Rattus norvegicus

64 known processes

Gclc

glutamate-cysteine ligase, catalytic subunit

(Aliases: MGC93096,Glclc)

Gclc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular modified amino acid metabolic processGO:0006575610.843
cellular amino acid metabolic processGO:00065201070.738
cellular amino acid biosynthetic processGO:0008652320.588
carboxylic acid metabolic processGO:00197522890.576
sulfur compound metabolic processGO:0006790700.528
organic acid metabolic processGO:00060822920.397
glutathione metabolic processGO:0006749150.296
small molecule biosynthetic processGO:00442831240.294
carboxylic acid biosynthetic processGO:0046394830.279
cellular amide metabolic processGO:0043603440.278
alpha amino acid metabolic processGO:1901605710.261
organonitrogen compound biosynthetic processGO:19015661670.247
single organism biosynthetic processGO:00447113420.246
response to inorganic substanceGO:00100353770.214
amide biosynthetic processGO:0043604100.196
response to extracellular stimulusGO:00099913800.191
oxoacid metabolic processGO:00434362900.191
cellular modified amino acid biosynthetic processGO:0042398180.188
response to woundingGO:00096112540.184
negative regulation of apoptotic processGO:00430661810.178
peptide metabolic processGO:0006518320.176
cellular response to oxygen containing compoundGO:19017013860.165
single organism reproductive processGO:00447022970.152
response to nutrientGO:00075842480.138
response to oxidative stressGO:00069791860.128
response to metal ionGO:00100382530.126
regulation of apoptotic processGO:00429813350.113
organic acid biosynthetic processGO:0016053830.106
negative regulation of cell deathGO:00605482290.089
intracellular signal transductionGO:00355563140.084
mesoderm developmentGO:000749820.079
response to nutrient levelsGO:00316673700.076
apoptotic processGO:00069153810.074
cofactor metabolic processGO:0051186950.074
macromolecular complex assemblyGO:00650032730.073
response to carbohydrateGO:00097431830.072
tube developmentGO:0035295890.071
regulation of organelle organizationGO:0033043800.070
coenzyme metabolic processGO:0006732860.067
oxidation reduction processGO:00551143040.063
organelle organizationGO:00069962660.063
cellular response to stressGO:00335542690.063
organic hydroxy compound metabolic processGO:19016151150.063
cellular response to organic cyclic compoundGO:00714072020.062
cellular lipid metabolic processGO:00442552080.060
response to oxygen levelsGO:00704822650.060
protein complex subunit organizationGO:00718223020.057
regulation of signal transductionGO:00099663180.056
lipid metabolic processGO:00066292830.054
neuron apoptotic processGO:0051402880.054
central nervous system developmentGO:00074173110.053
negative regulation of neuron apoptotic processGO:0043524450.052
cellular component assemblyGO:00226073600.050
regulation of cellular amine metabolic processGO:003323880.050
reactive oxygen species metabolic processGO:0072593370.049
response to vitaminGO:00332731310.049
macromolecule localizationGO:00330362520.049
regulation of programmed cell deathGO:00430673410.049
circulatory system processGO:00030131830.048
positive regulation of developmental processGO:00510942830.048
cellular amine metabolic processGO:0044106380.046
response to acid chemicalGO:00011012220.044
protein oligomerizationGO:00512591910.044
positive regulation of cell deathGO:00109421840.043
amine metabolic processGO:0009308380.043
protein complex biogenesisGO:00702712630.043
organophosphate metabolic processGO:00196373700.042
response to ethanolGO:00454711620.040
cellular ketone metabolic processGO:0042180510.039
macromolecular complex subunit organizationGO:00439333390.038
negative regulation of programmed cell deathGO:00430691830.038
reproductive processGO:00224143720.038
regulation of phosphorus metabolic processGO:00511743490.038
neuron deathGO:00709971270.038
response to axon injuryGO:0048678590.036
response to decreased oxygen levelsGO:00362932370.036
blood circulationGO:00080151830.036
regulation of neuron deathGO:19012141150.035
homeostatic processGO:00425923310.035
response to hydrogen peroxideGO:0042542890.035
negative regulation of molecular functionGO:00440921330.035
regulation of transcription dna templatedGO:00063553740.034
secretionGO:00469033070.033
response to lipopolysaccharideGO:00324961910.033
response to peptide hormoneGO:00434342780.033
regulation of cellular component organizationGO:00511283680.033
anatomical structure morphogenesisGO:00096532980.033
gastrulationGO:000736920.033
cellular component biogenesisGO:00440853680.033
brain developmentGO:00074202470.033
protein phosphorylationGO:00064683450.032
response to estrogenGO:00436272320.032
mesoderm formationGO:000170710.032
positive regulation of molecular functionGO:00440932300.032
protein complex assemblyGO:00064612630.031
benzene containing compound metabolic processGO:0042537220.031
protein homooligomerizationGO:0051260910.030
programmed cell deathGO:00125013920.030
regulation of cell differentiationGO:00455953200.030
cellular response to oxidative stressGO:0034599760.030
regulation of cell projection organizationGO:00313441750.030
growthGO:00400071650.030
reproductive system developmentGO:00614581280.030
mesoderm morphogenesisGO:004833210.030
single organism catabolic processGO:00447122830.029
nucleobase containing small molecule metabolic processGO:00550863160.029
cellular response to reactive oxygen speciesGO:0034614550.029
transcription dna templatedGO:00063513770.029
regulation of cell developmentGO:00602842630.028
agingGO:00075682410.028
dephosphorylationGO:0016311980.027
response to reactive oxygen speciesGO:00003021200.027
cell growthGO:00160491040.027
response to radiationGO:00093141370.027
positive regulation of phosphate metabolic processGO:00459372620.027
regulation of neuron projection developmentGO:00109751610.026
head developmentGO:00603222470.026
nucleoside phosphate metabolic processGO:00067532830.026
neurological system processGO:00508772190.026
reactive oxygen species biosynthetic processGO:190340980.026
regulation of catalytic activityGO:00507903040.026
response to glucocorticoidGO:00513842230.026
cellular response to nitrogen compoundGO:19016992100.026
regulation of cellular amino acid metabolic processGO:000652120.026
nitrogen compound transportGO:00717052290.025
single organism cellular localizationGO:19025801020.025
organic acid transportGO:00158491160.025
regulation of transferase activityGO:00513381230.025
negative regulation of cell communicationGO:00106481580.025
organic anion transportGO:00157111320.025
inflammatory responseGO:00069541500.025
rna biosynthetic processGO:00327743800.025
negative regulation of signalingGO:00230571570.025
response to nitrosative stressGO:005140920.024
cellular response to lipidGO:00713962010.024
p38mapk cascadeGO:003806610.024
response to peptideGO:19016522920.024
response to monosaccharideGO:00342841590.024
multicellular organism reproductionGO:00325042330.024
negative regulation of cell differentiationGO:0045596990.023
response to retinoic acidGO:0032526630.023
multicellular organismal reproductive processGO:00486092330.023
formation of primary germ layerGO:000170410.023
protein localizationGO:00081041910.023
positive regulation of macromolecule biosynthetic processGO:00105572470.023
reactive nitrogen species metabolic processGO:200105710.023
regulation of cellular ketone metabolic processGO:0010565270.023
regulation of synaptic transmissionGO:00508041410.023
cellular response to hormone stimulusGO:00328702470.023
regulation of intracellular signal transductionGO:19025312180.023
carbohydrate derivative biosynthetic processGO:19011371240.023
regulation of phosphate metabolic processGO:00192203490.023
regulation of molecular functionGO:00650093980.023
positive regulation of cellular biosynthetic processGO:00313282950.022
glycerolipid metabolic processGO:0046486670.022
regulation of hormone levelsGO:00108171870.022
positive regulation of multicellular organismal processGO:00512403870.022
regulation of cell proliferationGO:00421273590.022
positive regulation of cellular component organizationGO:00511302000.022
regulation of secretionGO:00510462240.022
digestive system developmentGO:0055123410.022
cellular response to corticosteroid stimulusGO:0071384690.022
response to hexoseGO:00097461440.022
developmental process involved in reproductionGO:00030061590.022
response to corticosteroidGO:00319602350.022
regulation of rna biosynthetic processGO:20011413810.021
vascular process in circulatory systemGO:0003018960.021
neuron differentiationGO:00301823680.021
response to ketoneGO:19016541820.021
positive regulation of programmed cell deathGO:00430681570.021
regulation of anatomical structure morphogenesisGO:00226031410.021
cellular response to metal ionGO:0071248550.021
response to glucoseGO:00097491360.021
positive regulation of cellular amine metabolic processGO:003324030.021
positive regulation of cellular amino acid metabolic processGO:004576410.021
transmembrane transportGO:00550854120.021
nucleic acid templated transcriptionGO:00976593790.020
positive regulation of cell communicationGO:00106472710.020
g protein coupled receptor signaling pathwayGO:00071862420.020
defense responseGO:00069521940.020
retinal metabolic processGO:004257430.020
catabolic processGO:00090563510.020
response to transition metal nanoparticleGO:19902671220.020
single organism organelle organizationGO:19025891800.020
alpha amino acid biosynthetic processGO:1901607230.020
response to cadmium ionGO:0046686350.020
positive regulation of catalytic activityGO:00430851840.020
wound healingGO:00420601220.020
tube formationGO:003514830.020
response to amino acidGO:0043200750.020
anatomical structure formation involved in morphogenesisGO:0048646830.019
regulation of reactive oxygen species metabolic processGO:2000377260.019
positive regulation of signal transductionGO:00099671750.019
negative regulation of cellular component organizationGO:0051129830.019
regulation of anion transportGO:0044070430.019
regenerationGO:00310991630.019
positive regulation of apoptotic processGO:00430651540.019
negative regulation of neuron deathGO:1901215690.019
cellular homeostasisGO:00197252520.019
regulation of system processGO:00440572080.019
response to toxic substanceGO:00096361330.019
regulation of protein metabolic processGO:00512462890.019
negative regulation of catalytic activityGO:00430861030.019
synaptic transmissionGO:00072682350.019
lipid localizationGO:0010876620.019
carbohydrate derivative metabolic processGO:19011353460.018
positive regulation of transcription from rna polymerase ii promoter in response to stressGO:003600330.018
regulation of multicellular organismal developmentGO:20000263760.018
regulation of phosphorylationGO:00423252480.018
transcription from rna polymerase ii promoterGO:00063662520.018
lipid biosynthetic processGO:00086101280.018
negative regulation of multicellular organismal processGO:00512412030.018
regulation of rna metabolic processGO:00512523910.017
response to interleukin 1GO:0070555550.017
cell type specific apoptotic processGO:00972851340.017
positive regulation of signalingGO:00230562700.017
regulation of secretion by cellGO:19035302080.017
peptidyl tyrosine modificationGO:0018212720.017
organophosphate biosynthetic processGO:00904071430.017
positive regulation of biosynthetic processGO:00098913190.017
cellular response to alcoholGO:0097306870.017
cellular response to organonitrogen compoundGO:00714171970.017
protein tetramerizationGO:0051262380.017
reproductive structure developmentGO:00486081280.017
cellular cation homeostasisGO:00300031800.017
regulation of nervous system developmentGO:00519602640.017
rna metabolic processGO:00160704060.017
cellular response to peptideGO:19016531330.017
response to growth factorGO:00708481890.017
negative regulation of cell proliferationGO:00082851190.016
hepaticobiliary system developmentGO:0061008900.016
anterior posterior pattern specificationGO:000995210.016
rhythmic processGO:00485111560.016
regulation of kinase activityGO:00435491170.016
anion transportGO:00068201780.016
cellular response to endogenous stimulusGO:00714953770.016
neuron projection developmentGO:00311752730.016
purine containing compound metabolic processGO:00725212530.016
circulatory system developmentGO:00723591340.016
response to hypoxiaGO:00016662310.016
response to external biotic stimulusGO:00432072210.016
neuron developmentGO:00486662860.016
carboxylic acid transportGO:00469421150.016
cellular response to abiotic stimulusGO:0071214850.016
regulation of response to stressGO:00801341260.015
monocarboxylic acid transportGO:0015718520.015
hormone metabolic processGO:0042445690.015
regulation of hormone secretionGO:00468831060.015
regulation of p38mapk cascadeGO:190074410.015
multi organism reproductive processGO:00447032620.015
placenta developmentGO:0001890220.015
positive regulation of gene expressionGO:00106282440.015
cellular response to glucocorticoid stimulusGO:0071385680.015
intracellular transportGO:00469071850.015
positive regulation of intracellular signal transductionGO:19025331380.015
alcohol metabolic processGO:0006066770.015
positive regulation of cell differentiationGO:00455972170.015
establishment of protein localizationGO:00451841410.015
amide transportGO:00428861050.015
positive regulation of ligase activityGO:005135110.015
positive regulation of nitrogen compound metabolic processGO:00511733340.015
pyridine containing compound metabolic processGO:0072524320.015
regulation of reactive oxygen species biosynthetic processGO:190342650.015
peptidyl tyrosine phosphorylationGO:0018108720.015
response to estradiolGO:00323551640.014
regulation of neuron differentiationGO:00456642080.014
regulation of arp2 3 complex mediated actin nucleationGO:003431520.014
response to bacteriumGO:00096172000.014
epithelium developmentGO:0060429960.014
prostaglandin secretionGO:003231060.014
negative regulation of macromolecule metabolic processGO:00106052600.014
embryonic pattern specificationGO:000988010.014
positive regulation of cell proliferationGO:00082842490.014
membrane organizationGO:0061024940.014
isoprenoid metabolic processGO:0006720450.014
cell projection organizationGO:00300303020.014
spermatogenesisGO:0007283990.013
cation homeostasisGO:00550801950.013
organelle inheritanceGO:004830820.013
response to molecule of bacterial originGO:00022371940.013
negative regulation of neurogenesisGO:0050768780.013
negative regulation of metabolic processGO:00098923310.013
regulation of peptide transportGO:0090087870.013
regulation of fatty acid transportGO:2000191100.013
cellular response to oxygen levelsGO:0071453600.013
regulation of ion transportGO:00432692450.013
protein autophosphorylationGO:0046777660.013
cation transportGO:00068123820.013
behaviorGO:00076102050.013
multi multicellular organism processGO:00447061380.013
regulation of embryonic developmentGO:004599520.013
actin filament based processGO:0030029860.013
chemical homeostasisGO:00488782920.013
signal releaseGO:00230611450.013
dna metabolic processGO:0006259960.013
cellular macromolecule localizationGO:00707271220.013
carbohydrate homeostasisGO:0033500750.013
negative regulation of phosphorus metabolic processGO:0010563800.013
gland developmentGO:00487321550.012
regulation of blood circulationGO:19035221100.012
response to nicotineGO:0035094510.012
muscle cell proliferationGO:0033002840.012
regulation of membrane potentialGO:00423911100.012
positive regulation of protein modification processGO:00314011420.012
positive regulation of hydrolase activityGO:0051345860.012
response to calcium ionGO:0051592590.012
regulation of insulin secretionGO:0050796650.012
negative regulation of cellular metabolic processGO:00313242810.012
stress activated protein kinase signaling cascadeGO:0031098370.012
dna replicationGO:0006260370.012
cytoskeleton dependent cytokinesisGO:006164020.012
carbohydrate metabolic processGO:00059751300.012
regulation of protein modification processGO:00313991940.012
oxidoreduction coenzyme metabolic processGO:0006733310.012
tissue developmentGO:00098882520.012
cytokine productionGO:0001816610.012
response to manganese ionGO:0010042130.012
positive regulation of lipid biosynthetic processGO:0046889250.012
regulation of protein kinase activityGO:00458591050.012
ion homeostasisGO:00508012120.012
purine nucleoside metabolic processGO:00422781690.012
nucleotide metabolic processGO:00091172790.012
cellular response to inorganic substanceGO:0071241650.011
immune responseGO:00069551040.011
peptide transportGO:0015833970.011
regulation of nucleic acid templated transcriptionGO:19035063800.011
positive regulation of defense responseGO:0031349370.011
digestive tract developmentGO:0048565390.011
ras protein signal transductionGO:0007265290.011
positive regulation of transcription dna templatedGO:00458931970.011
regulation of protein localizationGO:0032880810.011
negative regulation of protein metabolic processGO:00512481140.011
nicotinamide nucleotide metabolic processGO:0046496280.011
response to alkaloidGO:00432791320.011
regulation of peptide secretionGO:0002791820.011
cellular catabolic processGO:00442482950.011
nucleocytoplasmic transportGO:0006913480.011
liver developmentGO:0001889900.011
hydrogen peroxide metabolic processGO:0042743130.011
inner ear receptor cell differentiationGO:006011320.011
single organism behaviorGO:00447081300.011
cellular ion homeostasisGO:00068731840.011
morphogenesis of embryonic epitheliumGO:001633130.011
small gtpase mediated signal transductionGO:0007264360.011
regulation of lipid metabolic processGO:0019216680.011
cytoskeleton organizationGO:00070101110.011
heart morphogenesisGO:000300730.011
negative regulation of transportGO:00510511360.011
gamete generationGO:00072761240.011
alpha amino acid catabolic processGO:1901606200.011
regulation of tube sizeGO:0035150890.011
response to osmotic stressGO:0006970420.011
regulation of cell motilityGO:20001451310.011
glucose homeostasisGO:0042593750.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
cellular metal ion homeostasisGO:00068751720.011
positive regulation of cellular protein metabolic processGO:00322701670.011
regulation of muscle system processGO:0090257790.011
serine family amino acid metabolic processGO:0009069120.010
acid secretionGO:0046717480.010
positive regulation of reactive oxygen species metabolic processGO:2000379160.010
generation of precursor metabolites and energyGO:0006091620.010
steroid biosynthetic processGO:0006694480.010
reproductionGO:00000032450.010
regulation of response to external stimulusGO:00321011060.010
cellular response to steroid hormone stimulusGO:0071383930.010
multicellular organismal homeostasisGO:0048871490.010
positive regulation of endothelial cell migrationGO:001059540.010
negative regulation of muscle cell apoptotic processGO:0010656210.010
positive regulation of nucleobase containing compound metabolic processGO:00459353190.010
regulation of smoothened signaling pathwayGO:000858920.010
regulation of cellular response to stressGO:0080135490.010
cellular response to lipopolysaccharideGO:0071222550.010
positive regulation of immune system processGO:0002684900.010
chromosome segregationGO:000705920.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.022
disease of cellular proliferationDOID:1456600.022
cancerDOID:16200.022
disease of metabolismDOID:001466700.015
disease of anatomical entityDOID:700.014
nervous system diseaseDOID:86300.014
inherited metabolic disorderDOID:65500.011