IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Klhl23

kelch-like 23 (Drosophila)

(Aliases: RGD1307166)

Entrez: 311114
RGD: 1307166
Ensembl: ENSRNOG00000007981
UniProtKB: D3ZLV9

Process Predictions
Disease Predictions

Klhl23 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of ion transport	GO:0043269	245	0.096
cellular component biogenesis	GO:0044085	368	0.070	Rat
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.065
regulation of transcription dna templated	GO:0006355	374	0.064
calcium ion homeostasis	GO:0055074	162	0.063
divalent metal ion transport	GO:0070838	132	0.061
cellular chemical homeostasis	GO:0055082	247	0.060
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.059
positive regulation of cell development	GO:0010720	176	0.057	Rat
response to oxygen levels	GO:0070482	265	0.054
protein complex subunit organization	GO:0071822	302	0.054	Rat
calcium ion transport	GO:0006816	131	0.053
positive regulation of cellular biosynthetic process	GO:0031328	295	0.053
cell projection organization	GO:0030030	302	0.052	Rat
multicellular organism reproduction	GO:0032504	233	0.052
macromolecular complex assembly	GO:0065003	273	0.051	Rat
cellular calcium ion homeostasis	GO:0006874	160	0.050
negative regulation of cellular metabolic process	GO:0031324	281	0.049
neuron differentiation	GO:0030182	368	0.048	Rat
cellular homeostasis	GO:0019725	252	0.048
cellular cation homeostasis	GO:0030003	180	0.047
regulation of multicellular organismal development	GO:2000026	376	0.047	Rat
regulation of cellular component organization	GO:0051128	368	0.046	Rat
carbohydrate derivative metabolic process	GO:1901135	346	0.046
regulation of cell differentiation	GO:0045595	320	0.046	Rat
rna metabolic process	GO:0016070	406	0.045
single organism reproductive process	GO:0044702	297	0.045
positive regulation of neuron projection development	GO:0010976	99	0.044	Rat
neuron projection development	GO:0031175	273	0.044	Rat
positive regulation of multicellular organismal process	GO:0051240	387	0.043	Rat
ion homeostasis	GO:0050801	212	0.043
anatomical structure morphogenesis	GO:0009653	298	0.040
regulation of rna biosynthetic process	GO:2001141	381	0.040
nucleic acid templated transcription	GO:0097659	379	0.040
homeostatic process	GO:0042592	331	0.040
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.039
regulation of neurogenesis	GO:0050767	247	0.039	Rat
regulation of metal ion transport	GO:0010959	118	0.039
regulation of cell development	GO:0060284	263	0.038	Rat
positive regulation of developmental process	GO:0051094	283	0.038	Rat
regulation of cellular localization	GO:0060341	263	0.038	Rat
cellular component movement	GO:0006928	248	0.037
cation transport	GO:0006812	382	0.037
positive regulation of ion transport	GO:0043270	94	0.037
cellular metal ion homeostasis	GO:0006875	172	0.036
reproductive process	GO:0022414	372	0.036
regulation of calcium ion transport	GO:0051924	77	0.036
regulation of cell proliferation	GO:0042127	359	0.036
divalent inorganic cation homeostasis	GO:0072507	165	0.034
intracellular signal transduction	GO:0035556	314	0.034
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.034
positive regulation of biosynthetic process	GO:0009891	319	0.033
macromolecular complex subunit organization	GO:0043933	339	0.033	Rat
rna biosynthetic process	GO:0032774	380	0.033
single organism carbohydrate metabolic process	GO:0044723	118	0.033
positive regulation of cell differentiation	GO:0045597	217	0.033	Rat
regulation of neuron differentiation	GO:0045664	208	0.032	Rat
response to inorganic substance	GO:0010035	377	0.032	Rat
positive regulation of phosphate metabolic process	GO:0045937	262	0.032
cellular component assembly	GO:0022607	360	0.032	Rat
cellular ion homeostasis	GO:0006873	184	0.031
carbohydrate metabolic process	GO:0005975	130	0.031
regulation of phosphorylation	GO:0042325	248	0.031
protein complex biogenesis	GO:0070271	263	0.031	Rat
inorganic cation transmembrane transport	GO:0098662	202	0.031
chemical homeostasis	GO:0048878	292	0.031
nucleobase containing small molecule metabolic process	GO:0055086	316	0.031
regulation of nervous system development	GO:0051960	264	0.031	Rat
positive regulation of intracellular signal transduction	GO:1902533	138	0.030
central nervous system development	GO:0007417	311	0.030	Rat
divalent inorganic cation transport	GO:0072511	134	0.030
circulatory system development	GO:0072359	134	0.030
signal transduction by phosphorylation	GO:0023014	144	0.030
regulation of intracellular signal transduction	GO:1902531	218	0.030
transcription from rna polymerase ii promoter	GO:0006366	252	0.029
ribose phosphate biosynthetic process	GO:0046390	87	0.029
response to wounding	GO:0009611	254	0.029
multicellular organismal signaling	GO:0035637	44	0.029
transmembrane transport	GO:0055085	412	0.029
positive regulation of neuron differentiation	GO:0045666	126	0.028	Rat
positive regulation of cellular component organization	GO:0051130	200	0.028	Rat
brain development	GO:0007420	247	0.028	Rat
multicellular organismal reproductive process	GO:0048609	233	0.028
apoptotic process	GO:0006915	381	0.028
positive regulation of molecular function	GO:0044093	230	0.027
ras protein signal transduction	GO:0007265	29	0.027
protein complex assembly	GO:0006461	263	0.027	Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.027
locomotion	GO:0040011	237	0.027
cellular response to stress	GO:0033554	269	0.026
cation homeostasis	GO:0055080	195	0.026
regulation of nucleic acid templated transcription	GO:1903506	380	0.026
cation transmembrane transport	GO:0098655	263	0.026
metal ion transport	GO:0030001	289	0.026
multi organism reproductive process	GO:0044703	262	0.026
reproduction	GO:0000003	245	0.026
sequestering of calcium ion	GO:0051208	8	0.025
neuron development	GO:0048666	286	0.025	Rat
regulation of molecular function	GO:0065009	398	0.025
tissue development	GO:0009888	252	0.025
regulation of apoptotic process	GO:0042981	335	0.025
regulation of catalytic activity	GO:0050790	304	0.024
negative regulation of developmental process	GO:0051093	125	0.024
transmission of nerve impulse	GO:0019226	42	0.024
positive regulation of phosphorus metabolic process	GO:0010562	262	0.024
negative regulation of multicellular organismal process	GO:0051241	203	0.024
negative regulation of cell death	GO:0060548	229	0.024
cellular response to organic cyclic compound	GO:0071407	202	0.024	Rat
regulation of cellular amino acid metabolic process	GO:0006521	2	0.024
programmed cell death	GO:0012501	392	0.024
cellular amine metabolic process	GO:0044106	38	0.024
positive regulation of cell projection organization	GO:0031346	111	0.024	Rat
cellular amino acid metabolic process	GO:0006520	107	0.024
response to mechanical stimulus	GO:0009612	134	0.024
response to extracellular stimulus	GO:0009991	380	0.024
positive regulation of transport	GO:0051050	245	0.023
blood circulation	GO:0008015	183	0.023
regulation of programmed cell death	GO:0043067	341	0.023
regulation of phosphorus metabolic process	GO:0051174	349	0.023
aging	GO:0007568	241	0.023
positive regulation of cell communication	GO:0010647	271	0.023
intracellular transport	GO:0046907	185	0.023	Rat
cytosolic calcium ion homeostasis	GO:0051480	140	0.022
purine containing compound metabolic process	GO:0072521	253	0.022
oxidation reduction process	GO:0055114	304	0.022
ribonucleoside metabolic process	GO:0009119	174	0.022
amine metabolic process	GO:0009308	38	0.022
negative regulation of macromolecule metabolic process	GO:0010605	260	0.022	Rat
regulation of neuron projection development	GO:0010975	161	0.022	Rat
secretion	GO:0046903	307	0.022
sequestering of metal ion	GO:0051238	9	0.022
organophosphate metabolic process	GO:0019637	370	0.022
positive regulation of secretion	GO:0051047	140	0.022
regulation of cell projection organization	GO:0031344	175	0.021	Rat
head development	GO:0060322	247	0.021	Rat
glycosyl compound metabolic process	GO:1901657	182	0.021
positive regulation of cell death	GO:0010942	184	0.021
positive regulation of signaling	GO:0023056	270	0.021
negative regulation of gene expression	GO:0010629	199	0.021	Rat
organic acid metabolic process	GO:0006082	292	0.021	Rat
response to carbohydrate	GO:0009743	183	0.021
ribonucleotide metabolic process	GO:0009259	231	0.021
regulation of phosphate metabolic process	GO:0019220	349	0.021
single organism biosynthetic process	GO:0044711	342	0.021
organophosphate biosynthetic process	GO:0090407	143	0.021
metal ion homeostasis	GO:0055065	186	0.021
transcription dna templated	GO:0006351	377	0.021
regulation of rna metabolic process	GO:0051252	391	0.021
response to alkaloid	GO:0043279	132	0.021
growth	GO:0040007	165	0.021
response to ethanol	GO:0045471	162	0.021
circulatory system process	GO:0003013	183	0.021
purine nucleotide metabolic process	GO:0006163	229	0.021
negative regulation of metabolic process	GO:0009892	331	0.020	Rat
ribose phosphate metabolic process	GO:0019693	235	0.020
sexual reproduction	GO:0019953	148	0.020
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0014808	4	0.020
cardiovascular system development	GO:0072358	134	0.020
response to decreased oxygen levels	GO:0036293	237	0.020
cellular response to oxygen containing compound	GO:1901701	386	0.020
regulation of cellular amine metabolic process	GO:0033238	8	0.020
ion transmembrane transport	GO:0034220	365	0.020
peptidyl amino acid modification	GO:0018193	126	0.020
cell type specific apoptotic process	GO:0097285	134	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.019
g protein coupled receptor signaling pathway	GO:0007186	242	0.019
localization of cell	GO:0051674	202	0.019
response to monosaccharide	GO:0034284	159	0.019
inflammatory response	GO:0006954	150	0.019
positive regulation of nervous system development	GO:0051962	178	0.019	Rat
positive regulation of gene expression	GO:0010628	244	0.019
small gtpase mediated signal transduction	GO:0007264	36	0.018
regulation of hydrolase activity	GO:0051336	143	0.018
positive regulation of cellular amine metabolic process	GO:0033240	3	0.018
response to nutrient levels	GO:0031667	370	0.018
purine ribonucleotide metabolic process	GO:0009150	227	0.018
positive regulation of transcription dna templated	GO:0045893	197	0.018
positive regulation of phosphorylation	GO:0042327	177	0.018
cellular carbohydrate metabolic process	GO:0044262	72	0.018
sex differentiation	GO:0007548	113	0.018
protein phosphorylation	GO:0006468	345	0.018
regulation of anatomical structure morphogenesis	GO:0022603	141	0.018
regulation of secretion	GO:0051046	224	0.018
regulation of protein metabolic process	GO:0051246	289	0.018
positive regulation of cellular protein metabolic process	GO:0032270	167	0.018
response to glucose	GO:0009749	136	0.018
male mating behavior	GO:0060179	3	0.018
inorganic ion transmembrane transport	GO:0098660	229	0.018
phototransduction visible light	GO:0007603	2	0.018
regulation of protein phosphorylation	GO:0001932	183	0.017
regulation of cellular ketone metabolic process	GO:0010565	27	0.017
oxoacid metabolic process	GO:0043436	290	0.017	Rat
positive regulation of cell proliferation	GO:0008284	249	0.017
detection of visible light	GO:0009584	3	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.017
regulation of transporter activity	GO:0032409	50	0.017
positive regulation of neurogenesis	GO:0050769	165	0.017	Rat
cell motility	GO:0048870	202	0.017
mesenchymal cell proliferation	GO:0010463	4	0.016
nucleoside metabolic process	GO:0009116	179	0.016
cell migration	GO:0016477	197	0.016
positive regulation of calcium ion transport	GO:0051928	36	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.016
ovulation cycle	GO:0042698	67	0.016
maintenance of location	GO:0051235	17	0.016	Rat
negative regulation of programmed cell death	GO:0043069	183	0.016
calcium ion transport into cytosol	GO:0060402	38	0.016
regulation of membrane potential	GO:0042391	110	0.016
regulation of transmembrane transport	GO:0034762	122	0.016
negative regulation of transport	GO:0051051	136	0.016	Rat
response to metal ion	GO:0010038	253	0.016	Rat
developmental process involved in reproduction	GO:0003006	159	0.016
response to nutrient	GO:0007584	248	0.015
calcium ion transmembrane transport	GO:0070588	70	0.015
positive regulation of protein phosphorylation	GO:0001934	135	0.015
response to ketone	GO:1901654	182	0.015
defense response	GO:0006952	194	0.015
axis specification	GO:0009798	4	0.015
response to acid chemical	GO:0001101	222	0.015
purine ribonucleoside metabolic process	GO:0046128	168	0.015
cellular response to hormone stimulus	GO:0032870	247	0.015
response to reactive oxygen species	GO:0000302	120	0.015
positive regulation of response to stimulus	GO:0048584	285	0.015
vascular process in circulatory system	GO:0003018	96	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.015
cellular ketone metabolic process	GO:0042180	51	0.015
response to estradiol	GO:0032355	164	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.015
positive regulation of catalytic activity	GO:0043085	184	0.015
carbohydrate derivative biosynthetic process	GO:1901137	124	0.015
positive regulation of signal transduction	GO:0009967	175	0.015
cellular response to lipid	GO:0071396	201	0.015
negative regulation of apoptotic process	GO:0043066	181	0.015
negative regulation of cell proliferation	GO:0008285	119	0.015
nucleobase containing compound catabolic process	GO:0034655	152	0.015
positive regulation of rna biosynthetic process	GO:1902680	197	0.014
nucleotide metabolic process	GO:0009117	279	0.014
cellular response to external stimulus	GO:0071496	118	0.014
learning or memory	GO:0007611	90	0.014
spermatogenesis	GO:0007283	99	0.014
carboxylic acid metabolic process	GO:0019752	289	0.014	Rat
nucleoside triphosphate metabolic process	GO:0009141	144	0.014
neurological system process	GO:0050877	219	0.014
cytosolic calcium ion transport	GO:0060401	39	0.014
regulation of neuron death	GO:1901214	115	0.014
nucleoside phosphate biosynthetic process	GO:1901293	102	0.014
gliogenesis	GO:0042063	93	0.014
rhythmic process	GO:0048511	156	0.014
negative regulation of mitotic cell cycle phase transition	GO:1901991	3	0.014
regulation of kinase activity	GO:0043549	117	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.014
nitrogen compound transport	GO:0071705	229	0.014
positive regulation of rap gtpase activity	GO:0032854	4	0.014
leukocyte cell cell adhesion	GO:0007159	4	0.014
regulation of secretion by cell	GO:1903530	208	0.014
purine nucleoside metabolic process	GO:0042278	169	0.014
positive regulation of kinase activity	GO:0033674	77	0.014
neuronal action potential	GO:0019228	35	0.014
negative regulation of cellular biosynthetic process	GO:0031327	161	0.014
response to estrogen	GO:0043627	232	0.014
female sex differentiation	GO:0046660	59	0.014
cellular catabolic process	GO:0044248	295	0.014
detection of chemical stimulus involved in sensory perception of bitter taste	GO:0001580	4	0.014
positive regulation of cellular component movement	GO:0051272	102	0.013
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.013
regulation of ion transmembrane transport	GO:0034765	121	0.013
positive regulation of cell migration	GO:0030335	96	0.013
cell projection morphogenesis	GO:0048858	123	0.013
positive regulation of protein modification process	GO:0031401	142	0.013
regulation of anatomical structure size	GO:0090066	135	0.013
protein oligomerization	GO:0051259	191	0.013	Rat
regeneration	GO:0031099	163	0.013
purine containing compound catabolic process	GO:0072523	138	0.013
nucleoside phosphate metabolic process	GO:0006753	283	0.013
regulation of signal transduction	GO:0009966	318	0.013
response to hypoxia	GO:0001666	231	0.013
rho protein signal transduction	GO:0007266	11	0.013
purine ribonucleotide catabolic process	GO:0009154	136	0.013
male gamete generation	GO:0048232	99	0.013
regulation of ion transmembrane transporter activity	GO:0032412	48	0.012
meiotic cell cycle process	GO:1903046	3	0.012
blood vessel development	GO:0001568	69	0.012
gonad development	GO:0008406	104	0.012
sulfur compound metabolic process	GO:0006790	70	0.012	Rat
regulation of homeostatic process	GO:0032844	101	0.012
response to camp	GO:0051591	91	0.012
positive regulation of mapk cascade	GO:0043410	92	0.012
negative regulation of signaling	GO:0023057	157	0.012
muscle system process	GO:0003012	115	0.012
ovulation cycle process	GO:0022602	50	0.012
cell growth	GO:0016049	104	0.012
positive regulation of rna metabolic process	GO:0051254	203	0.012
monovalent inorganic cation transport	GO:0015672	172	0.012
female gonad development	GO:0008585	53	0.012
negative regulation of cell cycle phase transition	GO:1901988	4	0.012
energy derivation by oxidation of organic compounds	GO:0015980	46	0.012
regulation of cellular component biogenesis	GO:0044087	86	0.012
muscle tissue development	GO:0060537	58	0.012
axon development	GO:0061564	96	0.012
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.012
negative regulation of viral process	GO:0048525	4	0.012
regulation of protein modification process	GO:0031399	194	0.012
adult locomotory behavior	GO:0008344	4	0.012
negative regulation of neuron differentiation	GO:0045665	62	0.012
liver development	GO:0001889	90	0.012
cellular response to endogenous stimulus	GO:0071495	377	0.012
sensory perception of pain	GO:0019233	73	0.011
ribonucleotide biosynthetic process	GO:0009260	85	0.011
regulation of ion homeostasis	GO:2000021	63	0.011
regulation of sequestering of calcium ion	GO:0051282	26	0.011
positive regulation of protein metabolic process	GO:0051247	178	0.011
positive regulation of cellular component biogenesis	GO:0044089	55	0.011
positive regulation of transferase activity	GO:0051347	81	0.011
alternative mrna splicing via spliceosome	GO:0000380	4	0.011
chromosome segregation	GO:0007059	2	0.011
regulation of transferase activity	GO:0051338	123	0.011
neuron death	GO:0070997	127	0.011
regulation of blood circulation	GO:1903522	110	0.011
response to hydrogen peroxide	GO:0042542	89	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.011
second messenger mediated signaling	GO:0019932	51	0.011
response to other organism	GO:0051707	220	0.011
heart development	GO:0007507	72	0.011
mapk cascade	GO:0000165	140	0.011
cardiac muscle contraction	GO:0060048	27	0.011
cyclic nucleotide biosynthetic process	GO:0009190	63	0.011
chromatin assembly or disassembly	GO:0006333	1	0.011
negative regulation of ion transport	GO:0043271	51	0.011
neuron apoptotic process	GO:0051402	88	0.011
muscle structure development	GO:0061061	87	0.011
hepaticobiliary system development	GO:0061008	90	0.011
gamete generation	GO:0007276	124	0.011
action potential	GO:0001508	54	0.011
negative regulation of cell communication	GO:0010648	158	0.011
positive regulation of nucleotide metabolic process	GO:0045981	91	0.011
cytoplasmic transport	GO:0016482	115	0.011	Rat
response to bacterium	GO:0009617	200	0.011
regulation of neuron apoptotic process	GO:0043523	83	0.011
purine ribonucleotide biosynthetic process	GO:0009152	81	0.011
nucleotide catabolic process	GO:0009166	139	0.011
negative regulation of neuron death	GO:1901215	69	0.011
response to hexose	GO:0009746	144	0.011
catabolic process	GO:0009056	351	0.011
positive regulation of protein kinase activity	GO:0045860	73	0.011
release of sequestered calcium ion into cytosol	GO:0051209	25	0.010
negative regulation of molecular function	GO:0044092	133	0.010
negative regulation of neurogenesis	GO:0050768	78	0.010
nucleotide biosynthetic process	GO:0009165	98	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.010
cell cell signaling	GO:0007267	335	0.010
cellular response to carbohydrate stimulus	GO:0071322	72	0.010
regulation of cell migration	GO:0030334	128	0.010
regulation of erk1 and erk2 cascade	GO:0070372	41	0.010
mitotic cell cycle checkpoint	GO:0007093	1	0.010
response to purine containing compound	GO:0014074	126	0.010
regulation of cellular component movement	GO:0051270	150	0.010
regulation of cellular protein metabolic process	GO:0032268	267	0.010
development of primary female sexual characteristics	GO:0046545	56	0.010
organic substance catabolic process	GO:1901575	316	0.010
nucleoside phosphate catabolic process	GO:1901292	140	0.010
purine nucleotide biosynthetic process	GO:0006164	83	0.010
oligopeptide transport	GO:0006857	4	0.010
response to growth factor	GO:0070848	189	0.010
negative regulation of cell development	GO:0010721	82	0.010
single organism catabolic process	GO:0044712	283	0.010
actin cytoskeleton organization	GO:0030036	73	0.010	Rat
positive regulation of mesenchymal cell proliferation	GO:0002053	4	0.010
regulation of locomotion	GO:0040012	148	0.010
syncytium formation	GO:0006949	4	0.010
generation of precursor metabolites and energy	GO:0006091	62	0.010

Klhl23 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.045
disease of anatomical entity	DOID:7	0.045
myopathy	DOID:423	0.035
muscular disease	DOID:0080000	0.035
musculoskeletal system disease	DOID:17	0.035
muscle tissue disease	DOID:66	0.035
brain disease	DOID:936	0.024
central nervous system disease	DOID:331	0.024
muscular dystrophy	DOID:9884	0.020
cardiovascular system disease	DOID:1287	0.017

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