulation of cellular component movement	GO:0051270	150	0.067
cell motility	GO:0048870	202	0.060
response to extracellular stimulus	GO:0009991	380	0.057
response to wounding	GO:0009611	254	0.054
neuron differentiation	GO:0030182	368	0.054
negative regulation of multicellular organismal process	GO:0051241	203	0.054
homeostatic process	GO:0042592	331	0.053
response to metal ion	GO:0010038	253	0.050
organonitrogen compound biosynthetic process	GO:1901566	167	0.049
regulation of programmed cell death	GO:0043067	341	0.048	Mouse
positive regulation of neurogenesis	GO:0050769	165	0.048
head development	GO:0060322	247	0.048
single organism biosynthetic process	GO:0044711	342	0.046
protein phosphorylation	GO:0006468	345	0.043
cell type specific apoptotic process	GO:0097285	134	0.043
response to transition metal nanoparticle	GO:1990267	122	0.043
behavior	GO:0007610	205	0.043
negative regulation of cellular protein metabolic process	GO:0032269	106	0.043
programmed cell death	GO:0012501	392	0.042	Mouse
positive regulation of cell projection organization	GO:0031346	111	0.041
regulation of cellular protein metabolic process	GO:0032268	267	0.041
regulation of neuron differentiation	GO:0045664	208	0.041
multi organism reproductive process	GO:0044703	262	0.040
positive regulation of neuron projection development	GO:0010976	99	0.040
response to carbohydrate	GO:0009743	183	0.039
ion homeostasis	GO:0050801	212	0.038
localization of cell	GO:0051674	202	0.038
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.037
regulation of cellular ketone metabolic process	GO:0010565	27	0.037
response to molecule of bacterial origin	GO:0002237	194	0.037
cellular amine metabolic process	GO:0044106	38	0.036
response to acid chemical	GO:0001101	222	0.036
secretion by cell	GO:0032940	248	0.035
glial cell differentiation	GO:0010001	65	0.034
positive regulation of apoptotic process	GO:0043065	154	0.034	Mouse
negative regulation of cell death	GO:0060548	229	0.033
positive regulation of cell development	GO:0010720	176	0.033
regulation of cellular amine metabolic process	GO:0033238	8	0.033
response to decreased oxygen levels	GO:0036293	237	0.032
locomotion	GO:0040011	237	0.032
positive regulation of nervous system development	GO:0051962	178	0.032
response to peptide	GO:1901652	292	0.031
response to hypoxia	GO:0001666	231	0.031
response to estrogen	GO:0043627	232	0.031
response to oxygen levels	GO:0070482	265	0.031
response to growth factor	GO:0070848	189	0.031
cellular calcium ion homeostasis	GO:0006874	160	0.030
chemical homeostasis	GO:0048878	292	0.030
cellular response to endogenous stimulus	GO:0071495	377	0.030
reproductive process	GO:0022414	372	0.030
organophosphate biosynthetic process	GO:0090407	143	0.030
regulation of cell development	GO:0060284	263	0.029
cellular chemical homeostasis	GO:0055082	247	0.029
cellular homeostasis	GO:0019725	252	0.028
regulation of cellular component organization	GO:0051128	368	0.028
regulation of blood pressure	GO:0008217	83	0.028
regulation of cell cycle	GO:0051726	73	0.028
cellular catabolic process	GO:0044248	295	0.028
regulation of cellular amino acid metabolic process	GO:0006521	2	0.027
regulation of multicellular organismal development	GO:2000026	376	0.027
calcium ion homeostasis	GO:0055074	162	0.027
response to lipopolysaccharide	GO:0032496	191	0.027
regulation of locomotion	GO:0040012	148	0.027
negative regulation of molecular function	GO:0044092	133	0.026
protein maturation	GO:0051604	68	0.026
regulation of nervous system development	GO:0051960	264	0.026
response to glucocorticoid	GO:0051384	223	0.026
negative regulation of apoptotic process	GO:0043066	181	0.026
cellular response to oxygen containing compound	GO:1901701	386	0.026
positive regulation of cell death	GO:0010942	184	0.025	Mouse
cellular ketone metabolic process	GO:0042180	51	0.025
regulation of cell projection organization	GO:0031344	175	0.025
negative regulation of programmed cell death	GO:0043069	183	0.025
amine metabolic process	GO:0009308	38	0.025
positive regulation of cell differentiation	GO:0045597	217	0.025
gliogenesis	GO:0042063	93	0.025
actin filament based process	GO:0030029	86	0.024
positive regulation of cellular component organization	GO:0051130	200	0.024
regulation of protein metabolic process	GO:0051246	289	0.024
catabolic process	GO:0009056	351	0.024
neuron apoptotic process	GO:0051402	88	0.023
cellular response to lipid	GO:0071396	201	0.023
negative regulation of cellular metabolic process	GO:0031324	281	0.023
regulation of phosphorus metabolic process	GO:0051174	349	0.023
regulation of cell differentiation	GO:0045595	320	0.023
positive regulation of signal transduction	GO:0009967	175	0.023	Mouse
regeneration	GO:0031099	163	0.022
response to camp	GO:0051591	91	0.022
response to nutrient levels	GO:0031667	370	0.022
multi multicellular organism process	GO:0044706	138	0.022
carbohydrate derivative biosynthetic process	GO:1901137	124	0.022
response to other organism	GO:0051707	220	0.022
cell cell signaling	GO:0007267	335	0.022
positive regulation of neuron differentiation	GO:0045666	126	0.021
cell migration	GO:0016477	197	0.021
cation transport	GO:0006812	382	0.021
divalent metal ion transport	GO:0070838	132	0.021
negative regulation of metabolic process	GO:0009892	331	0.021
cytosolic calcium ion homeostasis	GO:0051480	140	0.021
regulation of neuron projection development	GO:0010975	161	0.021
divalent inorganic cation homeostasis	GO:0072507	165	0.021
regulation of metal ion transport	GO:0010959	118	0.021
anatomical structure morphogenesis	GO:0009653	298	0.021
response to nutrient	GO:0007584	248	0.021
regulation of protein modification process	GO:0031399	194	0.021
camp biosynthetic process	GO:0006171	47	0.020
regulation of catalytic activity	GO:0050790	304	0.020
positive regulation of multicellular organismal process	GO:0051240	387	0.020
immune response	GO:0006955	104	0.020
regulation of phosphorylation	GO:0042325	248	0.020
organelle organization	GO:0006996	266	0.020
cation homeostasis	GO:0055080	195	0.020
protein processing	GO:0016485	68	0.020
ion transmembrane transport	GO:0034220	365	0.019
positive regulation of cellular amine metabolic process	GO:0033240	3	0.019
neuron projection development	GO:0031175	273	0.019
cell morphogenesis involved in differentiation	GO:0000904	119	0.019
response to bacterium	GO:0009617	200	0.019
response to monosaccharide	GO:0034284	159	0.019
aging	GO:0007568	241	0.019
defense response	GO:0006952	194	0.019
cellular cation homeostasis	GO:0030003	180	0.018
negative regulation of protein metabolic process	GO:0051248	114	0.018
positive regulation of developmental process	GO:0051094	283	0.018
metal ion homeostasis	GO:0055065	186	0.018
cellular response to reactive oxygen species	GO:0034614	55	0.018
nitrogen compound transport	GO:0071705	229	0.018
response to glucose	GO:0009749	136	0.017
positive regulation of cell proliferation	GO:0008284	249	0.017
response to reactive oxygen species	GO:0000302	120	0.017
multicellular organismal reproductive process	GO:0048609	233	0.017
cellular ion homeostasis	GO:0006873	184	0.017
single organism reproductive process	GO:0044702	297	0.017
response to hexose	GO:0009746	144	0.017
cellular amino acid biosynthetic process	GO:0008652	32	0.017
regulation of response to wounding	GO:1903034	69	0.017
cellular response to cytokine stimulus	GO:0071345	127	0.017
negative regulation of cell proliferation	GO:0008285	119	0.017
cell projection organization	GO:0030030	302	0.017
negative regulation of macromolecule metabolic process	GO:0010605	260	0.017
regulation of neurogenesis	GO:0050767	247	0.016
positive regulation of programmed cell death	GO:0043068	157	0.016	Mouse
cellular metal ion homeostasis	GO:0006875	172	0.016
response to peptide hormone	GO:0043434	278	0.016
salivary gland development	GO:0007431	3	0.016
regulation of protein processing	GO:0070613	50	0.016
response to axon injury	GO:0048678	59	0.016
single organism behavior	GO:0044708	130	0.016
intracellular signal transduction	GO:0035556	314	0.016
cellular response to steroid hormone stimulus	GO:0071383	93	0.016
positive regulation of lipid kinase activity	GO:0090218	2	0.015
cellular response to stress	GO:0033554	269	0.015
cellular response to growth factor stimulus	GO:0071363	162	0.015
multicellular organism reproduction	GO:0032504	233	0.015
neuron development	GO:0048666	286	0.015
regulation of cell motility	GO:2000145	131	0.015
regulation of protein maturation	GO:1903317	50	0.015
nucleobase containing small molecule metabolic process	GO:0055086	316	0.015
organophosphate metabolic process	GO:0019637	370	0.015
response to cocaine	GO:0042220	39	0.015
tissue development	GO:0009888	252	0.015
response to interleukin 1	GO:0070555	55	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.015
response to insulin	GO:0032868	133	0.014
carbohydrate derivative metabolic process	GO:1901135	346	0.014
cellular component biogenesis	GO:0044085	368	0.014
response to amphetamine	GO:0001975	25	0.014
hemostasis	GO:0007599	26	0.014
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.014
reproductive structure development	GO:0048608	128	0.014
regulation of wound healing	GO:0061041	14	0.014
positive regulation of ion transport	GO:0043270	94	0.014
regulation of cell growth	GO:0001558	85	0.014
metal ion transport	GO:0030001	289	0.014
actin cytoskeleton organization	GO:0030036	73	0.014
response to amine	GO:0014075	46	0.014
regulation of phosphate metabolic process	GO:0019220	349	0.014
response to ketone	GO:1901654	182	0.013
neuron death	GO:0070997	127	0.013
negative regulation of protein maturation	GO:1903318	47	0.013
divalent inorganic cation transport	GO:0072511	134	0.013
cell activation	GO:0001775	97	0.013
positive regulation of signaling	GO:0023056	270	0.013	Mouse
negative regulation of proteolysis	GO:0045861	41	0.013
response to external biotic stimulus	GO:0043207	221	0.013
negative regulation of peptidase activity	GO:0010466	38	0.013
regulation of response to external stimulus	GO:0032101	106	0.013
gland development	GO:0048732	155	0.013
developmental process involved in reproduction	GO:0003006	159	0.013
developmental growth	GO:0048589	100	0.013
sexual reproduction	GO:0019953	148	0.013
positive regulation of mapk cascade	GO:0043410	92	0.013
macromolecular complex subunit organization	GO:0043933	339	0.013
embryo implantation	GO:0007566	15	0.013
calcium ion transport	GO:0006816	131	0.012
cyclic nucleotide biosynthetic process	GO:0009190	63	0.012
proteolysis	GO:0006508	175	0.012
response to oxidative stress	GO:0006979	186	0.012
female pregnancy	GO:0007565	122	0.012
positive regulation of transport	GO:0051050	245	0.012
signal transduction by phosphorylation	GO:0023014	144	0.012
regulation of cellular localization	GO:0060341	263	0.012
organic substance catabolic process	GO:1901575	316	0.012
eye morphogenesis	GO:0048592	4	0.012
regulation of protein phosphorylation	GO:0001932	183	0.012
negative regulation of catalytic activity	GO:0043086	103	0.012
motor neuron axon guidance	GO:0008045	1	0.012
positive regulation of cell communication	GO:0010647	271	0.012	Mouse
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.012
development of primary sexual characteristics	GO:0045137	107	0.012
regulation of endopeptidase activity	GO:0052548	51	0.012
negative regulation of gene expression	GO:0010629	199	0.012
response to fatty acid	GO:0070542	65	0.012
response to purine containing compound	GO:0014074	126	0.012
cellular response to hormone stimulus	GO:0032870	247	0.012
organic acid biosynthetic process	GO:0016053	83	0.012
regulation of hydrolase activity	GO:0051336	143	0.012
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.012
positive regulation of phosphate metabolic process	GO:0045937	262	0.012
regulation of secretion by cell	GO:1903530	208	0.012
synaptic transmission	GO:0007268	235	0.012
glutamate secretion	GO:0014047	19	0.012
regulation of ion transport	GO:0043269	245	0.011
nucleotide metabolic process	GO:0009117	279	0.011
regulation of camp biosynthetic process	GO:0030817	38	0.011
adult locomotory behavior	GO:0008344	4	0.011
negative regulation of response to external stimulus	GO:0032102	37	0.011
response to estradiol	GO:0032355	164	0.011
regulation of peptidase activity	GO:0052547	55	0.011
negative regulation of developmental process	GO:0051093	125	0.011
cellular response to inorganic substance	GO:0071241	65	0.011
reproductive system development	GO:0061458	128	0.011
dendrite development	GO:0016358	72	0.011
actin crosslink formation	GO:0051764	3	0.011
response to organophosphorus	GO:0046683	102	0.011
positive regulation of gene expression	GO:0010628	244	0.011
lipid biosynthetic process	GO:0008610	128	0.011
peptide metabolic process	GO:0006518	32	0.011
gonad development	GO:0008406	104	0.011
positive regulation of phosphorus metabolic process	GO:0010562	262	0.011
regulation of lyase activity	GO:0051339	22	0.010
arginine metabolic process	GO:0006525	6	0.010
response to toxic substance	GO:0009636	133	0.010
positive regulation of protein metabolic process	GO:0051247	178	0.010
axon choice point recognition	GO:0016198	2	0.010
innate immune response	GO:0045087	35	0.010
forebrain development	GO:0030900	98	0.010
regulation of anatomical structure size	GO:0090066	135	0.010
camp metabolic process	GO:0046058	63	0.010
regulation of hormone levels	GO:0010817	187	0.010
negative regulation of endopeptidase activity	GO:0010951	36	0.010
cellular response to oxidative stress	GO:0034599	76	0.010
sex differentiation	GO:0007548	113	0.010
positive regulation of secretion by cell	GO:1903532	128	0.010

Itm2c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.043
nervous system disease	DOID:863	0.026
disease of anatomical entity	DOID:7	0.026
inherited metabolic disorder	DOID:655	0.021
lysosomal storage disease	DOID:3211	0.021
lipid storage disease	DOID:9455	0.019
sensory system disease	DOID:0050155	0.011
central nervous system disease	DOID:331	0.011

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