Rattus norvegicus

69 known processes

A2m

alpha-2-macroglobulin

(Aliases: A2MAC1,MGC114358,A2m1,A2maa,RATA2MAC1,Mam)

A2m biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to cytokineGO:00340972150.522
response to nutrientGO:00075842480.406
inflammatory responseGO:00069541500.386
cell cell signalingGO:00072673350.351
response to other organismGO:00517072200.344
response to estrogenGO:00436272320.341
negative regulation of multicellular organismal processGO:00512412030.323
negative regulation of cell proliferationGO:00082851190.323
cellular response to interleukin 6GO:007135490.321
cellular response to interleukin 1GO:0071347370.294
reproductive processGO:00224143720.292
positive regulation of multicellular organismal processGO:00512403870.276
regulation of programmed cell deathGO:00430673410.265
response to inorganic substanceGO:00100353770.253
g protein coupled receptor signaling pathwayGO:00071862420.249
intracellular signal transductionGO:00355563140.242
vasculature developmentGO:0001944700.240
positive regulation of neurogenesisGO:00507691650.230
response to extracellular stimulusGO:00099913800.222
response to nutrient levelsGO:00316673700.207
response to estradiolGO:00323551640.202
positive regulation of response to stimulusGO:00485842850.200
response to lipopolysaccharideGO:00324961910.197
regulation of secretion by cellGO:19035302080.190
regulation of neurogenesisGO:00507672470.184
response to metal ionGO:00100382530.183
immune responseGO:00069551040.179
response to molecule of bacterial originGO:00022371940.172
neuron differentiationGO:00301823680.172
homeostatic processGO:00425923310.170
muscle cell proliferationGO:0033002840.168
programmed cell deathGO:00125013920.163
response to mechanical stimulusGO:00096121340.159
regulation of multicellular organismal developmentGO:20000263760.158
regulation of nervous system developmentGO:00519602640.152
positive regulation of signalingGO:00230562700.151
response to biotic stimulusGO:00096072260.150
response to bacteriumGO:00096172000.145
response to interleukin 1GO:0070555550.143
neuron projection developmentGO:00311752730.140
neuron developmentGO:00486662860.139
response to external biotic stimulusGO:00432072210.137
organic acid metabolic processGO:00060822920.137
synaptic transmissionGO:00072682350.135
positive regulation of developmental processGO:00510942830.135
neuron projection morphogenesisGO:00488121220.135
carboxylic acid metabolic processGO:00197522890.133
immune system processGO:00023762040.130
cellular chemical homeostasisGO:00550822470.128
locomotionGO:00400112370.123
positive regulation of cellular biosynthetic processGO:00313282950.121
regulation of cell proliferationGO:00421273590.121
female pregnancyGO:00075651220.120
regulation of cellular protein metabolic processGO:00322682670.119
regulation of transcription dna templatedGO:00063553740.115
positive regulation of phosphorus metabolic processGO:00105622620.113
regulation of cellular component organizationGO:00511283680.111
regulation of phosphorus metabolic processGO:00511743490.109
negative regulation of cellular metabolic processGO:00313242810.109
epithelial cell proliferationGO:0050673540.107
response to hypoxiaGO:00016662310.107
negative regulation of developmental processGO:00510931250.106
wound healingGO:00420601220.104
secretionGO:00469033070.104
ion homeostasisGO:00508012120.104
cellular response to endogenous stimulusGO:00714953770.104
positive regulation of phosphate metabolic processGO:00459372620.103
macromolecular complex subunit organizationGO:00439333390.103
negative regulation of peptidase activityGO:0010466380.103
transcription dna templatedGO:00063513770.103
neurological system processGO:00508772190.101
defense responseGO:00069521940.100
cellular response to stressGO:00335542690.099
cardiovascular system developmentGO:00723581340.098
growthGO:00400071650.097
circulatory system developmentGO:00723591340.095
protein processingGO:0016485680.095
response to chromateGO:004668730.094
cation transportGO:00068123820.092
anatomical structure morphogenesisGO:00096532980.091
positive regulation of nitrogen compound metabolic processGO:00511733340.091
regulation of metal ion transportGO:00109591180.090
positive regulation of cell proliferationGO:00082842490.090
chemical homeostasisGO:00488782920.089
cellular response to oxygen containing compoundGO:19017013860.089
proteolysisGO:00065081750.089
regulation of protein maturationGO:1903317500.088
positive regulation of transportGO:00510502450.087
retina development in camera type eyeGO:0060041270.086
cellular component assemblyGO:00226073600.086
negative regulation of metabolic processGO:00098923310.084
regulation of secretionGO:00510462240.084
negative regulation of macromolecule metabolic processGO:00106052600.083
single organism behaviorGO:00447081300.083
cell growthGO:00160491040.082
reproductionGO:00000032450.082
ribonucleotide biosynthetic processGO:0009260850.081
single organism reproductive processGO:00447022970.080
regulation of phosphate metabolic processGO:00192203490.080
metal ion homeostasisGO:00550651860.079
multicellular organismal reproductive processGO:00486092330.079
blood vessel developmentGO:0001568690.078
nucleic acid templated transcriptionGO:00976593790.078
regulation of apoptotic processGO:00429813350.078
regulation of ion transportGO:00432692450.078
regulation of signal transductionGO:00099663180.077
positive regulation of signal transductionGO:00099671750.077
response to corticosteroidGO:00319602350.077
kidney developmentGO:0001822670.077
apoptotic processGO:00069153810.076
protein maturationGO:0051604680.076
positive regulation of secretionGO:00510471400.075
negative regulation of proteolysisGO:0045861410.074
regulation of phosphorylationGO:00423252480.073
localization of cellGO:00516742020.072
regulation of synaptic transmissionGO:00508041410.072
response to oxidative stressGO:00069791860.071
renal system developmentGO:0072001670.071
cellular component biogenesisGO:00440853680.071
response to campGO:0051591910.071
rhythmic processGO:00485111560.071
multi organism reproductive processGO:00447032620.070
response to decreased oxygen levelsGO:00362932370.070
macromolecular complex assemblyGO:00650032730.070
regulation of blood vessel sizeGO:0050880890.070
regulation of cell morphogenesis involved in differentiationGO:0010769720.069
positive regulation of purine nucleotide metabolic processGO:1900544910.069
protein complex biogenesisGO:00702712630.069
cellular component movementGO:00069282480.068
positive regulation of cell communicationGO:00106472710.067
regulation of rna metabolic processGO:00512523910.067
mapk cascadeGO:00001651400.066
positive regulation of biosynthetic processGO:00098913190.066
cellular response to interferon gammaGO:0071346140.066
cellular response to cytokine stimulusGO:00713451270.066
protein transportGO:00150311320.065
response to woundingGO:00096112540.065
peptidyl amino acid modificationGO:00181931260.065
regulation of cellular amino acid metabolic processGO:000652120.065
response to transition metal nanoparticleGO:19902671220.064
mesenchymal cell proliferationGO:001046340.064
oxoacid metabolic processGO:00434362900.064
purine nucleotide biosynthetic processGO:0006164830.063
central nervous system developmentGO:00074173110.063
astrocyte developmentGO:001400240.063
regulation of nucleotide biosynthetic processGO:0030808470.062
cell projection morphogenesisGO:00488581230.062
signal transduction by phosphorylationGO:00230141440.062
positive regulation of cell deathGO:00109421840.061
cell motilityGO:00488702020.061
response to ethanolGO:00454711620.061
positive regulation of nervous system developmentGO:00519621780.060
response to hexoseGO:00097461440.060
tissue remodelingGO:0048771400.060
positive regulation of phosphorylationGO:00423271770.060
negative regulation of gene expressionGO:00106291990.059
agingGO:00075682410.059
positive regulation of nucleobase containing compound metabolic processGO:00459353190.059
response to oxygen levelsGO:00704822650.059
regulation of cellular localizationGO:00603412630.058
metal ion transportGO:00300012890.058
regulation of molecular functionGO:00650093980.058
urogenital system developmentGO:0001655780.058
regulation of cellular amine metabolic processGO:003323880.058
regulation of calcium ion transportGO:0051924770.058
amine metabolic processGO:0009308380.057
camera type eye developmentGO:0043010480.057
multi multicellular organism processGO:00447061380.057
cellular response to mechanical stimulusGO:0071260480.057
positive regulation of molecular functionGO:00440932300.057
regulation of hydrolase activityGO:00513361430.056
positive regulation of nucleotide metabolic processGO:0045981910.056
positive regulation of intracellular signal transductionGO:19025331380.056
cell projection organizationGO:00300303020.055
regulation of cell developmentGO:00602842630.055
cellular response to hormone stimulusGO:00328702470.055
cellular metal ion homeostasisGO:00068751720.054
positive regulation of cell developmentGO:00107201760.054
protein localizationGO:00081041910.054
anterior posterior pattern specificationGO:000995210.054
regulation of cellular component movementGO:00512701500.054
response to glucocorticoidGO:00513842230.054
cellular amine metabolic processGO:0044106380.054
renal system processGO:0003014400.053
regulation of catalytic activityGO:00507903040.053
regulation of protein metabolic processGO:00512462890.053
nucleoside phosphate biosynthetic processGO:19012931020.053
cellular response to abiotic stimulusGO:0071214850.052
regulation of vasculature developmentGO:1901342440.052
regulation of nucleic acid templated transcriptionGO:19035063800.051
eye morphogenesisGO:004859240.051
negative regulation of protein maturationGO:1903318470.051
nucleoside phosphate metabolic processGO:00067532830.051
response to purine containing compoundGO:00140741260.051
response to peptideGO:19016522920.050
secretion by cellGO:00329402480.050
cell migrationGO:00164771970.050
regulation of serine type peptidase activityGO:190257110.049
cellular response to growth factor stimulusGO:00713631620.049
regulation of anatomical structure sizeGO:00900661350.049
positive regulation of mesenchymal cell proliferationGO:000205340.049
response to reactive oxygen speciesGO:00003021200.048
cellular homeostasisGO:00197252520.048
forebrain developmentGO:0030900980.048
organic anion transportGO:00157111320.048
circulatory system processGO:00030131830.048
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.048
muscle contractionGO:0006936880.047
negative regulation of protein processingGO:0010955470.047
positive regulation of secretion by cellGO:19035321280.046
negative regulation of cell developmentGO:0010721820.046
response to glucoseGO:00097491360.046
divalent inorganic cation transportGO:00725111340.046
purine ribonucleotide metabolic processGO:00091502270.046
regulation of angiogenesisGO:0045765390.046
response to peptide hormoneGO:00434342780.046
renal sodium excretionGO:0035812200.045
regulation of protein processingGO:0070613500.045
negative regulation of nitrogen compound metabolic processGO:00511721610.045
negative regulation of signalingGO:00230571570.045
catabolic processGO:00090563510.044
ameboidal type cell migrationGO:0001667260.044
acid secretionGO:0046717480.044
positive regulation of cell differentiationGO:00455972170.044
response to monosaccharideGO:00342841590.044
negative regulation of cell differentiationGO:0045596990.044
tube developmentGO:0035295890.044
astrocyte differentiationGO:0048708190.043
positive regulation of catalytic activityGO:00430851840.043
negative regulation of programmed cell deathGO:00430691830.043
positive regulation of transcription dna templatedGO:00458931970.043
negative regulation of cell communicationGO:00106481580.043
positive regulation of cellular amino acid metabolic processGO:004576410.043
regulation of neuron differentiationGO:00456642080.043
regulation of cellular ketone metabolic processGO:0010565270.043
eye developmentGO:0001654500.043
rna metabolic processGO:00160704060.043
nucleobase containing small molecule metabolic processGO:00550863160.043
response to vitaminGO:00332731310.042
protein complex assemblyGO:00064612630.042
regulation of mesenchymal cell proliferationGO:001046440.042
response to growth factorGO:00708481890.042
blood vessel morphogenesisGO:0048514580.042
cytosolic calcium ion homeostasisGO:00514801400.042
excretionGO:0007588240.041
regulation of locomotionGO:00400121480.041
rna biosynthetic processGO:00327743800.041
nucleotide metabolic processGO:00091172790.040
cellular amino acid metabolic processGO:00065201070.040
positive regulation of extracellular matrix organizationGO:190305540.040
ribose phosphate metabolic processGO:00196932350.040
protein oligomerizationGO:00512591910.040
neuron deathGO:00709971270.039
developmental growthGO:00485891000.039
regulation of protein modification processGO:00313991940.039
intracellular transportGO:00469071850.039
regulation of immune system processGO:00026821230.039
positive regulation of immune system processGO:0002684900.039
glial cell differentiationGO:0010001650.038
negative regulation of apoptotic processGO:00430661810.038
cellular response to lipidGO:00713962010.038
response to fatty acidGO:0070542650.038
positive regulation of cellular protein metabolic processGO:00322701670.038
calcium ion transportGO:00068161310.038
carbohydrate derivative metabolic processGO:19011353460.038
regulation of anatomical structure morphogenesisGO:00226031410.038
cellular response to organic cyclic compoundGO:00714072020.038
response to organophosphorusGO:00466831020.038
positive regulation of rna metabolic processGO:00512542030.038
carbohydrate derivative biosynthetic processGO:19011371240.037
negative regulation of response to stimulusGO:00485851550.037
regulation of rna biosynthetic processGO:20011413810.037
immune effector processGO:0002252530.037
organonitrogen compound biosynthetic processGO:19015661670.037
positive regulation of cellular amine metabolic processGO:003324030.036
regulation of neural precursor cell proliferationGO:2000177160.036
nucleotide biosynthetic processGO:0009165980.036
positive regulation of cellular component movementGO:00512721020.036
reactive oxygen species metabolic processGO:0072593370.036
axon developmentGO:0061564960.036
regulation of growthGO:00400081050.036
regulation of cell differentiationGO:00455953200.036
protein complex subunit organizationGO:00718223020.036
purine containing compound metabolic processGO:00725212530.036
multicellular organism reproductionGO:00325042330.036
head developmentGO:00603222470.036
cell type specific apoptotic processGO:00972851340.035
negative regulation of kidney developmentGO:009018520.035
vascular process in circulatory systemGO:0003018960.035
positive regulation of protein transportGO:0051222410.035
cellular calcium ion homeostasisGO:00068741600.035
cellular cation homeostasisGO:00300031800.035
regulation of reactive oxygen species biosynthetic processGO:190342650.035
regulation of cell growthGO:0001558850.035
protein activation cascadeGO:0072376120.034
cell morphogenesis involved in neuron differentiationGO:00486671060.034
acute inflammatory responseGO:0002526580.034
response to radiationGO:00093141370.034
regulation of catabolic processGO:00098941130.034
embryonic skeletal system developmentGO:004870630.034
regulation of blood circulationGO:19035221100.034
regulation of cell motilityGO:20001451310.034
purine nucleotide metabolic processGO:00061632290.034
regenerationGO:00310991630.034
purine ribonucleotide biosynthetic processGO:0009152810.034
cellular ion homeostasisGO:00068731840.033
cellular response to nitrogen compoundGO:19016992100.033
carboxylic acid transportGO:00469421150.033
response to muscle activity involved in regulation of muscle adaptationGO:001487320.033
negative regulation of molecular functionGO:00440921330.033
positive regulation of cytosolic calcium ion concentrationGO:00072041220.033
single organism intracellular transportGO:19025821660.033
negative regulation of serine type peptidase activityGO:190257210.032
regulation of purine nucleotide metabolic processGO:19005421150.032
sensory organ developmentGO:0007423740.032
regulation of intracellular signal transductionGO:19025312180.032
reactive oxygen species biosynthetic processGO:190340980.032
negative regulation of nervous system developmentGO:0051961790.032
response to carbohydrateGO:00097431830.032
cellular response to lipopolysaccharideGO:0071222550.032
astrocyte activationGO:004814340.031
regulation of cyclic nucleotide biosynthetic processGO:0030802450.031
muscle system processGO:00030121150.031
monovalent inorganic cation transportGO:00156721720.031
positive regulation of mapk cascadeGO:0043410920.031
negative regulation of cellular protein metabolic processGO:00322691060.031
ribose phosphate biosynthetic processGO:0046390870.030
regulation of excretionGO:0044062210.030
cellular ketone metabolic processGO:0042180510.030
regulation of tube sizeGO:0035150890.030
t helper 1 type immune responseGO:004208810.030
regulation of system processGO:00440572080.030
angiogenesisGO:0001525530.030
positive regulation of nucleic acid templated transcriptionGO:19035081970.029
negative regulation of endopeptidase activityGO:0010951360.029
regulation of cytokine productionGO:0001817560.029
transcription from rna polymerase ii promoterGO:00063662520.029
positive regulation of blood circulationGO:1903524650.029
cell part morphogenesisGO:00329901230.029
protein targetingGO:0006605610.029
gastrulationGO:000736920.028
positive regulation of macromolecule biosynthetic processGO:00105572470.028
cyclic purine nucleotide metabolic processGO:0052652620.028
regulation of nucleotide metabolic processGO:00061401170.028
anion transportGO:00068201780.028
multicellular organismal signalingGO:0035637440.028
cellular response to molecule of bacterial originGO:0071219560.028
divalent metal ion transportGO:00708381320.028
positive regulation of extracellular matrix constituent secretionGO:000333120.028
response to ketoneGO:19016541820.028
purine containing compound biosynthetic processGO:0072522850.027
extracellular structure organizationGO:0043062130.027
regulation of synaptic plasticityGO:0048167700.027
transmission of nerve impulseGO:0019226420.027
positive regulation of apoptotic processGO:00430651540.027
stress activated mapk cascadeGO:0051403350.027
cation homeostasisGO:00550801950.027
regulation of cell migrationGO:00303341280.027
multicellular organism growthGO:003526410.027
camp metabolic processGO:0046058630.027
organophosphate biosynthetic processGO:00904071430.026
single organism catabolic processGO:00447122830.026
cellular sodium ion homeostasisGO:000688340.026
divalent inorganic cation homeostasisGO:00725071650.026
cellular response to organonitrogen compoundGO:00714171970.026
regulation of interleukin 6 productionGO:0032675120.026
nitrogen compound transportGO:00717052290.026
regulation of cell projection organizationGO:00313441750.026
regulation of axonogenesisGO:0050770370.026
response to toxic substanceGO:00096361330.026
behaviorGO:00076102050.025
regulation of mapk cascadeGO:00434081160.025
response to vitamin b6GO:003451610.025
reproductive system developmentGO:00614581280.025
regulation of defense responseGO:0031347680.025
signal releaseGO:00230611450.025
endothelial cell proliferationGO:0001935200.025
b cell mediated immunityGO:001972440.025
negative regulation of metanephros developmentGO:007221720.025
negative regulation of catalytic activityGO:00430861030.025
negative regulation of serine type endopeptidase activityGO:190000410.025
ion transmembrane transportGO:00342203650.025
response to interleukin 6GO:0070741130.024
gliogenesisGO:0042063930.024
positive regulation of gene expressionGO:00106282440.024
protein phosphorylationGO:00064683450.024
response to nicotineGO:0035094510.024
carbohydrate homeostasisGO:0033500750.024
reproductive structure developmentGO:00486081280.024
response to interferon gammaGO:0034341200.024
peptidyl tyrosine phosphorylationGO:0018108720.024
norepinephrine secretionGO:0048243160.024
extracellular matrix organizationGO:0030198130.024
negative regulation of response to external stimulusGO:0032102370.023
gland developmentGO:00487321550.023
regulation of neuron projection developmentGO:00109751610.023
hormone secretionGO:00468791150.023
negative regulation of protein metabolic processGO:00512481140.023
cation transmembrane transportGO:00986552630.023
regulation of protein phosphorylationGO:00019321830.023
renin angiotensin regulation of aldosterone productionGO:000201830.023
ribonucleotide metabolic processGO:00092592310.023
response to retinoic acidGO:0032526630.023
response to hydrogen peroxideGO:0042542890.022
regulation of endopeptidase activityGO:0052548510.022
brain renin angiotensin systemGO:000203530.022
regulation of serine type endopeptidase activityGO:190000310.022
cellular response to external stimulusGO:00714961180.022
axonogenesisGO:0007409710.022
feeding behaviorGO:0007631530.022
cytokine mediated signaling pathwayGO:0019221430.022
transmembrane transportGO:00550854120.022
regulation of amine transportGO:0051952540.022
regulation of transcription from rna polymerase ii promoterGO:00063572340.022
response to lead ionGO:0010288330.021
anatomical structure formation involved in morphogenesisGO:0048646830.021
anion transmembrane transportGO:0098656770.021
negative regulation of neuron deathGO:1901215690.021
negative regulation of signal transductionGO:0009968830.021
organ morphogenesisGO:0009887750.021
retina morphogenesis in camera type eyeGO:006004210.021
regulation of carbohydrate catabolic processGO:0043470140.021
vasodilationGO:0042311440.021
cell morphogenesis involved in differentiationGO:00009041190.021
regulation of neuron deathGO:19012141150.021
regulation of peptidase activityGO:0052547550.021
positive regulation of vasodilationGO:0045909290.021
positive regulation of protein metabolic processGO:00512471780.021
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.021
sex differentiationGO:00075481130.020
positive regulation of rna biosynthetic processGO:19026801970.020
negative regulation of cell deathGO:00605482290.020
leukocyte activationGO:0045321760.020
metanephric epithelium developmentGO:007220740.020
amine transportGO:0015837570.020
regulation of cellular catabolic processGO:00313291010.020
regulation of renal sodium excretionGO:0035813200.020
organelle organizationGO:00069962660.020
regulation of proteolysisGO:0030162660.020
macromolecule localizationGO:00330362520.020
positive regulation of kinase activityGO:0033674770.020
regulation of systemic arterial blood pressureGO:0003073300.020
potassium ion transportGO:0006813970.020
chemotaxisGO:0006935660.020
smooth muscle contractionGO:0006939370.020
regulation of body fluid levelsGO:0050878900.019
digestive system developmentGO:0055123410.019
positive regulation of nucleotide biosynthetic processGO:0030810360.019
positive regulation of cell projection organizationGO:00313461110.019
establishment of protein localizationGO:00451841410.019
nucleoside triphosphate metabolic processGO:00091411440.019
cell activationGO:0001775970.019
ovulation cycleGO:0042698670.019
embryonic skeletal system morphogenesisGO:004870430.019
response to corticosteroneGO:0051412400.019
negative regulation of cellular component organizationGO:0051129830.019
cell activation involved in immune responseGO:0002263160.019
single organism biosynthetic processGO:00447113420.019
cognitionGO:0050890920.019
regulation of metanephros developmentGO:007221540.018
regulation of hormone secretionGO:00468831060.018
cell differentiation involved in kidney developmentGO:006100540.018
positive regulation of hydrolase activityGO:0051345860.018
developmental process involved in reproductionGO:00030061590.018
single organism organelle organizationGO:19025891800.018
maternal process involved in female pregnancyGO:0060135380.018
regulation of extracellular matrix constituent secretionGO:000333020.018
single organism nuclear importGO:1902593350.018
organic acid transportGO:00158491160.018
enzyme linked receptor protein signaling pathwayGO:00071671160.018
negative regulation of neurogenesisGO:0050768780.018
reactive nitrogen species metabolic processGO:200105710.018
positive regulation of protein modification processGO:00314011420.018
positive regulation of neuron projection developmentGO:0010976990.018
motor neuron axon guidanceGO:000804510.018
negative regulation of synaptic transmission dopaminergicGO:003222740.018
regulation of purine nucleotide biosynthetic processGO:1900371460.018
regulation of transferase activityGO:00513381230.018
organic substance catabolic processGO:19015753160.017
response to acid chemicalGO:00011012220.017
sexual reproductionGO:00199531480.017
brain developmentGO:00074202470.017
cellular response to peptide hormone stimulusGO:00713751200.017
blood circulationGO:00080151830.017
cytokine productionGO:0001816610.017
regulation of neuronal synaptic plasticityGO:0048168310.017
protein importGO:0017038370.017
inorganic cation transmembrane transportGO:00986622020.017
tonic smooth muscle contractionGO:001482040.017
kidney vasculature developmentGO:006144060.017
neurotransmitter uptakeGO:000150430.017
heart processGO:0003015570.017
heart morphogenesisGO:000300730.017

A2m disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.043
disease of anatomical entityDOID:700.043
disease of metabolismDOID:001466700.034
sensory system diseaseDOID:005015500.027
eye diseaseDOID:561400.018
eye and adnexa diseaseDOID:149200.018