Rattus norvegicus

28 known processes

Pola2

polymerase (DNA directed), alpha 2

Pola2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organic substance catabolic processGO:19015753160.129
secretionGO:00469033070.123
oxoacid metabolic processGO:00434362900.120
carboxylic acid metabolic processGO:00197522890.105
response to estrogenGO:00436272320.094
catabolic processGO:00090563510.092
cellular catabolic processGO:00442482950.090
organic acid metabolic processGO:00060822920.087
protein complex assemblyGO:00064612630.087
single organism biosynthetic processGO:00447113420.077
intracellular signal transductionGO:00355563140.075
response to oxygen levelsGO:00704822650.072
macromolecular complex subunit organizationGO:00439333390.070
programmed cell deathGO:00125013920.070
regulation of molecular functionGO:00650093980.068
response to inorganic substanceGO:00100353770.068
response to extracellular stimulusGO:00099913800.066
cellular component biogenesisGO:00440853680.064
regulation of phosphate metabolic processGO:00192203490.062
response to nutrient levelsGO:00316673700.062
protein phosphorylationGO:00064683450.060
macromolecular complex assemblyGO:00650032730.060
positive regulation of nitrogen compound metabolic processGO:00511733340.059
regulation of programmed cell deathGO:00430673410.059
cellular response to stressGO:00335542690.058
organophosphate metabolic processGO:00196373700.058
protein complex subunit organizationGO:00718223020.058
regulation of apoptotic processGO:00429813350.057
cellular component assemblyGO:00226073600.056
regulation of phosphorus metabolic processGO:00511743490.055
regulation of cellular component organizationGO:00511283680.055
single organism catabolic processGO:00447122830.055
chemical homeostasisGO:00488782920.055
rna metabolic processGO:00160704060.054
cellular amino acid metabolic processGO:00065201070.053
regulation of phosphorylationGO:00423252480.053
regulation of cellular localizationGO:00603412630.051
nitrogen compound transportGO:00717052290.051
protein oligomerizationGO:00512591910.051
nucleoside phosphate metabolic processGO:00067532830.050
cell cell signalingGO:00072673350.050
response to growth factorGO:00708481890.050
protein complex biogenesisGO:00702712630.049
anatomical structure morphogenesisGO:00096532980.049
response to nutrientGO:00075842480.049
regulation of cell proliferationGO:00421273590.048
response to decreased oxygen levelsGO:00362932370.048
single organism reproductive processGO:00447022970.048
negative regulation of metabolic processGO:00098923310.046
carbohydrate derivative metabolic processGO:19011353460.045
response to estradiolGO:00323551640.044
rhythmic processGO:00485111560.044
regulation of catalytic activityGO:00507903040.044
response to metal ionGO:00100382530.043
response to biotic stimulusGO:00096072260.042
nucleic acid templated transcriptionGO:00976593790.042
regulation of intracellular signal transductionGO:19025312180.041
regulation of secretionGO:00510462240.041
homeostatic processGO:00425923310.041
regulation of rna biosynthetic processGO:20011413810.041
apoptotic processGO:00069153810.040
response to peptideGO:19016522920.040
positive regulation of phosphate metabolic processGO:00459372620.040
positive regulation of cell communicationGO:00106472710.040
ion transmembrane transportGO:00342203650.039
response to hypoxiaGO:00016662310.039
reproductionGO:00000032450.038
neuron differentiationGO:00301823680.038
cation transportGO:00068123820.038
regulation of cell differentiationGO:00455953200.038
regulation of protein metabolic processGO:00512462890.037
reproductive processGO:00224143720.037
transcription dna templatedGO:00063513770.037
proteolysisGO:00065081750.037
positive regulation of transcription dna templatedGO:00458931970.037
response to other organismGO:00517072200.037
ion homeostasisGO:00508012120.036
regulation of multicellular organismal developmentGO:20000263760.035
response to external biotic stimulusGO:00432072210.035
regulation of rna metabolic processGO:00512523910.035
cellular amine metabolic processGO:0044106380.035
cellular response to oxygen containing compoundGO:19017013860.035
locomotionGO:00400112370.035
transmembrane transportGO:00550854120.035
positive regulation of cellular biosynthetic processGO:00313282950.034
cellular response to growth factor stimulusGO:00713631620.034
response to vitaminGO:00332731310.034
multicellular organismal reproductive processGO:00486092330.034
secretion by cellGO:00329402480.033
cardiovascular system developmentGO:00723581340.033
reproductive system developmentGO:00614581280.033
regulation of cellular ketone metabolic processGO:0010565270.033
regulation of cellular protein metabolic processGO:00322682670.033
regulation of cellular amino acid metabolic processGO:000652120.033
negative regulation of cellular metabolic processGO:00313242810.032
regulation of nucleic acid templated transcriptionGO:19035063800.032
response to amino acidGO:0043200750.032
metal ion transportGO:00300012890.032
positive regulation of gene expressionGO:00106282440.032
positive regulation of phosphorus metabolic processGO:00105622620.032
carbohydrate metabolic processGO:00059751300.032
amine metabolic processGO:0009308380.032
dna metabolic processGO:0006259960.032
response to glucoseGO:00097491360.032
response to monosaccharideGO:00342841590.031
multi organism reproductive processGO:00447032620.031
response to peptide hormoneGO:00434342780.031
positive regulation of macromolecule biosynthetic processGO:00105572470.031
positive regulation of biosynthetic processGO:00098913190.031
tissue developmentGO:00098882520.031
cellular ketone metabolic processGO:0042180510.030
cellular response to lipidGO:00713962010.030
response to woundingGO:00096112540.029
neurological system processGO:00508772190.029
response to hexoseGO:00097461440.029
cellular chemical homeostasisGO:00550822470.029
positive regulation of cellular component organizationGO:00511302000.029
response to acid chemicalGO:00011012220.029
aromatic compound catabolic processGO:00194391680.028
multicellular organism reproductionGO:00325042330.028
purine containing compound metabolic processGO:00725212530.028
macromolecule localizationGO:00330362520.028
Mouse
response to carbohydrateGO:00097431830.028
regulation of transcription dna templatedGO:00063553740.028
regulation of cell developmentGO:00602842630.028
positive regulation of programmed cell deathGO:00430681570.028
positive regulation of molecular functionGO:00440932300.027
cellular response to organic cyclic compoundGO:00714072020.027
nucleobase containing small molecule metabolic processGO:00550863160.027
cellular homeostasisGO:00197252520.027
positive regulation of developmental processGO:00510942830.027
defense responseGO:00069521940.027
lipid metabolic processGO:00066292830.026
regulation of secretion by cellGO:19035302080.026
positive regulation of phosphorylationGO:00423271770.026
brain developmentGO:00074202470.026
regulation of transcription from rna polymerase ii promoterGO:00063572340.026
positive regulation of secretion by cellGO:19035321280.026
response to corticosteroidGO:00319602350.026
positive regulation of cellular protein metabolic processGO:00322701670.025
regulation of membrane potentialGO:00423911100.025
positive regulation of apoptotic processGO:00430651540.025
small molecule biosynthetic processGO:00442831240.025
positive regulation of response to stimulusGO:00485842850.025
agingGO:00075682410.025
response to ethanolGO:00454711620.025
cellular ion homeostasisGO:00068731840.025
developmental process involved in reproductionGO:00030061590.025
regulation of signal transductionGO:00099663180.025
response to bacteriumGO:00096172000.025
regulation of cellular amine metabolic processGO:003323880.025
neuron developmentGO:00486662860.025
cellular response to endogenous stimulusGO:00714953770.025
regenerationGO:00310991630.024
rna biosynthetic processGO:00327743800.024
regulation of protein modification processGO:00313991940.024
positive regulation of cell proliferationGO:00082842490.024
response to lipopolysaccharideGO:00324961910.024
cellular lipid metabolic processGO:00442552080.024
oxidation reduction processGO:00551143040.024
negative regulation of gene expressionGO:00106291990.024
response to toxic substanceGO:00096361330.024
positive regulation of signalingGO:00230562700.024
response to oxidative stressGO:00069791860.024
cell motilityGO:00488702020.024
reproductive structure developmentGO:00486081280.024
response to molecule of bacterial originGO:00022371940.023
nucleobase containing compound catabolic processGO:00346551520.023
neuron projection developmentGO:00311752730.023
cation homeostasisGO:00550801950.023
positive regulation of rna metabolic processGO:00512542030.023
glycosyl compound metabolic processGO:19016571820.023
small gtpase mediated signal transductionGO:0007264360.023
transcription from rna polymerase ii promoterGO:00063662520.023
circadian regulation of gene expressionGO:003292230.023
regulation of hormone levelsGO:00108171870.023
nucleotide metabolic processGO:00091172790.023
positive regulation of secretionGO:00510471400.022
head developmentGO:00603222470.022
amide transportGO:00428861050.022
central nervous system developmentGO:00074173110.022
regulation of proteasomal protein catabolic processGO:006113640.022
immune system processGO:00023762040.022
regulation of response to stressGO:00801341260.022
nucleoside metabolic processGO:00091161790.022
gland developmentGO:00487321550.022
positive regulation of multicellular organismal processGO:00512403870.022
single organism carbohydrate metabolic processGO:00447231180.021
chromosome segregationGO:000705920.021
negative regulation of cell deathGO:00605482290.021
purine nucleotide metabolic processGO:00061632290.021
regulation of neurogenesisGO:00507672470.021
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.020
small molecule catabolic processGO:0044282590.020
cell migrationGO:00164771970.020
protein localizationGO:00081041910.020
Mouse
positive regulation of cellular amine metabolic processGO:003324030.020
purine ribonucleotide metabolic processGO:00091502270.020
positive regulation of cellular amino acid metabolic processGO:004576410.020
negative regulation of macromolecule metabolic processGO:00106052600.020
positive regulation of cell deathGO:00109421840.020
lipid oxidationGO:0034440300.020
hormone transportGO:00099141210.019
negative regulation of nucleobase containing compound metabolic processGO:00459341530.019
cellular nitrogen compound catabolic processGO:00442701630.019
cell adhesionGO:00071551100.019
ras protein signal transductionGO:0007265290.019
positive regulation of cell differentiationGO:00455972170.019
stress activated protein kinase signaling cascadeGO:0031098370.019
cellular response to organonitrogen compoundGO:00714171970.019
cellular cation homeostasisGO:00300031800.019
ribonucleoside metabolic processGO:00091191740.019
positive regulation of protein modification processGO:00314011420.019
positive regulation of nucleobase containing compound metabolic processGO:00459353190.019
regulation of cell motilityGO:20001451310.019
regulation of nervous system developmentGO:00519602640.019
gamete generationGO:00072761240.019
anion transportGO:00068201780.019
organonitrogen compound catabolic processGO:19015651790.019
growthGO:00400071650.019
response to cytokineGO:00340972150.019
response to temperature stimulusGO:0009266940.019
cation transmembrane transportGO:00986552630.019
negative regulation of apoptotic processGO:00430661810.018
response to hydrogen peroxideGO:0042542890.018
organic cyclic compound catabolic processGO:19013611750.018
negative regulation of biosynthetic processGO:00098901680.018
cellular response to nitrogen compoundGO:19016992100.018
positive regulation of signal transductionGO:00099671750.018
circulatory system developmentGO:00723591340.018
response to ketoneGO:19016541820.018
carboxylic acid transportGO:00469421150.018
cell morphogenesisGO:00009021420.018
positive regulation of transportGO:00510502450.018
positive regulation of protein metabolic processGO:00512471780.018
development of primary sexual characteristicsGO:00451371070.018
negative regulation of response to stimulusGO:00485851550.018
eye morphogenesisGO:004859240.018
organelle organizationGO:00069962660.018
muscle system processGO:00030121150.017
negative regulation of nitrogen compound metabolic processGO:00511721610.017
glycosyl compound catabolic processGO:19016581260.017
female gonad developmentGO:0008585530.017
heterocycle catabolic processGO:00467001670.017
renal system developmentGO:0072001670.017
positive regulation of rna biosynthetic processGO:19026801970.017
intracellular transportGO:00469071850.017
Mouse
cellular response to external stimulusGO:00714961180.017
behaviorGO:00076102050.017
negative regulation of rna metabolic processGO:00512531230.017
positive regulation of catalytic activityGO:00430851840.017
signal releaseGO:00230611450.017
positive regulation of protein phosphorylationGO:00019341350.017
organ regenerationGO:00311001010.016
epithelium developmentGO:0060429960.016
coenzyme metabolic processGO:0006732860.016
alpha amino acid metabolic processGO:1901605710.016
tube developmentGO:0035295890.016
negative regulation of cell communicationGO:00106481580.016
cellular calcium ion homeostasisGO:00068741600.016
metal ion homeostasisGO:00550651860.016
mapk cascadeGO:00001651400.016
muscle structure developmentGO:0061061870.016
carboxylic acid catabolic processGO:0046395490.016
lipid catabolic processGO:0016042460.016
urogenital system developmentGO:0001655780.016
purine nucleoside metabolic processGO:00422781690.015
regulation of ion transportGO:00432692450.015
biological adhesionGO:00226101100.015
protein homooligomerizationGO:0051260910.015
negative regulation of transportGO:00510511360.015
cell cycle checkpointGO:000007520.015
sexual reproductionGO:00199531480.015
regulation of protein kinase activityGO:00458591050.015
response to purine containing compoundGO:00140741260.015
gonad developmentGO:00084061040.015
regulation of system processGO:00440572080.015
single organism intracellular transportGO:19025821660.015
Mouse
cellular component morphogenesisGO:00329891550.015
regulation of catabolic processGO:00098941130.015
peptidyl amino acid modificationGO:00181931260.015
sex differentiationGO:00075481130.015
negative regulation of innate immune responseGO:004582440.015
cellular lipid catabolic processGO:0044242370.015
regulation of homeostatic processGO:00328441010.015
peptide transportGO:0015833970.015
response to radiationGO:00093141370.015
regulation of mapk cascadeGO:00434081160.014
circadian rhythmGO:0007623880.014
ribose phosphate metabolic processGO:00196932350.014
mitotic sister chromatid separationGO:005130610.014
organophosphate catabolic processGO:00464341480.014
alcohol metabolic processGO:0006066770.014
cellular response to nutrient levelsGO:0031669600.014
cell projection organizationGO:00300303020.014
regulation of protein phosphorylationGO:00019321830.014
cellular response to hormone stimulusGO:00328702470.014
carbohydrate derivative biosynthetic processGO:19011371240.014
negative regulation of chromosome organizationGO:200125110.014
negative regulation of molecular functionGO:00440921330.014
response to reactive oxygen speciesGO:00003021200.014
fatty acid oxidationGO:0019395290.014
synaptic transmissionGO:00072682350.014
regulation of cellular component biogenesisGO:0044087860.014
cellular response to cytokine stimulusGO:00713451270.014
muscle contractionGO:0006936880.014
organonitrogen compound biosynthetic processGO:19015661670.014
negative regulation of transcription dna templatedGO:00458921160.014
negative regulation of macromolecule biosynthetic processGO:00105581480.014
negative regulation of rna biosynthetic processGO:19026791180.014
positive regulation of nucleic acid templated transcriptionGO:19035081970.014
ribonucleoside catabolic processGO:00424541260.014
response to alkaloidGO:00432791320.014
organophosphate biosynthetic processGO:00904071430.013
regulation of cell projection organizationGO:00313441750.013
protein targetingGO:0006605610.013
Mouse
cell cell signaling involved in cell fate commitmentGO:004516820.013
epithelial cell differentiationGO:0030855710.013
ribonucleotide metabolic processGO:00092592310.013
regulation of transferase activityGO:00513381230.013
cellular response to peptideGO:19016531330.013
regulation of hormone secretionGO:00468831060.013
nucleoside triphosphate catabolic processGO:00091431230.013
wound healingGO:00420601220.013
regulation of dna metabolic processGO:0051052600.013
regulation of locomotionGO:00400121480.013
regulation of neuron projection developmentGO:00109751610.013
regulation of cellular catabolic processGO:00313291010.013
organic anion transportGO:00157111320.013
negative regulation of cellular biosynthetic processGO:00313271610.013
regulation of fat cell differentiationGO:004559830.013
positive regulation of neurogenesisGO:00507691650.013
negative regulation of mitotic cell cycle phase transitionGO:190199130.013
kidney developmentGO:0001822670.013
glycerolipid metabolic processGO:0046486670.013
heart developmentGO:0007507720.013
double strand break repairGO:000630210.013
negative regulation of signalingGO:00230571570.013
signal transduction by phosphorylationGO:00230141440.013
nucleoside triphosphate metabolic processGO:00091411440.013
hexose metabolic processGO:0019318580.013
metaphase anaphase transition of mitotic cell cycleGO:000709110.012
lipid biosynthetic processGO:00086101280.012
establishment of protein localizationGO:00451841410.012
Mouse
spermatogenesisGO:0007283990.012
gastrulationGO:000736920.012
calcium ion homeostasisGO:00550741620.012
regulation of sister chromatid segregationGO:003304510.012
purine ribonucleoside metabolic processGO:00461281680.012
regulation of lipid metabolic processGO:0019216680.012
cofactor metabolic processGO:0051186950.012
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.012
regulation of anatomical structure morphogenesisGO:00226031410.012
cellular macromolecule localizationGO:00707271220.012
Mouse
reactive oxygen species metabolic processGO:0072593370.012
positive regulation of intracellular signal transductionGO:19025331380.012
positive regulation of transferase activityGO:0051347810.012
axis specificationGO:000979840.012
purine ribonucleotide catabolic processGO:00091541360.012
negative regulation of cell cycle phase transitionGO:190198840.012
spindle organizationGO:000705120.012
anatomical structure formation involved in morphogenesisGO:0048646830.012
regulation of kinase activityGO:00435491170.012
cytoskeleton organizationGO:00070101110.012
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.012
negative regulation of programmed cell deathGO:00430691830.012
g protein coupled receptor signaling pathwayGO:00071862420.012
regulation of anatomical structure sizeGO:00900661350.011
cytoplasmic transportGO:00164821150.011
Mouse
localization of cellGO:00516742020.011
response to transition metal nanoparticleGO:19902671220.011
regulation of mitotic sister chromatid separationGO:001096510.011
inorganic cation transmembrane transportGO:00986622020.011
appendage morphogenesisGO:003510740.011
cellular divalent inorganic cation homeostasisGO:00725031620.011
regulation of metal ion transportGO:00109591180.011
cellular component movementGO:00069282480.011
cellular protein localizationGO:00346131220.011
Mouse
ribonucleotide catabolic processGO:00092611360.011
regulation of growthGO:00400081050.011
regulation of hydrolase activityGO:00513361430.011
action potentialGO:0001508540.011
carbohydrate derivative catabolic processGO:19011361470.011
meiotic cell cycle processGO:190304630.011
regulation of peptide transportGO:0090087870.011
monosaccharide metabolic processGO:0005996610.011
protein heterooligomerizationGO:0051291890.011
single organism organelle organizationGO:19025891800.011
positive regulation of hydrolase activityGO:0051345860.011
rho protein signal transductionGO:0007266110.011
regulation of chromosome segregationGO:005198310.011
organic acid transportGO:00158491160.011
cellular metal ion homeostasisGO:00068751720.011
positive regulation of cell developmentGO:00107201760.011
regulation of peptide secretionGO:0002791820.011
immune responseGO:00069551040.011
cell activationGO:0001775970.011
monocarboxylic acid metabolic processGO:00327871520.010
regulation of organelle organizationGO:0033043800.010
positive regulation of cell projection organizationGO:00313461110.010
purine ribonucleoside triphosphate catabolic processGO:00092071220.010
monovalent inorganic cation transportGO:00156721720.010
regulation of ion transmembrane transportGO:00347651210.010
cellular amino acid biosynthetic processGO:0008652320.010
regulation of synaptic transmissionGO:00508041410.010
metaphase anaphase transition of cell cycleGO:004478410.010
dephosphorylationGO:0016311980.010
nucleoside phosphate biosynthetic processGO:19012931020.010
organic acid catabolic processGO:0016054490.010
regulation of neuron differentiationGO:00456642080.010
regulation of reactive oxygen species metabolic processGO:2000377260.010
regulation of cell morphogenesisGO:0022604770.010
embryonic appendage morphogenesisGO:003511340.010
muscle cell proliferationGO:0033002840.010
nucleoside phosphate catabolic processGO:19012921400.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:003114510.010
peptide hormone secretionGO:0030072840.010
organ morphogenesisGO:0009887750.010

Pola2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.024
organ system cancerDOID:005068600.020
disease of cellular proliferationDOID:1456600.020
intestinal cancerDOID:1015500.020
gastrointestinal system cancerDOID:311900.020
cancerDOID:16200.020
inherited metabolic disorderDOID:65500.016
disease of anatomical entityDOID:700.015
musculoskeletal system diseaseDOID:1700.015
nervous system diseaseDOID:86300.014